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Glutathione synthetase ATP-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]


Superfamily statistics
Genomes (3,185) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 48,449 374,280 50
Proteins 44,826 348,983 47


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.0001175InformativeDirect
Enzyme Commission (EC)Ligases that form carbon-carbon bonds1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Cyclo-ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0.004511InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Glutathione synthase0Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0Highly InformativeDirect
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Biotin carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzin0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0.000000000000002328Highly InformativeDirect
Enzyme Commission (EC)Pyruvate carboxylase0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001025Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000001639Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000004259Highly InformativeDirect
Enzyme Commission (EC)Methylcrotonoyl-CoA carboxylase0.00001238Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine cyclo-ligase0.0007799Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1202Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.243Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.000001463Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.007026Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.000003941InformativeDirect
Phenotypic Abnormality (PA)Aciduria0.0006832InformativeDirect
Phenotypic Abnormality (PA)Hyperammonemia0.000002763Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8773Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.05355InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.0006193Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.003192Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.009265Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.04202Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0005466Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.003264Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1162Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.05696Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.06569Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00001221InformativeDirect
Worm Phenotype (WP)pigmentation variant0.002062InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.01671InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.09965InformativeInherited
Worm Phenotype (WP)osmotic avoidance variant0.00000001561Highly InformativeDirect
Worm Phenotype (WP)clear0.00006715Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.0003014Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3184Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.2945Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0006482InformativeDirect
Yeast Phenotype (YP)prion formation0.0002557Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)pericardial region0InformativeDirect
Zebrafish Anatomy (ZA)heart0Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005255Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009591Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01647Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1353Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.6949InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Forming carbon-carbon bonds0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001073Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00009707Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.004492Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Glutathione synthetase ATP-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]