SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 0 127
Proteins 36,697 0 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01938Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02127Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3623Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003062InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001601InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002125InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3705InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009867Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09255Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1357Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000428Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00001397Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001225Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002028Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.004194Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005589Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2766Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000000009822Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0000000339Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.000004759Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00005125Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00005949Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00007912Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00008026Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.00009526Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0006623Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.001882Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.02165Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.03711Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.00000000008049InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000001839InformativeDirect
Worm Phenotype (WP)life span variant0.0001266InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002137InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.003693InformativeInherited
Worm Phenotype (WP)mitosis variant0.01882InformativeInherited
Worm Phenotype (WP)gonad development variant0.02676InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4117InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7771InformativeInherited
Worm Phenotype (WP)passage through meiosis defective early emb0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0.00000000000003183Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.0000000065Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000006278Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001867Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00002001Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.0000453Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001581Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0002651Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0727Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.0000917Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2194Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.05277Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0003778InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0004532InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001021InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002185InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000007917InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000009155InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001317InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05186InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003246Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.00000005592Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.8205Moderately InformativeInherited
Biological processStress response0.00000000001106InformativeDirect
Biological processPurine biosynthesis0.000004197InformativeDirect
Biological processNodulation0.00006218Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeriplasm0.0001722InformativeDirect
Cellular componentProteasome0Highly InformativeDirect
DomainRepeat0.000000461Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000481InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0.000000192Least InformativeDirect
Molecular functionFlavoprotein0.8817Moderately InformativeInherited
Molecular functionSodium0InformativeDirect
Molecular functionFMN0.0002781InformativeDirect
Molecular function3Fe-4S0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAllosteric enzyme0InformativeDirect
Post-translational modificationAutocatalytic cleavage0InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 59 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]