SUPERFAMILY 1.75 HMM library and genome assignments server


SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,859) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,078 22,211 6
Proteins 7,913 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.17971Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.18531Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.37561Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.35191Least InformativeInherited
Biological Process (BP)biosynthetic process0.0047140.5544Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.011390Least InformativeInherited
Biological Process (BP)organophosphate metabolic process3.425e-070Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00087491.208e-05Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.0076270.9255Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process3.312e-050.1871Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.033971Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0051830.04203Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0034660.04232Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0046560.04076Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.074930.2877Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.074090.1347Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.049750.2407Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00061057.031e-08InformativeDirect
Biological Process (BP)nucleotide biosynthetic process1.094e-055.273e-05InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process1.1e-067.028e-09InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00025190.0001315InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00069830.03915InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00016921InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process9.622e-080.0001171Highly InformativeDirect
Biological Process (BP)polyol metabolic process3.395e-070Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process5.605e-072.022e-05Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00028560Moderately InformativeDirect
Molecular Function (MF)kinase activity9.914e-050InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.157e-052.055e-05InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds4.024e-093.122e-07InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.061850.2346Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle2.48e-050.008454Least InformativeInherited
Cellular Component (CC)cytoskeleton1.809e-060.002166Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.375 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5544 Least Informative Inherited
Biological Process (BP) developmental process 0.2359 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09466 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.208e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.02586 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01707 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1882 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9422 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1871 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9255 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01208 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.04203 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04232 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.04076 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2877 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2407 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1347 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 7.031e-08 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 5.273e-05 Informative Direct
Biological Process (BP) phosphorylation 7.489e-08 Informative Direct
Biological Process (BP) actin filament-based process 4.828e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 7.028e-09 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001315 Informative Direct
Biological Process (BP) growth 0.002066 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003807 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.1982 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.03915 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 2.666e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0002963 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.0001171 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 2.022e-05 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 6.74e-06 Highly Informative Direct
Biological Process (BP) cell growth 0.001505 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02598 Highly Informative Inherited
Molecular Function (MF) binding 0.8012 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.055e-05 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 3.122e-07 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2346 Least Informative Inherited
Cellular Component (CC) membrane 0.1799 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.008454 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001823 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002166 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.2457 Moderately Informative Inherited
Cellular Component (CC) apical plasma membrane 8.061e-06 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.068e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.03482InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0001001Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.00611Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02039Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001392InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002162InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006703InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.5943Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4098InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.8949InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding8.52e-05InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]