SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,110) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 282,397 384,172 233
Proteins 275,406 378,621 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process00Least InformativeDirect
Biological Process (BP)response to stimulus0.000000000002940Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00000046920Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process10.000007604Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)reproduction0.00000000000025880Moderately InformativeDirect
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00021930.00000000000002124Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.000000000016510Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0000030960Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000060040Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000009490.0003357Moderately InformativeDirect
Biological Process (BP)regulation of localization0.74550.000001183Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.15871Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.79051Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.17121Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.3963Moderately InformativeInherited
Biological Process (BP)organelle organization0.044930.3111Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus10.01192Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.17380Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.034840Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.000000026010.001778Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0029840.000000000000007367Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.72320.1171Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.02570Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.13660Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.010920.000000004128Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.16720Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.05390Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.13650Moderately InformativeInherited
Biological Process (BP)system development10.9189Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0049371Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process10.2664Moderately InformativeInherited
Biological Process (BP)immune system process0.047890Moderately InformativeInherited
Biological Process (BP)microtubule-based process0.0000030910.0000000000006101InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)cell cycle process00InformativeDirect
Biological Process (BP)regulation of protein modification process0.00075220InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.0002240InformativeDirect
Biological Process (BP)intracellular signal transduction0.000000000097870InformativeDirect
Biological Process (BP)growth0.000057370InformativeDirect
Biological Process (BP)single organism reproductive process0.000000000017270InformativeDirect
Biological Process (BP)multi-organism reproductive process0.0000021960.000003463InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000085970InformativeDirect
Biological Process (BP)regulation of cell cycle00InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.21271InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.044341InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.23541InformativeInherited
Biological Process (BP)positive regulation of cell death0.70330.0499InformativeInherited
Biological Process (BP)regulation of apoptotic process0.0000005050.1917InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0014550.00000000005439InformativeInherited
Biological Process (BP)regulation of cellular localization0.000000066550.001091InformativeInherited
Biological Process (BP)regulation of catabolic process0.020980.00000004366InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)response to metal ion11InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.38931InformativeInherited
Biological Process (BP)regulation of growth0.67970.000000000000001945InformativeInherited
Biological Process (BP)regulation of cell proliferation10.000000007052InformativeInherited
Biological Process (BP)regulation of organelle organization0.59670.6256InformativeInherited
Biological Process (BP)organelle assembly0.28490.1063InformativeInherited
Biological Process (BP)cytoskeleton organization0.012950InformativeInherited
Biological Process (BP)mitotic cell cycle0.044920.00000772InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.029590.0000003394InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.73570InformativeInherited
Biological Process (BP)regulation of phosphorylation0.010720InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.18740.000003838InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.040510InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.33280.0003384InformativeInherited
Biological Process (BP)membrane organization11InformativeInherited
Biological Process (BP)multicellular organism reproduction0.090930.02494InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.006160.05779InformativeInherited
Biological Process (BP)post-embryonic development0.44170.00004244InformativeInherited
Biological Process (BP)reproductive system development0.52030.9343InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.16880.000002608InformativeInherited
Biological Process (BP)vesicle-mediated transport0.03410.00001679InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.035980.0000000000001932InformativeInherited
Biological Process (BP)ammonium ion metabolic process11InformativeInherited
Biological Process (BP)positive regulation of immune response0.1891InformativeInherited
Biological Process (BP)regulation of defense response11InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.79471InformativeInherited
Biological Process (BP)cell cycle checkpoint0.000000000052250Highly InformativeDirect
Biological Process (BP)MAPK cascade0.000064240.0000004726Highly InformativeDirect
Biological Process (BP)activation of innate immune response0.0000083540.0001213Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.0000066720.0000001236Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000026730.000028Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00042770.000001122Highly InformativeDirect
Biological Process (BP)cell division0.00000097480Highly InformativeDirect
Biological Process (BP)regulation of nuclear division0.00039380.000000003937Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00015590.00000000002006Highly InformativeDirect
Biological Process (BP)cellular response to cadmium ion0.000025340.00000003904Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00056440Highly InformativeDirect
Biological Process (BP)regulation of proteolysis involved in cellular protein catabolic process0.0000047020.0000000003317Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.00000014140.0000000001404Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.44140.01944Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.39361Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.057110.5989Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.1360.00007072Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.0000032610.002796Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.00060080.01643Highly InformativeInherited
Biological Process (BP)nucleus organization0.021570.06915Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.051650.05072Highly InformativeInherited
Biological Process (BP)pattern specification process0.0041770.236Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0023430.000002319Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.088610.000000001098Highly InformativeInherited
Biological Process (BP)positive regulation of protein serine/threonine kinase activity0.10950.005164Highly InformativeInherited
Biological Process (BP)regulation of chromosome organization0.00021550.5748Highly InformativeInherited
Biological Process (BP)positive regulation of homeostatic process0.031170.9872Highly InformativeInherited
Biological Process (BP)positive regulation of mitotic cell cycle phase transition0.65711Highly InformativeInherited
Biological Process (BP)phosphatidylcholine metabolic process0.048350.1091Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.11030.00006903Highly InformativeInherited
Molecular Function (MF)binding0.00016550Least InformativeDirect
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000069970Moderately InformativeDirect
Molecular Function (MF)anion binding0.0000011080Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.00000000092990Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.85120.2331Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.00006390InformativeDirect
Molecular Function (MF)signal transducer activity00InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)enzyme binding0.0016040InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)kinase binding0.000010620.000000000001043Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.00056490.000000001106Least InformativeDirect
Cellular Component (CC)macromolecular complex0.62111Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.26881Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0000000036831Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0000000011160Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000026860.0000000000001349Moderately InformativeDirect
Cellular Component (CC)transferase complex0.000000060690.00000000145Moderately InformativeDirect
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane10Moderately InformativeInherited
Cellular Component (CC)whole membrane11Moderately InformativeInherited
Cellular Component (CC)nuclear part0.000023460.1446Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.00000021811Moderately InformativeInherited
Cellular Component (CC)vesicle10.475Moderately InformativeInherited
Cellular Component (CC)microtubule cytoskeleton0.00010650.000000007041InformativeDirect
Cellular Component (CC)transferase complex, transferring phosphorus-containing groups00InformativeDirect
Cellular Component (CC)synapse0.0036220.0000000000002318InformativeInherited
Cellular Component (CC)cilium0.000019570.004645InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.87781InformativeInherited
Cellular Component (CC)membrane region0.0032180.0499InformativeInherited
Cellular Component (CC)plasma membrane region0.077240.7963InformativeInherited
Cellular Component (CC)secretory granule0.00097121InformativeInherited
Cellular Component (CC)EKC/KEOPS complex0.0000011390.0004929Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.00026370.00000000000001496Highly InformativeDirect
Cellular Component (CC)spindle0.000000000035220Highly InformativeDirect
Cellular Component (CC)cell-substrate adherens junction0.000078840.0002222Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex0.0000028320.0000003209Highly InformativeDirect
Cellular Component (CC)midbody0.0002280.0000000000416Highly InformativeDirect
Cellular Component (CC)chromosome passenger complex0.00078880.00000001358Highly InformativeDirect
Cellular Component (CC)plasma membrane raft0.0000020030.000223Highly InformativeDirect
Cellular Component (CC)ciliary base0.00060970.0001472Highly InformativeDirect
Cellular Component (CC)germ cell nucleus0.0013360.12Highly InformativeInherited
Cellular Component (CC)sperm part0.00000023430.07252Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)