SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,104) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 280,071 384,172 233
Proteins 273,147 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000046870Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0000023320Least InformativeDirect
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.000000000028370Moderately InformativeDirect
Biological Process (BP)immune system process0.000004470Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000057550.000000000007747Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00052460.00000000000008954Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000062480Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00058660Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.94390Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.4830Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.66090.008328Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organelle organization10.8969Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.93811Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.001040Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.51130Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0095760.00000000001652Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.064780Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00023640.04956Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.2226Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0027020Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.011340Moderately InformativeInherited
Biological Process (BP)tissue development0.030490.000000047Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.90981Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.84911Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.61781Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)system process10.6593Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.60780Moderately InformativeInherited
Biological Process (BP)organ development0.83670.1023Moderately InformativeInherited
Biological Process (BP)regulation of localization10.0000005902Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.027060.0000000000003733Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0071130.04093Moderately InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0000022770InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.000050570InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process0.0000000000015750InformativeDirect
Biological Process (BP)intracellular signal transduction00InformativeDirect
Biological Process (BP)growth0.00045640InformativeDirect
Biological Process (BP)regulation of kinase activity0.0000010150.00000001061InformativeDirect
Biological Process (BP)single organism reproductive process0.00051570.0000001961InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000012510InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.000013010InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.000000000058220InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process0.000030390InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.00074270.000003317InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00029180.0005014InformativeDirect
Biological Process (BP)regulation of intracellular transport0.017970.01433InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport10.183InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process10.5879InformativeInherited
Biological Process (BP)positive regulation of developmental process0.015690.0000709InformativeInherited
Biological Process (BP)regulation of cell development0.12390.0001585InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.78040.0000000000005907InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.1590.000000002939InformativeInherited
Biological Process (BP)response to cytokine stimulus0.66820.9753InformativeInherited
Biological Process (BP)regulation of protein localization0.15530.8155InformativeInherited
Biological Process (BP)positive regulation of transport0.86920.9567InformativeInherited
Biological Process (BP)regulation of organelle organization10InformativeInherited
Biological Process (BP)blood circulation0.00034090.4814InformativeInherited
Biological Process (BP)cytoskeleton organization0.018890InformativeInherited
Biological Process (BP)microtubule-based process0.024780.00000000002343InformativeInherited
Biological Process (BP)organelle assembly0.022740.0000234InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly11InformativeInherited
Biological Process (BP)sexual reproduction0.000081560.3692InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.32141InformativeInherited
Biological Process (BP)response to inorganic substance0.5391InformativeInherited
Biological Process (BP)alcohol metabolic process0.27991InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.009490InformativeInherited
Biological Process (BP)regulation of defense response0.86241InformativeInherited
Biological Process (BP)defense response10.9163InformativeInherited
Biological Process (BP)immune response0.88410.0002011InformativeInherited
Biological Process (BP)mitotic cell cycle0.0043790.0000002034InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.018550InformativeInherited
Biological Process (BP)response to organic cyclic compound0.10821InformativeInherited
Biological Process (BP)response to bacterium0.000010590.04283InformativeInherited
Biological Process (BP)response to lipid0.01531InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0032450.0000000000003211InformativeInherited
Biological Process (BP)reproductive system development0.44420.000001162InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.1890.000000000000001938InformativeInherited
Biological Process (BP)regulation of cell cycle process10.2221InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle10.6044InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.26750.3971InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.023110.000001048InformativeInherited
Biological Process (BP)muscle system process0.0042521InformativeInherited
Biological Process (BP)positive regulation of immune system process10.1589InformativeInherited
Biological Process (BP)regulation of immune response0.85520.96InformativeInherited
Biological Process (BP)sensory organ development0.30130.2276InformativeInherited
Biological Process (BP)regulation of ion transport0.29630.1681InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.52990.7434InformativeInherited
Biological Process (BP)embryonic organ development0.24970.007088InformativeInherited
Biological Process (BP)cellular component morphogenesis0.0017610InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.11141InformativeInherited
Biological Process (BP)DNA damage checkpoint0.00000095440Highly InformativeDirect
Biological Process (BP)protein phosphorylation00Highly InformativeDirect
Biological Process (BP)striated muscle contraction0.0000038780.0000002076Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000000015450.0000001019Highly InformativeDirect
Biological Process (BP)peptidyl-serine modification00Highly InformativeDirect
Biological Process (BP)cell cycle phase0.00000025990.00006089Highly InformativeDirect
Biological Process (BP)stress-activated protein kinase signaling cascade0.0000000000000063980Highly InformativeDirect
Biological Process (BP)ethanolamine-containing compound metabolic process0.000023580.00000000005927Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.000042670.000000000003348Highly InformativeDirect
Biological Process (BP)innate immune response0.000060570Highly InformativeDirect
Biological Process (BP)regulation of innate immune response0.00000000023470.0000000000001751Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase activity0.0000014650.000000000001588Highly InformativeDirect
Biological Process (BP)response to cadmium ion0.000072090.00002904Highly InformativeDirect
Biological Process (BP)cell division0.00066280Highly InformativeDirect
Biological Process (BP)heart contraction0.00023340.0000001584Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00027460.0002946Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00039520Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.00009030Highly InformativeDirect
Biological Process (BP)regulation of striated muscle cell differentiation11Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.007140.004323Highly InformativeInherited
Biological Process (BP)regulation of intracellular protein transport0.0011870.03619Highly InformativeInherited
Biological Process (BP)spindle organization0.0032190.0000000000003033Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway10.0001385Highly InformativeInherited
Biological Process (BP)female gamete generation0.77380.1551Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0026370.03923Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.021190.000000000001045Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0042760Highly InformativeInherited
Biological Process (BP)response to lipopolysaccharide0.000027780.01495Highly InformativeInherited
Biological Process (BP)regulation of striated muscle tissue development10Highly InformativeInherited
Biological Process (BP)post-embryonic development0.067070.0000000000008977Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.34250.003466Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0040580Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.00000021010.00261Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.0011680.8619Highly InformativeInherited
Biological Process (BP)placenta development0.0041390.000000002788Highly InformativeInherited
Molecular Function (MF)binding0.0000000000061120Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00049170Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.74031Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)nucleotide binding0.000000024940.0000000000001326InformativeDirect
Molecular Function (MF)magnesium ion binding0.00041180InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside binding0.000000000013850InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.00000000000074940InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)enzyme binding0.010620.000000000005741InformativeInherited
Molecular Function (MF)enzyme activator activity0.20050.3079InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity0.000090520.00000005896Highly InformativeDirect
Molecular Function (MF)kinase binding0.00030890.00000000004724Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.28121Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00006981Least InformativeInherited
Cellular Component (CC)protein complex0.180.04429Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.038520.000007026Least InformativeInherited
Cellular Component (CC)cytoskeleton0.000000040180Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0013021Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.000017470.0000000001662InformativeDirect
Cellular Component (CC)cell junction0.0000000016450InformativeDirect
Cellular Component (CC)spindle0.0000000000000041860Highly InformativeDirect
Cellular Component (CC)midbody0.00028430.000000000001728Highly InformativeDirect
Cellular Component (CC)adherens junction10.00001443Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)