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SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,869) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,386 22,211 6
Proteins 8,215 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.00053740Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.055371Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.085081Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.054371Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.1071Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.16971Least InformativeInherited
Biological Process (BP)biosynthetic process0.00072920.0204Least InformativeInherited
Biological Process (BP)single-organism cellular process0.012680.0000000218Least InformativeInherited
Biological Process (BP)primary metabolic process0.4911Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.00000098580.000003198Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.000000004610Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.17180.619Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.084441Moderately InformativeInherited
Biological Process (BP)nucleobase-containing compound biosynthetic process0.000026720.001733Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00068640.000000000003252InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.000000005880.0008215InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.00000000073610.00000000627InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00017460.0000103InformativeDirect
Biological Process (BP)polyol metabolic process0.00000010150Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.000000017540.0000001906Highly InformativeDirect
Molecular Function (MF)transferase activity0.23370Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00018290Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000048240InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0000085910.0000000895InformativeDirect
Molecular Function (MF)ligase activity0.00000000022920.00008073InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity00Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.013010.1821Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000021290.001916Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000218 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.6512 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.0204 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000000002976 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000003198 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) system development 0.5097 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.619 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0608 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06034 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2478 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.001733 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.9455 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.2139 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07058 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.000000000003252 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0000000000002696 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0008215 Informative Direct
Biological Process (BP) post-embryonic development 0.0006412 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000000627 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000103 Informative Direct
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) cell death 0.09264 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.003756 Informative Inherited
Biological Process (BP) cell development 0.04791 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.1195 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1295 Informative Inherited
Biological Process (BP) metamorphosis 0.00009369 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.0000006579 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0000001906 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.00004211 Highly Informative Direct
Biological Process (BP) lipid modification 0.003097 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7973 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.148 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000895 Informative Direct
Molecular Function (MF) ligase activity 0.00008073 Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.1018 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1821 Least Informative Inherited
Cellular Component (CC) membrane 0.01999 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.3611 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001328 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.001916 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0.0004692 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001102 Informative Direct
Cellular Component (CC) cell projection part 0.0483 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.00001888 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000000000001068Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.0483InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0002285Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.01013Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.01694Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001857InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002804InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0005792InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06716Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006175InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.4361Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4199InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0.00008784InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]