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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 229,894 127
Proteins 36,697 229,213 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01622Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03608Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08555Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1048Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.002564Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01921Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.07951Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.09555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1438Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.2149Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.2217Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3795Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4783Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0002912InformativeDirect
Phenotypic Abnormality (PA)Abnormality of B cell physiology0.002624InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.007303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.012InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.01233InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating lipid concentration0.01447InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.03261InformativeInherited
Phenotypic Abnormality (PA)Hypertriglyceridemia0.00006461Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0000721Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal immunoglobulin level0.002529Highly InformativeInherited
Phenotypic Abnormality (PA)Fever0.005894Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01929Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02123Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003062InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001593InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002112InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3706InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009618Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09251Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1371Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.00001108Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001115Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00002548Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0002203Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0006436Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.005853Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.006766Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3133Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000005929Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.00000002169Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000004102Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00003435Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007598Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00008307Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0001045Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.000675Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.001984Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.03757Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.04066Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05538Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.267Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.8623Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.0000000001006InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001639InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.000001963InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00007747InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002101InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0007128InformativeDirect
Worm Phenotype (WP)life span variant0.003301InformativeInherited
Worm Phenotype (WP)cell component localization variant0.006168InformativeInherited
Worm Phenotype (WP)mitosis variant0.02033InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4166InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.532InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.00000000000003589Highly InformativeDirect
Worm Phenotype (WP)cell cycle progression variant0.0000000002566Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000006807Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000002083Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000003964Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00001978Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.0000349Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.00003622Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.000149Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0728Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009372Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08049Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.267Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.06596Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.0004916InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001186InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.002192InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002182InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000005095Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000001351InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000008155InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.00000127InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05698InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003928Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]