DNA/RNA polymerases superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:	DNA/RNA polymerases [ 56671]
Superfamily:	DNA/RNA polymerases [ 56672] (6)
Families:	DNA polymerase I [ 56673] (4)
	Lesion bypass DNA polymerase (Y-family), catalytic domain [ 100888] (4)
	Reverse transcriptase [ 56686] (2)
	T7 RNA polymerase [ 56691]
	RNA-dependent RNA-polymerase [ 56694] (2)
	dsRNA phage RNA-dependent RNA-polymerase [ 64480]

Superfamily statistics

	Genomes (2,444)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	56,047	293,130	164
Proteins	55,383	292,598	164

Functional annotation

General category	Information
Detailed category	DNA replication/repair

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	heterocycle metabolic process	4.304e-08	0	Least Informative	Direct
Biological Process (BP)	cellular aromatic compound metabolic process	5.228e-08	0	Least Informative	Direct
Biological Process (BP)	organic cyclic compound metabolic process	1.985e-07	0	Least Informative	Direct
Biological Process (BP)	cellular macromolecule metabolic process	6.987e-07	0	Least Informative	Direct
Biological Process (BP)	nitrogen compound metabolic process	1.63e-06	0	Least Informative	Direct
Biological Process (BP)	response to stimulus	0.03692	0.0003767	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	0.009114	0	Least Informative	Inherited
Biological Process (BP)	biosynthetic process	0.1363	1.158e-14	Least Informative	Inherited
Biological Process (BP)	cellular response to stress	1.442e-07	0	Moderately Informative	Direct
Biological Process (BP)	cellular macromolecule biosynthetic process	0.002399	0	Moderately Informative	Inherited
Biological Process (BP)	DNA metabolic process	0	0	Informative	Direct
Biological Process (BP)	response to DNA damage stimulus	7.067e-11	0	Informative	Direct
Biological Process (BP)	DNA replication	7.549e-05	0	Highly Informative	Direct
Molecular Function (MF)	transferase activity	1.756e-05	0	Least Informative	Direct
Molecular Function (MF)	transferase activity, transferring phosphorus-containing groups	1.073e-09	0	Moderately Informative	Direct
Molecular Function (MF)	nucleotidyltransferase activity	0	0	Informative	Direct
Molecular Function (MF)	DNA polymerase activity	0	0	Highly Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	heterocycle metabolic process	0	Least Informative	Direct
Biological Process (BP)	cellular aromatic compound metabolic process	0	Least Informative	Direct
Biological Process (BP)	organic cyclic compound metabolic process	0	Least Informative	Direct
Biological Process (BP)	cellular macromolecule metabolic process	0	Least Informative	Direct
Biological Process (BP)	nitrogen compound metabolic process	0	Least Informative	Direct
Biological Process (BP)	single-organism cellular process	0	Least Informative	Direct
Biological Process (BP)	response to stimulus	0.0003767	Least Informative	Direct
Biological Process (BP)	biosynthetic process	1.158e-14	Least Informative	Direct
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	cellular response to stress	0	Moderately Informative	Direct
Biological Process (BP)	cellular macromolecule biosynthetic process	0	Moderately Informative	Direct
Biological Process (BP)	homeostatic process	0.1741	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	organelle organization	0.9646	Moderately Informative	Inherited
Biological Process (BP)	RNA metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	aromatic compound biosynthetic process	0.004562	Moderately Informative	Inherited
Biological Process (BP)	heterocycle biosynthetic process	0.005334	Moderately Informative	Inherited
Biological Process (BP)	cellular nitrogen compound biosynthetic process	0.007932	Moderately Informative	Inherited
Biological Process (BP)	organic cyclic compound biosynthetic process	0.03191	Moderately Informative	Inherited
Biological Process (BP)	DNA metabolic process	0	Informative	Direct
Biological Process (BP)	response to DNA damage stimulus	0	Informative	Direct
Biological Process (BP)	mitochondrion organization	5.062e-08	Informative	Direct
Biological Process (BP)	anatomical structure homeostasis	6.906e-08	Informative	Direct
Biological Process (BP)	cell cycle process	0.7823	Informative	Inherited
Biological Process (BP)	chromosome organization	0.08543	Informative	Inherited
Biological Process (BP)	DNA replication	0	Highly Informative	Direct
Biological Process (BP)	DNA repair	9.852e-13	Highly Informative	Direct
Biological Process (BP)	cell cycle phase	1.972e-07	Highly Informative	Direct
Biological Process (BP)	mitotic cell cycle	1.599e-05	Highly Informative	Direct
Biological Process (BP)	aging	0.0005045	Highly Informative	Direct
Molecular Function (MF)	transferase activity	0	Least Informative	Direct
Molecular Function (MF)	hydrolase activity	0.1137	Least Informative	Inherited
Molecular Function (MF)	binding	0.008194	Least Informative	Inherited
Molecular Function (MF)	transferase activity, transferring phosphorus-containing groups	0	Moderately Informative	Direct
Molecular Function (MF)	hydrolase activity, acting on ester bonds	0	Moderately Informative	Direct
Molecular Function (MF)	heterocyclic compound binding	3.94e-14	Moderately Informative	Direct
Molecular Function (MF)	organic cyclic compound binding	1.043e-13	Moderately Informative	Direct
Molecular Function (MF)	nucleotidyltransferase activity	0	Informative	Direct
Molecular Function (MF)	nuclease activity	0	Informative	Direct
Molecular Function (MF)	peptidase activity	2.272e-11	Informative	Direct
Molecular Function (MF)	RNA binding	2.283e-08	Informative	Direct
Molecular Function (MF)	DNA polymerase activity	0	Highly Informative	Direct
Molecular Function (MF)	chromatin binding	4.602e-06	Highly Informative	Direct
Molecular Function (MF)	RNA polymerase activity	1	Highly Informative	Inherited
Cellular Component (CC)	intracellular organelle part	0	Least Informative	Direct
Cellular Component (CC)	intracellular membrane-bounded organelle	0.0003672	Least Informative	Direct
Cellular Component (CC)	intracellular non-membrane-bounded organelle	0.2938	Least Informative	Inherited
Cellular Component (CC)	cytoplasmic part	1	Least Informative	Inherited
Cellular Component (CC)	protein complex	0.0349	Least Informative	Inherited
Cellular Component (CC)	nuclear part	0	Moderately Informative	Direct
Cellular Component (CC)	intracellular organelle lumen	0.07653	Moderately Informative	Inherited
Cellular Component (CC)	mitochondrial part	0.05692	Moderately Informative	Inherited
Cellular Component (CC)	chromosome	0	Informative	Direct
Cellular Component (CC)	replisome	0	Highly Informative	Direct
Cellular Component (CC)	DNA polymerase complex	0	Highly Informative	Direct
Cellular Component (CC)	nuclear chromosome part	4.897e-10	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Nucleotidyltransferases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on ester bonds	0	Least Informative	Direct
Enzyme Commission (EC)	Transferring one-carbon groups	1	Least Informative	Inherited
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	Moderately Informative	Direct
Enzyme Commission (EC)	In phosphorous-containing anhydrides	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0	Moderately Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0	Moderately Informative	Direct
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	Moderately Informative	Direct
Enzyme Commission (EC)	Serine endopeptidases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Omega peptidases	0.587	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Methyltransferases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	mRNA (nucleoside-2'-O-)-methyltransferase	0	Informative	Direct
Enzyme Commission (EC)	mRNA (guanine-N(7)-)-methyltransferase	0	Informative	Direct
Enzyme Commission (EC)	Retroviral ribonuclease H	0	Informative	Direct
Enzyme Commission (EC)	Flavivirin	0	Informative	Direct
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	Nucleoside-triphosphatase	0	Informative	Direct
Enzyme Commission (EC)	Exoribonuclease H	0	Informative	Direct
Enzyme Commission (EC)	Aspartic endopeptidases	0	Informative	Direct
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	Hepacivirin	0	Highly Informative	Direct
Enzyme Commission (EC)	Picornain 3C	0	Highly Informative	Direct
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	Ribonuclease H	2.098e-14	Highly Informative	Direct
Enzyme Commission (EC)	Picornain 2A	2.396e-10	Highly Informative	Direct
Enzyme Commission (EC)	Nuclear-inclusion-a endopeptidase	1.069e-09	Highly Informative	Direct
Enzyme Commission (EC)	Pestivirus NS3 polyprotein peptidase	1.803e-07	Highly Informative	Direct
Enzyme Commission (EC)	Calicivirin	2.573e-06	Highly Informative	Direct
Enzyme Commission (EC)	Helper-component proteinase	3.673e-06	Highly Informative	Direct

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	immune system phenotype	0.0008647	Least Informative	Direct
Mammalian Phenotype (MP)	cellular phenotype	0.08773	Least Informative	Inherited
Mammalian Phenotype (MP)	tumorigenesis	0.0005702	Moderately Informative	Direct
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.1695	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.1727	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.2146	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell differentiation	0.3003	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.7398	Moderately Informative	Inherited
Mammalian Phenotype (MP)	malignant tumors	7.437e-05	Informative	Direct
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.01702	Informative	Inherited
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.2876	Informative	Inherited
Mammalian Phenotype (MP)	T cell derived lymphoma	0.0001832	Highly Informative	Direct
Mammalian Phenotype (MP)	chromosomal instability	0.0002169	Highly Informative	Direct

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	cell physiology variant	0.0006634	Least Informative	Direct
Worm Phenotype (WP)	cell organization biogenesis variant	0.02369	Moderately Informative	Inherited
Worm Phenotype (WP)	early embryonic lethal	0.02455	Moderately Informative	Inherited
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.001572	Informative	Inherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)

	YP term	FDR (all)	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	resistance to chemicals	0	Least Informative	Direct
Yeast Phenotype (YP)	UV resistance	0.0009877	Highly Informative	Direct

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	radiation sensitive	3.66e-08	Informative	Direct
Fly Phenotype (FP)	stress response defective	0.0006542	Informative	Direct
Fly Phenotype (FP)	DNA repair defective	1.625e-07	Highly Informative	Direct

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)

	ZA term	FDR (all)	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	multi-tissue structure	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	cavitated compound organ	0	Least Informative	Direct

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	0 seed germination stage	4.733e-08	Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	Least Informative	Direct
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Nucleotidyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides	0	Moderately Informative	Direct
Enzyme Commission (EC)	Transferring one-carbon groups	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0	Informative	Direct
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	Informative	Direct
Enzyme Commission (EC)	Cysteine endopeptidases	0	Informative	Direct
Enzyme Commission (EC)	In phosphorous-containing anhydrides	0	Informative	Direct
Enzyme Commission (EC)	RNA helicase	0	Informative	Direct
Enzyme Commission (EC)	Omega peptidases	0.7159	Informative	Inherited
Enzyme Commission (EC)	Serine endopeptidases	1	Informative	Inherited
Enzyme Commission (EC)	mRNA (guanine-N(7)-)-methyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	mRNA (nucleoside-2'-O)-methyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	Highly Informative	Direct
Enzyme Commission (EC)	Exoribonuclease H	0	Highly Informative	Direct
Enzyme Commission (EC)	Retroviral ribonuclease H	0	Highly Informative	Direct
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	Flavivirin	0	Highly Informative	Direct
Enzyme Commission (EC)	Picornain 3C	0	Highly Informative	Direct
Enzyme Commission (EC)	HIV-1 retropepsin	0	Highly Informative	Direct
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	Picornain 2A	2.096e-10	Highly Informative	Direct
Enzyme Commission (EC)	HIV-2 retropepsin	2.954e-05	Highly Informative	Direct

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)

	DB term	FDR (all)	SDDB level	Annotation (direct or inherited)
Drugbank ATC_code (DB)	antiinfectives for systemic use	1.109e-05	Moderately Informative	Direct
Drugbank ATC_code (DB)	dermatologicals	0.0259	Moderately Informative	Inherited
Drugbank ATC_code (DB)	antibiotics and chemotherapeutics for dermatological use	4.239e-05	Informative	Direct
Drugbank ATC_code (DB)	antiinfectives	0.0002132	Informative	Direct

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	1	Least Informative	Inherited
Biological process	DNA damage	0	Moderately Informative	Direct
Biological process	Ion transport	0	Moderately Informative	Direct
Biological process	Host-virus interaction	0	Moderately Informative	Direct
Biological process	Apoptosis	4.36e-10	Moderately Informative	Direct
Biological process	DNA recombination	0	Informative	Direct
Biological process	DNA replication	0	Informative	Direct
Biological process	Viral RNA replication	0	Informative	Direct
Biological process	Viral immunoevasion	0	Informative	Direct
Biological process	Virus entry into host cell	0	Informative	Direct
Biological process	Viral attachment to host cell	4.755e-10	Informative	Direct
Biological process	mRNA capping	0	Highly Informative	Direct
Biological process	Capsid maturation	0	Highly Informative	Direct
Biological process	Activation of host autophagy by virus	0	Highly Informative	Direct
Biological process	Modulation of host ubiquitin pathway by viral deubiquitinase	0	Highly Informative	Direct
Biological process	Fusion of virus membrane with host endosomal membrane	0	Highly Informative	Direct
Biological process	Viral genome integration	0	Highly Informative	Direct
Biological process	Viral ion channel	0	Highly Informative	Direct
Biological process	Modulation of host cell apoptosis by virus	1.826e-15	Highly Informative	Direct
Biological process	DNA synthesis	5.745e-13	Highly Informative	Direct
Biological process	Inhibition of host TYK2 by virus	6.638e-10	Highly Informative	Direct
Biological process	Modulation of host cell cycle by virus	5.423e-07	Highly Informative	Direct
Biological process	SOS response	1	Highly Informative	Inherited
Biological process	Host gene expression shutoff by virus	1	Highly Informative	Inherited
Cellular component	Membrane	0	Least Informative	Direct
Cellular component	Mitochondrion	0.08137	Moderately Informative	Inherited
Cellular component	Virion	0	Informative	Direct
Cellular component	Host cytoplasm	0	Informative	Direct
Cellular component	Host membrane	0	Informative	Direct
Cellular component	Host nucleus	0	Informative	Direct
Cellular component	Chromosome	0.3316	Informative	Inherited
Cellular component	Host cytoplasmic vesicle	0	Highly Informative	Direct
Cellular component	Host endoplasmic reticulum	0	Highly Informative	Direct
Cellular component	Host endosome	0	Highly Informative	Direct
Cellular component	Viral nucleoprotein	8.146e-12	Highly Informative	Direct
Cellular component	Telomere	1.85e-07	Highly Informative	Direct
Coding sequence diversity	Ribosomal frameshifting	0	Moderately Informative	Direct
Coding sequence diversity	Alternative promoter usage	0.0004105	Moderately Informative	Direct
Coding sequence diversity	RNA suppression of termination	0	Informative	Direct
Developmental stage	Early protein	2.743e-05	Least Informative	Direct
Disease	AIDS	0	Moderately Informative	Direct
Disease	Oncogene	0	Moderately Informative	Direct
Domain	Transmembrane	0.0002162	Least Informative	Direct
Domain	SH3-binding	0	Informative	Direct
Molecular function	Metal-binding	0	Least Informative	Direct
Molecular function	Zinc	0	Least Informative	Direct
Molecular function	Nucleotide-binding	7.266e-15	Least Informative	Direct
Molecular function	DNA-binding	0	Moderately Informative	Direct
Molecular function	Magnesium	0	Moderately Informative	Direct
Molecular function	RNA-binding	0	Moderately Informative	Direct
Molecular function	Zinc-finger	0	Moderately Informative	Direct
Molecular function	Helicase	0	Informative	Direct
Post-translational modification	Hydrolase	0	Least Informative	Direct
Post-translational modification	Transferase	0	Least Informative	Direct
Post-translational modification	Nuclease	0	Moderately Informative	Direct
Post-translational modification	Nucleotidyltransferase	0	Moderately Informative	Direct
Post-translational modification	Protease	0	Moderately Informative	Direct
Post-translational modification	Capsid protein	0	Informative	Direct
Post-translational modification	DNA-directed DNA polymerase	0	Informative	Direct
Post-translational modification	Ion channel	0	Informative	Direct
Post-translational modification	Thiol protease	0	Informative	Direct
Post-translational modification	Endonuclease	3.166e-14	Informative	Direct
Post-translational modification	Aspartyl protease	0	Highly Informative	Direct
Post-translational modification	RNA-directed DNA polymerase	0	Highly Informative	Direct
Post-translational modification	RNA-directed RNA polymerase	0	Highly Informative	Direct
Post-translational modification	Phosphoprotein	0	Least Informative	Direct
Post-translational modification	Cleavage on pair of basic residues	0	Moderately Informative	Direct
Post-translational modification	Ubl conjugation	0	Moderately Informative	Direct
Post-translational modification	Myristate	0	Informative	Direct
Post-translational modification	Autocatalytic cleavage	0.2706	Informative	Inherited
Post-translational modification	Covalent protein-RNA linkage	0	Highly Informative	Direct
Post-translational modification	Protein splicing	2.282e-14	Highly Informative	Direct

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 34 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a DNA/RNA polymerases domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 34 hidden Markov models representing the DNA/RNA polymerases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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DNA/RNA polymerases superfamily