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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 229,894 127
Proteins 36,697 229,213 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03184Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.07786Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.08728Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3606Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3731Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.06548Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1253Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.448Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4508Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.7553Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0002954InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.001888InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.008367InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating lipid concentration0.01632InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.07955InformativeInherited
Phenotypic Abnormality (PA)Abnormal immune system morphology0.1277InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Increased antibody level in blood0.00004875Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0000501Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertriglyceridemia0.00006992Highly InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0.0002055Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.0009155Highly InformativeDirect
Phenotypic Abnormality (PA)Fever0.003637Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.1124Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01929Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02122Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01263Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003057InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001599InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.00212InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3706InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009858Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09256Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1359Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000004314Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001513Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001254Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002309Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.004293Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005864Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2971Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000007658Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000003282Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.000004379Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004641Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00005541Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00007136Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007442Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00007495Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006377Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00143Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.001787Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.02016Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.04148Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000007659InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001388InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00006709InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001997InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.003456InformativeInherited
Worm Phenotype (WP)cell component localization variant0.009749InformativeInherited
Worm Phenotype (WP)mitosis variant0.01886InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4201InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7748InformativeInherited
Worm Phenotype (WP)passage through meiosis defective early emb0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0.00000000000002936Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.00000002473Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000005957Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001853Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00001857Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00003476Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001585Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0002418Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0728Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009372Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08049Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2549Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.141Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.0006156InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001435InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.002183InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002182InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000004711Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000001334InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000008295InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001267InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0575InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003949Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]