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Metallo-hydrolase/oxidoreductase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metallo-hydrolase/oxidoreductase [ 56280]
Superfamily:   Metallo-hydrolase/oxidoreductase [ 56281] (14)
Families:   Zn metallo-beta-lactamase [ 56282]
  Hypothetical protein TM0207 [ 103317]
  Glyoxalase II (hydroxyacylglutathione hydrolase) [ 56288]
  ROO N-terminal domain-like [ 56291] (3)
  Methyl parathion hydrolase [ 111227]
  Coenzyme PQQ synthesis protein B, PqqB [ 118146]
  RNase Z-like [ 143916]
  Pce catalytic domain-like [ 143921]
  YhfI-like [ 143924]
  beta-CASP RNA-metabolising hydrolases [ 143927] (4)
  TM0894-like [ 143930]
  Ava3068-like [ 160858]
  Alkylsulfatase-like [ 160861]
  PqsE-like [ 160864]


Superfamily statistics
Genomes (3,236) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,479 229,562 47
Proteins 38,833 227,828 46


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process10.5561Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.18470.00000000000004085Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.05840.0000000000001847Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.91950.00000001776Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.72330.000000001047Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.72911Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0025480.000000000000001925Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.12180.8013Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.020950.01009Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0000043250.02631Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.00036180.08338Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0064280.03346Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.012310.0757Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.00003710.00002864InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.0000012840.0002089InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.0000001460.000000125InformativeDirect
Biological Process (BP)secondary metabolic process0.0016570.01945InformativeInherited
Biological Process (BP)lactate metabolic process0.00000000065530.00000000007287Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.000000000002610.000000002568Highly InformativeDirect
Biological Process (BP)methylglyoxal metabolic process0.0000003460.00000006221Highly InformativeDirect
Biological Process (BP)ketone catabolic process0.000000011090.0000000003071Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.00027170.0009628Highly InformativeDirect
Biological Process (BP)aldehyde catabolic process0.000000053950.000000002355Highly InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.000000085580Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000000021520Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.000023450Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.0000000002160.00000001489Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding0.062010.8932Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000059980.0004902InformativeDirect
Molecular Function (MF)nuclease activity0.050910.000004696InformativeInherited
Molecular Function (MF)RNA binding0.0031420.01231InformativeInherited
Molecular Function (MF)endoribonuclease activity0.00016640.00000008086Highly InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity0.000072340.0000000001677Highly InformativeDirect
Molecular Function (MF)thiolester hydrolase activity0.000000000019070.000000008944Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000001776 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000000000001847 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000001047 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000000004085 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.5561 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) gene expression 0.00000002075 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.01009 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.6509 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1481 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02631 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.08338 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.03346 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.8013 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.5554 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0757 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.00002864 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0002089 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0002473 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000000125 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001952 Informative Direct
Biological Process (BP) secondary metabolic process 0.01945 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.1084 Informative Inherited
Biological Process (BP) ncRNA processing 0.004279 Informative Inherited
Biological Process (BP) chromosome organization 0.4467 Informative Inherited
Biological Process (BP) DNA metabolic process 0.03767 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.01152 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.7072 Informative Inherited
Biological Process (BP) lactate metabolic process 0.00000000007287 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000000002568 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.00002574 Highly Informative Direct
Biological Process (BP) methylglyoxal metabolic process 0.00000006221 Highly Informative Direct
Biological Process (BP) ketone catabolic process 0.0000000003071 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0009628 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.000000002355 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0004743 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.00005199 Highly Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0 Highly Informative Direct
Biological Process (BP) mRNA processing 0.02596 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00000001489 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.8932 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.000004696 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0004902 Informative Direct
Molecular Function (MF) RNA binding 0.01231 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.00000008086 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0000000001677 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0.000000008944 Highly Informative Direct
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Molecular Function (MF) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo 0.5914 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1869 Least Informative Inherited
Cellular Component (CC) protein complex 0.04536 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4224 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000009264 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.007121 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.5536 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.00000001464 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.01339 Informative Inherited
Cellular Component (CC) chromosome 0.7603 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.003632Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)In cyclic amides0.0000000008264InformativeDirect
Enzyme Commission (EC)Beta-lactamase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.01233Least InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processtRNA processing0InformativeDirect
Biological processmRNA processing0.00000000000001219InformativeDirect
Biological processElectron transport0.0000000000001284InformativeDirect
Biological processAntibiotic resistance0.00000007431InformativeDirect
Biological processPhospholipid metabolism0.2398Highly InformativeInherited
Cellular componentPeriplasm0.000005959InformativeDirect
Cellular componentChromosome0.5343InformativeInherited
Cellular componentTelomere0.00003297Highly InformativeDirect
Coding sequence diversityAlternative initiation0.00003376Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionFlavoprotein0.09029Moderately InformativeInherited
Molecular functionFMN0.0000000000005153InformativeDirect
Molecular functioncAMP0.000001474Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 31 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-hydrolase/oxidoreductase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 31 hidden Markov models representing the Metallo-hydrolase/oxidoreductase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]