SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,183) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,334 283,659 50
Proteins 44,715 264,501 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000000001102 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00004529 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.46 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9416 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.000000000000001945 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000002085 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000009245 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00000967 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0001849 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0002729 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0004215 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.5951 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.001153 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.007284 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.845 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01897 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.6565 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.5574 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.0042 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9303 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.02115 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5875 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.00138 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4291 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.4205 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.0000000000003405 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000003888 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000001843 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000005533 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00001518 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00005153 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002286 Informative Direct
Biological Process (BP) cell-cell signaling 0.4025 Informative Inherited
Biological Process (BP) organelle assembly 0.0855 Informative Inherited
Biological Process (BP) protein oligomerization 0.04533 Informative Inherited
Biological Process (BP) response to metal ion 0.2805 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.05314 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.02996 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.36 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5154 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.3558 Informative Inherited
Biological Process (BP) secretion by cell 0.3883 Informative Inherited
Biological Process (BP) central nervous system development 0.9385 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.2969 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.1133 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.002936 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001285 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.5605 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.08097 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.01544 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00000000001292 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00000000001544 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000000001871 Highly Informative Direct
Biological Process (BP) detoxification 0.00001294 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00002373 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00006319 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00008078 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0001163 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0001761 Highly Informative Direct
Biological Process (BP) signal release 0.0002168 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0003269 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0.0003355 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0004151 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0009832 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.2133 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.1177 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06216 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.002211 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000005359 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3705 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.3407 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0.000000000000004806 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000000006357 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00000948 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00002712 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00003565 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00008061 Informative Direct
Molecular Function (MF) kinase activity 0.02756 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.001484 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.2155 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.002715 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.00000000000008641 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.000000000003925 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.000000002624 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00000004805 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.00001474 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0006966 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.001188 Highly Informative Inherited
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) vitamin binding 0.002963 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.06713 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0000000002127 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.9317 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9416 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.04005 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.8609 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.3907 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.01092 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.0000002608 Informative Direct
Cellular Component (CC) synapse 0.001644 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.0349 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.687 Informative Inherited
Cellular Component (CC) synaptic vesicle 0.000000566 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.05434 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.000006516Moderately InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.0001092InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.0001099InformativeDirect
Phenotypic Abnormality (PA)Hyperammonemia0.000003605Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8772Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.05461InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.1671InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.000618Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.003187Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.009709Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.04195Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0004852Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00152Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1124Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.05877Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.09287Moderately InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.000009898InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00001181InformativeDirect
Worm Phenotype (WP)pigmentation variant0.002078InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.01667InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.1052InformativeInherited
Worm Phenotype (WP)osmotic avoidance variant0.00000001415Highly InformativeDirect
Worm Phenotype (WP)phasmid morphology variant0.0000001505Highly InformativeDirect
Worm Phenotype (WP)clear0.00006869Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.0002989Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3183Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.2945Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0006481InformativeDirect
Yeast Phenotype (YP)prion formation0.0002556Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)anatomical space0InformativeDirect
Zebrafish Anatomy (ZA)heart0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005255Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009591Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01647Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1353Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.6947InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001122Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00009644Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.004278Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Forming carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.000006577Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.0263InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection0.000003007Moderately InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMicrotubule0.000000000003567InformativeDirect
Coding sequence diversityAlternative promoter usage0.0006458Moderately InformativeDirect
DomainRepeat0.000004505Least InformativeDirect
DomainTransit peptide0.0000003728Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.8862Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)gluconeogenesis0.000002219InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0001072InformativeDirect
UniPathway (UP)metabolic intermediate degradation0.5995InformativeInherited
UniPathway (UP)fatty acid biosynthesis0.718InformativeInherited
UniPathway (UP)oligopeptide biosynthesis0Highly InformativeDirect
UniPathway (UP)L-leucine degradation0.0000003771Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation0.000003266Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis0.00003713Highly InformativeDirect
UniPathway (UP)carbon fixation0.0001259Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.0002319Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]