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DNA/RNA polymerases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   DNA/RNA polymerases [ 56671]
Superfamily:   DNA/RNA polymerases [ 56672] (6)
Families:   DNA polymerase I [ 56673] (4)
  Lesion bypass DNA polymerase (Y-family), catalytic domain [ 100888] (4)
  Reverse transcriptase [ 56686] (2)
  T7 RNA polymerase [ 56691]
  RNA-dependent RNA-polymerase [ 56694] (2)
  dsRNA phage RNA-dependent RNA-polymerase [ 64480]


Superfamily statistics
Genomes (3,184) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 57,646 387,299 164
Proteins 56,877 386,536 164


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.85950Least InformativeInherited
Biological Process (BP)biosynthetic process0.27960Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.31230Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.16110Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.23510Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.16270Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.21760Least InformativeInherited
Biological Process (BP)nucleobase-containing compound biosynthetic process0.00043640Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.0026940Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.000068440InformativeDirect
Molecular Function (MF)transferase activity0.038750Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00004160Moderately InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity0.00000000060220InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000000001902 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.3242 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000007239 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000000000001582 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000000002542 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000000009587 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000002334 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.000002384 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000004356 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000008542 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.00002931 Moderately Informative Direct
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.4441 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.004535 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002834 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04029 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of molecular function 0 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) multi-organism cellular process 0 Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) regulation of cellular localization 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00000000001994 Informative Direct
Biological Process (BP) mitochondrion organization 0.0001292 Informative Direct
Biological Process (BP) response to radiation 0.0001483 Informative Direct
Biological Process (BP) ion homeostasis 0.6094 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) DNA replication 0 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) viral life cycle 0.000000000000448 Highly Informative Direct
Biological Process (BP) response to UV 0.00000009431 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000002125 Highly Informative Direct
Biological Process (BP) chromosome organization 0.000006264 Highly Informative Direct
Biological Process (BP) digestion 0.00003822 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.0004144 Highly Informative Direct
Biological Process (BP) aging 0.0004393 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.001278 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.4357 Highly Informative Inherited
Biological Process (BP) cell maturation 0.01596 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.01617 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1416 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5615 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.01248 Least Informative Inherited
Molecular Function (MF) binding 0.059 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000000000194 Moderately Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.000003442 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0002242 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) chromatin binding 0.00000001156 Highly Informative Direct
Molecular Function (MF) RNA polymerase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000007138 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000000616 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.1282 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000003668 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.5547 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000000000000981 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 1 Informative Inherited
Cellular Component (CC) replisome 0 Highly Informative Direct
Cellular Component (CC) DNA polymerase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.000000000009398 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0.587Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0InformativeDirect
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0InformativeDirect
Enzyme Commission (EC)Aspartic endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Hepacivirin0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease H0.00000000000002098Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.0000000002396Highly InformativeDirect
Enzyme Commission (EC)Nuclear-inclusion-a endopeptidase0.000000001069Highly InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase0.0000001803Highly InformativeDirect
Enzyme Commission (EC)Calicivirin0.000002573Highly InformativeDirect
Enzyme Commission (EC)Helper-component proteinase0.000003673Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1055Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1739Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.0672Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1497Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.00277InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.06035InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.009044Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0112Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.06817Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0001701Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.1845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.00006196InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.000354InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.001242InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.001095Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1561Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03824Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3458Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.3645Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002554InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.04308InformativeInherited
Yeast Phenotype (YP)mutation frequency0.00004632Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)radiation sensitive0.0000002301Highly InformativeDirect
Fly Phenotype (FP)chemical sensitive0.0008469Highly InformativeDirect
Fly Phenotype (FP)stress response defective0.07483Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.00000004214InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0InformativeDirect
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Omega peptidases0.8406InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10Highly InformativeDirect
Enzyme Commission (EC)RNA-directed DNA polymerase0Highly InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)Picornain 3C0Highly InformativeDirect
Enzyme Commission (EC)HIV-1 retropepsin0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Picornain 2A0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)HIV-2 retropepsin0.00002078Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.000006159Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.298Least InformativeInherited
Drugbank ATC_code (DB)antiinfectives0.006854Moderately InformativeInherited
Drugbank ATC_code (DB)antivirals for systemic use0.0000000000001666InformativeDirect
Drugbank ATC_code (DB)antivirals0.000002316Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDNA damage0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processApoptosis0.00000000249Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Biological processDNA replication0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processVirus entry into host cell0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0InformativeDirect
Biological processDNA integration0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0Highly InformativeDirect
Biological processViral genome integration0Highly InformativeDirect
Biological processVirus exit from host cell0Highly InformativeDirect
Biological processDNA synthesis0.00000000000007685Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.00000000002657Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0.00000000006541Highly InformativeDirect
Biological processIntron homing0.00000005139Highly InformativeDirect
Biological processSOS response1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentVirion0Moderately InformativeDirect
Cellular componentMitochondrion0.06569Moderately InformativeInherited
Cellular componentCapsid protein0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost membrane0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentChromosome0.06206InformativeInherited
Cellular componentHost cytoplasmic vesicle0Highly InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentHost endosome0Highly InformativeDirect
Cellular componentTelomere0.000000002217Highly InformativeDirect
Cellular componentDNA-directed RNA polymerase0.000504Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Coding sequence diversityRNA suppression of termination0InformativeDirect
Developmental stageEarly protein0.0000003763Least InformativeDirect
DiseaseAIDS0Moderately InformativeDirect
DiseaseOncogene0Moderately InformativeDirect
DomainTransmembrane0.7314Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionViral nucleoprotein0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDNA-directed DNA polymerase0InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationEndonuclease0.00000000002667InformativeDirect
Post-translational modificationAspartyl protease0Highly InformativeDirect
Post-translational modificationRNA-directed DNA polymerase0Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationUbl conjugation0.00000000008841Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.2349InformativeInherited
Post-translational modificationCovalent protein-RNA linkage0Highly InformativeDirect
Post-translational modificationProtein splicing0.00000000000002826Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 34 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA/RNA polymerases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 34 hidden Markov models representing the DNA/RNA polymerases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]