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Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,178) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,145 233,197 50
Proteins 44,532 215,931 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000001052 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000001294 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9744 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.00758 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.000000000000007239 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000001103 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.000002469 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000036 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000005097 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0009978 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.04283 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.6586 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.5108 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.002729 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02529 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.01162 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.001704 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.5608 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7288 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001784 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.2732 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0121 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.000000000000448 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0000000475 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000001823 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000002898 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.000007339 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00002873 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0005895 Informative Direct
Biological Process (BP) organelle assembly 0.04709 Informative Inherited
Biological Process (BP) protein oligomerization 0.02313 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1102 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.0587 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.2427 Informative Inherited
Biological Process (BP) microtubule-based process 0.02198 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.1752 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.5896 Informative Inherited
Biological Process (BP) secretion 0.04316 Informative Inherited
Biological Process (BP) central nervous system development 0.9149 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.004118 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001579 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.2424 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6553 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.005788 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.5456 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.05428 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.03596 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.689 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00000000002001 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00000000008343 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000000001008 Highly Informative Direct
Biological Process (BP) detoxification 0.0000003367 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00001072 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00002528 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.00002735 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00006052 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00009834 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.000156 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0001573 Highly Informative Direct
Biological Process (BP) signal release 0.0002065 Highly Informative Direct
Biological Process (BP) synaptic signaling 0.0003374 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0008503 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.05358 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.6021 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.2982 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.001264 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000001113 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.9528 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4403 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.3444 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine nucleoside binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) amide binding 0.000000000000001646 Informative Direct
Molecular Function (MF) magnesium ion binding 0.000007866 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00001686 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00002113 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00003352 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000351 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 0.0423 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.2022 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.003289 Informative Inherited
Molecular Function (MF) modified amino acid binding 0.00000000000005499 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.000000003332 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.00000002293 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00000004225 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000001103 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.000009764 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0006372 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.1407 Highly Informative Inherited
Molecular Function (MF) acid-amino acid ligase activity 0.006652 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000002996 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8776 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.7667 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9513 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.0519 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.02349 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.00646 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.0000001016 Informative Direct
Cellular Component (CC) lipid particle 0.00009088 Informative Direct
Cellular Component (CC) transport vesicle 0.0001759 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0003145 Informative Direct
Cellular Component (CC) secretory vesicle 0.0006266 Informative Direct
Cellular Component (CC) synapse 0.001075 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7068 Informative Inherited
Cellular Component (CC) cell projection part 0.002274 Informative Inherited
Cellular Component (CC) synaptic vesicle 0.0000003708 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.07509 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.000006188Moderately InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.00007729InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.000116InformativeDirect
Phenotypic Abnormality (PA)Hyperammonemia0.000003346Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8484Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.07329InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.1436InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.000521Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.002858Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.008187Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.03817Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.05197Least InformativeInherited
Worm Phenotype (WP)pigmentation variant0.002084InformativeInherited
Worm Phenotype (WP)muscle system morphology variant0.03586InformativeInherited
Worm Phenotype (WP)clear0.00006979Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.0002963Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.307Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.2998Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0006528InformativeDirect
Yeast Phenotype (YP)prion formation0.0002578Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)coelom0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005255Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009591Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01647Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1353Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.7114InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001188Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)0.00001571Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00009477Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.004413Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Forming carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.01025Least InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)biotin0.00000000003219InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.000006406Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.02613InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection0.000000826Moderately InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMicrotubule0.000000000002479InformativeDirect
Coding sequence diversityAlternative promoter usage0.0005652Moderately InformativeDirect
DomainRepeat0.000004895Least InformativeDirect
DomainTransit peptide0.0000007681Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.8867Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)gluconeogenesis0.000002232InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0001179InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.7198InformativeInherited
UniPathway (UP)metabolic intermediate degradation0.78InformativeInherited
UniPathway (UP)oligopeptide biosynthesis0Highly InformativeDirect
UniPathway (UP)L-leucine degradation0.000000378Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation0.0000275Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis0.0000373Highly InformativeDirect
UniPathway (UP)carbon fixation0.000126Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.0002322Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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