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Hect, E3 ligase catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Hect, E3 ligase catalytic domain [ 56203]
Superfamily:   Hect, E3 ligase catalytic domain [ 56204]
Families:   Hect, E3 ligase catalytic domain [ 56205] (2)


Superfamily statistics
Genomes (502) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,454 18,478 2
Proteins 7,292 18,106 2


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.000004854 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1966 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4952 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0000004342 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0001086 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000001159 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0003735 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001732 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0005331 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00001978 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000007795 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0002806 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.00000419 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.03027 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2656 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09956 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.001049 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.6063 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4429 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0211 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.0221 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6863 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2857 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0000000000127 Informative Direct
Biological Process (BP) intracellular protein transport 0.00001735 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0006205 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00000009155 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00007613 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0007465 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00009627 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0009728 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000002669 Informative Direct
Biological Process (BP) regulation of locomotion 0.04537 Informative Inherited
Biological Process (BP) regulation of ion transport 0.004551 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.005216 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4295 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3449 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001643 Informative Inherited
Biological Process (BP) membrane organization 0.001385 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.05307 Informative Inherited
Biological Process (BP) negative regulation of transport 0.003829 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.02292 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01434 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.003715 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.009968 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02874 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.08672 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2523 Informative Inherited
Biological Process (BP) protein localization to organelle 0.001177 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.000003384 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000008217 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.00008172 Highly Informative Direct
Biological Process (BP) viral process 0.0002953 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000008936 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0003419 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0001965 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0.00000004202 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00001957 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00008116 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.000000000000001945 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0009486 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000007726 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.001995 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2051 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.08191 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.02732 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00000000785 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00007846 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.876 Least Informative Inherited
Cellular Component (CC) transferase complex 0.01043 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.02745 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.0005212 Informative Direct
Cellular Component (CC) Golgi apparatus 0.002297 Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.000008858 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.07706Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.01648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.3187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.4854Moderately InformativeInherited
Mammalian Phenotype (MP)decreased lean body mass0.0001191Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001021Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.001182Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.04831Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000002317Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000004772Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0009149Moderately InformativeDirect
Worm Phenotype (WP)neuron migration variant0.0000000000007481InformativeDirect
Worm Phenotype (WP)germ cell ionizing radiation response variant0.000006366Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.000000001931Moderately InformativeDirect
Biological processApoptosis0.0000007342Moderately InformativeDirect
Biological processDNA damage0.000445Moderately InformativeDirect
Cellular componentNucleus0.000000000000001304Least InformativeDirect
Cellular componentCytoplasm0.000005954Least InformativeDirect
Cellular componentGolgi apparatus0.000000001652Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003728Moderately InformativeDirect
DiseaseDisease mutation0.000002532Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainANK repeat0.0000000003259InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00000000003265Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000002486Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR000569 SSF56204 Protein matches
Abstract The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [PubMed7708685]. Proteins containing this domain at the C-terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumor-suppressor protein for ubiquitin-mediated proteolysis.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Hect, E3 ligase catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Hect, E3 ligase catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]