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Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (502) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,454 18,478 2
Proteins 7,292 18,106 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00000004454 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.1933 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2677 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7991 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00000006138 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000006274 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0005479 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00006805 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000004604 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000004403 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0001757 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.000002165 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.001365 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2225 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3982 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.004959 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.4867 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.003583 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1681 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6413 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.005065 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.07059 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.01566 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.7465 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8393 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000000001422 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0004462 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000000000000007296 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00004388 Informative Direct
Biological Process (BP) protein transport 0.00000161 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0004732 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00005383 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0008234 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000009057 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.03305 Informative Inherited
Biological Process (BP) regulation of ion transport 0.004419 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.005205 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.00176 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001124 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.481 Informative Inherited
Biological Process (BP) generation of neurons 0.01096 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002998 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01529 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.006237 Informative Inherited
Biological Process (BP) negative regulation of transport 0.005135 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4662 Informative Inherited
Biological Process (BP) intracellular transport 0.01059 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.005364 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.006152 Informative Inherited
Biological Process (BP) regulation of locomotion 0.09665 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.08518 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2569 Informative Inherited
Biological Process (BP) endomembrane system organization 0.00001235 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.00008866 Highly Informative Direct
Biological Process (BP) viral process 0.0004021 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000007528 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0003459 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0000000000001125 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000002231 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0001065 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.00000003754 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00001614 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0001188 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.000000000000001925 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.00001415 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1371 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001073 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.3004 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.1201 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.03786 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00000001965 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001169 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.5599 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.01245 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.02739 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000884 Informative Direct
Cellular Component (CC) Golgi apparatus 0.007804 Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.00001828 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.000000001953Moderately InformativeDirect
Biological processApoptosis0.0000007353Moderately InformativeDirect
Biological processDNA damage0.0004378Moderately InformativeDirect
Biological processDNA repair0.000002294InformativeDirect
Cellular componentNucleus0.000000000000001306Least InformativeDirect
Cellular componentCytoplasm0.000005277Least InformativeDirect
Cellular componentGolgi apparatus0.000000001625Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003687Moderately InformativeDirect
DiseaseDisease mutation0.000002584Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0.0000000003144InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000000002748Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000002308Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]