SUPERFAMILY 1.75 HMM library and genome assignments server


Acyl-CoA dehydrogenase NM domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acyl-CoA dehydrogenase NM domain-like [ 56644]
Superfamily:   Acyl-CoA dehydrogenase NM domain-like [ 56645] (2)
Families:   Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [ 56646] (9)
  acyl-CoA oxidase N-terminal domains [ 75600] (2)


Superfamily statistics
Genomes (1,707) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 20,565 50,824 21
Proteins 20,299 50,204 21


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)multicellular organismal process01Least InformativeInherited
Biological Process (BP)developmental process01Least InformativeInherited
Biological Process (BP)single-organism cellular process01Least InformativeInherited
Biological Process (BP)response to stimulus01Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process01Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process01.302e-09Moderately InformativeDirect
Biological Process (BP)tissue development00.836Moderately InformativeInherited
Biological Process (BP)cell differentiation01Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process00.002257Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus00.7566Moderately InformativeInherited
Biological Process (BP)organ development01Moderately InformativeInherited
Biological Process (BP)single-organism developmental process01Moderately InformativeInherited
Biological Process (BP)muscle structure development00.0852InformativeInherited
Biological Process (BP)muscle tissue development00.01551InformativeInherited
Biological Process (BP)cardiovascular system development00.2144InformativeInherited
Biological Process (BP)amino-acid betaine metabolic process01.254e-12Highly InformativeDirect
Biological Process (BP)cardiocyte differentiation04.85e-05Highly InformativeDirect
Biological Process (BP)cardiac muscle tissue development00.0001979Highly InformativeDirect
Biological Process (BP)response to cold00.000573Highly InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle00.0008931Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1.302e-09 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.836 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3304 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.761 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.002257 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7566 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.009786 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0 Informative Direct
Biological Process (BP) muscle structure development 0.0852 Informative Inherited
Biological Process (BP) protein oligomerization 0.007958 Informative Inherited
Biological Process (BP) muscle tissue development 0.01551 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01065 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2144 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.8621 Informative Inherited
Biological Process (BP) amino-acid betaine metabolic process 1.254e-12 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 4.85e-05 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 0.0001979 Highly Informative Direct
Biological Process (BP) response to cold 0.000573 Highly Informative Direct
Biological Process (BP) monocarboxylic acid catabolic process 0 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 1.386e-09 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.0001143 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000325 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 1 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00853 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.8894 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.9124 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 4.491e-07 Informative Direct
Molecular Function (MF) nucleotide binding 0.0007964 Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0008931 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8074 Least Informative Inherited
Cellular Component (CC) mitochondrial part 2.793e-06 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.002292 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) external encapsulating structure 0.000274 Informative Direct
Cellular Component (CC) microbody part 2.586e-12 Highly Informative Direct
Cellular Component (CC) cell wall 4.505e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.1185Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 2.343e-12Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor3.663e-10Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor1.767e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.03817Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.05216Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.08537Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.0009Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.005088Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.02417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7023Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria4.109e-07InformativeDirect
Phenotypic Abnormality (PA)Lethargy1.476e-06InformativeDirect
Phenotypic Abnormality (PA)Hypoglycemia7.106e-06InformativeDirect
Phenotypic Abnormality (PA)Acidosis0.0001242InformativeDirect
Phenotypic Abnormality (PA)Abnormality of carboxylic acid metabolism0.0001956InformativeDirect
Phenotypic Abnormality (PA)Muscular hypotonia0.0004841InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.02213InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.02788InformativeInherited
Phenotypic Abnormality (PA)Decreased plasma carnitine8.341e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.0001242Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0002374Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.02903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis1.373e-06InformativeDirect
Mammalian Phenotype (MP)abnormal circulating amino acid level0.0005336InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glucose level0.007116InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.02808InformativeInherited
Mammalian Phenotype (MP)abnormal circulating carnitine level1.379e-12Highly InformativeDirect
Mammalian Phenotype (MP)hepatic steatosis1.794e-08Highly InformativeDirect
Mammalian Phenotype (MP)aciduria6.887e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.003428Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle3.457e-05InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.01038Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell5.211e-05InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0004183Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage9.078e-05InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0002818InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.0867InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups0.5679InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor6.185e-08Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen4.265e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processAromatic hydrocarbons catabolism4.622e-16InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
DiseaseDisease mutation3.452e-07Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionFlavoprotein0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationAcetylation0Moderately InformativeDirect
Post-translational modificationS-nitrosylation1.244e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.8977Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation1.465e-06Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism7.712e-05Moderately InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0InformativeDirect
UniPathway (UP)carnitine metabolism3.56e-14InformativeDirect
UniPathway (UP)siderophore metabolism2.105e-07InformativeDirect
UniPathway (UP)fatty acid degradation8.878e-16Highly InformativeDirect
UniPathway (UP)4-hydroxyphenylacetate degradation2.008e-13Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR009100 SSF56645 Protein matches
Abstract

Acyl-CoA dehydrogenases are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structural properties, but differ in the position of their catalytic bases and in their substrate binding specificity. Butyryl-CoA dehydrogenase [PubMed11812788] prefers short chain substrates, medium chain- and long-chain acyl-CoA dehydrogenases prefer medium and long chain substrates, respectively, and Isovaleryl-CoA dehydrogenase [PubMed9214289] prefers branched-chain substrates.

The monomeric enzyme is folded into three domains of approximately equal size, where the N-terminal domain is all-alpha, the middle domain is an open (5,8) barrel, and the C-terminal domain is a four-helical bundle. The constituent families differ in the numbers of C-terminal domains. This entry represents both the N-terminal and middle domains found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes. Acyl-CoA oxidase (ACO) catalyzes the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids [PubMed11872165].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA dehydrogenase NM domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the Acyl-CoA dehydrogenase NM domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]