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Carbon-nitrogen hydrolase superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Other enzymes |
Document: Function annotation of SCOP domain superfamilies
Gene Ontology (high-quality) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
Document: GO annotation of SCOP domains
Gene Ontology (high-coverage) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
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GO term |
FDR (all) |
IC level |
SDFO level |
Annotation (direct or inherited) |
| Biological Process (BP) |
water-soluble vitamin metabolic process |
4.678e-07 |
1.585 |
-- |
DIRECT |
| Biological Process (BP) |
organonitrogen compound metabolic process |
7.542e-05 |
0.699 |
-- |
DIRECT |
| Biological Process (BP) |
organic substance metabolic process |
1 |
0.2676 |
-- |
INHERITED FROM: organonitrogen compound metabolic process |
| Biological Process (BP) |
cellular process |
0.8391 |
0.1415 |
-- |
INHERITED FROM: cofactor metabolic process |
| Biological Process (BP) |
cellular metabolic process |
0.001995 |
0.2708 |
-- |
INHERITED FROM: cofactor metabolic process |
| Biological Process (BP) |
biological_process |
1 |
0 |
-- |
INHERITED FROM: water-soluble vitamin metabolic process || organonitrogen compound metabolic process || cofactor metabolic process || vitamin metabolic process |
| Biological Process (BP) |
metabolic process |
0.003148 |
0.2411 |
-- |
INHERITED FROM: vitamin metabolic process || water-soluble vitamin metabolic process || organonitrogen compound metabolic process || cofactor metabolic process |
| Biological Process (BP) |
small molecule metabolic process |
0.1378 |
0.6421 |
-- |
INHERITED FROM: vitamin metabolic process || water-soluble vitamin metabolic process |
| Biological Process (BP) |
nitrogen compound metabolic process |
0.003549 |
0.5171 |
Least Informative |
INHERITED FROM: organonitrogen compound metabolic process |
| Biological Process (BP) |
single-organism metabolic process |
0.04265 |
0.5376 |
Least Informative |
INHERITED FROM: vitamin metabolic process || water-soluble vitamin metabolic process |
| Biological Process (BP) |
cofactor metabolic process |
0.0005863 |
1.131 |
Moderately Informative |
DIRECT |
| Biological Process (BP) |
vitamin metabolic process |
0.0001404 |
1.495 |
Informative |
DIRECT |
| Molecular Function (MF) |
catalytic activity |
3.4e-07 |
0.2686 |
-- |
DIRECT |
| Molecular Function (MF) |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
0 |
1.423 |
-- |
DIRECT |
| Molecular Function (MF) |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles |
1.183e-11 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
ligase activity |
0.1063 |
1.356 |
-- |
INHERITED FROM: ligase activity, forming carbon-nitrogen bonds |
| Molecular Function (MF) |
molecular_function |
1 |
0 |
-- |
INHERITED FROM: hydrolase activity || catalytic activity || beta-ureidopropionase activity || hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds || ligase activity, forming carbon-nitrogen bonds || hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles |
| Molecular Function (MF) |
hydrolase activity |
1.642e-08 |
0.6657 |
Least Informative |
DIRECT |
| Molecular Function (MF) |
ligase activity, forming carbon-nitrogen bonds |
0.0007035 |
1.448 |
Informative |
DIRECT |
| Molecular Function (MF) |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
0.9334 |
1.565 |
Informative |
INHERITED FROM: beta-ureidopropionase activity |
Document: GO annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
Mouse Phenotype (MP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: MP annotation of SCOP domains
Worm Phenotype (WP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: WP annotation of SCOP domains
Xenopus Anatomy (XA) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: XA annotation of SCOP domains
Arabidopsis Plant Ontology (AP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: AP annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
UniProtKB KeyWords (KW) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: KW annotation of SCOP domains
UniProtKB UniPathway (UP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: UP annotation of SCOP domains
InterPro annotation
| Cross references | IPR003010 SSF56317 Protein matches |
| Abstract | This family contains nitrilases that break carbon-nitrogen bonds and appear to be involved in the reduction of organic nitrogen compounds and ammonia production [ 7987228]. They all have distinct substrate specificity and include cyanide hydratases, aliphatic amidases, beta-alanine synthase, and a few other proteins with unknown molecular function. Sequence conservation over the entire length, as well as the similarity in the reactions catalyzed by the known enzymes in this family, points to a common catalytic mechanism. They have an invariant cysteine that is part of the catalytic site in nitrilases. Another highly conserved motif includes an invariant glutamic acid that might also be involved in catalysis [7987228]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 4 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Carbon-nitrogen hydrolase domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 4 hidden Markov models representing the Carbon-nitrogen hydrolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
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