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4'-phosphopantetheinyl transferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   4'-phosphopantetheinyl transferase [ 56213]
Superfamily:   4'-phosphopantetheinyl transferase [ 56214] (2)
Families:   Holo-(acyl carrier protein) synthase ACPS [ 64418]
  4'-Phosphopantetheinyl transferase SFP [ 56215]


Superfamily statistics
Genomes (3,030) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,950 37,326 6
Proteins 5,226 28,021 5


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.038560.000189Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.03180.000000001998Least InformativeInherited
Biological Process (BP)primary metabolic process0.0053961Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0013960.001319Moderately InformativeInherited
Molecular Function (MF)transferase activity0.0000067320Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.0000000060720.00003661Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000001998 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000189 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2396 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9954 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1732 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0.0001414 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001828 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0005319 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.01512 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.002555 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2897 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001319 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1022 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.001718 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1321 Moderately Informative Inherited
Biological Process (BP) secondary metabolic process 0.000001198 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00002785 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000121 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002106 Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.000000000000005563 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000001949 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00004525 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00003661 Moderately Informative Direct
Cellular Component (CC) protein complex 0.0235 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases for other substituted phosphate group0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processAntibiotic biosynthesis0.0006523Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationPhosphopantetheine0.00000002602Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008278 SSF56214 Protein matches
Abstract

These proteins transfer the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [PubMed7559576]. This superfamily consists of two subtypes: The ACPS type such as ACPS_ECOLI and the Sfp type such as SFP_BACSU. The structure of the Sfp type is known [PubMed10581256], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4'-phosphopantetheinyl transferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the 4'-phosphopantetheinyl transferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]