SUPERFAMILY 1.75 HMM library and genome assignments server

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SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,867) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,326 22,211 6
Proteins 8,157 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.10821Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.11121Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.26431Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.24381Least InformativeInherited
Biological Process (BP)biosynthetic process0.0022360.4225Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.005930Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.000000038480Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.015510.9235Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0014890.00001226Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0000049080.1923Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.050691Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.00086870.01476Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00051980.01478Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00078170.01441Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.032490.1953Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.034750.08561Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.020420.1575Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.00000051840.00001974InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000028410.0000000003339InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0004890.0001651InformativeDirect
Biological Process (BP)alcohol metabolic process0.0012660.0000001194InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process0.0013850.0507InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.6641InformativeInherited
Biological Process (BP)purine ribonucleotide biosynthetic process0.00050950.0004364Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.00000037390Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.00000060580.00001908Highly InformativeDirect
Molecular Function (MF)transferase activity0.13480Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00028510Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000098650InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000020720.00002552InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.0000000031820.0000001661InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.062150.237Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000018990.006914Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0000016460.002302Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3032 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4225 Least Informative Inherited
Biological Process (BP) developmental process 0.1742 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07087 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00001226 Moderately Informative Direct
Biological Process (BP) cellular localization 0.01998 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01348 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01483 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.1411 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9408 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1923 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9235 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.009932 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01476 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01478 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01441 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1953 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.1575 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.08561 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0000001194 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00001974 Informative Direct
Biological Process (BP) phosphorylation 0.0000002503 Informative Direct
Biological Process (BP) actin filament-based process 0.00003811 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000000003339 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001651 Informative Direct
Biological Process (BP) growth 0.001334 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003793 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.2867 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.0507 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.000002358 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.000612 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.0004364 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.00001908 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000853 Highly Informative Direct
Biological Process (BP) cell growth 0.001658 Highly Informative Inherited
Biological Process (BP) developmental growth 0.0292 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7041 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00002552 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.0000001661 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.237 Least Informative Inherited
Cellular Component (CC) membrane 0.1458 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.006914 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001425 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002302 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.3125 Moderately Informative Inherited
Cellular Component (CC) apical plasma membrane 0.000008121 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000000000001068Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.03548InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0001082Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.006415Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02043Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001608InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002473InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006617InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.5939Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4145InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.9146InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0.00008434InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]