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4'-phosphopantetheinyl transferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   4'-phosphopantetheinyl transferase [ 56213]
Superfamily:   4'-phosphopantetheinyl transferase [ 56214] (2)
Families:   Holo-(acyl carrier protein) synthase ACPS [ 64418]
  4'-Phosphopantetheinyl transferase SFP [ 56215]


Superfamily statistics
Genomes (3,028) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,946 42,890 6
Proteins 5,224 31,636 5


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.039430.0003771Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.033710.00000000956Least InformativeInherited
Biological Process (BP)primary metabolic process0.0058111Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0014230.003812Moderately InformativeInherited
Molecular Function (MF)transferase activity0.0000073160Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000000063380.00001096Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000956 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0003771 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.9532 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1105 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2982 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9869 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.0001133 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000175 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0005286 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.005936 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07984 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2442 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.00179 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1045 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003812 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.02821 Moderately Informative Inherited
Biological Process (BP) secondary metabolic process 0.0000008146 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00008407 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00009617 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0007032 Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.000000000000007367 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000002246 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00003178 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00001096 Moderately Informative Direct
Cellular Component (CC) macromolecular complex 0.2415 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases for other substituted phosphate group0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I2.486e-16Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase9.829e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processAntibiotic biosynthesis0.0005388Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationPhosphopantetheine0.00000001737Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008278 SSF56214 Protein matches
Abstract

These proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [PubMed7559576]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the Sfp type such as SFP_BACSU. The structure of the Sfp type is known [PubMed10581256], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4'-phosphopantetheinyl transferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the 4'-phosphopantetheinyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]