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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 229,894 127
Proteins 36,697 229,213 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01936Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02125Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3622Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003061InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0016InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002123InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3704InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009862Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09253Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1357Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000004283Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001482Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001192Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000225Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00429Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005835Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2964Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000007656Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000003231Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.000004376Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004596Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00005655Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00007132Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007435Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00007439Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006375Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00137Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.00177Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.02078Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.04156Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000007656InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001388InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00006704InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001996InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.003455InformativeInherited
Worm Phenotype (WP)cell component localization variant0.009869InformativeInherited
Worm Phenotype (WP)mitosis variant0.01896InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4219InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7721InformativeInherited
Worm Phenotype (WP)passage through meiosis defective early emb0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0.00000000000002935Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.00000002473Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000005956Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001853Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00001856Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00003474Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001584Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0002416Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0728Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009372Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08049Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2457Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05495Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.0004599InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001054InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.00204InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002182InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00000457Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000001459InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000008437InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001335InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.04801InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003954Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]