SUPERFAMILY 1.75 HMM library and genome assignments server


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,449 139,222 127
Proteins 36,260 139,061 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process04.563e-11Least InformativeDirect
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.8841Least InformativeInherited
Biological Process (BP)response to stimulus0.4171Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process10.4564Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.004927Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.81281Least InformativeInherited
Biological Process (BP)cellular response to stress7.598e-070.0008739Moderately InformativeDirect
Biological Process (BP)cellular catabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity0.018550.4555Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00019530.0719Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.03060.3106Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.024880.5088Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00015890.05208Moderately InformativeInherited
Biological Process (BP)immune system process3.093e-060.03077Moderately InformativeInherited
Biological Process (BP)response to organic substance0.19090.5067Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.5082Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.041151Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.01340.7186Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.010921Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.6071Moderately InformativeInherited
Biological Process (BP)signal transduction0.69251Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.26940.8524Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.74171Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process11.197e-10Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.89551Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.85750Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)mitotic cell cycle1.292e-103.003e-05InformativeDirect
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)response to DNA damage stimulus5.418e-100.0001047InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle01.241e-12InformativeDirect
Biological Process (BP)aspartate family amino acid metabolic process3.382e-051.814e-06InformativeDirect
Biological Process (BP)protein catabolic process00InformativeDirect
Biological Process (BP)cellular amide metabolic process2.1e-060InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process8.783e-100.0002199InformativeDirect
Biological Process (BP)intracellular signal transduction0.0021960.3657InformativeInherited
Biological Process (BP)cell cycle process1.033e-060.0272InformativeInherited
Biological Process (BP)positive regulation of protein modification process1.017e-060.001417InformativeInherited
Biological Process (BP)negative regulation of catalytic activity0.00059560.004048InformativeInherited
Biological Process (BP)cytoskeleton organization0.54581InformativeInherited
Biological Process (BP)microtubule-based process0.070980.8645InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0082870.004092InformativeInherited
Biological Process (BP)protein complex assembly0.0045870.0001355InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.0045370.02891InformativeInherited
Biological Process (BP)regulation of cell cycle process0.62881InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process2.631e-050.009384InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal2.374e-060.002459InformativeInherited
Biological Process (BP)cellular metabolic compound salvage0.0097430.000913InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.36430.0002575InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0021912.364e-09InformativeInherited
Biological Process (BP)lipid catabolic process0.40950.5907InformativeInherited
Biological Process (BP)carbohydrate catabolic process11InformativeInherited
Biological Process (BP)hexose metabolic process0.0022590.005226InformativeInherited
Biological Process (BP)DNA damage checkpoint1.225e-061.6e-05Highly InformativeDirect
Biological Process (BP)glycolysis6.228e-072.424e-06Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process00Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00088590Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process7.83e-080.0009169Highly InformativeDirect
Biological Process (BP)response to salt stress3.248e-054.811e-05Highly InformativeDirect
Biological Process (BP)photorespiration1.257e-056.334e-07Highly InformativeDirect
Biological Process (BP)proteasomal protein catabolic process3.449e-096.931e-12Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process6.593e-145.729e-09Highly InformativeDirect
Biological Process (BP)protein ubiquitination2.756e-100.000411Highly InformativeDirect
Biological Process (BP)antigen processing and presentation00Highly InformativeDirect
Biological Process (BP)cell cycle phase1.549e-081.516e-09Highly InformativeDirect
Biological Process (BP)lipid modification3.824e-080.0006335Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination07.232e-11Highly InformativeDirect
Biological Process (BP)negative regulation of protein modification process2.309e-060.000102Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process09.182e-15Highly InformativeDirect
Biological Process (BP)response to topologically incorrect protein1.946e-096.305e-09Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism1.595e-081.202e-05Highly InformativeDirect
Biological Process (BP)multi-organism cellular process1.949e-092.672e-06Highly InformativeDirect
Biological Process (BP)mitotic cell cycle phase transition0.00042560.0002548Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process6.365e-062.52e-05Highly InformativeDirect
Biological Process (BP)regulation of ligase activity00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process1.995e-125.503e-08Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition1.995e-123.004e-08Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle1.72e-152.777e-12Highly InformativeDirect
Biological Process (BP)spindle organization0.052670.07823Highly InformativeInherited
Biological Process (BP)fatty acid catabolic process4.89e-080.01672Highly InformativeInherited
Molecular Function (MF)hydrolase activity05.825e-10Least InformativeDirect
Molecular Function (MF)transferase activity10.7656Least InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds2.225e-068.564e-09InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.46490InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups5.265e-050Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.78680.5894Highly InformativeInherited
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.75791Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.37451Least InformativeInherited
Cellular Component (CC)cytosol00Moderately InformativeDirect
Cellular Component (CC)ribonucleoprotein complex0.32250.5402Moderately InformativeInherited
Cellular Component (CC)cytoplasmic mRNA processing body2.963e-096.447e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.563e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4564 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004927 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 1.197e-10 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0008739 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0004259 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0008594 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.4555 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.0719 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3106 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5088 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05208 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03077 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5082 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5067 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7186 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2125 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.09413 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8524 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8722 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7336 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 3.003e-05 Informative Direct
Biological Process (BP) protein complex assembly 0.0001355 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0002575 Informative Direct
Biological Process (BP) fatty acid metabolic process 2.364e-09 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0.0001047 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 1.241e-12 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 1.814e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0004563 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.000913 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0002199 Informative Direct
Biological Process (BP) intracellular signal transduction 0.3657 Informative Inherited
Biological Process (BP) cell cycle process 0.0272 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.009384 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.001417 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.004048 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8645 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1233 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004092 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02891 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.6299 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.002459 Informative Inherited
Biological Process (BP) sexual reproduction 0.06551 Informative Inherited
Biological Process (BP) single organism reproductive process 0.08829 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.05008 Informative Inherited
Biological Process (BP) lipid catabolic process 0.5907 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4199 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.00169 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.005226 Informative Inherited
Biological Process (BP) DNA damage checkpoint 1.6e-05 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 5.598e-08 Highly Informative Direct
Biological Process (BP) glycolysis 2.424e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0009033 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 5.721e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.0009169 Highly Informative Direct
Biological Process (BP) response to salt stress 4.811e-05 Highly Informative Direct
Biological Process (BP) photorespiration 6.334e-07 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 6.931e-12 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 5.729e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0.000411 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.516e-09 Highly Informative Direct
Biological Process (BP) lipid modification 0.0006335 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 7.232e-11 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.000102 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 9.182e-15 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 6.305e-09 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.202e-05 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 2.672e-06 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.0002548 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 2.52e-05 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0008919 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 5.503e-08 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 4.547e-12 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 3.004e-08 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 2.777e-12 Highly Informative Direct
Biological Process (BP) spindle organization 0.07823 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.05244 Highly Informative Inherited
Biological Process (BP) protein processing 0.5981 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.08311 Highly Informative Inherited
Biological Process (BP) unsaturated fatty acid metabolic process 0.002977 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 0.01672 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.07958 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.04606 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 5.825e-10 Least Informative Direct
Molecular Function (MF) transferase activity 0.7656 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8.564e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.001881 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.05169 Informative Inherited
Molecular Function (MF) endopeptidase activity 3.895e-05 Highly Informative Direct
Molecular Function (MF) transaminase activity 1.598e-10 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 3.589e-10 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.5894 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001052 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.5817 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.5402 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.289 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 8.823e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.001428 Informative Inherited
Cellular Component (CC) cell surface 0.9053 Informative Inherited
Cellular Component (CC) cytoplasmic mRNA processing body 6.447e-06 Highly Informative Direct
Cellular Component (CC) anchored to membrane 6.565e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.004077 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides5.578e-13Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N4.896e-08InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)7.489e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01236Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6838Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal5.842e-13Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant1.055e-09Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant3.133e-09Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant2.838e-05Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant3.212e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant5.927e-05Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0003556Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.006891Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1769Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant8.938e-11InformativeDirect
Worm Phenotype (WP)somatic gonad development variant2.011e-08InformativeDirect
Worm Phenotype (WP)life span variant5.456e-06InformativeDirect
Worm Phenotype (WP)cell division variant6.344e-05InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0001311InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0007551InformativeDirect
Worm Phenotype (WP)organism stress response variant0.01428InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7861InformativeInherited
Worm Phenotype (WP)gonad vesiculated3.692e-14Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant7.326e-08Highly InformativeDirect
Worm Phenotype (WP)stress induced lethality increased1.448e-07Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb1.096e-06Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant1.527e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0002546Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03778Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring1.708e-06InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.3888Moderately InformativeInherited
Fly Anatomy (FA)epithelial furrow0.0006539Highly InformativeDirect
Fly Anatomy (FA)gastrula embryo0.007686Highly InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.08816Least InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0004873Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.03633Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0008953InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage2.179e-08InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides2.277e-13InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor1.027e-06InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors2.312e-05InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05419InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0002644Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0.8947Moderately InformativeInherited
Biological processStress response1.234e-12InformativeDirect
Biological processPurine biosynthesis4.734e-06InformativeDirect
Biological processNodulation5.996e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001635InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat5.811e-08Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0003724InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding2.819e-11Least InformativeDirect
Molecular functionFlavoprotein0.6836Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN1.376e-05InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4561Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.7629Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)energy metabolism1.121e-15Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism3.925e-13Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism2.78e-12Moderately InformativeDirect
UniPathway (UP)purine metabolism2.902e-07Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.1275Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-glutamate metabolism0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway2.271e-16InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.234e-06InformativeDirect
UniPathway (UP)L-asparagine biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0Highly InformativeDirect
UniPathway (UP)L-glutamate biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis8.55e-13Highly InformativeDirect
UniPathway (UP)leukotriene biosynthesis1.142e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]