SUPERFAMILY 1.75 HMM library and genome assignments server


Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (2,443) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 38,603 111,623 50
Proteins 35,703 103,654 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.44431Least InformativeInherited
Biological Process (BP)single-organism cellular process0.62851Least InformativeInherited
Biological Process (BP)microtubule-based process3.107e-052.762e-07InformativeDirect
Biological Process (BP)response to inorganic substance0.00076330.006289InformativeInherited
Biological Process (BP)response to cadmium ion7.422e-060.0001037Highly InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds5.484e-091InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 2.705e-13 Least Informative Direct
Biological Process (BP) biosynthetic process 8.333e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 2.816e-10 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.791e-08 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.88e-08 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 5.16e-07 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002804 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3468 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03098 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.304 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2963 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01845 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.2361 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.001412 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7835 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1746 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.003527 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5856 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.4231 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.1835 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 2.762e-07 Informative Direct
Biological Process (BP) cellular amide metabolic process 7.835e-15 Informative Direct
Biological Process (BP) fatty acid metabolic process 4.738e-10 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 1.214e-08 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 6.894e-07 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 2.15e-06 Informative Direct
Biological Process (BP) hexose metabolic process 0.0001019 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.4357 Informative Inherited
Biological Process (BP) protein oligomerization 0.05364 Informative Inherited
Biological Process (BP) response to inorganic substance 0.006289 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.1186 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6709 Informative Inherited
Biological Process (BP) cell projection organization 0.6566 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.699 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.7456 Informative Inherited
Biological Process (BP) synaptic transmission 0.02408 Informative Inherited
Biological Process (BP) secretion 0.07779 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.09786 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.2954 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0337 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3741 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.7787 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.01002 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001034 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.002061 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.1998 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.0382 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.00592 Informative Inherited
Biological Process (BP) response to cadmium ion 0.0001037 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 2.076e-15 Highly Informative Direct
Biological Process (BP) polyol metabolic process 1.728e-10 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 1.043e-09 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 1.308e-07 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 1.776e-07 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 4.983e-07 Highly Informative Direct
Biological Process (BP) cell projection assembly 2.91e-05 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0001321 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.0001471 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0002932 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.0003044 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0003148 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0003666 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0004707 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0004965 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.009549 Highly Informative Inherited
Biological Process (BP) signal release 0.001107 Highly Informative Inherited
Biological Process (BP) nonribosomal peptide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.05033 Highly Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.5206 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 2.568e-06 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.299 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.34 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.9208 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 1.128e-05 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.000998 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.6846 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.001517 Informative Inherited
Molecular Function (MF) sulfur compound binding 0 Highly Informative Direct
Molecular Function (MF) magnesium ion binding 1.338e-07 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 3.343e-05 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0003451 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.03282 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.4275 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 8.318e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9214 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05148 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 6.211e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02881 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5627 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1759 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01284 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.09752 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.006138 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0002004 Informative Direct
Cellular Component (CC) synapse 0.0002029 Informative Direct
Cellular Component (CC) coated vesicle 0.0003293 Informative Direct
Cellular Component (CC) cell projection part 0.002736 Informative Inherited
Cellular Component (CC) cilium part 4.782e-10 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 1.15e-05 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0008704 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.01165 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.05694 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase2.328e-15Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase2.558e-15Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase1.025e-10Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase1.639e-07Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase4.259e-06Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase1.238e-05Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.0719Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09934Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis2.041e-06Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.04699Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperammonemia5.136e-05InformativeDirect
Phenotypic Abnormality (PA)Seizures0.0003275InformativeDirect
Phenotypic Abnormality (PA)Coma0.00035InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0007239InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.001649InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01557InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4937Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.54Moderately InformativeInherited
Mammalian Phenotype (MP)increased synaptic depression1.698e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.0009543InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.004499InformativeInherited
Worm Phenotype (WP)clear3.943e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001922Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization0.4118Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0008893InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0.01002Least InformativeInherited
Plant ANatomical entity (PAN)plant cell0.2072Least InformativeInherited
Plant ANatomical entity (PAN)guard cell7.501e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase1.261e-10Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)7.688e-06Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase5.337e-05Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.003771Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins7.396e-05Least InformativeDirect
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis2.877e-05Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.02764InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection1.113e-10Moderately InformativeDirect
Cellular componentMicrotubule0.0001127InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0001358Moderately InformativeDirect
DomainRepeat3.858e-07Least InformativeDirect
DomainTransit peptide1.361e-06Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)gluconeogenesis4.508e-06InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0001234InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.6314InformativeInherited
UniPathway (UP)fatty acid biosynthesis0.6664InformativeInherited
UniPathway (UP)metabolic intermediate degradation0.7773InformativeInherited
UniPathway (UP)glutathione biosynthesis0Highly InformativeDirect
UniPathway (UP)L-leucine degradation3.984e-07Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation1.893e-05Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis9.733e-05Highly InformativeDirect
UniPathway (UP)carbon fixation0.0001291Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.000179Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]