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Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (497) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,359 7,923 2
Proteins 7,198 7,798 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.000007967 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1315 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2994 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000000003412 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003536 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000002684 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005043 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0008789 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0001065 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000009331 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.00000524 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.3161 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.6784 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04292 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02927 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1956 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.09895 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.517 Moderately Informative Inherited
Biological Process (BP) cell communication 0.1277 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.04466 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03752 Moderately Informative Inherited
Biological Process (BP) signaling 0.3595 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7151 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0000000005235 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000001007 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0003373 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0005966 Informative Direct
Biological Process (BP) protein localization to organelle 0.0004046 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0009992 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000121 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0006215 Informative Direct
Biological Process (BP) regulation of locomotion 0.03321 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.003925 Informative Inherited
Biological Process (BP) regulation of protein localization 0.2802 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4058 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.003409 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.008503 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.02683 Informative Inherited
Biological Process (BP) regulation of ion transport 0.004202 Informative Inherited
Biological Process (BP) negative regulation of transport 0.002694 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.002148 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.019 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.0023 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.244 Informative Inherited
Biological Process (BP) protein targeting 0.02897 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.0000002345 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000008715 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.0001106 Highly Informative Direct
Biological Process (BP) endosomal transport 0.0000001859 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00001041 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0000003724 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0002191 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.00000001271 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000009375 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00004632 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.000000000000001902 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0006263 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.00003923 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.001883 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.08805 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1964 Least Informative Inherited
Molecular Function (MF) protein binding 0.00000007636 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.07385 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.02083 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.000000005131 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000008904 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.6696 Least Informative Inherited
Cellular Component (CC) transferase complex 0.01343 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.06852 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0003528 Informative Direct
Cellular Component (CC) Golgi apparatus 0.001957 Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000002099Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0003714Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.01517Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000002118Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000008781Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.005481Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0.00000000002023InformativeDirect
Worm Phenotype (WP)germ cell ionizing radiation response variant0.0000101Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.000000001364Moderately InformativeDirect
Biological processApoptosis0.0000006789Moderately InformativeDirect
Biological processDNA damage0.000407Moderately InformativeDirect
Cellular componentNucleus9.774e-16Least InformativeDirect
Cellular componentCytoplasm0.000005781Least InformativeDirect
Cellular componentGolgi apparatus0.000001586Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003335Moderately InformativeDirect
DiseaseDisease mutation0.0001721Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0.0000000002675InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000000003055Least InformativeDirect
Post-translational modificationUbl conjugation0.000000000001322Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]