SUPERFAMILY 1.75 HMM library and genome assignments server


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,990 139,222 127
Proteins 35,810 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process04.877e-11Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.96191Least InformativeInherited
Biological Process (BP)response to stimulus0.61151Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.4607Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.00509Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.90231Least InformativeInherited
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.033120.5589Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0004340.1014Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.042010.3767Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.16110.8716Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00036070.07745Moderately InformativeInherited
Biological Process (BP)immune system process1.012e-050.04968Moderately InformativeInherited
Biological Process (BP)response to organic substance0.25350.6765Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.5039Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.12761Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.06041Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.02110.8045Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.018171Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.711Moderately InformativeInherited
Biological Process (BP)signal transduction0.79241Moderately InformativeInherited
Biological Process (BP)cellular response to stress2.782e-060.002007Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.29840.9209Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.8331Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process11.116e-10Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.89691Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.85560Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle2.749e-106.022e-05InformativeDirect
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus5.086e-100.000104InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle02.834e-12InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process5.703e-052.025e-06InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process2.806e-060InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process2.966e-090.0002137InformativeDirect
Biological Process (BP)intracellular signal transduction0.0037940.4357InformativeInherited
Biological Process (BP)cell cycle process2.276e-060.04327InformativeInherited
Biological Process (BP)positive regulation of protein modification process2.276e-060.002307InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.0006050.005985InformativeInherited
Biological Process (BP)cytoskeleton organization0.60721InformativeInherited
Biological Process (BP)microtubule-based process0.088460.8961InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.012080.004109InformativeInherited
Biological Process (BP)protein complex assembly0.15020.008781InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly2.132e-060.001389InformativeInherited
Biological Process (BP)regulation of cell cycle process0.61371InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process4.858e-050.01294InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal1.503e-060.003823InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.01290.0009151InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.3590.0002208InformativeInherited
Biological Process (BP)fatty acid metabolic process0.003585.465e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.41320.588InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0037860.007574InformativeInherited
Biological Process (BP)DNA damage checkpoint1.286e-061.56e-05Highly InformativeDirect
Biological Process (BP)glycolysis1.337e-062.665e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00097030Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process6.393e-080.0008814Highly InformativeDirect
Biological Process (BP)response to salt stress5.482e-057.507e-05Highly InformativeDirect
Biological Process (BP)photorespiration1.772e-058.669e-07Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process2.53e-097.929e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process8.773e-148.066e-09Highly InformativeDirect
Biological Process (BP)protein ubiquitination4.804e-100.0006568Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)lipid modification7.757e-080.0006459Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination3.3e-151.41e-10Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process2.435e-060.0001518Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process01.761e-14Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein2.406e-098.644e-09Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism6.628e-091.222e-05Highly InformativeDirect
Biological Process (BP)multi-organism cellular process1.938e-092.718e-06Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00052920.0002541Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process1.043e-052.469e-05Highly InformativeDirect
Biological Process (BP)interphase4.585e-139.428e-10Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process3.876e-128.543e-08Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition4.352e-124.912e-08Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle3.3e-154.215e-12Highly InformativeDirect
Biological Process (BP)fatty acid catabolic process9.105e-080.01696Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.029690.5497Highly InformativeInherited
Molecular Function (MF)hydrolase activity05.799e-10Least InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds2.082e-068.349e-09InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.51320InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups6.7e-050Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.78930.594Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.41471Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.7531Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.32880.5413Moderately InformativeInherited
Cellular Component (CC)proteasome complex00Highly InformativeDirect
Cellular Component (CC)cytoplasmic mRNA processing body3.292e-096.343e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.877e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4607 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.00509 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.116e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0004152 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0008276 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.5589 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1014 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3767 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8716 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.07745 Moderately Informative Inherited
Biological Process (BP) immune system process 0.04968 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5039 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6765 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.8045 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.002007 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2079 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.09466 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9209 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.876 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7383 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 6.022e-05 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0002208 Informative Direct
Biological Process (BP) fatty acid metabolic process 5.465e-09 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.000104 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 2.834e-12 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 2.025e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0006781 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0009151 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0002137 Informative Direct
Biological Process (BP) intracellular signal transduction 0.4357 Informative Inherited
Biological Process (BP) cell cycle process 0.04327 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.01294 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.002307 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.005985 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8961 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1575 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004109 Informative Inherited
Biological Process (BP) protein complex assembly 0.008781 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001389 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6222 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.003823 Informative Inherited
Biological Process (BP) sexual reproduction 0.08897 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1194 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.06965 Informative Inherited
Biological Process (BP) lipid catabolic process 0.588 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.423 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001707 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.007574 Informative Inherited
Biological Process (BP) DNA damage checkpoint 1.56e-05 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 8.718e-08 Highly Informative Direct
Biological Process (BP) glycolysis 2.665e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0009315 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 9.484e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0008814 Highly Informative Direct
Biological Process (BP) response to salt stress 7.507e-05 Highly Informative Direct
Biological Process (BP) photorespiration 8.669e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 7.929e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 8.066e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0006568 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006459 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.41e-10 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0001518 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.761e-14 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 8.644e-09 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 6.669e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.222e-05 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 2.718e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0002541 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.469e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0008947 Highly Informative Direct
Biological Process (BP) interphase 9.428e-10 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 8.543e-08 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 4.55e-12 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 4.912e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 4.215e-12 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.06161 Highly Informative Inherited
Biological Process (BP) protein processing 0.5948 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.003089 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01696 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.07885 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04382 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.5497 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 5.799e-10 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8.349e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.003017 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.04983 Informative Inherited
Molecular Function (MF) endopeptidase activity 3.476e-05 Highly Informative Direct
Molecular Function (MF) transaminase activity 2.901e-10 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 5.747e-10 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.594 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.003779 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.3663 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5413 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.002287 Informative Inherited
Cellular Component (CC) cell surface 0.8753 Informative Inherited
Cellular Component (CC) proteasome complex 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 6.343e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 1.008e-06 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00555 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides5.578e-13Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N4.896e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)7.489e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal5.842e-13Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant1.055e-09Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant3.133e-09Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant2.838e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant3.212e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant5.927e-05Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant8.938e-11InformativeDirect
Worm Phenotype (WP)somatic gonad development variant2.011e-08InformativeDirect
Worm Phenotype (WP)life span variant5.456e-06InformativeDirect
Worm Phenotype (WP)cell division variant6.344e-05InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated3.692e-14Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant7.326e-08Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.448e-07Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb1.096e-06Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant1.527e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03492Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring1.702e-06InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.08794Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004788Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03634Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008945InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage2.179e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides2.246e-13InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor9.916e-07InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors2.215e-05InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05396InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002363Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8948Moderately InformativeInherited
Biological processStress response1.203e-12InformativeDirect
Biological processPurine biosynthesis4.709e-06InformativeDirect
Biological processNodulation6.011e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001637InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat5.649e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003734InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding2.467e-11Least InformativeDirect
Molecular functionFlavoprotein0.6767Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN1.341e-05InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4417Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7521Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism8.98e-16Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism3.375e-13Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.63e-12Moderately InformativeDirect
UniPathway (UP)purine metabolism2.638e-07Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1274Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway2.274e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.177e-06InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis8.181e-13Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis1.13e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]