SUPERFAMILY 1.75 HMM library and genome assignments server

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C-type lectin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Families:   C-type lectin domain [ 56437] (28)
  Aerolysin/Pertussis toxin (APT) domain [ 56467] (2)
  Invasin/intimin cell-adhesion fragment, C-terminal domain [ 56472] (2)
  Link domain [ 56477] (2)
  Endostatin [ 56480] (2)
  Noncollagenous (NC1) domain of collagen IV [ 75585]
  Sulfatase-modifying factor-like [ 143959] (2)
  Mtd variable domain [ 143964]


Superfamily statistics
Genomes (1,628) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,595 97,427 125
Proteins 18,207 78,944 121


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.001067Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02446Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.6968Moderately InformativeInherited
Disease Ontology (DO)nephritis0.04445InformativeInherited
Disease Ontology (DO)opportunistic mycosis0.0005529Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1403Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5077Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6618Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.02257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.05126Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.3091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.00004919InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lens0.3629InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.4307InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.00000007283Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0001166Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.04423Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5781Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.9088Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.000009058Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.00005883Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.1242Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4395Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal liver physiology0.0003383InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.05358InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.1263InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.3094InformativeInherited
Mammalian Phenotype (MP)podocyte foot process effacement0.0001545Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0005633Highly InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.03087Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.0789Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.09838Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant1Least InformativeInherited
Worm Phenotype (WP)adult body morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)male mating variant0.000000004869InformativeDirect
Worm Phenotype (WP)male morphology variant0.1419InformativeInherited
Worm Phenotype (WP)tail morphology variant0.1829InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.9708InformativeInherited
Worm Phenotype (WP)male mating defective0.000000000001415Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.03621Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.472Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.07323Moderately InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.00004188Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00000009176Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.06836Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00005128Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000006386InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000007452InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00002226InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous5.098e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 124 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 124 hidden Markov models representing the C-type lectin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]