SUPERFAMILY 1.75 HMM library and genome assignments server


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,140) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,439 139,222 127
Proteins 36,250 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process04.3e-11Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.83341Least InformativeInherited
Biological Process (BP)response to stimulus0.32081Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.4106Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.004675Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.74381Least InformativeInherited
Biological Process (BP)cellular response to stress4.59e-070.0005377Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.013860.4067Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00013170.05931Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0075040.1494Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.019330.4389Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization9.784e-050.03822Moderately InformativeInherited
Biological Process (BP)immune system process1.433e-060.02027Moderately InformativeInherited
Biological Process (BP)response to organic substance0.15720.4334Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.5135Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.034061Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.010360.6636Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0086441Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.54951Moderately InformativeInherited
Biological Process (BP)signal transduction0.63021Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.27250.808Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.68681Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process11.563e-10Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.89591Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.86530Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle7.113e-111.736e-05InformativeDirect
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus4.858e-109.828e-05InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle05.986e-13InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process3.216e-052.384e-06InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process3.855e-100.0001506InformativeDirect
Biological Process (BP)intracellular signal transduction0.001340.2819InformativeInherited
Biological Process (BP)cell cycle process5.808e-070.01925InformativeInherited
Biological Process (BP)positive regulation of protein modification process7.484e-070.001161InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00057810.003122InformativeInherited
Biological Process (BP)cytoskeleton organization0.5061InformativeInherited
Biological Process (BP)microtubule-based process0.059910.8214InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0071920.004081InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0043610.02894InformativeInherited
Biological Process (BP)regulation of cell cycle process0.64561InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process1.816e-050.007InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal2.358e-060.001755InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.0087860.0009212InformativeInherited
Biological Process (BP)peptide metabolic process0.010980InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.36950.0002456InformativeInherited
Biological Process (BP)fatty acid metabolic process0.002041.648e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.40470.5792InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0018850.004142InformativeInherited
Biological Process (BP)DNA damage checkpoint1.137e-061.492e-05Highly InformativeDirect
Biological Process (BP)glycolysis5.05e-072.473e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00089280Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process6.658e-080.0008864Highly InformativeDirect
Biological Process (BP)response to salt stress2.866e-054.941e-05Highly InformativeDirect
Biological Process (BP)photorespiration1.01e-055.049e-07Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process1.571e-092.229e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process3.617e-144.331e-09Highly InformativeDirect
Biological Process (BP)protein ubiquitination1.73e-100.0002956Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)cell cycle phase1.236e-081.253e-09Highly InformativeDirect
Biological Process (BP)lipid modification2.799e-080.0006322Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination04.945e-11Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process2.048e-066.865e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process07.318e-15Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein1.671e-095.665e-09Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism3.18e-081.366e-05Highly InformativeDirect
Biological Process (BP)multi-organism cellular process1.776e-092.485e-06Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00035560.0002355Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process5.263e-062.481e-05Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process1.269e-123.653e-08Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition1.132e-122.151e-08Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle01.769e-12Highly InformativeDirect
Biological Process (BP)spindle organization0.051530.07783Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process3.567e-080.01556Highly InformativeInherited
Molecular Function (MF)hydrolase activity03.138e-10Least InformativeDirect
Molecular Function (MF)transferase activity10.8151Least InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds2.122e-067.708e-09InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.4580InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups4.537e-050Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.83010.5975Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.68291Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.42721Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.31260.5353Moderately InformativeInherited
Cellular Component (CC)cytoplasmic mRNA processing body2.304e-095.692e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.3e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4106 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004675 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.563e-10 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0005377 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000511 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.4067 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.05931 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1494 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4389 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.03822 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02027 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5135 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4334 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6636 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2243 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.09652 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001036 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.808 Moderately Informative Inherited
Biological Process (BP) reproduction 0.9541 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8755 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.737 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 1.736e-05 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0002456 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.648e-09 Informative Direct
Biological Process (BP) response to DNA damage stimulus 9.828e-05 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 5.986e-13 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 2.384e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000421 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0009212 Informative Direct
Biological Process (BP) amide biosynthetic process 0.0001006 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0001506 Informative Direct
Biological Process (BP) intracellular signal transduction 0.2819 Informative Inherited
Biological Process (BP) cell cycle process 0.01925 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.007 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.001161 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.003122 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8214 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1074 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004081 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02894 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6191 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.001755 Informative Inherited
Biological Process (BP) sexual reproduction 0.04862 Informative Inherited
Biological Process (BP) single organism reproductive process 0.06724 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03705 Informative Inherited
Biological Process (BP) lipid catabolic process 0.5792 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4634 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.00176 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.004142 Informative Inherited
Biological Process (BP) DNA damage checkpoint 1.492e-05 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 4.073e-08 Highly Informative Direct
Biological Process (BP) glycolysis 2.473e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0007644 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 4.048e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0008864 Highly Informative Direct
Biological Process (BP) response to salt stress 4.941e-05 Highly Informative Direct
Biological Process (BP) photorespiration 5.049e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 2.229e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 4.331e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0002956 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.253e-09 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006322 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 4.945e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 6.865e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 7.318e-15 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 5.665e-09 Highly Informative Direct
Biological Process (BP) sulfur compound catabolic process 4.143e-07 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.366e-05 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 2.485e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0002355 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.481e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0008307 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 3.653e-08 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 3.927e-12 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 2.151e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 1.769e-12 Highly Informative Direct
Biological Process (BP) spindle organization 0.07783 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.04607 Highly Informative Inherited
Biological Process (BP) protein processing 0.6012 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.09006 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.002554 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01556 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.0719 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04496 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 3.138e-10 Least Informative Direct
Molecular Function (MF) transferase activity 0.8151 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7.708e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.001202 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.09588 Informative Inherited
Molecular Function (MF) endopeptidase activity 3.652e-05 Highly Informative Direct
Molecular Function (MF) transaminase activity 1.176e-10 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 4.245e-09 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.5975 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 5.504e-05 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.4995 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5353 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.2143 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0008343 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 5.428e-05 Informative Direct
Cellular Component (CC) cell surface 0.8801 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 5.692e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 5.009e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.003104 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides5.578e-13Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N4.896e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)7.489e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal5.842e-13Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant1.055e-09Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant3.133e-09Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant2.838e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant3.212e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant5.927e-05Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant8.938e-11InformativeDirect
Worm Phenotype (WP)somatic gonad development variant2.011e-08InformativeDirect
Worm Phenotype (WP)life span variant5.456e-06InformativeDirect
Worm Phenotype (WP)cell division variant6.344e-05InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated3.692e-14Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant7.326e-08Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.448e-07Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb1.096e-06Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant1.527e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03778Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring1.712e-06InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.3867Moderately InformativeInherited
Fly Anatomy (FA)epithelial furrow0.0006628Highly InformativeDirect
Fly Anatomy (FA)gastrula embryo0.007593Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.08834Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004875Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03633Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008949InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage2.179e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides2.232e-12InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1.094e-06InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors2.292e-05InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0543InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002645Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8947Moderately InformativeInherited
Biological processStress response1.234e-12InformativeDirect
Biological processPurine biosynthesis4.734e-06InformativeDirect
Biological processNodulation5.996e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001635InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat5.811e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003724InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding2.819e-11Least InformativeDirect
Molecular functionFlavoprotein0.6836Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN1.376e-05InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

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UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism3.806e-14Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism0.917Moderately InformativeInherited
UniPathway (UP)purine nucleotide biosynthesis1InformativeInherited
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway4.18e-11Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]