SUPERFAMILY 1.75 HMM library and genome assignments server


SAICAR synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SAICAR synthase-like [ 56103]
Superfamily:   SAICAR synthase-like [ 56104] (3)
Families:   SAICAR synthase [ 56105]
  Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]
  Inositol polyphosphate kinase (IPK) [ 111188]


Superfamily statistics
Genomes (2,867) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,326 22,211 6
Proteins 8,157 22,022 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)heterocycle metabolic process0.10941Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.11251Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.26611Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.24581Least InformativeInherited
Biological Process (BP)biosynthetic process0.0022350.424Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0058910Least InformativeInherited
Biological Process (BP)organophosphate metabolic process4.236e-080Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.015420.9242Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0014591.06e-05Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process5.194e-060.1912Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.052481Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.00094480.0175Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00057360.01755Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0008620.01719Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.034330.2168Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.034830.08683Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.021690.1594Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process5.252e-071.956e-05InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process2.92e-083.392e-10InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00052010.0001711InformativeDirect
Biological Process (BP)alcohol metabolic process0.0012981.258e-07InformativeInherited
Biological Process (BP)ribose phosphate biosynthetic process0.0013580.05052InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.67481InformativeInherited
Biological Process (BP)polyol metabolic process3.986e-070Highly InformativeDirect
Molecular Function (MF)transferase activity0.13480Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00028310Moderately InformativeDirect
Molecular Function (MF)kinase activity9.788e-050InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.057e-052.474e-05InformativeDirect
Molecular Function (MF)ligase activity9.601e-080.01113InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.061560.2344Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle1.937e-050.007047Least InformativeInherited
Cellular Component (CC)cytoskeleton1.629e-060.002344Moderately InformativeInherited
Cellular Component (CC)intermediate filament cytoskeleton00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.3116 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.424 Least Informative Inherited
Biological Process (BP) developmental process 0.1747 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07458 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.06e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.02054 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.01354 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01596 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.9345 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.1912 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9242 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01007 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0175 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01755 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.01719 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2168 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.1594 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.08683 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 1.258e-07 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 1.956e-05 Informative Direct
Biological Process (BP) phosphorylation 2.57e-07 Informative Direct
Biological Process (BP) actin filament-based process 3.816e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 3.392e-10 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001711 Informative Direct
Biological Process (BP) growth 0.001368 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003735 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.2752 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.05052 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase metabolic process 2.382e-06 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0006151 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) maintenance of location 8.262e-06 Highly Informative Direct
Biological Process (BP) cell growth 0.001696 Highly Informative Inherited
Biological Process (BP) developmental growth 0.02757 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.005132 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7156 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.474e-05 Informative Direct
Molecular Function (MF) ligase activity 0.01113 Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2344 Least Informative Inherited
Cellular Component (CC) membrane 0.152 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.007047 Least Informative Inherited
Cellular Component (CC) cytosol 0.00015 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.002344 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.318 Moderately Informative Inherited
Cellular Component (CC) apical plasma membrane 8.223e-06 Highly Informative Direct
Cellular Component (CC) intermediate filament cytoskeleton 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.9279Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.453InformativeInherited
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase1.068e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1789Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.04382InformativeInherited
Mammalian Phenotype (MP)abnormal spermiogenesis0.0001547Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0.00642Moderately InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.02043Moderately InformativeInherited
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0InformativeDirect
Yeast Phenotype (YP)intracellular transport0.0001601InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.0002474InformativeDirect
Yeast Phenotype (YP)utilization of nitrogen source0.0006591InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.06697Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.0006165InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.587Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.4121InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.9119InformativeInherited
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalmodulin-binding8.243e-05InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAICAR synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the SAICAR synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]