SUPERFAMILY 1.75 HMM library and genome assignments server

SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,868) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,360 22,211 6
Proteins 8,189 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.1360.00000000007676Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0065190Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.27131Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.11871Least InformativeInherited
Biological Process (BP)biosynthetic process0.0019990.4216Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.11531Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.24951Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.000000053450Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.033760.08119Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.092490.3103Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0019510.00002166Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0000078370.1998Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.00088980.01765Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.057611Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0021050.158Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00059630.01804Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.033880.2129Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.00097440.01797Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.00000052080.00001225InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000029010.0000000003318InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0008040.0002764InformativeDirect
Biological Process (BP)alcohol metabolic process0.001360.00000009778InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process0.0011410.04294InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.70651InformativeInherited
Biological Process (BP)inositol phosphate metabolic process0.0000000047880Highly InformativeDirect
Biological Process (BP)polyol biosynthetic process0.000000012280.00001498Highly InformativeDirect
Molecular Function (MF)transferase activity0.16710Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00029110Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000098290InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000021480.00002574InformativeDirect
Molecular Function (MF)ligase activity0.0000000048740.00005843InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.0000000000013240Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.063630.3111Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000013440.002741Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000180.002254Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000007676 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3543 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09424 Least Informative Inherited
Biological Process (BP) developmental process 0.1778 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4216 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00002166 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.08119 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05093 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9429 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.3103 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01263 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02285 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.6173 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01003 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01765 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01804 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1998 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2129 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.01797 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.158 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.00000009778 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00001225 Informative Direct
Biological Process (BP) phosphorylation 0.000002983 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000000003318 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0002764 Informative Direct
Biological Process (BP) cytoskeleton organization 0.003881 Informative Inherited
Biological Process (BP) actin filament-based process 0.004569 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.004477 Informative Inherited
Biological Process (BP) growth 0.001358 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.04294 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.3503 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.000002449 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0004095 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) polyol biosynthetic process 0.00001498 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00002769 Highly Informative Direct
Biological Process (BP) developmental growth 0.02407 Highly Informative Inherited
Biological Process (BP) cell growth 0.0197 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7397 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00002574 Informative Direct
Molecular Function (MF) ligase activity 0.00005843 Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.3111 Least Informative Inherited
Cellular Component (CC) membrane 0.1517 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.002741 Least Informative Inherited
Cellular Component (CC) cytosol 0.00005812 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002254 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.2952 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.02604 Moderately Informative Inherited
Cellular Component (CC) plasma membrane region 0.001313 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.00001258 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000000000001068Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1789Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.04382InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0001547Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.00642Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02043Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001601InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002474InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006591InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.587Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4121InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.9119InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding0.00008243InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]