SUPERFAMILY 1.75 HMM library and genome assignments server

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SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,874) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,455 30,237 6
Proteins 8,283 29,744 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00044910.01347Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.053181Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.085721Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.71151Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.083781Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.052351Least InformativeInherited
Biological Process (BP)single-organism cellular process0.035430.000001549Least InformativeInherited
Biological Process (BP)primary metabolic process0.65311Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0062050Least InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.0000083530.00002245Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.000000000060590.000000000000003764Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.12390.5639Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.00062320.06585Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00028510.04689Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.045140.5171Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.098761Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00038750.0000000000004197InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000025370.00000008276InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00013280.00001204InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.00000017720.001699InformativeInherited
Biological Process (BP)polyol metabolic process0.000000080150Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.000000013030.0000001454Highly InformativeDirect
Molecular Function (MF)transferase activity0.16710Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00015910Moderately InformativeDirect
Molecular Function (MF)kinase activity0.000044060InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0000081230.00000007086InformativeDirect
Molecular Function (MF)ligase activity0.0000000053240.0003826InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.000000000000005410Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0094070.235Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000096180.016Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000010650.002302Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000001549 Least Informative Direct
Biological Process (BP) biosynthetic process 0.01347 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.795 Least Informative Inherited
Biological Process (BP) biological regulation 0.7169 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000000003438 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00002245 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.09559 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.5639 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.9134 Moderately Informative Inherited
Biological Process (BP) system development 0.5277 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2876 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0607 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06241 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.2668 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.06585 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04689 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5171 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0000000000004197 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000000000001612 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00000008276 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00001204 Informative Direct
Biological Process (BP) cell death 0.09561 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1445 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.004057 Informative Inherited
Biological Process (BP) actin filament-based process 0.01617 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.003287 Informative Inherited
Biological Process (BP) cell development 0.04127 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.001699 Informative Inherited
Biological Process (BP) post-embryonic development 0.001345 Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.0005558 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0000001454 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.008185 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7319 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00000007086 Informative Direct
Molecular Function (MF) ligase activity 0.0003826 Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.1105 Highly Informative Inherited
Cellular Component (CC) membrane 0.01808 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.235 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.016 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.2853 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001391 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.002302 Moderately Informative Inherited
Cellular Component (CC) apical part of cell 0.0004393 Informative Direct
Cellular Component (CC) plasma membrane region 0.00001613 Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0.000000000001068Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)reproductive system phenotype0.3189Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.05636InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0002841Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.01011Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.01631Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001881InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002807InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0005756InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06716Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006175InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.401Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4189InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0.0000146InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]