SUPERFAMILY 1.75 HMM library and genome assignments server


SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,867) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,326 22,211 6
Proteins 8,157 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.18141Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.18651Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.37821Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.35411Least InformativeInherited
Biological Process (BP)biosynthetic process0.0046540.5469Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.010110Least InformativeInherited
Biological Process (BP)organophosphate metabolic process2.854e-070Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00087941.224e-05Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.0076480.9273Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process2.762e-050.1889Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.033761Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0048160.03392Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00320.03411Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0044160.03313Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.073970.2855Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.07460.136Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.050140.24Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00062177.225e-08InformativeDirect
Biological Process (BP)nucleotide biosynthetic process1.009e-055.488e-05InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process9.96e-074.921e-09InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00026520.0001371InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00069730.0395InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.0001541InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process8.773e-080.000121Highly InformativeDirect
Biological Process (BP)polyol metabolic process2.967e-070Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process5.743e-072.157e-05Highly InformativeDirect
Molecular Function (MF)transferase activity0.13390Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00025890Moderately InformativeDirect
Molecular Function (MF)kinase activity9.03e-050InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor1.935e-052.045e-05InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds3.588e-091.994e-07InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.062320.2388Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle1.793e-050.007181Least InformativeInherited
Cellular Component (CC)cytoskeleton1.605e-060.002165Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3075 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5469 Least Informative Inherited
Biological Process (BP) developmental process 0.1804 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07201 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.224e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.01998 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01367 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9421 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1889 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9273 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01012 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03392 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03411 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.03313 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2855 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.24 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.136 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 7.225e-08 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 5.488e-05 Informative Direct
Biological Process (BP) phosphorylation 7.27e-08 Informative Direct
Biological Process (BP) actin filament-based process 3.85e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 4.921e-09 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001371 Informative Direct
Biological Process (BP) growth 0.001203 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003891 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.1885 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.0395 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 2.324e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0003099 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.000121 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 2.157e-05 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 8.604e-06 Highly Informative Direct
Biological Process (BP) cell growth 0.001664 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02869 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.6971 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.045e-05 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.994e-07 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2388 Least Informative Inherited
Cellular Component (CC) membrane 0.1777 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.007181 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001433 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002165 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.3064 Moderately Informative Inherited
Cellular Component (CC) apical plasma membrane 7.538e-06 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.068e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.03529InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0001094Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.006389Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02042Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001573InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.000244InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006684InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.5934Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4088InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.8933InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding8.434e-05InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]