SUPERFAMILY 1.75 HMM library and genome assignments server


SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,822) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 7,426 10,994 6
Proteins 7,281 10,890 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.17931Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.18531Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.37641Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.35241Least InformativeInherited
Biological Process (BP)biosynthetic process0.0044730.4767Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0098890Least InformativeInherited
Biological Process (BP)organophosphate metabolic process1.74e-070Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.00087983.643e-05Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.0077380.8985Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process1.439e-060.1954Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.032991Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0014830.01985Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00084180.02023Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0011870.01884Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.07380.297Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.073210.1358Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.046810.199Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00061653.219e-07InformativeDirect
Biological Process (BP)nucleotide biosynthetic process1.892e-065.035e-05InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process2.086e-071.661e-09InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00024340.0001025InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00062140.03645InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process3.646e-051InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process1.662e-080.0001056Highly InformativeDirect
Biological Process (BP)polyol metabolic process7.262e-080Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process1.208e-071.082e-05Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups4.19e-050Moderately InformativeDirect
Molecular Function (MF)kinase activity1.391e-050InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.863e-062.663e-05InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds3.051e-106.743e-08InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.1557 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5004 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4767 Least Informative Inherited
Biological Process (BP) developmental process 0.05975 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02016 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 3.643e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.01757 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1367 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9226 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1954 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.8985 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.009381 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01985 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02023 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01884 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.297 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.199 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1358 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 3.219e-07 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 5.035e-05 Informative Direct
Biological Process (BP) phosphorylation 6.271e-08 Informative Direct
Biological Process (BP) actin filament-based process 4.206e-05 Informative Direct
Biological Process (BP) growth 0.000714 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.661e-09 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001025 Informative Direct
Biological Process (BP) response to nutrient levels 0.005187 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003722 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.1897 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.03645 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 1.352e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0003358 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.0001056 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 1.082e-05 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 7.453e-06 Highly Informative Direct
Biological Process (BP) cell growth 0.001567 Highly Informative Inherited
Biological Process (BP) developmental growth 0.0245 Highly Informative Inherited
Molecular Function (MF) binding 0.5114 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.663e-05 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 6.743e-08 Informative Direct
Cellular Component (CC) cytoplasmic part 0.575 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001427 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.068e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1179Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.02592InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis6.289e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.005646Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02462Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.00013InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0001744InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006686InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.6334Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4231InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.9057InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalmodulin-binding8.811e-05InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]