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FAD-binding/transporter-associated domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-binding/transporter-associated domain-like [ 56175]
Superfamily:   FAD-binding/transporter-associated domain-like [ 56176] (4)
Families:   FAD-linked oxidases, N-terminal domain [ 56177] (5)
  Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain [ 56184]
  CO dehydrogenase flavoprotein N-terminal domain-like [ 56187] (5)
  CorC/HlyC domain-like [ 160820] (12)


Superfamily statistics
Genomes (3,096) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 28,525 153,316 42
Proteins 28,363 152,780 42


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000001268 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.9218 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1612 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.0000000558 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0007515 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.1224 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.07835 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.03394 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1823 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.04554 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.04194 Moderately Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.00001201 Informative Direct
Biological Process (BP) amine metabolic process 0.00009298 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0001427 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0002467 Informative Direct
Biological Process (BP) alcohol metabolic process 0.03485 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.002296 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.3054 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.006853 Informative Inherited
Biological Process (BP) purine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0005819 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0008941 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000000000005127 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00367 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0.00000001228 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0000005347 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0008457 Informative Direct
Molecular Function (MF) identical protein binding 0.001942 Informative Inherited
Molecular Function (MF) iron-sulfur cluster binding 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0000000000752 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.00000001598 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000009435 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.005295 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) microbody 0.0001245 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.9538Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.03512Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.02818InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000016Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000008129Highly InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.2146Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCell cycle0Moderately InformativeDirect
Biological processIon transport0.000000005979Moderately InformativeDirect
Biological processCell shape0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAlkaloid metabolism0.0000000000000168Highly InformativeDirect
Biological processPurine metabolism0.000001367Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCell membrane0.07426Moderately InformativeInherited
Cellular componentSecreted0.158Moderately InformativeInherited
Cellular componentPeroxisome0.00000000000001155InformativeDirect
Cellular componentCell inner membrane0.0000007123InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
DomainSignal0.0003025Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionIron-sulfur0.00000005551Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0.00002073Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-binding/transporter-associated domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the FAD-binding/transporter-associated domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]