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SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,874) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,455 30,237 6
Proteins 8,283 29,744 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.6071Least InformativeInherited
Biological Process (BP)biosynthetic process0.00010320.01554Least InformativeInherited
Biological Process (BP)single-organism cellular process0.017060.0000009468Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.026241Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.02681Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0019970Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.045921Least InformativeInherited
Biological Process (BP)primary metabolic process0.57581Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.047841Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.00000053850.000004294Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.0000000000023750Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.0001620.03303Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00005090.02231Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.18140.6021Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.052591Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.019980.3814Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00073320.000000000001073InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.0000000056860.0007094InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.00000000062570.000000006971InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00024950.00001558InformativeDirect
Biological Process (BP)polyol metabolic process0.000000089530Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.000000016090.0000001833Highly InformativeDirect
Molecular Function (MF)transferase activity0.23680Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0001870Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000050110InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0000092390.00000002611InformativeDirect
Molecular Function (MF)ligase activity0.00000000021280.0001697InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity00Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.010050.2415Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0001340.03367Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000014430.002728Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000009468 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5264 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.7217 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.684 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01554 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.7742 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000000005617 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000004294 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.1866 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02231 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.539 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4415 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1483 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4914 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.4227 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.6021 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2358 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.08047 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.08253 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3111 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7326 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03303 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.5186 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002487 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6644 Moderately Informative Inherited
Biological Process (BP) cell communication 0.1294 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.04275 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.3133 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6983 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3814 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.000000000001073 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000000000007433 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0007094 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0002551 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.0001968 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001325 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000000006971 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00001558 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.4077 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01626 Informative Inherited
Biological Process (BP) post-embryonic development 0.00174 Informative Inherited
Biological Process (BP) regulation of growth 0.003527 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1798 Informative Inherited
Biological Process (BP) cell death 0.1102 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.00304 Informative Inherited
Biological Process (BP) cell development 0.06137 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3364 Informative Inherited
Biological Process (BP) response to radiation 0.01875 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.1077 Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.0000006419 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0005149 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.0000000269 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.000002117 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0000001833 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0003677 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0003754 Highly Informative Direct
Biological Process (BP) lipid modification 0.008184 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7873 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000002611 Informative Direct
Molecular Function (MF) ligase activity 0.0001697 Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.1285 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6175 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2415 Least Informative Inherited
Cellular Component (CC) membrane 0.003875 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.03367 Least Informative Inherited
Cellular Component (CC) cell projection 0.0003785 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002728 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1433 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0.0006247 Informative Direct
Cellular Component (CC) plasma membrane region 0.000002175 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.5142 Informative Inherited
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0006048 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000000000001068Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0.0000143InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]