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Metallo-dependent phosphatases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metallo-dependent phosphatases [ 56299]
Superfamily:   Metallo-dependent phosphatases [ 56300] (12)
Families:   Purple acid phosphatase-like [ 56301] (2)
  DNA double-strand break repair nuclease [ 64427]
  5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain [ 56307]
  Protein serine/threonine phosphatase [ 56310] (5)
  Phosphoesterase-related [ 82803]
  TT1561-like [ 103320] (2)
  YfcE-like [ 111233] (4)
  Hypothetical protein aq 1666 [ 118152]
  DR1281-like [ 118155] (2)
  TTHA0625-like [ 143938]
  GpdQ-like [ 160875] (2)
  ADPRibase-Mn-like [ 160880]


Superfamily statistics
Genomes (3,167) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 45,254 190,174 54
Proteins 44,819 185,060 54


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.98911Least InformativeInherited
Biological Process (BP)protein metabolic process0.0099460.000006644Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.027820.2429Least InformativeInherited
Biological Process (BP)single-organism cellular process0.48991Least InformativeInherited
Biological Process (BP)localization0.064581Least InformativeInherited
Biological Process (BP)biosynthetic process0.98781Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)lipid biosynthetic process0.00022290.0000136Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.84521Moderately InformativeInherited
Biological Process (BP)cellular localization0.00000046310.05386Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.000000096330.01391Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0024860.2999Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0061140.5666Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.0075250.8975Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.051171Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.073310.00000000007104Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.0000000000095590InformativeDirect
Biological Process (BP)dephosphorylation0.000096240InformativeDirect
Biological Process (BP)nucleic acid phosphodiester bond hydrolysis0.01390.000000001008InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0000073630.001107InformativeInherited
Biological Process (BP)cytoplasmic transport0.0081660.001134InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.00056440.05281InformativeInherited
Biological Process (BP)phospholipid metabolic process0.000011450.3657InformativeInherited
Biological Process (BP)glycolipid biosynthetic process0.0000000000084530.0000000000108Highly InformativeDirect
Biological Process (BP)lipoprotein metabolic process0.000000069420.0000002892Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.0000000018030.000007364Highly InformativeDirect
Biological Process (BP)Golgi vesicle transport0.00000000002170.00000006801Highly InformativeDirect
Biological Process (BP)RNA phosphodiester bond hydrolysis, endonucleolytic0.00013350Highly InformativeDirect
Biological Process (BP)glycerophospholipid biosynthetic process0.012360.0003062Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00000000053710Least InformativeDirect
Molecular Function (MF)binding0.69031Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00000000001840Moderately InformativeDirect
Molecular Function (MF)cation binding0.00000012270Moderately InformativeDirect
Molecular Function (MF)anion binding0.50471Moderately InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.0000014770InformativeDirect
Molecular Function (MF)lipid binding0.000026510.04321InformativeInherited
Molecular Function (MF)nuclease activity0.88151InformativeInherited
Molecular Function (MF)endoribonuclease activity0.000067630.0000004497Highly InformativeDirect
Molecular Function (MF)endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo0.0000051580.0000007012Highly InformativeDirect
Molecular Function (MF)manganese ion binding0.0000066690.000000001128Highly InformativeDirect
Molecular Function (MF)phosphatidylinositol binding0.000000000048090.00002123Highly InformativeDirect
Molecular Function (MF)glycolipid binding0.00000000000035480.0000000000001742Highly InformativeDirect
Molecular Function (MF)iron ion binding0.02270.006359Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.31431Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.76261Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.74891Least InformativeInherited
Cellular Component (CC)protein complex0.50680.0000001536Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0028440.1181Moderately InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.000044480Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000006644 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2429 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9115 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00000000007104 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0000136 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05386 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3996 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.004592 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3857 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6873 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.9107 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.737 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.2999 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5666 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01391 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.8975 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9994 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.004151 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.00007176 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.0001577 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) cell cycle process 0.0000001838 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000000001008 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0654 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001107 Informative Inherited
Biological Process (BP) response to light stimulus 0.1045 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.2219 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1848 Informative Inherited
Biological Process (BP) lipid catabolic process 0.009871 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.05709 Informative Inherited
Biological Process (BP) RNA processing 0.03679 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.001134 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0578 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.3657 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.05281 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.8952 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.3164 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4321 Informative Inherited
Biological Process (BP) regulation of immune response 0.8044 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.2638 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.62 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1187 Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.00009772 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.0007366 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) meiosis 0.00007553 Highly Informative Direct
Biological Process (BP) RNA splicing 0.000009189 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.0000000000108 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.0000005397 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0000002892 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.00000001746 Highly Informative Direct
Biological Process (BP) response to drug 0 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.0007032 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.00002141 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0003062 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000007364 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000006801 Highly Informative Direct
Biological Process (BP) RNA phosphodiester bond hydrolysis, endonucleolytic 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0.001131 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.00533 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.1018 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3213 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.1341 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.002763 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1591 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.007743 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.01085 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated cytotoxicity 0.001323 Highly Informative Inherited
Biological Process (BP) cell cycle phase 0.002032 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.06382 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.000000001584 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1043 Informative Inherited
Molecular Function (MF) lipid binding 0.04321 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) endoribonuclease activity 0.0000004497 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.000001914 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000009686 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo 0.0000007012 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.000000001128 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.00002123 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0001241 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000000001742 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.006359 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 1 Highly Informative Inherited
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0000001536 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.1181 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9514 Moderately Informative Inherited
Cellular Component (CC) protein serine/threonine phosphatase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00005707Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.000000000002986Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0.00000001228Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.4837Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.09125Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3017Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.3847Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00000009147InformativeDirect
Worm Phenotype (WP)cell stress response variant0.2254InformativeInherited
Worm Phenotype (WP)protein expression variant0.3253InformativeInherited
Worm Phenotype (WP)genotoxic induced apoptosis variant0.000007183Highly InformativeDirect
Worm Phenotype (WP)germ cell ionizing radiation response variant0.0004906Highly InformativeDirect
Worm Phenotype (WP)cell ionizing radiation response variant0.0006182Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.0006806Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sleep defective0.0003306Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00000000001005InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00015InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processCell cycle0.04612Moderately InformativeInherited
Biological processMeiosis0.000000000000001858InformativeDirect
Biological processLipid biosynthesis0.00000000000006956InformativeDirect
Biological processMitosis0.0000008552InformativeDirect
Biological processBiological rhythms0.0005494InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processER-Golgi transport0.000000535Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0.0006848Moderately InformativeDirect
Cellular componentVacuole0.0000002048InformativeDirect
Cellular componentGPI-anchor0.00006337InformativeDirect
Cellular componentLysosome0.0009234InformativeDirect
Cellular componentCentromere0.00000000001191Highly InformativeDirect
Cellular componentKinetochore0.00002377Highly InformativeDirect
DomainSignal0.000000002028Least InformativeDirect
DomainKelch repeat0.0002833Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Molecular functionCalmodulin-binding0.000000000000003661InformativeDirect
Molecular functioncAMP0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationExonuclease0InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0.0006876InformativeDirect
Post-translational modificationGlycoprotein0.000002445Least InformativeDirect
Post-translational modificationMethylation0.0000000003019Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)membrane lipid metabolism0.0000000391Moderately InformativeDirect
UniPathway (UP)sphingolipid metabolism0.0000000000006908InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent phosphatases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Metallo-dependent phosphatases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]