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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,143) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,475 139,222 127
Proteins 36,287 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.000000000000044090.0002507Least InformativeDirect
Biological Process (BP)macromolecule metabolic process00.7757Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.4321Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.0001782Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.0006031Least InformativeInherited
Biological Process (BP)immune system process00.00000007467Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.043311Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.1451Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.71491Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.12171Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.094750.09674Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.18961Moderately InformativeInherited
Biological Process (BP)cell communication0.68231Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.039551Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.018620.8557Moderately InformativeInherited
Biological Process (BP)signaling0.59321Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.05321Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.12131Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.046461Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.85661Moderately InformativeInherited
Biological Process (BP)response to organic substance0.082490.4337Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.76871Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.18471Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.86430.000000000009933Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.42530.04115Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.63531Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.042541Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.18091Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)glutamine family amino acid metabolic process0.000011590.000000007187InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.000065640.0001871InformativeDirect
Biological Process (BP)regulation of catabolic process0.0000000095250.00002855InformativeDirect
Biological Process (BP)regulation of proteolysis0.000005060.0004396InformativeDirect
Biological Process (BP)regulation of defense response0.000000045930.00001857InformativeDirect
Biological Process (BP)response to cytokine0.000000000019040.00000004015InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.000080210.208InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.00028890.03973InformativeInherited
Biological Process (BP)regulation of protein modification process0.00047160.5389InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.00021410.2922InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.00098390.382InformativeInherited
Biological Process (BP)negative regulation of cell communication0.0000054070.1858InformativeInherited
Biological Process (BP)negative regulation of signaling0.000005060.1818InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0000059290.1725InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.00038450.6734InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.00035360.07404InformativeInherited
Biological Process (BP)negative regulation of molecular function0.0009970.04022InformativeInherited
Biological Process (BP)regulation of transferase activity0.00000042430.003973InformativeInherited
Biological Process (BP)mitotic cell cycle0.00011540.06828InformativeInherited
Biological Process (BP)cell cycle process0.0097840.6532InformativeInherited
Biological Process (BP)regulation of cell cycle0.000080210.06408InformativeInherited
Biological Process (BP)regulation of immune response0.00000038030.001859InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0000000040310.00109InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.82810.303InformativeInherited
Biological Process (BP)phosphorylation0.0032610.6569InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.0041760.3846InformativeInherited
Biological Process (BP)positive regulation of immune system process0.000074780.01467InformativeInherited
Biological Process (BP)intracellular signal transduction0.00071830.2998InformativeInherited
Biological Process (BP)MAPK cascade0.000000000028220.0000006839Highly InformativeDirect
Biological Process (BP)antigen processing and presentation of exogenous peptide antigen00Highly InformativeDirect
Biological Process (BP)innate immune response-activating signal transduction0.0000000000000045270.00000000001579Highly InformativeDirect
Biological Process (BP)positive regulation of catabolic process0.00000000000029120.00000005413Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.000044510.000000167Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.0000000000049510.000000006079Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000001720.00000005197Highly InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.0000000000790.0000003966Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.000000000014590.0000001503Highly InformativeDirect
Biological Process (BP)regulation of RNA stability00.000000000004661Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.000000000013010.0000005845Highly InformativeDirect
Biological Process (BP)negative regulation of transferase activity0.00000065080.000003424Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.000000000000017080.00000001512Highly InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle phase transition0.000000000290.002205Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.000000047660.001176Highly InformativeInherited
Biological Process (BP)glutamine family amino acid catabolic process0.00000044440.008762Highly InformativeInherited
Biological Process (BP)modification-dependent protein catabolic process0.4511Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation0.0000025570.005658Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000070240.00000004572InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.98631InformativeInherited
Molecular Function (MF)exopeptidase activity10.9895Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.084990.5315Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.93431Least InformativeInherited
Cellular Component (CC)vacuole0.00052640.000008669Moderately InformativeDirect
Cellular Component (CC)cytosolic part0.0000000041260.000000001088Moderately InformativeDirect
Cellular Component (CC)vesicle0.9880.2358Moderately InformativeInherited
Cellular Component (CC)extracellular region part10.5101Moderately InformativeInherited
Cellular Component (CC)extracellular organelle0.01730.00001158InformativeInherited
Cellular Component (CC)ribonucleoprotein granule0.00000022460.001972InformativeInherited
Cellular Component (CC)cytoplasmic mRNA processing body0.00000000002570.000000575Highly InformativeDirect
Cellular Component (CC)extracellular exosome0.00069410.0000248Highly InformativeDirect
Cellular Component (CC)peptidase complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 0.0002507 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0001782 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0006031 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7757 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.00000007467 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000000009933 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000221 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00000001059 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.09674 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8557 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.8296 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4337 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.1021 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.5604 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.04115 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.2541 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.2267 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.2055 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.2724 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000000000000003692 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.000000007187 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.0001871 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00002855 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0004396 Informative Direct
Biological Process (BP) regulation of defense response 0.00001857 Informative Direct
Biological Process (BP) response to cytokine 0.00000004015 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.0001803 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002688 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.208 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03973 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.5389 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.2922 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.382 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1858 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1818 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1725 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.6734 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.04022 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.003973 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.06828 Informative Inherited
Biological Process (BP) cell cycle process 0.6532 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.06408 Informative Inherited
Biological Process (BP) regulation of immune response 0.001859 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.839 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.00109 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.303 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.07404 Informative Inherited
Biological Process (BP) phosphorylation 0.6569 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.3846 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.03919 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4115 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.008581 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.003459 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.006299 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.01467 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2998 Informative Inherited
Biological Process (BP) MAPK cascade 0.0000006839 Highly Informative Direct
Biological Process (BP) antigen processing and presentation of exogenous peptide antigen 0 Highly Informative Direct
Biological Process (BP) innate immune response-activating signal transduction 0.00000000001579 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.000000001407 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.0000869 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.0000000004558 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0002213 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00000005413 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000000167 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000006079 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00000002451 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.00000005197 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000003966 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0000001503 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.00002773 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0.000000000004661 Highly Informative Direct
Biological Process (BP) dicarboxylic acid biosynthetic process 0.000006506 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000005845 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.000003424 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000001065 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000001512 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.002205 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.001176 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.008762 Highly Informative Inherited
Biological Process (BP) protein maturation 0.03858 Highly Informative Inherited
Biological Process (BP) endocytosis 0.2015 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.005658 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.000000000002553 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00000004572 Informative Direct
Molecular Function (MF) ligase activity 0.03466 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.005084 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.000000000000003237 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000001861 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.000000002339 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.9895 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5315 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.000008669 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.000000001088 Moderately Informative Direct
Cellular Component (CC) vesicle 0.2358 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.5101 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular organelle 0.00001158 Informative Direct
Cellular Component (CC) cell surface 0.6957 Informative Inherited
Cellular Component (CC) side of membrane 0.004786 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.001972 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0.000000575 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00004262 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0.0000004546 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0000248 Highly Informative Direct
Cellular Component (CC) peptidase complex 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.5223 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01711Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02054Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09445Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3612Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003265InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001552InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002139InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3762InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.001039Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.08439Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1343Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000001977Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001262Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001011Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0001013Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.003439Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.007368Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6698Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000009891Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000003387Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.000001451Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004518Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00005538Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007425Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0000784Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00009433Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006637Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.001765Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.02368Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.04552Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000008177InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001805InformativeDirect
Worm Phenotype (WP)life span variant0.00006963InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002099InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.006761InformativeInherited
Worm Phenotype (WP)mitosis variant0.02574InformativeInherited
Worm Phenotype (WP)gonad development variant0.02744InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4128InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.8005InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.00000000000003152Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000000003241Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000006412Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001924Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb0.000002682Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.000004137Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00002024Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001656Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0005912Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.07258Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009269Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08062Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)portion of tissue0.4887Moderately InformativeInherited
Fly Anatomy (FA)gastrula embryo0.01269InformativeInherited
Fly Anatomy (FA)epithelial furrow0.0006483Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.05798Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.01123Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.01579Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002864InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0008963InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002185InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.0000000000001541InformativeDirect
Enzyme Commission (EC)In linear amides0.000000000005746InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.000001132InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000004114InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.03983InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0008939Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.00000000003047Least InformativeDirect
Drugbank ATC_code (DB)other antineoplastic agents0Moderately InformativeDirect
Drugbank ATC_code (DB)bortezomib0.00000005454Highly InformativeDirect
Drugbank ATC_code (DB)carfilzomib0.0005745Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.000000003448Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.8691Moderately InformativeInherited
Biological processStress response0.000000000005482InformativeDirect
Biological processPurine biosynthesis0.0000047InformativeDirect
Biological processNodulation0.00006209Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001874InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.0000002763Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0004139InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.00000001963Least InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.0006183InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4716Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.78Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism2.305e-16Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.000000000000108Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000000000004087Moderately InformativeDirect
UniPathway (UP)purine metabolism0.0000003182Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1256Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway4.579e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.0000002458InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.00000000000007425Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.00001162Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]