SUPERFAMILY 1.75 HMM library and genome assignments server


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,098) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 267,674 0 233
Proteins 261,235 0 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process1.821e-090Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis1.339e-060Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction5.286e-110Moderately InformativeDirect
Biological Process (BP)immune system process9.399e-060Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.0009560Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process6.417e-056.352e-13Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00021612.484e-13Moderately InformativeDirect
Biological Process (BP)single-organism developmental process2.2e-080Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process6.828e-050Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00016720Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.60380Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.74440.06615Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.97280Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.7783Moderately InformativeInherited
Biological Process (BP)regulation of localization18.344e-06Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.30066.286e-05Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.93591Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.67760Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0050742.806e-11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.04220Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0001640.04827Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.2121Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0026010Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.010640Moderately InformativeInherited
Biological Process (BP)tissue development0.016462.734e-10Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.86551Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.82471Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.67321Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.92791Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.6638Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.62010Moderately InformativeInherited
Biological Process (BP)organ development0.83610.1694Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.029731.422e-14Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.007730.03358Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway2.268e-060InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.00026990InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process1.703e-120InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth3.317e-070InformativeDirect
Biological Process (BP)regulation of kinase activity9.121e-071.51e-07InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process1.705e-060InformativeDirect
Biological Process (BP)glycerolipid metabolic process1.424e-050InformativeDirect
Biological Process (BP)cellular process involved in reproduction6.434e-100InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00057382.696e-06InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00017030.0003043InformativeDirect
Biological Process (BP)regulation of apoptotic process0.92611InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.6753InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0057875.412e-09InformativeInherited
Biological Process (BP)regulation of cell development0.096665.176e-05InformativeInherited
Biological Process (BP)response to cytokine stimulus0.64520.8739InformativeInherited
Biological Process (BP)regulation of organelle organization10InformativeInherited
Biological Process (BP)blood circulation0.00035470.4508InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.56290InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.065720InformativeInherited
Biological Process (BP)cytoskeleton organization0.02040InformativeInherited
Biological Process (BP)microtubule-based process0.028197.657e-13InformativeInherited
Biological Process (BP)protein complex assembly0.61121InformativeInherited
Biological Process (BP)organelle assembly0.030015.534e-06InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)regulation of growth0.7250InformativeInherited
Biological Process (BP)sexual reproduction0.0001170.1988InformativeInherited
Biological Process (BP)single organism reproductive process0.0010056.895e-08InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.38990.8588InformativeInherited
Biological Process (BP)regulation of intracellular transport0.016460.03066InformativeInherited
Biological Process (BP)positive regulation of transport0.82911InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.90251InformativeInherited
Biological Process (BP)response to inorganic substance0.52481InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)alcohol metabolic process0.24021InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.23050InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0093860InformativeInherited
Biological Process (BP)defense response10.7874InformativeInherited
Biological Process (BP)immune response0.91719.703e-05InformativeInherited
Biological Process (BP)mitotic cell cycle0.0028091.578e-09InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.045020InformativeInherited
Biological Process (BP)response to organic cyclic compound0.13361InformativeInherited
Biological Process (BP)response to lipid0.022471InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0077189.175e-14InformativeInherited
Biological Process (BP)reproductive system development0.52654.904e-06InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.54991.09e-09InformativeInherited
Biological Process (BP)regulation of cell cycle process10.2152InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.9136InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.23220.3439InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.019331.454e-07InformativeInherited
Biological Process (BP)muscle system process0.0033461InformativeInherited
Biological Process (BP)response to other organism0.0013613.253e-11InformativeInherited
Biological Process (BP)positive regulation of immune system process10.2816InformativeInherited
Biological Process (BP)regulation of response to stress0.0033370.0007927InformativeInherited
Biological Process (BP)regulation of immune response0.85650.888InformativeInherited
Biological Process (BP)sensory organ development0.27240.09823InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.5570.7485InformativeInherited
Biological Process (BP)embryonic organ development0.24150.02727InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0016070InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.11791InformativeInherited
Biological Process (BP)DNA damage checkpoint1.104e-060Highly InformativeDirect
Biological Process (BP)microtubule cytoskeleton organization8.861e-054.669e-07Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction4.26e-061.369e-07Highly InformativeDirect
Biological Process (BP)regulation of cell size8.222e-093.423e-08Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)fruiting body development0.00040581.772e-07Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade6.477e-150Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process2.564e-057.401e-11Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition8.973e-052.397e-11Highly InformativeDirect
Biological Process (BP)innate immune response7.415e-050Highly InformativeDirect
Biological Process (BP)regulation of innate immune response4.22e-104.724e-14Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity2.938e-073.424e-14Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.00048220Highly InformativeDirect
Biological Process (BP)response to cadmium ion8.038e-053.003e-05Highly InformativeDirect
Biological Process (BP)cell division0.00056390Highly InformativeDirect
Biological Process (BP)heart contraction0.00021389.035e-08Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00013490.0007408Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00067280Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.00012670Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.0074850.01599Highly InformativeInherited
Biological Process (BP)regulation of cell growth0.4450Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.045821.804e-10Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.014580Highly InformativeInherited
Biological Process (BP)female gamete generation0.80630.0714Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0012010.01724Highly InformativeInherited
Biological Process (BP)regulation of nucleocytoplasmic transport0.010790.7215Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0067090.03607Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.010473.331e-12Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0072380Highly InformativeInherited
Biological Process (BP)phosphatidylinositol metabolic process10.3265Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide1.656e-050.03092Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)positive regulation of cell differentiation0.0028490.6851Highly InformativeInherited
Biological Process (BP)post-embryonic development0.055287.202e-13Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34120.003474Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.002740.0004895Highly InformativeInherited
Biological Process (BP)immune response-regulating signaling pathway0.98460.001038Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.0017430.8137Highly InformativeInherited
Biological Process (BP)activation of immune response0.0017273.051e-11Highly InformativeInherited
Biological Process (BP)placenta development0.0044613.86e-09Highly InformativeInherited
Molecular Function (MF)binding3.615e-120Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00037650Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.63051Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding1.907e-082.187e-13InformativeDirect
Molecular Function (MF)magnesium ion binding0.00013130InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding1.281e-110InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding6.529e-130InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.014764.13e-12InformativeInherited
Molecular Function (MF)enzyme activator activity0.10340.403InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity1.643e-051.858e-07Highly InformativeDirect
Molecular Function (MF)kinase binding0.00075119.304e-11Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.37951Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle4.227e-051Least InformativeInherited
Cellular Component (CC)protein complex0.10610.001651Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.039973.329e-05Least InformativeInherited
Cellular Component (CC)cytoskeleton1.506e-070Moderately InformativeDirect
Cellular Component (CC)nuclear part0.00098631Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton9.122e-061.386e-11InformativeDirect
Cellular Component (CC)spindle2.224e-140Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex2.915e-150Highly InformativeDirect
Cellular Component (CC)midbody0.00038311.829e-12Highly InformativeDirect
Cellular Component (CC)neuromuscular junction4.116e-073.198e-10Highly InformativeDirect
Cellular Component (CC)adherens junction13.434e-06Highly InformativeInherited
Cellular Component (CC)cell-substrate junction0.0037260.00605Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)