SUPERFAMILY 1.75 HMM library and genome assignments server


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,100) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 35,157 65,538 127
Proteins 34,997 65,433 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process09.427e-10Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process1.496e-141Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.74911Least InformativeInherited
Biological Process (BP)response to stimulus0.14651Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.2726Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.001165Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.61531Least InformativeInherited
Biological Process (BP)macromolecule catabolic process00Moderately InformativeDirect
Biological Process (BP)cellular response to stress9.766e-070.0002422Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.010460.3409Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function2.705e-050.01475Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.012190.1751Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.070840.6236Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization4.734e-050.02279Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0010360.1886Moderately InformativeInherited
Biological Process (BP)immune system process2.972e-070.008177Moderately InformativeInherited
Biological Process (BP)response to organic substance0.073030.32Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.4037Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.024351Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0065280.5651Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0052521Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.43541Moderately InformativeInherited
Biological Process (BP)signal transduction0.56661Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.18310.5988Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.60661Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process13.611e-11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.89121Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.76550Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization0.99541Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus8.477e-100.0001204InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process2.016e-055.442e-06InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process9.452e-070InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process2.814e-100.0002079InformativeDirect
Biological Process (BP)regulation of cell cycle5.139e-141.389e-06InformativeDirect
Biological Process (BP)intracellular signal transduction0.0011470.276InformativeInherited
Biological Process (BP)cell cycle process3.751e-070.0176InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process4.822e-060.009766InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00047140.00227InformativeInherited
Biological Process (BP)cytoskeleton organization0.47291InformativeInherited
Biological Process (BP)microtubule-based process0.048270.7498InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0058970.003944InformativeInherited
Biological Process (BP)protein complex assembly0.16040.009865InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly3.358e-070.001348InformativeInherited
Biological Process (BP)negative regulation of cell death1.132e-050.003047InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process1.072e-050.004273InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.0074880.0009462InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.35190.00016InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0014657.08e-10InformativeInherited
Biological Process (BP)lipid catabolic process0.31620.4844InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0015820.003492InformativeInherited
Biological Process (BP)cell cycle checkpoint2.504e-127.806e-08Highly InformativeDirect
Biological Process (BP)glycolysis3.617e-072.391e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.0005840Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process6.357e-080.0009314Highly InformativeDirect
Biological Process (BP)photorespiration9.345e-064.84e-07Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process1.724e-130Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process9.134e-151.665e-09Highly InformativeDirect
Biological Process (BP)protein ubiquitination4.267e-110.0001907Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)cell cycle phase3.051e-088.857e-09Highly InformativeDirect
Biological Process (BP)lipid modification2.233e-080.0006692Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination02.619e-11Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process1.491e-063.197e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process03.746e-15Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein3.418e-101.42e-09Highly InformativeDirect
Biological Process (BP)multi-organism cellular process1.11e-091.491e-06Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00064330.0003322Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process4.445e-062.298e-05Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process8.21e-132.043e-08Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition4.501e-138.611e-09Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle05.664e-13Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.021130.00694Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process2.847e-080.01877Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.015670.4118Highly InformativeInherited
Molecular Function (MF)hydrolase activity03.694e-08Least InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides01.094e-06InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.41420InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups4.323e-050Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.58120.3451Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.81631Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.64871Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.03070.1311Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.28080.4924Moderately InformativeInherited
Cellular Component (CC)proteasome complex00Highly InformativeDirect
Cellular Component (CC)cytoplasmic mRNA processing body1.652e-094.871e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 9.427e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2726 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001165 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 3.611e-11 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0002422 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0008108 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.3409 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01475 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1751 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6236 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02279 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1886 Moderately Informative Inherited
Biological Process (BP) immune system process 0.008177 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.4037 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.32 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5651 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2017 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1306 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001437 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5988 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8861 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8624 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7261 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00016 Informative Direct
Biological Process (BP) fatty acid metabolic process 7.08e-10 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001204 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 5.442e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0002289 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0009462 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0002079 Informative Direct
Biological Process (BP) regulation of cell cycle 1.389e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 0.276 Informative Inherited
Biological Process (BP) cell cycle process 0.0176 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004273 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.009766 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.00227 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.7498 Informative Inherited
Biological Process (BP) response to inorganic substance 0.08377 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.003944 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8782 Informative Inherited
Biological Process (BP) protein complex assembly 0.009865 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001348 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.003047 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.5449 Informative Inherited
Biological Process (BP) sexual reproduction 0.035 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04505 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.02462 Informative Inherited
Biological Process (BP) lipid catabolic process 0.4844 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4967 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001181 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.003492 Informative Inherited
Biological Process (BP) cell cycle checkpoint 7.806e-08 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 3.553e-08 Highly Informative Direct
Biological Process (BP) glycolysis 2.391e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 2.338e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0009314 Highly Informative Direct
Biological Process (BP) photorespiration 4.84e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.665e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0001907 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 8.857e-09 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006692 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 2.619e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 3.197e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 3.746e-15 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 1.42e-09 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.0002239 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 1.491e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0003322 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.298e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000837 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.043e-08 Highly Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 1.16e-07 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 8.611e-09 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 5.664e-13 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.04095 Highly Informative Inherited
Biological Process (BP) protein processing 0.6426 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.00694 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.00314 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01877 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.08257 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04358 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.4118 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 3.694e-08 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1.094e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.002957 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.05051 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.0007816 Highly Informative Direct
Molecular Function (MF) transaminase activity 8.123e-11 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 1.873e-10 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.3451 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006383 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.9539 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1311 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.4924 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1685 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0004401 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0008432 Informative Direct
Cellular Component (CC) cell surface 0.7985 Informative Inherited
Cellular Component (CC) proteasome complex 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 4.871e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 4.338e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.002471 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides5.578e-13Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N4.896e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)7.489e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal5.842e-13Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant1.055e-09Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant3.133e-09Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant2.838e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant3.212e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant5.927e-05Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant8.938e-11InformativeDirect
Worm Phenotype (WP)somatic gonad development variant2.011e-08InformativeDirect
Worm Phenotype (WP)life span variant5.456e-06InformativeDirect
Worm Phenotype (WP)cell division variant6.344e-05InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated3.692e-14Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant7.326e-08Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.448e-07Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb1.096e-06Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant1.527e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03123Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring1.703e-06InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.0864Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004705Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03598Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008728InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage2.179e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides3.4e-13InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1.335e-06InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors2.704e-05InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05641InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002442Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.9035Moderately InformativeInherited
Biological processStress response1.058e-12InformativeDirect
Biological processPurine biosynthesis5.065e-06InformativeDirect
Biological processNodulation5.934e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001747InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat5.587e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003706InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding5.137e-12Least InformativeDirect
Molecular functionFlavoprotein0.6807Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN1.342e-05InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.9031Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)nitrogen metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism5.742e-06Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1064Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.955e-06InformativeDirect
UniPathway (UP)purine nucleotide metabolism0.7713InformativeInherited
UniPathway (UP)purine biosynthesis1InformativeInherited
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)purine biosynthesis via de novo pathway3.196e-10Highly InformativeDirect
UniPathway (UP)leukotriene metabolism9.03e-09Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis8.671e-08Highly InformativeDirect
UniPathway (UP)IMP biosynthesis2.928e-07Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]