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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]

Superfamily statistics
Genomes (3,113) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 284,555 942,316 233
Proteins 277,493 921,325 233

Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Guanylate cyclase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol 4-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0.0000000000005248Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0.000000003239Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001997Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5576Least InformativeInherited
Disease Ontology (DO)genetic disease0.00267Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.008584Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.03793Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07586Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.1252Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1628Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0000000002345InformativeDirect
Disease Ontology (DO)malignant glioma0.000002838InformativeDirect
Disease Ontology (DO)liver carcinoma0.00008594InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.000103InformativeDirect
Disease Ontology (DO)respiratory system cancer0.008263InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9767InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0000004681Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00002574Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00008684Highly InformativeDirect
Disease Ontology (DO)bile duct adenocarcinoma0.0002771Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.00003768InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1008Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.5383Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.000076Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.0122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1711Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2211Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2504Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.009227InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.1664InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.348InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.6792InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the stomach0.00003695Highly InformativeDirect
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0007711Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal venous morphology0.461Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0000000664Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000002045Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001338Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0002198Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03111Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9242Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.000000007036Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005173Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00008121Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0002465Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.003011Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.003937Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.005705Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.0164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7292Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00002584InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.03942InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.08535InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.2151InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2423InformativeInherited
Mammalian Phenotype (MP)increased respiratory system tumor incidence0.0002518Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0005161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal associative learning0.0005588Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000001138Least InformativeDirect
Worm Phenotype (WP)larval lethal0.00008745Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0008516Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.002778Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01191Least InformativeInherited
Worm Phenotype (WP)retarded heterochronic variations0.03569Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.09747Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.468Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6518Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000000001145Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00000006773Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00003815Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.003516Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.02937Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1192Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2287Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.3797Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.392Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.6235Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.7846Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9345Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant1Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00000007022InformativeDirect
Worm Phenotype (WP)metal response variant0.00003019InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.00009271InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002364InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0008744InformativeDirect
Worm Phenotype (WP)protein modification variant0.003305InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.003869InformativeInherited
Worm Phenotype (WP)oxygen response variant0.004184InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.04268InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.05108InformativeInherited
Worm Phenotype (WP)egg laying variant0.1065InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1387InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.2006InformativeInherited
Worm Phenotype (WP)vulva development variant0.278InformativeInherited
Worm Phenotype (WP)drug resistant0.4641InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5205InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.5687InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.5857InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.7744InformativeInherited
Worm Phenotype (WP)VPC competence variant0.7856InformativeInherited
Worm Phenotype (WP)cell number increased0.8199InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.9041InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant1InformativeInherited
Worm Phenotype (WP)endosome morphology variant1InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.0000000000001205Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000001082Highly InformativeDirect
Worm Phenotype (WP)mutagen induced apoptosis variant0.0000001169Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0000006032Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.00002244Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.00002741Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00003554Highly InformativeDirect
Worm Phenotype (WP)alkaline pH chemotaxis variant0.00009655Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0001474Highly InformativeDirect
Worm Phenotype (WP)second messenger mediated signaling variant0.0001932Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.0005249Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0007778Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.0008275Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0008334Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.001083Highly InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.002003Highly InformativeInherited
Worm Phenotype (WP)P granule defective0.004685Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.008597Highly InformativeInherited
Worm Phenotype (WP)octanol chemotaxis variant0.01468Highly InformativeInherited
Worm Phenotype (WP)response to food variant0.0259Highly InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.05458Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.1043Highly InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.111Highly InformativeInherited
Worm Phenotype (WP)egg retention0.4153Highly InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.8963Highly InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0.9263Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1818Least InformativeInherited
Yeast Phenotype (YP)resistance to chemicals0.3184Least InformativeInherited
Yeast Phenotype (YP)cell cycle progression0.9474InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.00000005191Highly InformativeDirect
Yeast Phenotype (YP)cell cycle progression in G2 phase0.000005669Highly InformativeDirect
Yeast Phenotype (YP)osmotic stress resistance0.00003531Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.000348Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.2054Least InformativeInherited
Fly Phenotype (FP)neuroanatomy defective0.00002085Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0.00028Moderately InformativeDirect
Fly Phenotype (FP)size defective0.0000000000001251InformativeDirect
Fly Phenotype (FP)wild-type0.0000002638InformativeDirect
Fly Phenotype (FP)cell number defective0.000002717InformativeDirect
Fly Phenotype (FP)cell cycle defective0.00001348InformativeDirect
Fly Phenotype (FP)visible0.00003942InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0001674InformativeDirect
Fly Phenotype (FP)sterile0.0005153InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0005667InformativeDirect
Fly Phenotype (FP)cell size defective0.0000001825Highly InformativeDirect
Fly Phenotype (FP)cell death defective0.000001738Highly InformativeDirect
Fly Phenotype (FP)stress response defective0.009521Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0.0000001582Least InformativeDirect
Fly Anatomy (FA)nervous system0.005223Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.008085Least InformativeInherited
Fly Anatomy (FA)larva0.01302Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01433Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01829Least InformativeInherited
Fly Anatomy (FA)adult0.1169Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4989Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.003517Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.01404Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.01451Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02153Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05006Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.06131Moderately InformativeInherited
Fly Anatomy (FA)head0.07401Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07682Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.1068Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1556Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.0003263InformativeDirect
Fly Anatomy (FA)imaginal disc0.0004227InformativeDirect
Fly Anatomy (FA)epithelial cell0.0006282InformativeDirect
Fly Anatomy (FA)cell component0.0008587InformativeDirect
Fly Anatomy (FA)digestive system0.0431InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.6539InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.02097Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.03782Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3062Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.06137Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.133InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1993InformativeInherited
Zebrafish Anatomy (ZA)trunk0.2255InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.2972InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.5645InformativeInherited
Zebrafish Anatomy (ZA)vein0.1119Highly InformativeInherited
Zebrafish Anatomy (ZA)intersegmental vessel0.4084Highly InformativeInherited
Zebrafish Anatomy (ZA)integument0.5305Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.1235Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2889Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9657Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.004463InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0182InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.0000738Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0002399Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0004987Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.08365Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)cultured plant cell0.00008913Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011009 SSF56112 Protein matches

Protein kinases catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell [PubMed12191603]. The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond, and with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase, an atypical protein kinase that regulates the F-actin capping activity in plasmodia [PubMed10357805]; the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [PubMed11090628]; the catalytic domain of the MHCK/EF2 kinase, an atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals [PubMed11389851]; choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [PubMed12791258]; and 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [PubMed11467935].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 78 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Protein kinase-like (PK-like) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 78 hidden Markov models representing the Protein kinase-like (PK-like) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]