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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0002015Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5556Least InformativeInherited
Disease Ontology (DO)genetic disease0.002679Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008636Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.03863Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07702Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1251Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1631Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002178InformativeDirect
Disease Ontology (DO)malignant glioma0.00000284InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008648InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.0001041InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008315InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.976InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004741Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00002591Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0000877Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0002792Highly InformativeDirect
Disease Ontology (DO)ataxia telangiectasia0.0007451Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0000361InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07962Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5118Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0001076Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.06195Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2206Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2532Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.2598Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.01108InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.0296InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.1562InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.647InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the stomach0.00003361Highly InformativeDirect
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0007982Highly InformativeDirect
Phenotypic Abnormality (PA)Hemangioma0.0008708Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006645Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002047Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001339Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002199Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03112Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9241Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000007041Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005177Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00008127Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002466Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003012Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003938Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.005707Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01641Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002586InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.03942InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08534InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.2151InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2423InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005163Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.000559Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000001479Least InformativeDirect
Worm Phenotype (WP)larval lethal0.00005402Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0006544Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001586Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01753Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.02856Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04333Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4497Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6336Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00000000004643Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0000001716Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.0001368Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.001578Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.0294Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1421Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2231Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.3492Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4453Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.8554Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9392Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant1Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00000003569InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002835InformativeDirect
Worm Phenotype (WP)positive chemotaxis variant0.00002136InformativeDirect
Worm Phenotype (WP)metal response variant0.00003199InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.00008608InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001076InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0003673InformativeDirect
Worm Phenotype (WP)oxygen response variant0.004649InformativeInherited
Worm Phenotype (WP)protein modification variant0.004858InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.02612InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.03954InformativeInherited
Worm Phenotype (WP)egg laying variant0.1931InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.1971InformativeInherited
Worm Phenotype (WP)vulva development variant0.3224InformativeInherited
Worm Phenotype (WP)drug resistant0.4286InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5388InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.5941InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.6066InformativeInherited
Worm Phenotype (WP)VPC competence variant0.7693InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.7835InformativeInherited
Worm Phenotype (WP)cell number increased0.8143InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9163InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)endosome morphology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000000001568Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000001288Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001194Highly InformativeDirect
Worm Phenotype (WP)non apoptotic cell death variant0.0000003825Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0000006729Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.000003883Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000034Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00003464Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00007649Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001269Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0001996Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005637Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0006287Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.0009721Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.001475Highly InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.002111Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.005027Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.009513Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01538Highly InformativeInherited
Worm Phenotype (WP)response to food variant0.02618Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.06752Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1228Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1415Highly InformativeInherited
Worm Phenotype (WP)egg retention0.4167Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8931Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9335Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1826Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3258Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9496InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005064Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005636Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.0000344Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0003452Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1584Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.0003442Moderately InformativeDirect
Fly Phenotype (FP)wild-type0.0000002917InformativeDirect
Fly Phenotype (FP)cell number defective0.0000003203InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0.00001011InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001946InformativeDirect
Fly Phenotype (FP)visible0.00002071InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001648InformativeDirect
Fly Phenotype (FP)sterile0.0005487InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0005653InformativeDirect
Fly Phenotype (FP)size defective0.000000000004301Highly InformativeDirect
Fly Phenotype (FP)cell size defective0.0000001726Highly InformativeDirect
Fly Phenotype (FP)increased occurrence of cell division0.0000008785Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.000002707Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.004255Least InformativeInherited
Fly Anatomy (FA)larva0.00629Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.00738Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.007497Least InformativeInherited
Fly Anatomy (FA)adult0.09021Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4884Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)portion of tissue0.0002633Moderately InformativeDirect
Fly Anatomy (FA)gonad0.003707Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.01114Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01474Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01658Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03733Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03966Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04802Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05433Moderately InformativeInherited
Fly Anatomy (FA)head0.07499Moderately InformativeInherited
Fly Anatomy (FA)neuron0.08012Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.1148Moderately InformativeInherited
Fly Anatomy (FA)imaginal disc0.0002472InformativeDirect
Fly Anatomy (FA)ovariole0.0003433InformativeDirect
Fly Anatomy (FA)cell component0.0006662InformativeDirect
Fly Anatomy (FA)epithelial cell0.00073InformativeDirect
Fly Anatomy (FA)gut section0.01999InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.0241InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.6441InformativeInherited
Fly Anatomy (FA)epithelial tube0.7879InformativeInherited
Fly Anatomy (FA)midgut epithelium0.007882Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.002522Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.04759Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3557Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.07403Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.081InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1778InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1886InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.4661InformativeInherited
Zebrafish Anatomy (ZA)vein0.1025Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.4012Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4242Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1521Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3031Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8363Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4613Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.0003213InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.004369InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.007322InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.00007719Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0004888Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.111Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008949Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 299 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 299 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]