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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,148) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 36,675 173,742 127
Proteins 36,482 173,135 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process00.7381Least InformativeInherited
Biological Process (BP)primary metabolic process0.0000000065830.05686Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.01016Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.48841Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.15421Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.32571Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.51011Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.39060.6116Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00033790.08403Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.24861Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.63221Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.10821Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.12681Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.891Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.14641Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.28541Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.14071Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.56121Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.8230.9152Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.59761Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.59621Moderately InformativeInherited
Biological Process (BP)immune system process0.00015920.1387Moderately InformativeInherited
Biological Process (BP)response to organic substance0.34920.977Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.85210.00000000000112Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.8332Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.65711Moderately InformativeInherited
Biological Process (BP)single organism signaling0.99541Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.16680.8218Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)glutamine family amino acid metabolic process0.00011860.000000003224InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.00065790.0003149InformativeDirect
Biological Process (BP)regulation of defense response0.00001820.0006752InformativeDirect
Biological Process (BP)response to cytokine0.0000000097340.000001644InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)regulation of cell cycle0.000000000021830.00005346InformativeDirect
Biological Process (BP)regulation of protein modification process0.0077530.9253InformativeInherited
Biological Process (BP)regulation of proteolysis0.0011810.007082InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0010180.4986InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0013380.1912InformativeInherited
Biological Process (BP)regulation of catabolic process0.00007250.01473InformativeInherited
Biological Process (BP)negative regulation of signaling0.00012860.486InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated0.025311InformativeInherited
Biological Process (BP)regulation of transferase activity0.000011180.0255InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.007470.3437InformativeInherited
Biological Process (BP)mitotic cell cycle0.11190.2193InformativeInherited
Biological Process (BP)cell cycle process0.001010.404InformativeInherited
Biological Process (BP)negative regulation of molecular function0.0021280.1584InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.0039370.6813InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.000078410.2778InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.00000055090.01252InformativeInherited
Biological Process (BP)intracellular signal transduction0.010920.6803InformativeInherited
Biological Process (BP)cell-cell signaling0.0000052790.1424InformativeInherited
Biological Process (BP)regulation of organelle organization0.00013170.3041InformativeInherited
Biological Process (BP)negative regulation of cell communication0.00012860.487InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.00023270.4535InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.013010.7865InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.0066771InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.044390.5728InformativeInherited
Biological Process (BP)positive regulation of immune response0.000043090.005758InformativeInherited
Biological Process (BP)phosphorylation0.033660.8645InformativeInherited
Biological Process (BP)MAPK cascade0.0000000011610.000008151Highly InformativeDirect
Biological Process (BP)response to hypoxia0.000001420.00008975Highly InformativeDirect
Biological Process (BP)activation of innate immune response0.00000000000066590.00000001331Highly InformativeDirect
Biological Process (BP)immune response-activating signal transduction0.000000093460.00000261Highly InformativeDirect
Biological Process (BP)positive regulation of catabolic process0.0000000011610.00004398Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.00000000022130.0000001257Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.0000037910.000001129Highly InformativeDirect
Biological Process (BP)regulation of chromosome organization0.000000010860.00003913Highly InformativeDirect
Biological Process (BP)cellular response to decreased oxygen levels0.000000000020350.000000006511Highly InformativeDirect
Biological Process (BP)regulation of DNA-templated transcription in response to stress0.000000000000014790.00000000003191Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000000000014760.0000004503Highly InformativeDirect
Biological Process (BP)post-translational protein modification0.00000000000054680.000000003683Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.00000000094170.000008894Highly InformativeDirect
Biological Process (BP)negative regulation of transferase activity0.00000042520.00001418Highly InformativeDirect
Biological Process (BP)proteolysis involved in cellular protein catabolic process0.0000000000000031190.00000000000001439Highly InformativeDirect
Biological Process (BP)regulation of nuclear division0.0000000038110.0000006414Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00000000000026130.0000000003298Highly InformativeDirect
Biological Process (BP)regulation of proteolysis involved in cellular protein catabolic process0.00000000000044350.00000000216Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.0000000000017370.0000002791Highly InformativeDirect
Biological Process (BP)negative regulation of cell cycle phase transition0.29180.3509Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.00000042060.00716Highly InformativeInherited
Biological Process (BP)positive regulation of mitotic cell cycle phase transition0.083910.0006533Highly InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.0001261Highly InformativeInherited
Biological Process (BP)glutamine family amino acid catabolic process0.00000027340.008615Highly InformativeInherited
Biological Process (BP)negative regulation of mitotic cell cycle0.076630.1597Highly InformativeInherited
Biological Process (BP)glycoprotein metabolic process0.013210.03755Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation0.000082150.0306Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000000010910.0000000000008808InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.99651InformativeInherited
Molecular Function (MF)exopeptidase activity10.6201Highly InformativeInherited
Cellular Component (CC)macromolecular complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.044411Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytosolic part0.000000001720.0000000005291Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein granule0.0000026110.01214InformativeInherited
Cellular Component (CC)P-body0.0000000024970.00001132Highly InformativeDirect
Cellular Component (CC)peptidase complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01016 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7381 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05686 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000000112 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000008806 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000002786 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.3178 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.04662 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6116 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.08403 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.9152 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1387 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.977 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8332 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8218 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00000001322 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.000000003224 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.0003149 Informative Direct
Biological Process (BP) regulation of defense response 0.0006752 Informative Direct
Biological Process (BP) response to cytokine 0.000001644 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.00004816 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000005773 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00005346 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.00006581 Informative Direct
Biological Process (BP) regulation of protein modification process 0.9253 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.007082 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4986 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.1912 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.01473 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.486 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.0255 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2193 Informative Inherited
Biological Process (BP) cell cycle process 0.404 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1584 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.6813 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2778 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.01252 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.6803 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1424 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3041 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3437 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.487 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4535 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7865 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.007893 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.5728 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.3695 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.005758 Informative Inherited
Biological Process (BP) phosphorylation 0.8645 Informative Inherited
Biological Process (BP) MAPK cascade 0.000008151 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00008975 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.00000001331 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.00000261 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.00000003569 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.00003677 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0002041 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000000000000003764 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00004398 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000001257 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00008405 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000001129 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00003913 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.000000006511 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0002714 Highly Informative Direct
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.00000000003191 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0000004503 Highly Informative Direct
Biological Process (BP) dicarboxylic acid biosynthetic process 0.000001273 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000003683 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000008894 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00001418 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.00000000000001439 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.0000006414 Highly Informative Direct
Biological Process (BP) regulation of chromosome segregation 0.0000000003298 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000108 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle phase transition 0.0006533 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00000000216 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000002791 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.3509 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.00716 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid catabolic process 0.008615 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.1597 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.03755 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.0306 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000000000008808 Informative Direct
Molecular Function (MF) ligase activity 0.04002 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.01484 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00000001395 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.00000001734 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.6201 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.0000000005291 Moderately Informative Direct
Cellular Component (CC) vesicle 0.716 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) extracellular organelle 0.0002936 Informative Direct
Cellular Component (CC) extracellular space 0.376 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.01214 Informative Inherited
Cellular Component (CC) P-body 0.00001132 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 0.0002235 Highly Informative Direct
Cellular Component (CC) peptidase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01949Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02138Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.01406Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3635Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003057InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.00162InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002149InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3715InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009839Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09257Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1369Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000396Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001313Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001149Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0001846Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.003303Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005413Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5258Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000008457Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000003269Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.000004065Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004007Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00005969Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007775Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00007783Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00008779Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006592Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.001784Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.01852Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.02319Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000007809InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001731InformativeDirect
Worm Phenotype (WP)life span variant0.0001114InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002124InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.003768InformativeInherited
Worm Phenotype (WP)mitosis variant0.02065InformativeInherited
Worm Phenotype (WP)gonad development variant0.02656InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4093InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7814InformativeInherited
Worm Phenotype (WP)passage through meiosis defective early emb0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0.00000000000003196Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000000005819Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000006258Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001857Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00001919Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00004023Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001665Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0002703Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.07276Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009169Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.07999Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.3421Moderately InformativeInherited
Fly Anatomy (FA)gastrula embryo0.01141InformativeInherited
Fly Anatomy (FA)epithelial furrow0.0005714Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.06082Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.01088Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.01626Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002859InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.000905InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002185InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.000000000002277InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000009375InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001355InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05308InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003422Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.000000004878Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.8308Moderately InformativeInherited
Biological processStress response0.000000000007887InformativeDirect
Biological processPurine biosynthesis0.000004594InformativeDirect
Biological processNodulation0.00006347Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.000184InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.0000003288Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0004504InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.00000002964Least InformativeDirect
Molecular functionFlavoprotein0.8658Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.0002775InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.3724Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7976Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0000000000001375Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000000000001142Moderately InformativeDirect
UniPathway (UP)purine metabolism0.0000003701Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.2978Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway4.598e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.0000002667InformativeDirect
UniPathway (UP)organosulfur metabolism0.047InformativeInherited
UniPathway (UP)nonprotein amino-acid biosynthesis0.7021InformativeInherited
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.00000000000008239Highly InformativeDirect
UniPathway (UP)organosulfur biosynthesis0.000003173Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.00001186Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]