SUPERFAMILY 1.75 HMM library and genome assignments server


Heme-dependent catalase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Heme-dependent catalase-like [ 56633]
Superfamily:   Heme-dependent catalase-like [ 56634] (2)
Families:   Heme-dependent catalases [ 56635] (2)
  Allene oxide synthase [ 118183]


Superfamily statistics
Genomes (1,431) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,167 8,934 28
Proteins 3,141 8,916 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.723e-139.526e-14Least InformativeDirect
Biological Process (BP)single-organism cellular process4.003e-050.008119Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.17480.3203Least InformativeInherited
Biological Process (BP)protein metabolic process0.014310.05209Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.25131Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0055910.02414Least InformativeInherited
Biological Process (BP)regulation of cellular process0.23080.4033Least InformativeInherited
Biological Process (BP)developmental process0.17410.8275Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.23250.06903Least InformativeInherited
Biological Process (BP)regulation of signaling0.00082650.000719Moderately InformativeDirect
Biological Process (BP)cellular response to stress2.761e-061.112e-05Moderately InformativeDirect
Biological Process (BP)cellular catabolic process1.691e-102.551e-12Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.00017327.459e-06Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process5.286e-075.462e-08Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.00045590.0001295Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus5.613e-074.922e-07Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process1.015e-075.836e-08Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound6.617e-062.55e-08Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.036920.1281Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process2.467e-050.02283Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process3.313e-050.02809Moderately InformativeInherited
Biological Process (BP)regulation of gene expression3.483e-050.02943Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0025210.001122Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0010660.0007429Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.029520.02965Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.22670.4186Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.54261Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process2.143e-081.705e-07InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)steroid metabolic process1.47e-095.106e-10InformativeDirect
Biological Process (BP)response to light stimulus2.309e-067.081e-05InformativeDirect
Biological Process (BP)positive regulation of signal transduction2.243e-085.772e-07InformativeDirect
Biological Process (BP)response to inorganic substance3.892e-111.158e-14InformativeDirect
Biological Process (BP)negative regulation of molecular function1.129e-081.606e-08InformativeDirect
Biological Process (BP)glycerolipid metabolic process1.299e-059.652e-05InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound3.229e-075.398e-08InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.00077430.002705InformativeInherited
Biological Process (BP)response to external stimulus0.15140.5249InformativeInherited
Biological Process (BP)acylglycerol metabolic process6.771e-140Highly InformativeDirect
Biological Process (BP)aging1.622e-075.474e-06Highly InformativeDirect
Biological Process (BP)aerobic respiration5.419e-131.158e-14Highly InformativeDirect
Biological Process (BP)sterol metabolic process2.069e-132.421e-13Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.037e-105.086e-14Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide8.196e-111.352e-13Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of sequence-specific DNA binding transcription factor activity1.598e-154.008e-15Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity6.227e-149.243e-13Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.94521Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides1.22e-117.256e-14InformativeDirect
Molecular Function (MF)peroxidase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.002178.621e-05Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.00019760.005673Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle1.201e-050.00505Least InformativeInherited
Cellular Component (CC)membrane0.0020360.02644Least InformativeInherited
Cellular Component (CC)organelle membrane2.483e-058.431e-07Moderately InformativeDirect
Cellular Component (CC)microbody00InformativeDirect
Cellular Component (CC)microbody membrane4.774e-121.173e-13Highly InformativeDirect
Cellular Component (CC)microbody part00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 9.526e-14 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.008119 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3203 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.05209 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.02414 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.4033 Least Informative Inherited
Biological Process (BP) developmental process 0.8275 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.06903 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0.0007429 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000719 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1.112e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.551e-12 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 7.459e-06 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 5.462e-08 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001295 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.922e-07 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 5.836e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.55e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.1281 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.02283 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.02809 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02943 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.001122 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02965 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4186 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 1.705e-07 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) steroid metabolic process 5.106e-10 Informative Direct
Biological Process (BP) response to light stimulus 7.081e-05 Informative Direct
Biological Process (BP) positive regulation of signal transduction 5.772e-07 Informative Direct
Biological Process (BP) response to inorganic substance 1.158e-14 Informative Direct
Biological Process (BP) negative regulation of molecular function 1.606e-08 Informative Direct
Biological Process (BP) glycerolipid metabolic process 9.652e-05 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 5.398e-08 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.002705 Informative Inherited
Biological Process (BP) response to external stimulus 0.5249 Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0 Highly Informative Direct
Biological Process (BP) aging 5.474e-06 Highly Informative Direct
Biological Process (BP) aerobic respiration 1.158e-14 Highly Informative Direct
Biological Process (BP) sterol metabolic process 2.421e-13 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 5.086e-14 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 1.352e-13 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 4.008e-15 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 9.243e-13 Highly Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7.256e-14 Informative Direct
Molecular Function (MF) peroxidase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 8.621e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.005673 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00505 Least Informative Inherited
Cellular Component (CC) membrane 0.02644 Least Informative Inherited
Cellular Component (CC) organelle membrane 8.431e-07 Moderately Informative Direct
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) microbody membrane 1.173e-13 Highly Informative Direct
Cellular Component (CC) microbody part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Peroxidases0InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)life span variant0InformativeDirect

Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)pedicel0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentPeroxisome0InformativeDirect
Cellular componentPeriplasm3.733e-10InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationMitogen6.627e-16Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011614 SSF56634 Protein matches
Abstract

Catalases are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [PubMed11351128]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via transition metals, this radical being able to damage a wide variety of molecules within a cell, leading to oxidative stress and cell death. Catalases act to neutralise hydrogen peroxide toxicity, and are produced by all aerobic organisms ranging from bacteria to man. Most catalases are mono-functional, haem-containing enzymes, although there are also bifunctional haem-containing peroxidase/catalases that are closely related to plant peroxidases, and non-haem, manganese-containing catalases that are found in bacteria [PubMed14745498].

This entry represents a conserved region within catalase enzymes .


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heme-dependent catalase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Heme-dependent catalase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]