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Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [ 56424]
Superfamily:   Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [ 56425]
Families:   Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain [ 56426] (5)


Superfamily statistics
Genomes (2,865) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,721 44,227 27
Proteins 7,706 44,204 27


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000007241 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6278 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000001278 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0001226 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.3864 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.734 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.05951 Moderately Informative Inherited
Biological Process (BP) electron transport chain 0 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.0000001439 Informative Direct
Biological Process (BP) cellular respiration 0 Informative Direct
Biological Process (BP) ATP metabolic process 0.000001349 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.00001408 Informative Direct
Biological Process (BP) phosphorylation 0.647 Informative Inherited
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.4189 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.007662 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.00272 Moderately Informative Inherited
Molecular Function (MF) electron carrier activity 0.00000000004801 Informative Direct
Molecular Function (MF) coenzyme binding 0.000001066 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0 Highly Informative Direct
Cellular Component (CC) membrane 0.00001554 Least Informative Direct
Cellular Component (CC) protein complex 0.00000006686 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.02291 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.06904 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001709 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial respiratory chain 0.00000004207 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.000000005473 Informative Direct
Cellular Component (CC) respiratory chain complex 0 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase0Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.00000031Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.1982Moderately InformativeInherited
Biological processElectron transport0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processSteroid metabolism0.00000002942InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Cellular componentMembrane0.0001688Least InformativeDirect
Cellular componentMitochondrion0.0000000000001847Moderately InformativeDirect
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentMitochondrion inner membrane0.00000003312InformativeDirect
Cellular componentPeriplasm0.0002203InformativeDirect
Cellular componentCell inner membrane0.0007551InformativeDirect
DiseaseTumor suppressor0.0000000000000206Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0.000000000000004409InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]