SUPERFAMILY 1.75 HMM library and genome assignments server

N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,142) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,489 139,222 127
Proteins 36,299 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00.00000000004902Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.84141Least InformativeInherited
Biological Process (BP)response to stimulus0.32771Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.4117Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.004219Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.75481Least InformativeInherited
Biological Process (BP)cellular response to stress0.0000004540.0006167Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.012690.4018Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.000098930.05372Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0081580.1634Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.020310.4566Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00010170.04162Moderately InformativeInherited
Biological Process (BP)immune system process0.0000014260.02036Moderately InformativeInherited
Biological Process (BP)response to organic substance0.16430.4484Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.037131Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.011480.6782Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.010251Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.58261Moderately InformativeInherited
Biological Process (BP)signal transduction0.62791Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.27360.8147Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.70881Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process10.000000000158Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.89761Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.85280Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle0.00000000006990.00001696InformativeDirect
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus0.0000000004490.00008805InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle00.0000000000006197InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.000031940.000002339InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.0000000004060.0001885InformativeDirect
Biological Process (BP)intracellular signal transduction0.0013660.2857InformativeInherited
Biological Process (BP)cell cycle process0.0000005580.01933InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.000010390.0177InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00065860.003264InformativeInherited
Biological Process (BP)cytoskeleton organization0.50331InformativeInherited
Biological Process (BP)microtubule-based process0.060490.8204InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0071530.004055InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0041280.02786InformativeInherited
Biological Process (BP)regulation of cell cycle process0.63821InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.00001910.00701InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.0000021780.001791InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.008750.0009059InformativeInherited
Biological Process (BP)peptide metabolic process0.011870InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.37630.0002743InformativeInherited
Biological Process (BP)fatty acid metabolic process0.002060.000000001684InformativeInherited
Biological Process (BP)lipid catabolic process0.39670.5806InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0018730.004144InformativeInherited
Biological Process (BP)DNA damage checkpoint0.000001140.00001666Highly InformativeDirect
Biological Process (BP)glycolysis0.00000050070.000002506Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00089050Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.000000066650.0008876Highly InformativeDirect
Biological Process (BP)response to salt stress0.000028440.00004977Highly InformativeDirect
Biological Process (BP)photorespiration0.000010070.0000004997Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.0000000012830.000000000002494Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.000000000000036250.00000000454Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00000000015840.0003065Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)cell cycle phase0.000000012640.000000001266Highly InformativeDirect
Biological Process (BP)lipid modification0.000000027730.0006525Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination00.0000000000571Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process0.0000019550.00008017Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process00.000000000000005594Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.0000000015680.000000005206Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.000000001480.000002505Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.0003560.0002359Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.0000052350.0000249Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.0000000000012530.0000000371Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.00000000000099160.00000002149Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle00.000000000001735Highly InformativeDirect
Biological Process (BP)spindle organization0.051140.07611Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process0.000000035340.01573Highly InformativeInherited
Molecular Function (MF)hydrolase activity00.0000000002981Least InformativeDirect
Molecular Function (MF)transferase activity10.813Least InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000020990.000000008803InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.45820InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups0.000045060Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.81650.58Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.67891Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.43291Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.31060.5226Moderately InformativeInherited
Cellular Component (CC)cytoplasmic mRNA processing body0.0000000022370.000005548Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000000004902 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4117 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004219 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000000158 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0006167 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0005128 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.4018 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.05372 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1634 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4566 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04162 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02036 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4484 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6782 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1257 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001082 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8147 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9572 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9181 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7885 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.00001696 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0002743 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000001684 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.00008805 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000000006197 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.000002339 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000422 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0009059 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000758 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0001885 Informative Direct
Biological Process (BP) intracellular signal transduction 0.2857 Informative Inherited
Biological Process (BP) cell cycle process 0.01933 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.00701 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.0177 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.003264 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8204 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1111 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004055 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9387 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02786 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6333 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.001791 Informative Inherited
Biological Process (BP) sexual reproduction 0.05139 Informative Inherited
Biological Process (BP) single organism reproductive process 0.07012 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03833 Informative Inherited
Biological Process (BP) lipid catabolic process 0.5806 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4607 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001602 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.004144 Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.00001666 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.00000004479 Highly Informative Direct
Biological Process (BP) glycolysis 0.000002506 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0008053 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000441 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0008876 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00004977 Highly Informative Direct
Biological Process (BP) photorespiration 0.0000004997 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000000000002494 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000000454 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0003065 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000000001266 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006525 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0000000000571 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00008017 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.000000000000005594 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.000000005206 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 0.0000003998 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000002505 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0002359 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000249 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0007998 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.0000000371 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000000003821 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.00000002149 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.000000000001735 Highly Informative Direct
Biological Process (BP) spindle organization 0.07611 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.04707 Highly Informative Inherited
Biological Process (BP) protein processing 0.6059 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.09239 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.002491 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01573 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.0692 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04508 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000002981 Least Informative Direct
Molecular Function (MF) transferase activity 0.813 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000000008803 Informative Direct
Molecular Function (MF) ligase activity 0.6471 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.09772 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.0000359 Highly Informative Direct
Molecular Function (MF) transaminase activity 0.0000000001154 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000004175 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.58 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00005557 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.5017 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5226 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.2125 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0008135 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00005342 Informative Direct
Cellular Component (CC) cell surface 0.8785 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 0.000005548 Highly Informative Direct
Cellular Component (CC) anchored to membrane 0.0000004587 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.003138 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000005842Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.000000001055Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.000000003133Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00002838Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00003212Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00005927Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000008938InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00000002011InformativeDirect
Worm Phenotype (WP)life span variant0.000005456InformativeDirect
Worm Phenotype (WP)cell division variant0.00006344InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.00000000000003692Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000007326Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased0.0000001448Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb0.000001096Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.000001527Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03782Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.000001716InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.3867Moderately InformativeInherited
Fly Anatomy (FA)epithelial furrow0.000661Highly InformativeDirect
Fly Anatomy (FA)gastrula embryo0.007593Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.08908Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004933Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03659Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008953InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002179InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.000000000002111InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.000001051InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.00002204InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05482InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002545Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic agents0.003247Moderately InformativeInherited
Drugbank ATC_code (DB)other antineoplastic agents0.0004716InformativeDirect
Drugbank ATC_code (DB)bortezomib0.0000001236Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8926Moderately InformativeInherited
Biological processStress response0.000000000001429InformativeDirect
Biological processPurine biosynthesis0.000005747InformativeDirect
Biological processNodulation0.00005956Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001693InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.00000006483Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003793InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.0000000001024Least InformativeDirect
Molecular functionFlavoprotein0.6854Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.000014InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4544Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7642Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0.000000000000001345Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0000000000004074Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000000000002887Moderately InformativeDirect
UniPathway (UP)purine metabolism0.0000002984Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1276Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway4.527e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.000001223InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.0000000000008475Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.00001141Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]