SUPERFAMILY 1.75 HMM library and genome assignments server

Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,177) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,183 233,197 50
Proteins 44,573 215,931 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.45431Least InformativeInherited
Biological Process (BP)single-organism cellular process0.64870.01593Least InformativeInherited
Biological Process (BP)microtubule-based process0.00003260.00000005422InformativeDirect
Biological Process (BP)response to inorganic substance0.00056870.01269InformativeInherited
Biological Process (BP)response to cadmium ion0.0000028320.00002207Highly InformativeDirect
Molecular Function (MF)ligase activity0.0000000024250InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.0000000000045220.2328Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000000001562 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01593 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00000000001607 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00000000002632 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000002482 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00000001291 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000002411 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00002407 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0003129 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.4777 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.02518 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2555 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2311 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.8971 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.7792 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.07141 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7701 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.008502 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0164 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.8327 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.00000005422 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000000003081 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000000000176 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0.0000000006508 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000002251 Informative Direct
Biological Process (BP) organelle assembly 0.000000002489 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000001467 Informative Direct
Biological Process (BP) hexose metabolic process 0.0000001616 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000002639 Informative Direct
Biological Process (BP) peptide metabolic process 0.00005647 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000605 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0001691 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000178 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.6064 Informative Inherited
Biological Process (BP) protein oligomerization 0.06794 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.9255 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01269 Informative Inherited
Biological Process (BP) cell projection organization 0.06755 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.1161 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02289 Informative Inherited
Biological Process (BP) localization of cell 0.9539 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) secretion by cell 0.05707 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.001265 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.3165 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.02412 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.637 Informative Inherited
Biological Process (BP) sexual reproduction 0.9805 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.2684 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01541 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.01119 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.4411 Informative Inherited
Biological Process (BP) synaptic transmission 0.02418 Informative Inherited
Biological Process (BP) response to cadmium ion 0.00002207 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00000000000003082 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000000002698 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000000001186 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.0000000003303 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.0000000007577 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000000001223 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.00000001285 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.00001285 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00001983 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0.00001994 Highly Informative Direct
Biological Process (BP) signal release 0.00004949 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0003315 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.000497 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0006451 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.01097 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.111 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.005148 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2022 Highly Informative Inherited
Biological Process (BP) glutathione metabolic process 0.006763 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.05845 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0000000000001268 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000000445 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000006268 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.9925 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.9363 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.8467 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000000000007683 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000002484 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000008287 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000003893 Informative Direct
Molecular Function (MF) magnesium ion binding 0.00002188 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00007384 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0001028 Informative Direct
Molecular Function (MF) nucleotide binding 0.05527 Informative Inherited
Molecular Function (MF) kinase activity 0.07646 Informative Inherited
Molecular Function (MF) carboxy-lyase activity 0.0000009387 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00002909 Highly Informative Direct
Molecular Function (MF) hydroxymethyl-, formyl- and related transferase activity 0.000177 Highly Informative Direct
Molecular Function (MF) peptide binding 1 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.4478 Highly Informative Inherited
Molecular Function (MF) monocarboxylic acid binding 0.3125 Highly Informative Inherited
Molecular Function (MF) acid-amino acid ligase activity 0.2328 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00000000001136 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8633 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00002452 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.01632 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.2229 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.002371 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.00005683 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.00007452 Informative Direct
Cellular Component (CC) synapse 0.0004346 Informative Direct
Cellular Component (CC) ciliary part 0.0000008853 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.05606Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09928Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.000002438Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0.04534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.305Moderately InformativeInherited
Phenotypic Abnormality (PA)Hyperammonemia0.00005692InformativeDirect
Phenotypic Abnormality (PA)Seizures0.0003492InformativeDirect
Phenotypic Abnormality (PA)Coma0.0003866InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0007432InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.001717InformativeInherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.01366InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.6976Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.15InformativeInherited
Mammalian Phenotype (MP)abnormal social investigation0.0003352Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aggression-related behavior0.0005339Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.001303Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.0009543InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.004499InformativeInherited
Worm Phenotype (WP)clear0.00003943Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001922Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.2694Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3381Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0008129InformativeDirect
Yeast Phenotype (YP)prion formation0.0003504Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005228Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009546Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01642Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1352Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.4109InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with paired acceptors0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001292Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)0.00001485Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00009057Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004066Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)1Highly InformativeInherited
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.08523Least InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)biotin0.00000000006479InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.00001221Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processLipid biosynthesis0.03072InformativeInherited
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCell projection0.000000001032Moderately InformativeDirect
Cellular componentMicrotubule0.000118InformativeDirect
Cellular componentCilium0Highly InformativeDirect
Coding sequence diversityAlternative promoter usage0.0003726Moderately InformativeDirect
DomainRepeat0.00000044Least InformativeDirect
DomainTransit peptide0.000001189Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionBiotin0Highly InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)gluconeogenesis0.000004616InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0001194InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.7195InformativeInherited
UniPathway (UP)metabolic intermediate degradation0.7749InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.8466InformativeInherited
UniPathway (UP)oligopeptide biosynthesis0Highly InformativeDirect
UniPathway (UP)L-leucine degradation0.0000003821Highly InformativeDirect
UniPathway (UP)propanoyl-CoA degradation0.00002266Highly InformativeDirect
UniPathway (UP)malonyl-CoA biosynthesis0.00008771Highly InformativeDirect
UniPathway (UP)carbon fixation0.0001266Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.0001764Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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