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Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (180) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,328 13,550 21
Proteins 5,149 13,088 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)extracellular region part0.0012470Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.00000001373 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000001298 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000369 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0.0000000796 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000672 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.2976 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.07358 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8811 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9632 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.009784 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2545 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.003088 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.03658 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8745 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.05236 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.04295 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7223 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8146 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.005349 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01306 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02813 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.07399 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.3523 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02896 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6018 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2145 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.001536 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.001641 Moderately Informative Inherited
Biological Process (BP) system development 0.001134 Moderately Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.0000002099 Informative Direct
Biological Process (BP) generation of neurons 0.000001297 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001546 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000001619 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000003576 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00002586 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00004241 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000747 Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.00008382 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0002665 Informative Direct
Biological Process (BP) locomotion 0.0003538 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0005635 Informative Direct
Biological Process (BP) circulatory system development 0.0005854 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0008294 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0009503 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.5316 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7324 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1675 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2185 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7055 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.1444 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0357 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.004282 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.008892 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.0261 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.002306 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.003062 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3184 Informative Inherited
Biological Process (BP) response to bacterium 0.283 Informative Inherited
Biological Process (BP) defense response to other organism 0.3404 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02815 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01803 Informative Inherited
Biological Process (BP) immune response 0.02381 Informative Inherited
Biological Process (BP) cell development 0.1364 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1442 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0013 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.3842 Informative Inherited
Biological Process (BP) system process 0.6688 Informative Inherited
Biological Process (BP) regulation of secretion 0.02981 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.01009 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) regulation of growth 0.08905 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1641 Informative Inherited
Biological Process (BP) biological adhesion 0.00000000000001267 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00000000000004133 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00000001295 Highly Informative Direct
Biological Process (BP) coagulation 0.00000001893 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000002995 Highly Informative Direct
Biological Process (BP) neutral lipid metabolic process 0.00000008612 Highly Informative Direct
Biological Process (BP) regeneration 0.0000001502 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000005522 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000009301 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00001379 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00001395 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00003718 Highly Informative Direct
Biological Process (BP) neuron development 0.00004126 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0.00004732 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00006454 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0001084 Highly Informative Direct
Biological Process (BP) hemostasis 0.0001951 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0001974 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0002724 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0006129 Highly Informative Direct
Biological Process (BP) kidney development 0.04915 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.005404 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.0746 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.005826 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.08103 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.002905 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.002431 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.003412 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1662 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.001529 Highly Informative Inherited
Biological Process (BP) wound healing 0.9208 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 0.01512 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4301 Highly Informative Inherited
Molecular Function (MF) binding 0.0226 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00000000000000324 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000005419 Moderately Informative Direct
Molecular Function (MF) anion binding 0.07406 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000008374 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00002079 Informative Direct
Molecular Function (MF) enzyme activator activity 0.08972 Informative Inherited
Molecular Function (MF) signal transducer activity 0.00189 Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.00000000015 Highly Informative Direct
Molecular Function (MF) heparin binding 0.000000001703 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000001349 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.8437 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.1266 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0002775 Moderately Informative Direct
Cellular Component (CC) cell projection 0.01487 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5301 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0000001713 Informative Direct
Cellular Component (CC) extracellular organelle 0.000007512 Informative Direct
Cellular Component (CC) secretory granule 0.00005968 Informative Direct
Cellular Component (CC) transporter complex 0.0003993 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.07985 Informative Inherited
Cellular Component (CC) neuron projection 0.1876 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) blood microparticle 0.00002931 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.7477 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.08343Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.004209InformativeInherited
Disease Ontology (DO)congenital afibrinogenemia0.000000307Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.1122Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2109Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3155Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3218Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4081Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.563Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.07676Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.08651Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.1263Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.1737Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.19Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3753Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.8338Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.0003378InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.0006403InformativeDirect
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.001049InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombosis0.00173InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.004413InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.1512InformativeInherited
Phenotypic Abnormality (PA)Splenic rupture0.000000005613Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating fibrinogen0.0000004213Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous abortion0.0000006311Highly InformativeDirect
Phenotypic Abnormality (PA)Joint swelling0.00005392Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombophlebitis0.0001172Highly InformativeDirect
Phenotypic Abnormality (PA)Gingival bleeding0.0001609Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.0002324Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.2887Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.0007155Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.00000003439InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0.00000000000006084Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionChitin-binding0.000000000001355Highly InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000004984Moderately InformativeDirect
Post-translational modificationToxin0.002742InformativeInherited
Post-translational modificationHemostasis impairing toxin0.00000039Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0.00000002758InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]