SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 0 233
Proteins 277,493 0 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001997Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5576Least InformativeInherited
Disease Ontology (DO)genetic disease0.00267Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008584Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.03793Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07586Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1252Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1628Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002345InformativeDirect
Disease Ontology (DO)malignant glioma0.000002838InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008594InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.000103InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008263InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9767InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004681Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00002574Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008684Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0002771Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.00002958InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1611Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5483Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00002913Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.0443Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.148Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1618Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2265Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.009517InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.1734InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.6612InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the stomach0.00003762Highly InformativeDirect
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0007703Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal venous morphology0.4727Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.00000006801Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002086Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001353Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002235Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03113Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9238Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000007129Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005221Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00007975Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002492Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00301Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003996Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.005749Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.9539Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002541InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.03954InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08615InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.2151InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.243InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005162Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.000559Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000001231Least InformativeDirect
Worm Phenotype (WP)larval lethal0.00005828Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0005746Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001642Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01275Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.02924Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0954Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4592Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6314Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000000000167Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0000001248Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.001216Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.03517Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1343Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2499Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.3703Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.3788Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.5805Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.8144Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9622Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00000008368InformativeDirect
Worm Phenotype (WP)life span variant0.00001727InformativeDirect
Worm Phenotype (WP)metal response variant0.00003601InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0001168InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002513InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.002487InformativeInherited
Worm Phenotype (WP)protein modification variant0.003495InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.004143InformativeInherited
Worm Phenotype (WP)oxygen response variant0.004702InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.04549InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.05148InformativeInherited
Worm Phenotype (WP)egg laying variant0.1041InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1374InformativeInherited
Worm Phenotype (WP)vulva development variant0.3132InformativeInherited
Worm Phenotype (WP)drug resistant0.474InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5266InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.5875InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.6032InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.7783InformativeInherited
Worm Phenotype (WP)cell number increased0.8084InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9154InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)endosome morphology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000000001567Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000001289Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001193Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0000006659Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.000004647Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00002424Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00003971Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00009669Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001532Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0001932Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005622Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0007776Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.0008854Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.001147Highly InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.002111Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.005038Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.009723Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01539Highly InformativeInherited
Worm Phenotype (WP)response to food variant0.02696Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.05488Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1163Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.1236Highly InformativeInherited
Worm Phenotype (WP)egg retention0.4153Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.9034Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9261Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1818Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3184Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9474InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005191Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005669Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.00003531Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.000348Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.173Least InformativeInherited
Fly Phenotype (FP)neuroanatomy defective0.00001201Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.0002909Moderately InformativeDirect
Fly Phenotype (FP)size defective0.0000000000001148InformativeDirect
Fly Phenotype (FP)wild-type0.0000001089InformativeDirect
Fly Phenotype (FP)cell number defective0.000001132InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001308InformativeDirect
Fly Phenotype (FP)visible0.00003431InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001176InformativeDirect
Fly Phenotype (FP)sterile0.000512InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0005498InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0009767InformativeDirect
Fly Phenotype (FP)cell size defective0.0000001508Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.0000009843Highly InformativeDirect
Fly Phenotype (FP)stress response defective0.007887Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0.0000001833Least InformativeDirect
Fly Anatomy (FA)nervous system0.003361Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.007485Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01035Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01483Least InformativeInherited
Fly Anatomy (FA)adult0.08181Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6387Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.003356Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.01364Moderately InformativeInherited
Fly Anatomy (FA)adult head0.01483Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01972Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02391Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.03523Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04587Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.05093Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05378Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0566Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.0868Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1337Moderately InformativeInherited
Fly Anatomy (FA)pupa0.0001891InformativeDirect
Fly Anatomy (FA)ovariole0.0003913InformativeDirect
Fly Anatomy (FA)cell component0.0004471InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0007681InformativeDirect
Fly Anatomy (FA)epithelial cell0.0008251InformativeDirect
Fly Anatomy (FA)digestive system0.04493InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.6527InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.01948Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.07078Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3537Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.2007Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.2458Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.1287InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1437InformativeInherited
Zebrafish Anatomy (ZA)trunk vasculature0.2242InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.3034InformativeInherited
Zebrafish Anatomy (ZA)vein0.1099Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.3983Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1183Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2412Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9596Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.006605InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01743InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.00007397Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0003894Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.08271Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008913Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processCell cycle0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0.01216Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processStress response0InformativeDirect
Biological processMeiosis0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processInflammatory response0.00000000000000853InformativeDirect
Biological processChemotaxis0.000000000003072InformativeDirect
Biological processEndocytosis0.000007926InformativeDirect
Biological processSensory transduction0.00008003InformativeDirect
Biological processmRNA processing0.0008731InformativeDirect
Biological processSteroid metabolism0.2509InformativeInherited
Biological processAbscisic acid signaling pathway0Highly InformativeDirect
Biological processGrowth regulation0.0000000000004182Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000000000009972Highly InformativeDirect
Biological processExocytosis0.000000006186Highly InformativeDirect
Biological processUnfolded protein response0.000000007448Highly InformativeDirect
Biological processVision0.000000007613Highly InformativeDirect
Biological processPhagocytosis0.00000002793Highly InformativeDirect
Biological processChromosome partition0.000005806Highly InformativeDirect
Biological processAuxin signaling pathway0.000006243Highly InformativeDirect
Biological processOsteogenesis0.00001689Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0001653Highly InformativeDirect
Biological processAdaptive immunity0.0003244Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0004622Highly InformativeDirect
Biological processSterol biosynthesis0.00103Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0.00000000000002492Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000224Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0006567Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentVirion1Moderately InformativeInherited
Cellular componentChromosome0InformativeDirect
Cellular componentMitochondrion outer membrane0.0000002389InformativeDirect
Cellular componentCentromere0Highly InformativeDirect
Cellular componentKinetochore0Highly InformativeDirect
Cellular componentTelomere0.00000001958Highly InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000004073Highly InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.0002096Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainEGF-like domain0.00000000001928InformativeDirect
DomainKringle0.0003601Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functioncAMP0.000000000001906Highly InformativeDirect
Molecular functioncGMP0.0000205Highly InformativeDirect
Molecular functioncGMP-binding0.0001051Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationActivator0.00001056Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00000000002148InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches
Abstract

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 78 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 78 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]