SUPERFAMILY 1.75 HMM library and genome assignments server

N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,142) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,489 139,222 127
Proteins 36,299 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00.00000000006078Least InformativeDirect
Biological Process (BP)response to stimulus0.32521Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.89911Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.77751Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.85811Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.000002697Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.4101Least InformativeInherited
Biological Process (BP)cellular response to stress0.00000048160.0006272Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.82511Moderately InformativeInherited
Biological Process (BP)signal transduction0.62451Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.019950.4705Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.019420.7289Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.17211Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00011070.06052Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.53021Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.039111Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.012850.4117Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.94121Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.024770.04096Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00089270.4815Moderately InformativeInherited
Biological Process (BP)response to organic substance0.16920.4548Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.27430.8235Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.90740.8333Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process10.000000007064Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.084770.7953Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.80561Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.82060Moderately InformativeInherited
Biological Process (BP)immune system process0.0000013980.0206Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle0.0000000018310.0003884InformativeDirect
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle00.000000000002015InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process0.0000340.000002973InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.0000000032890.0001532InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000016350.0007491InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00000099450.005537InformativeInherited
Biological Process (BP)secondary metabolic process0.0027640.4005InformativeInherited
Biological Process (BP)intracellular signal transduction0.0018220.3803InformativeInherited
Biological Process (BP)cell cycle process0.00000071730.02583InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.000098540.003507InformativeInherited
Biological Process (BP)cytoskeleton organization0.50631InformativeInherited
Biological Process (BP)microtubule-based process0.061660.8288InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0040850.02334InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11InformativeInherited
Biological Process (BP)regulation of cell cycle process0.63131InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.0004720.01846InformativeInherited
Biological Process (BP)hexose metabolic process0.0019050.004385InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.011380.001174InformativeInherited
Biological Process (BP)peptide metabolic process0.016350InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.34640.0001927InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0020320.000000001604InformativeInherited
Biological Process (BP)lipid catabolic process0.34960.5182InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0070620.002813InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.0000025550.001839InformativeInherited
Biological Process (BP)glycolytic process0.00000060560.0000002206Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00088030Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.00000006630.0008893Highly InformativeDirect
Biological Process (BP)response to salt stress0.00002810.00004912Highly InformativeDirect
Biological Process (BP)photorespiration0.0000099660.0000004948Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process0.0000000041050.000000000008832Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.000000000000047780.00000000473Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00000000022720.0003204Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)lipid modification0.000000027450.0006441Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination00.0000000000813Highly InformativeDirect
Biological Process (BP)DNA integrity checkpoint00.0000000008008Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process00.000000000000007248Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein0.0000000015990.000000004833Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.000000026870.00001713Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.0000000022270.000005268Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.000041350.00002313Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.0000051760.00001537Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)negative regulation of transferase activity0.000000044070.00000677Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.0000000000026770.00000004119Highly InformativeDirect
Biological Process (BP)secondary metabolite catabolic process0.000014140.000707Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.0000000000010970.00000003306Highly InformativeDirect
Biological Process (BP)positive regulation of protein modification by small protein conjugation or removal00.0000000000004257Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle00.000000000000858Highly InformativeDirect
Biological Process (BP)spindle organization0.045990.06329Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process0.000000035010.01569Highly InformativeInherited
Biological Process (BP)glucose metabolic process0.00043260.001235Highly InformativeInherited
Molecular Function (MF)hydrolase activity00.0000000002739Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000020720.000000008316InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.46420InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups0.000045250Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.81840.6021Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.74161Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.251Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.31510.5263Moderately InformativeInherited
Cellular Component (CC)cytoplasmic ribonucleoprotein granule0.00000041710.003949Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.00000000006078 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000002697 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4101 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000007064 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0006272 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0008664 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7289 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.06052 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4117 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04096 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4815 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1179 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4548 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8235 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7816 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.8333 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.8845 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.7953 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.03995 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4705 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9123 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2836 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0206 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0003884 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0001927 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.000000001604 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.000000000002015 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.000002973 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0004166 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00006242 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0001532 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0007491 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.005537 Informative Inherited
Biological Process (BP) secondary metabolic process 0.4005 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3803 Informative Inherited
Biological Process (BP) cell cycle process 0.02583 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.003507 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8288 Informative Inherited
Biological Process (BP) single organism reproductive process 0.509 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1117 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9441 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02334 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.01846 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6197 Informative Inherited
Biological Process (BP) hexose metabolic process 0.004385 Informative Inherited
Biological Process (BP) cellular metabolic compound salvage 0.001174 Informative Inherited
Biological Process (BP) sexual reproduction 0.07932 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.03026 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) lipid catabolic process 0.5182 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4262 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.001392 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.002813 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.001839 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.00000004411 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0000002206 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0007144 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00004477 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0008893 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00004912 Highly Informative Direct
Biological Process (BP) photorespiration 0.0000004948 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000000000008832 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00000000473 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.0003204 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006441 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0000000000813 Highly Informative Direct
Biological Process (BP) DNA integrity checkpoint 0.0000000008008 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.000000000000007248 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.000000004833 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00001713 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000005268 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.00002313 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00001537 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0007991 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.00000677 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00000004119 Highly Informative Direct
Biological Process (BP) secondary metabolite catabolic process 0.000707 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000000003361 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.00000003306 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0000000000004257 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.000000000000858 Highly Informative Direct
Biological Process (BP) spindle organization 0.06329 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.04783 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.08703 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.002582 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01569 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.06924 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04163 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.001235 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000002739 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.000000008316 Informative Direct
Molecular Function (MF) ligase activity 0.02725 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.05318 Informative Inherited
Molecular Function (MF) endopeptidase activity 0.00003328 Highly Informative Direct
Molecular Function (MF) transaminase activity 0.0000000001154 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000000004184 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.6021 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00006603 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.5036 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.2361 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5263 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.0008185 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00006857 Informative Direct
Cellular Component (CC) cell surface 0.9644 Informative Inherited
Cellular Component (CC) side of membrane 0.01361 Informative Inherited
Cellular Component (CC) anchored component of membrane 0.0000004046 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.003163 Highly Informative Inherited
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.003949 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000005842Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.000000001055Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.000000003133Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00002838Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00003212Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00005927Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000008938InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00000002011InformativeDirect
Worm Phenotype (WP)life span variant0.000005456InformativeDirect
Worm Phenotype (WP)cell division variant0.00006344InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.00000000000003692Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000007326Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased0.0000001448Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb0.000001096Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.000001527Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03782Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.000001716InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.3867Moderately InformativeInherited
Fly Anatomy (FA)epithelial furrow0.000661Highly InformativeDirect
Fly Anatomy (FA)gastrula embryo0.007593Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.08908Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004933Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03659Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008953InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002179InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.000000000002111InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.000001051InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.00002204InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05482InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002545Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic agents0.003247Moderately InformativeInherited
Drugbank ATC_code (DB)other antineoplastic agents0.0004716InformativeDirect
Drugbank ATC_code (DB)bortezomib0.0000001236Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8926Moderately InformativeInherited
Biological processStress response0.000000000001429InformativeDirect
Biological processPurine biosynthesis0.000005747InformativeDirect
Biological processNodulation0.00005956Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001693InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.00000006483Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003793InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.0000000001024Least InformativeDirect
Molecular functionFlavoprotein0.6854Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.000014InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4544Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7642Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism0.000000000000001345Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0000000000004074Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism0.000000000002887Moderately InformativeDirect
UniPathway (UP)purine metabolism0.0000002984Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1276Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway4.527e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.000001223InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.0000000000008475Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis0.00001141Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]