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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,148) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 36,675 173,742 127
Proteins 36,482 173,135 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process00.7494Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)primary metabolic process0.0000000035250.05572Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.007925Least InformativeInherited
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.26421Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.12711Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.15341Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.62561Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.4661Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.44020.6727Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.13851Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.27421Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.5351Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10661Moderately InformativeInherited
Biological Process (BP)cell differentiation0.85941Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00013130.06238Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.14641Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.55861Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.6521Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.1960.8982Moderately InformativeInherited
Biological Process (BP)response to organic substance0.39411Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.33621Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.5851Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.58371Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.84850.00000000000127Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.80710.9045Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.8615Moderately InformativeInherited
Biological Process (BP)immune system process0.0002380.1603Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)glutamine family amino acid metabolic process0.00010480.00000000349InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.0006040.0003205InformativeDirect
Biological Process (BP)regulation of defense response0.000019110.0004992InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)regulation of cell cycle0.00000000001560.00005287InformativeDirect
Biological Process (BP)regulation of proteolysis0.0011340.007189InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0010440.5549InformativeInherited
Biological Process (BP)regulation of catabolic process0.000067830.01728InformativeInherited
Biological Process (BP)regulation of protein modification process0.0081310.9386InformativeInherited
Biological Process (BP)regulation of cell differentiation0.0065231InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00021310.427InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.000075280.2947InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0013110.1907InformativeInherited
Biological Process (BP)cell cycle process0.00075250.3926InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.0041650.2467InformativeInherited
Biological Process (BP)mitotic cell cycle0.11380.2157InformativeInherited
Biological Process (BP)negative regulation of molecular function0.001960.1436InformativeInherited
Biological Process (BP)regulation of transferase activity0.000010630.02585InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.0038730.6922InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00017461InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.00000021590.0113InformativeInherited
Biological Process (BP)intracellular signal transduction0.01090.7531InformativeInherited
Biological Process (BP)negative regulation of cell communication0.00012340.5042InformativeInherited
Biological Process (BP)negative regulation of signaling0.00012340.5031InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.01150.7856InformativeInherited
Biological Process (BP)phosphorylation0.032380.8612InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.0089831InformativeInherited
Biological Process (BP)regulation of organelle organization0.00012570.3125InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.040280.5621InformativeInherited
Biological Process (BP)regulation of immune response0.000016650.0179InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0015820.1001InformativeInherited
Biological Process (BP)MAPK cascade0.00000000087050.000008513Highly InformativeDirect
Biological Process (BP)response to hypoxia0.0000015270.0001018Highly InformativeDirect
Biological Process (BP)activation of innate immune response0.000000000000550.0000000152Highly InformativeDirect
Biological Process (BP)immune response-activating signal transduction0.000000083620.000002739Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.00000000023220.000000121Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.000000011630.0003732Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.00001040.000007702Highly InformativeDirect
Biological Process (BP)positive regulation of cellular catabolic process0.00000000016270.000007593Highly InformativeDirect
Biological Process (BP)regulation of chromosome organization0.0000000048250.00004211Highly InformativeDirect
Biological Process (BP)cellular response to decreased oxygen levels0.000000000012480.000000007416Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.00000000087050.000005032Highly InformativeDirect
Biological Process (BP)regulation of RNA stability00.0000000001276Highly InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter in response to stress0.0000000000000016250.00000000001589Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000000000012290.0000002138Highly InformativeDirect
Biological Process (BP)post-translational protein modification0.00000000000044930.000000002928Highly InformativeDirect
Biological Process (BP)cellular protein catabolic process00Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.00000000087050.000008513Highly InformativeDirect
Biological Process (BP)negative regulation of transferase activity0.00000044370.00001216Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00000000000014630.000000000298Highly InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle phase transition00.000001392Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.0000000000024380.0000002529Highly InformativeDirect
Biological Process (BP)regulation of hemopoiesis0.000000016910.00003858Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.31990.07635Highly InformativeInherited
Biological Process (BP)negative regulation of cell cycle phase transition0.20260.2872Highly InformativeInherited
Biological Process (BP)cell-cell signaling0.0000042650.1401Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.00000047880.006718Highly InformativeInherited
Biological Process (BP)positive regulation of mitotic cell cycle0.013040.0003432Highly InformativeInherited
Biological Process (BP)regulation of mitotic nuclear division0.0019420.002266Highly InformativeInherited
Biological Process (BP)glutamine family amino acid catabolic process0.00000027220.008499Highly InformativeInherited
Biological Process (BP)negative regulation of mitotic cell cycle0.062540.1539Highly InformativeInherited
Biological Process (BP)glycoprotein metabolic process0.013690.05186Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation0.000097590.02952Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000000083360.0000000000006997InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.90961InformativeInherited
Molecular Function (MF)exopeptidase activity10.5926Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.03791Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vacuole0.0005120.00004794Moderately InformativeDirect
Cellular Component (CC)cytosolic part0.0000000014160.0000000003604Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein granule0.0000025320.01177InformativeInherited
Cellular Component (CC)P-body0.0000000027720.00001076Highly InformativeDirect
Cellular Component (CC)peptidase complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7494 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05572 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.007925 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000000127 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000007857 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000002595 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.04746 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6727 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8615 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.06238 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.3158 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8982 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.9045 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.4737 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8397 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7605 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.8632 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3473 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1603 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00000001107 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00000000349 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.0003205 Informative Direct
Biological Process (BP) regulation of defense response 0.0004992 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.00004078 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000005134 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00005287 Informative Direct
Biological Process (BP) regulation of proteolysis 0.007189 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.5549 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.01728 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.9386 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.427 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2947 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1907 Informative Inherited
Biological Process (BP) cell cycle process 0.3926 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.2467 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2157 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1436 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.02585 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.6922 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.0113 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7531 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5042 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5031 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7856 Informative Inherited
Biological Process (BP) phosphorylation 0.8612 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3125 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.5621 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.008169 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.3632 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.0132 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.003749 Informative Inherited
Biological Process (BP) regulation of immune response 0.0179 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1001 Informative Inherited
Biological Process (BP) MAPK cascade 0.000008513 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0001018 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.0000000152 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.000002739 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.00000004304 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.00003331 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001887 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000000000000001925 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000000121 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0003732 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00007827 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000007702 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.000007593 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00004211 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.000000007416 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.000005032 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0002461 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0.0000000001276 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.00000000001589 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0000002138 Highly Informative Direct
Biological Process (BP) dicarboxylic acid biosynthetic process 0.000001147 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000002928 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000008513 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0003432 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00001216 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.000000000298 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000009765 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.000001392 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000002529 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.00003858 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.2872 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.07635 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.1401 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.006718 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.002266 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.008499 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.1539 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.05186 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.02952 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000000000006997 Informative Direct
Molecular Function (MF) ligase activity 0.04516 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.01506 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.0000000121 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.00000001491 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.5926 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.00004794 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.0000000003604 Moderately Informative Direct
Cellular Component (CC) vesicle 0.6922 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular organelle 0.0002069 Informative Direct
Cellular Component (CC) extracellular space 0.3808 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.01177 Informative Inherited
Cellular Component (CC) P-body 0.00001076 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0001261 Highly Informative Direct
Cellular Component (CC) peptidase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.00000001099Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.8245Moderately InformativeInherited
Biological processStress response0.000000000008252InformativeDirect
Biological processPurine biosynthesis0.000004368InformativeDirect
Biological processNodulation0.00006264Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001782InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.0000003483Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0004377InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.00000003365Least InformativeDirect
Molecular functionFlavoprotein0.8628Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.0002671InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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