SUPERFAMILY 1.75 HMM library and genome assignments server


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,100) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 35,157 65,538 127
Proteins 34,997 65,433 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process08.415e-10Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process1.347e-141Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.751Least InformativeInherited
Biological Process (BP)response to stimulus0.14491Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.2739Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.001177Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.6131Least InformativeInherited
Biological Process (BP)cellular response to stress8.919e-070.0002357Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.010470.3397Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function2.792e-050.01456Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.012230.1734Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.069190.6185Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization4.598e-050.02198Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0010330.1879Moderately InformativeInherited
Biological Process (BP)immune system process2.934e-070.008043Moderately InformativeInherited
Biological Process (BP)response to organic substance0.070350.3191Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.4053Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.023891Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.0063890.5642Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0052511Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.43451Moderately InformativeInherited
Biological Process (BP)signal transduction0.56671Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.18510.5982Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.60481Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process13.799e-11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.88851Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.76890Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization0.99291Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus9.852e-100.0001255InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process2.031e-055.541e-06InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process9.701e-070InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process2.772e-100.0001999InformativeDirect
Biological Process (BP)regulation of cell cycle5.258e-141.375e-06InformativeDirect
Biological Process (BP)intracellular signal transduction0.0011580.277InformativeInherited
Biological Process (BP)cell cycle process3.812e-070.01769InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process4.878e-060.009934InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00044990.002198InformativeInherited
Biological Process (BP)cytoskeleton organization0.46591InformativeInherited
Biological Process (BP)microtubule-based process0.048450.7489InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0057410.003863InformativeInherited
Biological Process (BP)protein complex assembly0.15780.009741InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly3.404e-070.001368InformativeInherited
Biological Process (BP)negative regulation of cell death1.117e-050.002978InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process9.871e-060.004174InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.0075240.0009515InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.35170.0001624InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0014236.896e-10InformativeInherited
Biological Process (BP)lipid catabolic process0.31890.4864InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0015930.003514InformativeInherited
Biological Process (BP)cell cycle checkpoint2.536e-127.874e-08Highly InformativeDirect
Biological Process (BP)glycolysis3.647e-072.441e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00058680Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process6.352e-080.0009574Highly InformativeDirect
Biological Process (BP)photorespiration9.393e-064.863e-07Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process7.958e-140Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process9.095e-151.489e-09Highly InformativeDirect
Biological Process (BP)protein ubiquitination3.972e-110.0001778Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)cell cycle phase3.047e-088.897e-09Highly InformativeDirect
Biological Process (BP)lipid modification2.254e-080.0006723Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination02.643e-11Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process1.613e-063.187e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process03.749e-15Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein1.774e-101.176e-09Highly InformativeDirect
Biological Process (BP)multi-organism cellular process1.13e-091.499e-06Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00064260.0003341Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process4.475e-062.338e-05Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process8.312e-132.023e-08Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition4.555e-138.701e-09Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle05.722e-13Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.021350.007017Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process2.876e-080.01909Highly InformativeInherited
Biological Process (BP)microtubule cytoskeleton organization0.015740.4099Highly InformativeInherited
Molecular Function (MF)hydrolase activity03.754e-08Least InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides01.093e-06InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.41540InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups4.349e-050Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.58150.3456Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.81791Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.6451Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.028630.1299Moderately InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.28220.4942Moderately InformativeInherited
Cellular Component (CC)proteasome complex00Highly InformativeDirect
Cellular Component (CC)cytoplasmic mRNA processing body1.663e-094.914e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 8.415e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2739 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001177 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 3.799e-11 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0002357 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0008185 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.3397 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.01456 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1734 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.6185 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02198 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.1879 Moderately Informative Inherited
Biological Process (BP) immune system process 0.008043 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.4053 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.3191 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5642 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2017 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1303 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001434 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5982 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8813 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8619 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7256 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0001624 Informative Direct
Biological Process (BP) fatty acid metabolic process 6.896e-10 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001255 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 5.541e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0002205 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0009515 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0001999 Informative Direct
Biological Process (BP) regulation of cell cycle 1.375e-06 Informative Direct
Biological Process (BP) intracellular signal transduction 0.277 Informative Inherited
Biological Process (BP) cell cycle process 0.01769 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004174 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.009934 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.002198 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.7489 Informative Inherited
Biological Process (BP) response to inorganic substance 0.0828 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.003863 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8763 Informative Inherited
Biological Process (BP) protein complex assembly 0.009741 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.001368 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.002978 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.5429 Informative Inherited
Biological Process (BP) sexual reproduction 0.03341 Informative Inherited
Biological Process (BP) single organism reproductive process 0.04314 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.02339 Informative Inherited
Biological Process (BP) lipid catabolic process 0.4864 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4991 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001194 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.003514 Informative Inherited
Biological Process (BP) cell cycle checkpoint 7.874e-08 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 3.578e-08 Highly Informative Direct
Biological Process (BP) glycolysis 2.441e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0007553 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.95e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0009574 Highly Informative Direct
Biological Process (BP) photorespiration 4.863e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.489e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0001778 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 8.897e-09 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006723 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 2.643e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 3.187e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 3.749e-15 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 1.176e-09 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0.0002268 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 1.499e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0003341 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.338e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.000878 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.023e-08 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 4.097e-12 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 8.701e-09 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 5.722e-13 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.0425 Highly Informative Inherited
Biological Process (BP) protein processing 0.6459 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.007017 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.002964 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01909 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.08262 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.0439 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.4099 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 3.754e-08 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1.093e-06 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.002796 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0498 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.0007934 Highly Informative Direct
Molecular Function (MF) transaminase activity 7.856e-11 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 1.582e-10 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.3456 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006288 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.9535 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1299 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.4942 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1702 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0004329 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.0008474 Informative Direct
Cellular Component (CC) cell surface 0.7948 Informative Inherited
Cellular Component (CC) proteasome complex 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 4.914e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 4.406e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.002485 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides5.578e-13Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N4.896e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)7.489e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal5.842e-13Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant1.055e-09Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant3.133e-09Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant2.838e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant3.212e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant5.927e-05Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant8.938e-11InformativeDirect
Worm Phenotype (WP)somatic gonad development variant2.011e-08InformativeDirect
Worm Phenotype (WP)life span variant5.456e-06InformativeDirect
Worm Phenotype (WP)cell division variant6.344e-05InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated3.692e-14Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant7.326e-08Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.448e-07Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb1.096e-06Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant1.527e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03122Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring1.703e-06InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.0864Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004705Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03598Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008728InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage2.179e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides3.4e-13InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1.335e-06InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors2.704e-05InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05641InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002442Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.9035Moderately InformativeInherited
Biological processStress response1.058e-12InformativeDirect
Biological processPurine biosynthesis5.065e-06InformativeDirect
Biological processNodulation5.934e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001747InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat5.587e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003706InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding5.137e-12Least InformativeDirect
Molecular functionFlavoprotein0.6807Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN1.342e-05InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4477Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7574Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism1.125e-15Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism3.723e-13Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.6e-12Moderately InformativeDirect
UniPathway (UP)purine metabolism2.801e-07Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1272Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway2.277e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.22e-06InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis8.444e-13Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis1.14e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]