SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


C-type lectin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Families:   C-type lectin domain [ 56437] (28)
  Aerolysin/Pertussis toxin (APT) domain [ 56467] (2)
  Invasin/intimin cell-adhesion fragment, C-terminal domain [ 56472] (2)
  Link domain [ 56477] (2)
  Endostatin [ 56480] (2)
  Noncollagenous (NC1) domain of collagen IV [ 75585]
  Sulfatase-modifying factor-like [ 143959] (2)
  Mtd variable domain [ 143964]


Superfamily statistics
Genomes (1,628) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,595 97,427 125
Proteins 18,207 78,944 121


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.001041Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02398Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.6974Moderately InformativeInherited
Disease Ontology (DO)nephritis0.04349InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.0005471Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2161Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.0436Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0.1834Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.2157InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.4406InformativeInherited
Phenotypic Abnormality (PA)Abnormality of renal glomerulus morphology0.004048Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00000007391Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0001192Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.04495Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5806Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.9081Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0000000001416Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009022Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00005941Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.124Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4128Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4398Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.9989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal liver physiology0.0003402InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0534InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.1243InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.3093InformativeInherited
Mammalian Phenotype (MP)podocyte foot process effacement0.0001548Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0005643Highly InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.03086Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.07851Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.0984Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.1712InformativeInherited
Worm Phenotype (WP)tail morphology variant0.2115InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.9822InformativeInherited
Worm Phenotype (WP)male nervous system morphology variant0.05319Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)epithelium0.08723Moderately InformativeInherited
Fly Anatomy (FA)epithelial tube0.0004693InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.3156Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.0772Moderately InformativeInherited
Zebrafish Anatomy (ZA)lymph vessel0.00001506Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.001164Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.025Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00004966Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000000003328InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000009207InformativeDirect
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the C-type lectin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]