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Fibrinogen C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Fibrinogen C-terminal domain-like [ 56495]
Superfamily:   Fibrinogen C-terminal domain-like [ 56496]
Families:   Fibrinogen C-terminal domain-like [ 56497] (2)


Superfamily statistics
Genomes (180) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,328 13,550 21
Proteins 5,149 13,088 21


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)extracellular region part0.0031530Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0000000000009953 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000344 Least Informative Direct
Biological Process (BP) biological regulation 0.00000003806 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000391 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.00004705 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0007999 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000001313 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0002534 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.05142 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8113 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3244 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9339 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.04973 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9332 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.006485 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2768 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1929 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002111 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.8619 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008622 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7651 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02625 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02905 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04341 Moderately Informative Inherited
Biological Process (BP) defense response 0.2869 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.3191 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.1148 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.009272 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6512 Moderately Informative Inherited
Biological Process (BP) tissue development 0.9815 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.003117 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.0426 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.0004294 Informative Direct
Biological Process (BP) response to wounding 0.000000000002799 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0000006861 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00005082 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0003886 Informative Direct
Biological Process (BP) locomotion 0.000274 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000007898 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000004289 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0003405 Informative Direct
Biological Process (BP) generation of neurons 0.0000004516 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0009145 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00003135 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00002882 Informative Direct
Biological Process (BP) localization of cell 0.0004511 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000003769 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0007732 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.5607 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7032 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2017 Informative Inherited
Biological Process (BP) regulation of secretion 0.03173 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1858 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.008184 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00136 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.03048 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.07805 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3208 Informative Inherited
Biological Process (BP) defense response to other organism 0.2587 Informative Inherited
Biological Process (BP) immune response 0.01583 Informative Inherited
Biological Process (BP) regulation of growth 0.05277 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.09244 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.02325 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5685 Informative Inherited
Biological Process (BP) response to bacterium 0.2524 Informative Inherited
Biological Process (BP) cell development 0.1154 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.01435 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1423 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.3919 Informative Inherited
Biological Process (BP) system process 0.7718 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0331 Informative Inherited
Biological Process (BP) regulation of immune response 0.09118 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.04962 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) circulatory system development 0.001975 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2491 Informative Inherited
Biological Process (BP) angiogenesis 0.00002637 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000018 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0000001062 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.00008471 Highly Informative Direct
Biological Process (BP) hemostasis 0.0001088 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000001246 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.00001457 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.0005593 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000003959 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0000404 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0.000005792 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000000000003429 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00000000000008421 Highly Informative Direct
Biological Process (BP) regeneration 0.00000006535 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0000000001106 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0002503 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.0002062 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0007075 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0009943 Highly Informative Direct
Biological Process (BP) neuron development 0.00001096 Highly Informative Direct
Biological Process (BP) response to axon injury 0.0004255 Highly Informative Direct
Biological Process (BP) coagulation 0.000000003462 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00000225 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000005238 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00000002468 Highly Informative Direct
Biological Process (BP) wound healing 0.9434 Highly Informative Inherited
Biological Process (BP) kidney development 0.06088 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.001584 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.0365 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.001837 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.001325 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.1667 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.04288 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03417 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 0.01298 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.3733 Highly Informative Inherited
Molecular Function (MF) binding 0.07267 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000125 Moderately Informative Direct
Molecular Function (MF) anion binding 0.06953 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00001991 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000007062 Informative Direct
Molecular Function (MF) signal transducer activity 0.003347 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.09374 Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.0009448 Highly Informative Direct
Molecular Function (MF) heparin binding 0.000000001782 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0005569 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00000009569 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2233 Least Informative Inherited
Cellular Component (CC) protein complex 0.7722 Least Informative Inherited
Cellular Component (CC) vesicle 0.0004432 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0261 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5265 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.6626 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0000004283 Informative Direct
Cellular Component (CC) secretory granule 0.00007938 Informative Direct
Cellular Component (CC) extracellular organelle 0.000007471 Informative Direct
Cellular Component (CC) transporter complex 0.0005581 Informative Direct
Cellular Component (CC) neuron projection 0.2075 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.07382 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) main axon 0.0000000315 Highly Informative Direct
Cellular Component (CC) blood microparticle 0.00003007 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.7542 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processInnate immunity0InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0.00001088Moderately InformativeDirect
Cellular componentExtracellular matrix0.00000002759InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0.00000000000006192Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionChitin-binding0.000000000001873Highly InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000005641Moderately InformativeDirect
Post-translational modificationToxin0.003364InformativeInherited
Post-translational modificationHemostasis impairing toxin0.0000004336Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationHydroxylation0.00000003554InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002181 SSF56496 Protein matches
Abstract

This entry represents the C-terminal globular D domain of the alpha, beta and gamma chains. These domains are related to domains in other proteins: in the Parastichopus parvimensis (Sea cucumber) fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of the Drosophila scabrous protein that is involved in the regulation of neurogenesis, possibly through the inhibition of R8 cell differentiation; and in ficolin proteins, which display lectin activity towards N-acetylglucosamine through their fibrogen-like domains [PubMed12396010].

More information about these proteins can be found at Protein of the Month: Fibrinogen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Fibrinogen C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Fibrinogen C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]