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N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ntn hydrolase-like [ 56234] (2)
Superfamily:   N-terminal nucleophile aminohydrolases (Ntn hydrolases) [ 56235] (7)
Families:   Class II glutamine amidotransferases [ 56236] (6)
  Penicillin acylase, catalytic domain [ 56244] (2)
  Penicillin V acylase [ 56248]
  Proteasome subunits [ 56251] (3)
  (Glycosyl)asparaginase [ 56261]
  Gamma-glutamyltranspeptidase-like [ 143906] (3)
  SPO2555-like [ 160846]


Superfamily statistics
Genomes (3,150) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,893 229,894 127
Proteins 36,697 229,213 127


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000000005578Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0.00000004896InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0004956InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Glutamate synthase (NADH)0.00000007489Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01732Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03686Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.111Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.002745Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0196Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.08095Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.2222Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.2225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3918Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4841Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.000282InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.00743InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.01192InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01207InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating lipid concentration0.01544InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.08394InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.1153InformativeInherited
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.00006925Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertriglyceridemia0.00008628Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lymphocyte morphology0.0009229Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal immunoglobulin level0.002947Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01932Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02125Least InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.09041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.000003055InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.001604InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.002127InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.3712InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell physiology0.0009616Highly InformativeDirect
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.09308Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1364Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000008627Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00002422Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0003504Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0007526Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.007756Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.00951Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02135Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000000000001172Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.000000008857Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000004566Moderately InformativeDirect
Worm Phenotype (WP)cell cycle variant0.0000002227Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.00003483Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00004149Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00008816Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0007544Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.002121Moderately InformativeInherited
Worm Phenotype (WP)protein interaction variant0.005704Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01175Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.05325Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2833Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.3755Moderately InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.0000000001008InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0000000002293InformativeDirect
Worm Phenotype (WP)vesicle organization variant0.000003011InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00007901InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0002099InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.0004291InformativeDirect
Worm Phenotype (WP)life span variant0.004239InformativeInherited
Worm Phenotype (WP)cell component localization variant0.006103InformativeInherited
Worm Phenotype (WP)mitosis variant0.0316InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.4111InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7507InformativeInherited
Worm Phenotype (WP)passage through meiosis defective early emb0Highly InformativeDirect
Worm Phenotype (WP)gonad vesiculated0.00000000000003884Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.0000000653Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000001982Highly InformativeDirect
Worm Phenotype (WP)shortened life span0.000005145Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00002188Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.00003392Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0001356Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.0728Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.00009372Highly InformativeDirect
Yeast Phenotype (YP)toxin resistance0.08049Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2659Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.06471Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.0005001InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001199InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.002152InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00000002182InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00000522Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.0000000001313InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.0000008041InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.000001257InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.05659InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0003937Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N-terminal nucleophile aminohydrolases (Ntn hydrolases) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]