SUPERFAMILY 1.75 HMM library and genome assignments server


Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (495) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,328 7,923 2
Proteins 7,166 7,798 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process4.521e-090Least InformativeDirect
Biological Process (BP)multicellular organismal process1.641e-056.983e-05Least InformativeDirect
Biological Process (BP)developmental process4.244e-060.0001408Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process6.14e-080Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.16180.4212Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular protein modification process8.94e-123.131e-06Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.19431Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.40280.5457Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.072171Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17470Moderately InformativeInherited
Biological Process (BP)nervous system development0.15210.3245Moderately InformativeInherited
Biological Process (BP)tissue development0.082590.8216Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)tube development0.004620.1662InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0046830.6262InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.016470InformativeInherited
Biological Process (BP)tissue morphogenesis0.010360.5837InformativeInherited
Biological Process (BP)embryonic morphogenesis0.0067980.3643InformativeInherited
Biological Process (BP)protein catabolic process0.024870InformativeInherited
Biological Process (BP)proteolysis0.1430InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching1.346e-070.274InformativeInherited
Biological Process (BP)epithelium development0.13990.3298InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process4.677e-060Highly InformativeDirect
Biological Process (BP)morphogenesis of embryonic epithelium3.327e-080.0003283Highly InformativeDirect
Biological Process (BP)protein ubiquitination00Highly InformativeDirect
Biological Process (BP)epithelial tube formation3.056e-091.076e-05Highly InformativeDirect
Biological Process (BP)neural tube development7.409e-060.001157Highly InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds1.141e-143.333e-13InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity1.341e-150Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 6.983e-05 Least Informative Direct
Biological Process (BP) developmental process 0.0001408 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.4212 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3553 Least Informative Inherited
Biological Process (BP) localization 0.08183 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02538 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 3.131e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003072 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005929 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.441e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system process 0.4247 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7294 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.5457 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.04011 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2021 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004605 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002659 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08944 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08501 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7814 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9233 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9705 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.9748 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.268 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.3245 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7821 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8499 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1047 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8216 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 2.291e-05 Informative Direct
Biological Process (BP) blood circulation 0.000752 Informative Direct
Biological Process (BP) negative regulation of cell communication 2.204e-05 Informative Direct
Biological Process (BP) sexual reproduction 0.0005091 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0004521 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 1.467e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.666e-07 Informative Direct
Biological Process (BP) positive regulation of transport 7.524e-05 Informative Direct
Biological Process (BP) negative regulation of transport 7.906e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.05267 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.07807 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.004979 Informative Inherited
Biological Process (BP) protein localization to organelle 0.004937 Informative Inherited
Biological Process (BP) growth 0.08248 Informative Inherited
Biological Process (BP) tube development 0.1662 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6262 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.003367 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.5805 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2471 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.09634 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03438 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001919 Informative Inherited
Biological Process (BP) reproductive system development 0.01595 Informative Inherited
Biological Process (BP) gland development 0.0201 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.4429 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05638 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.003366 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9663 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5837 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3643 Informative Inherited
Biological Process (BP) single organism reproductive process 0.02206 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03806 Informative Inherited
Biological Process (BP) protein transport 0.004928 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.274 Informative Inherited
Biological Process (BP) epithelium development 0.3298 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 9.199e-05 Highly Informative Direct
Biological Process (BP) gonad development 0.0001698 Highly Informative Direct
Biological Process (BP) fertilization 0.0001706 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00054 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 1.189e-06 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0003283 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.761e-06 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.495e-06 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 1.51e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 2.347e-08 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 7.785e-07 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.532e-06 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 4.289e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0003927 Highly Informative Direct
Biological Process (BP) membrane fusion 7.443e-08 Highly Informative Direct
Biological Process (BP) epithelial tube formation 1.076e-05 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 4.488e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1.464e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0002412 Highly Informative Direct
Biological Process (BP) developmental growth 0.01313 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001271 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.05574 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.004088 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.00838 Highly Informative Inherited
Biological Process (BP) neural tube development 0.001157 Highly Informative Inherited
Molecular Function (MF) binding 0.001053 Least Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 3.333e-13 Informative Direct
Molecular Function (MF) enzyme binding 0.01237 Informative Inherited
Molecular Function (MF) channel regulator activity 6.886e-13 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 2.627e-09 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.002385 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02115 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7496 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5196 Least Informative Inherited
Cellular Component (CC) protein complex 0.9192 Least Informative Inherited
Cellular Component (CC) membrane 0.3622 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.002639 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.03598 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 3.903e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 3.254e-05 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant1.2e-09Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant1.058e-07Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis5.251e-06InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis5.654e-07Moderately InformativeDirect
Biological processDifferentiation0.0003433Moderately InformativeDirect
Biological processDNA damage0.0005513Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Cellular componentNucleus1.278e-15Least InformativeDirect
Cellular componentCytoplasm2.941e-05Least InformativeDirect
Cellular componentGolgi apparatus9.74e-07Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001945Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat1.985e-10InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein2.518e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]