SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,106) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 280,668 384,172 233
Proteins 273,740 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process00Least InformativeDirect
Biological Process (BP)response to stimulus0.000000000000051980Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000037250Least InformativeDirect
Biological Process (BP)single-organism cellular process0.1840Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.00000000000060710Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)signaling00Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.000000012630Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.000022790Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000030620Moderately InformativeDirect
Biological Process (BP)regulation of nitrogen compound metabolic process0.88831Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.66731Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0079580.0000000000001191Moderately InformativeInherited
Biological Process (BP)regulation of localization0.88030.00006527Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.062540Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus10.004191Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.8410.6359Moderately InformativeInherited
Biological Process (BP)response to stress0.30940.7807Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.24690Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.9381Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.20340Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.12780Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.66381Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.088870Moderately InformativeInherited
Biological Process (BP)organelle organization0.12710.001617Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.14471Moderately InformativeInherited
Biological Process (BP)immune system process0.018680Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.000019750.0000000004829InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process00InformativeDirect
Biological Process (BP)regulation of protein modification process0.00098910InformativeDirect
Biological Process (BP)intracellular signal transduction0.00000000037890InformativeDirect
Biological Process (BP)growth0.000038080InformativeDirect
Biological Process (BP)single organism reproductive process0.00000000002220InformativeDirect
Biological Process (BP)multi-organism reproductive process0.000015350.00003343InformativeDirect
Biological Process (BP)organelle fission0.000023070.000006963InformativeDirect
Biological Process (BP)regulation of transferase activity0.000000000020750InformativeDirect
Biological Process (BP)regulation of cell cycle00InformativeDirect
Biological Process (BP)positive regulation of cell death0.64390.05398InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00000033470.3121InformativeInherited
Biological Process (BP)regulation of cellular localization0.0000007410.007139InformativeInherited
Biological Process (BP)regulation of catabolic process0.11270.0008047InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0012130.0000000007671InformativeInherited
Biological Process (BP)regulation of growth0.71920.0000000000007721InformativeInherited
Biological Process (BP)regulation of cell proliferation10.00000007116InformativeInherited
Biological Process (BP)regulation of organelle organization0.25120.04904InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.066960.00009549InformativeInherited
Biological Process (BP)organelle assembly0.066160.00264InformativeInherited
Biological Process (BP)cytoskeleton organization0.016680InformativeInherited
Biological Process (BP)regulation of immune response11InformativeInherited
Biological Process (BP)positive regulation of immune system process0.97291InformativeInherited
Biological Process (BP)single-organism membrane organization11InformativeInherited
Biological Process (BP)multicellular organism reproduction0.13460.2448InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.14390.00004322InformativeInherited
Biological Process (BP)regulation of defense response11InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.33351InformativeInherited
Biological Process (BP)cell cycle checkpoint0.0000000021440Highly InformativeDirect
Biological Process (BP)MAPK cascade0.0001020.0000009932Highly InformativeDirect
Biological Process (BP)microtubule cytoskeleton organization0.000013970.00005806Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000110.0001639Highly InformativeDirect
Biological Process (BP)regulation of chromosome organization0.00000051420.00001309Highly InformativeDirect
Biological Process (BP)cell cycle phase transition0.0001910.000000002982Highly InformativeDirect
Biological Process (BP)cell division0.0000040620Highly InformativeDirect
Biological Process (BP)regulation of nuclear division0.00015680.00000001904Highly InformativeDirect
Biological Process (BP)negative regulation of chromosome segregation0.00017950Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00050170Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.00000025420.0000000002345Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.57180.03172Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.4360.8732Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.3561Highly InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.021260.00005478Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.043050.7227Highly InformativeInherited
Biological Process (BP)response to arsenic-containing substance0.0023020.05928Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.10170.0002248Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.0015930.01781Highly InformativeInherited
Biological Process (BP)nucleus organization0.018250.1979Highly InformativeInherited
Biological Process (BP)pattern specification process0.0047280.3053Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.043160.09343Highly InformativeInherited
Molecular Function (MF)binding0.00012240Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)protein binding0.000000000005140Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.0000083940Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000015520Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.0000000023130Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.86030.6857Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.91280.1539Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.00022810InformativeDirect
Molecular Function (MF)purine nucleoside binding00InformativeDirect
Molecular Function (MF)signal transducer activity00InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)ribonucleoside binding00InformativeDirect
Molecular Function (MF)ribonucleotide binding6.969e-160InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)enzyme binding0.0018490InformativeInherited
Molecular Function (MF)enzyme activator activity0.41710.5807InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)protein kinase regulator activity0.00063870.000000001124Highly InformativeDirect
Molecular Function (MF)kinase binding0.000038740.000000000006589Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0010240.0000006447Least InformativeInherited
Cellular Component (CC)protein complex0.019191Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000000072951Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.04531Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000000000048130Moderately InformativeDirect
Cellular Component (CC)transferase complex0.00000000061640.0000000000009973Moderately InformativeDirect
Cellular Component (CC)cell projection0.0012690.00000000002221Moderately InformativeInherited
Cellular Component (CC)nuclear part0.000015790.4657Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0000000031521Moderately InformativeInherited
Cellular Component (CC)synapse0.0030050.00000000002139InformativeInherited
Cellular Component (CC)cilium0.053080.06751InformativeInherited
Cellular Component (CC)cell projection part0.050490.0003803InformativeInherited
Cellular Component (CC)cell junction0.0025740.00000000000002858InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.01380.000001716InformativeInherited
Cellular Component (CC)centrosome0.00044920Highly InformativeDirect
Cellular Component (CC)spindle0.000000000028890Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex0.000018510.000008914Highly InformativeDirect
Cellular Component (CC)midbody0.00014410.0000000002542Highly InformativeDirect
Cellular Component (CC)cell-substrate junction0.017630.5085Highly InformativeInherited
Cellular Component (CC)anchoring junction0.20411Highly InformativeInherited
Cellular Component (CC)germ cell nucleus0.0013850.1126Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)