SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase-like (PK-like) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Protein kinase-like (PK-like) [ 56111]
Superfamily:   Protein kinase-like (PK-like) [ 56112] (7)
Families:   Protein kinases, catalytic subunit [ 88854] (63)
  Actin-fragmin kinase, catalytic domain [ 56168]
  MHCK/EF2 kinase [ 64408]
  Phoshoinositide 3-kinase (PI3K), catalytic domain [ 56171]
  Choline kinase [ 90040]
  APH phosphotransferases [ 64411] (5)
  RIO1-like kinases [ 111204]


Superfamily statistics
Genomes (3,113) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 284,555 762,548 233
Proteins 277,493 745,037 233


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)primary metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000025210Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0000021570Least InformativeDirect
Biological Process (BP)single-organism cellular process10.000201Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)reproduction0.0000000000011830Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000000023270Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0000057470Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000034270.0008662Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00058810.00000000000001763Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.11941Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.71471Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.02270.0000005731Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.15841Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.21640Moderately InformativeInherited
Biological Process (BP)organelle organization0.065110.2092Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus10.001457Moderately InformativeInherited
Biological Process (BP)regulation of localization0.74530.000002024Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00000017650.001693Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.13960Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.5233Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0044090.00000000003938Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.036190Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.06870Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.1910Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.13330Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.089080Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0034191Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process10.3435Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)immune system process0.081340Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.31860.00000000000001763Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process10.2236Moderately InformativeInherited
Biological Process (BP)regulation of cell cycle00InformativeDirect
Biological Process (BP)cell cycle process00InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)single organism reproductive process0.000000000066030InformativeDirect
Biological Process (BP)intracellular signal transduction0.00000000010050InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000082850InformativeDirect
Biological Process (BP)regulation of cellular localization0.000000077050.0002946InformativeDirect
Biological Process (BP)multi-organism reproductive process0.00000074980.000002343InformativeDirect
Biological Process (BP)microtubule-based process0.000016390.000000000001349InformativeDirect
Biological Process (BP)growth0.000062710InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00058110InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.046781InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.24621InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00000034810.1849InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0036720.0000000003087InformativeInherited
Biological Process (BP)regulation of catabolic process0.021380.0000001642InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)regulation of organelle organization0.77530.8371InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.43621InformativeInherited
Biological Process (BP)response to metal ion11InformativeInherited
Biological Process (BP)regulation of growth0.58170InformativeInherited
Biological Process (BP)regulation of cell proliferation10.000000002019InformativeInherited
Biological Process (BP)organelle assembly0.3120.1834InformativeInherited
Biological Process (BP)single-organism membrane organization0.89141InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.16460.0000005727InformativeInherited
Biological Process (BP)mitotic cell cycle0.05330.00001313InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.061510.000000471InformativeInherited
Biological Process (BP)regulation of protein modification process0.0013630InformativeInherited
Biological Process (BP)regulation of phosphorylation0.0096860InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.048450InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.27020.000002778InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.76630InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.20451InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.27790.0003618InformativeInherited
Biological Process (BP)multicellular organism reproduction0.093680.0604InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0056520.1093InformativeInherited
Biological Process (BP)post-embryonic development0.54270.0004467InformativeInherited
Biological Process (BP)reproductive system development0.61281InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway10.001675InformativeInherited
Biological Process (BP)vesicle-mediated transport0.04320.000008997InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.043480.0000000000002InformativeInherited
Biological Process (BP)ammonium ion metabolic process11InformativeInherited
Biological Process (BP)phospholipid metabolic process11InformativeInherited
Biological Process (BP)positive regulation of immune system process0.8941InformativeInherited
Biological Process (BP)regulation of immune response0.93021InformativeInherited
Biological Process (BP)regulation of defense response11InformativeInherited
Biological Process (BP)cellular component morphogenesis0.11940.0000316InformativeInherited
Biological Process (BP)cellular response to DNA damage stimulus0.93251InformativeInherited
Biological Process (BP)regulation of reproductive process0.00000076170.0000000002931Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.0000022140.000000005315Highly InformativeDirect
Biological Process (BP)cell cycle checkpoint0.0000061730Highly InformativeDirect
Biological Process (BP)activation of innate immune response0.0000072290.000153Highly InformativeDirect
Biological Process (BP)cellular response to cadmium ion0.000029460.00000001752Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000036240.0001904Highly InformativeDirect
Biological Process (BP)MAPK cascade0.000039250.00000001289Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00013380.0000001841Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00039010.000000000003156Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.00043180Highly InformativeDirect
Biological Process (BP)response to growth factor0.00051320Highly InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.00086010Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.44010.01502Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.056330.4903Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.461Highly InformativeInherited
Biological Process (BP)regulation of chromosome organization0.0053040.831Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.016410.7215Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.0011550.0894Highly InformativeInherited
Biological Process (BP)endomembrane system organization0.043790.0164Highly InformativeInherited
Biological Process (BP)response to arsenic-containing substance0.00035190.009806Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.13770.0000726Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.000007710.00636Highly InformativeInherited
Biological Process (BP)nucleus organization0.018060.09233Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.0066740.000002012Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.11880.0000000001618Highly InformativeInherited
Biological Process (BP)positive regulation of protein serine/threonine kinase activity0.17560.004168Highly InformativeInherited
Biological Process (BP)positive regulation of homeostatic process0.027810.9801Highly InformativeInherited
Biological Process (BP)positive regulation of organelle organization0.89050.4983Highly InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle phase transition10.2576Highly InformativeInherited
Biological Process (BP)phosphatidylcholine metabolic process0.048060.1297Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.12110.000131Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.00084190Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding0.000000000061180Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000045780Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000014490Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.82990.7403Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.93880.4602Moderately InformativeInherited
Molecular Function (MF)signal transducer activity00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)magnesium ion binding0.00017540InformativeDirect
Molecular Function (MF)enzyme binding0.0014970InformativeInherited
Molecular Function (MF)enzyme activator activity0.2980.7312InformativeInherited
Molecular Function (MF)protein kinase activity00Highly InformativeDirect
Molecular Function (MF)ATP binding00Highly InformativeDirect
Molecular Function (MF)kinase binding0.000005920.0000000000003865Highly InformativeDirect
Molecular Function (MF)kinase regulator activity0.00051970.000000004328Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.00031410.000000002908Least InformativeDirect
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0000000063561Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.24431Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)protein complex0.061071Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000000073030Moderately InformativeDirect
Cellular Component (CC)transferase complex0.000000091170.000000001268Moderately InformativeDirect
Cellular Component (CC)cell projection0.0000037170.000000000000379Moderately InformativeDirect
Cellular Component (CC)extracellular region part11Moderately InformativeInherited
Cellular Component (CC)plasma membrane10Moderately InformativeInherited
Cellular Component (CC)whole membrane11Moderately InformativeInherited
Cellular Component (CC)nuclear part0.000028960.1906Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.00000018671Moderately InformativeInherited
Cellular Component (CC)vesicle10.3659Moderately InformativeInherited
Cellular Component (CC)endomembrane system11Moderately InformativeInherited
Cellular Component (CC)transferase complex, transferring phosphorus-containing groups00InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00003120.00000000003145InformativeDirect
Cellular Component (CC)cilium0.000013120.005081InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part0.8131InformativeInherited
Cellular Component (CC)membrane region0.0030340.07727InformativeInherited
Cellular Component (CC)plasma membrane region0.086140.9155InformativeInherited
Cellular Component (CC)secretory granule0.0017121InformativeInherited
Cellular Component (CC)spindle0.000000000061560Highly InformativeDirect
Cellular Component (CC)acrosomal vesicle0.0000000088110.0001478Highly InformativeDirect
Cellular Component (CC)EKC/KEOPS complex0.0000011630.0004781Highly InformativeDirect
Cellular Component (CC)plasma membrane raft0.000001840.00018Highly InformativeDirect
Cellular Component (CC)protein kinase CK2 complex0.000002890.000000419Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.000072480Highly InformativeDirect
Cellular Component (CC)cell-substrate adherens junction0.000086360.0002991Highly InformativeDirect
Cellular Component (CC)midbody0.00022930.00000000009011Highly InformativeDirect
Cellular Component (CC)ciliary base0.00069630.0001761Highly InformativeDirect
Cellular Component (CC)chromosome passenger complex0.00083380.00000001556Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)