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Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,183) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,334 283,659 50
Proteins 44,715 264,501 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000000003667 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0001236 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.5188 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000507 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000002179 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000004279 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0002714 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0004275 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0004316 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01434 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3637 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9133 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.64 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.002557 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0107 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.001302 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9995 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003877 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.02451 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3093 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.7015 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6501 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.5663 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.0000000000004789 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000003677 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000002456 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000008793 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.000013 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00001843 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002113 Informative Direct
Biological Process (BP) protein oligomerization 0.05307 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.994 Informative Inherited
Biological Process (BP) response to metal ion 0.2813 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.3326 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.08551 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) organelle assembly 0.1109 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.376 Informative Inherited
Biological Process (BP) central nervous system development 0.9927 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5796 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001238 Informative Inherited
Biological Process (BP) cellular respiration 0.06723 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9725 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8841 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.3804 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.5746 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.06099 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.02078 Informative Inherited
Biological Process (BP) microtubule-based process 0.03911 Informative Inherited
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.00000000000006184 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00000000001354 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00000000001695 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000000001734 Highly Informative Direct
Biological Process (BP) detoxification 0.000014 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00003272 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.00004344 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00008612 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0000952 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0001747 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0002029 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.0002936 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.000845 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.2867 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.4202 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.0012 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.1313 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.07768 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.002174 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3014 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.0914 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000001426 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.425 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.9623 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.2941 Moderately Informative Inherited
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000009095 Informative Direct
Molecular Function (MF) magnesium ion binding 0.000009359 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00002891 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00004005 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0004357 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.2598 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.001355 Informative Inherited
Molecular Function (MF) kinase activity 0.02566 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.00000000000009825 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.000000000003796 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.0000000003453 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00000005364 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.00001577 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.0004399 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.000864 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) acid-amino acid ligase activity 0.001583 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.0283 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000000007984 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.06142 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.9534 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9593 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.8871 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4822 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cilium 0.0000004244 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.7218 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.03045 Informative Inherited
Cellular Component (CC) presynapse 0.0000002748 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.000005096 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.05886 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.000006076Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processCell shape0InformativeDirect
Biological processLipid biosynthesis0.02575InformativeInherited
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Cellular componentCell projection0.000001283Moderately InformativeDirect
Cellular componentCilium0InformativeDirect
Cellular componentMicrotubule0.0000000000008415InformativeDirect
Coding sequence diversityAlternative promoter usage0.0006506Moderately InformativeDirect
DomainRepeat0.000004985Least InformativeDirect
DomainTransit peptide0.0000003881Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]