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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 229,894 127
Proteins 36,697 229,213 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01496Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03483Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08217Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1027Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3916Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.002175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01946Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.07819Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1394Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.2061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.2183Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.2254Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3836Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4653Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.9045Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.00031InformativeDirect
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01135InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.01378InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating lipid concentration0.01446InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.03141InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.08128InformativeInherited
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.00004425Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertriglyceridemia0.00005746Highly InformativeDirect
Phenotypic Abnormality (PA)Increased antibody level in blood0.0000662Highly InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0.0002386Highly InformativeDirect
Phenotypic Abnormality (PA)Fever0.005513Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01932Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02126Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3613Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003064InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001598InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002116InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3707InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009844Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09254Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1371Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.000008237Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000008288Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00002327Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001727Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0006675Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.004934Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005998Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2985Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000000435Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.00000001848Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000003734Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00004402Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00007368Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007671Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0001022Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006566Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.001839Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01555Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.03505Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.04102Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.04773Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.2665Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.8682Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000007783InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001365InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.000001851InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00006949InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002066InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0006318InformativeDirect
Worm Phenotype (WP)life span variant0.002795InformativeInherited
Worm Phenotype (WP)cell component localization variant0.005832InformativeInherited
Worm Phenotype (WP)mitosis variant0.02074InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4028InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.54InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.00000000000002849Highly InformativeDirect
Worm Phenotype (WP)cell cycle progression variant0.0000000002342Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000005954Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001933Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000003822Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00001926Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.00003184Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00003561Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001531Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0728Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009372Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08049Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.263Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.147Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.0006257InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001486InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.00224InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002182InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00000464Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000001315InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000008079InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001242InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0567InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003957Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]