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HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,240) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 90,909 433,110 77
Proteins 90,364 431,535 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.37391Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)biosynthetic process0.32240.2397Least InformativeInherited
Biological Process (BP)primary metabolic process0.0038520.8591Least InformativeInherited
Biological Process (BP)single-organism cellular process0.67650.04447Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.7091Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.049870.07336Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000002950.00000004438Moderately InformativeDirect
Biological Process (BP)cellular amino acid metabolic process0.075460.05549Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.47941Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.049020.03446Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.81081Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.2071Moderately InformativeInherited
Biological Process (BP)lipid metabolic process10.01056Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.85761Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.11110.1182Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.33210.8694Moderately InformativeInherited
Biological Process (BP)organelle organization0.81141Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00000011180.01521Moderately InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0000017020.000000000000005614InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000027520.000007818InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.000024320.0000009621InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000010840.00000000009982InformativeDirect
Biological Process (BP)organophosphate catabolic process0.0000015640.00003444InformativeDirect
Biological Process (BP)membrane organization0.00093320InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0079420.05618InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.08370.007236InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.0029310.0006636InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0029441InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.26140.5364InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.0051330.01886InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00033710.001941InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.010920.1704InformativeInherited
Biological Process (BP)alcohol metabolic process0.14430.4497InformativeInherited
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Biological Process (BP)nucleus organization0.000000000017970.0000000336Highly InformativeDirect
Biological Process (BP)serine family amino acid metabolic process0.00059040.00006391Highly InformativeDirect
Biological Process (BP)endomembrane system organization0.0000006580.00003733Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000000077520.0001509Highly InformativeDirect
Biological Process (BP)L-methionine salvage0.0000000073120.000000002Highly InformativeDirect
Biological Process (BP)alcohol biosynthetic process0.0018580.0002239Highly InformativeInherited
Biological Process (BP)lipopolysaccharide metabolic process0.000073620.001426Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.0063030.02585Highly InformativeInherited
Biological Process (BP)polyol metabolic process0.0014020.02499Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.0000040421Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.081451Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.16010Moderately InformativeInherited
Molecular Function (MF)metal ion binding00.001Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)inorganic diphosphatase activity0.000000000012490.00002101Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.000000000062150.000000837Highly InformativeDirect
Cellular Component (CC)macromolecular complex11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.0004931Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.55230.00000003604Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.9404Least InformativeInherited
Cellular Component (CC)organelle envelope0.083340.005023Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.043910Moderately InformativeInherited
Cellular Component (CC)nuclear part0.15921Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.0000010020.0009338InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.000046140.000000244InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000000000033380.0000000261Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000000096240.000001444Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.04447 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8591 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.07336 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2397 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000004438 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01056 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.03446 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1182 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.8694 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1747 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.05549 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01521 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to metal ion 0.0009007 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000000000005614 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000007818 Informative Direct
Biological Process (BP) metal ion transport 0.0001897 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0000009621 Informative Direct
Biological Process (BP) regulation of ion transport 0.000214 Informative Direct
Biological Process (BP) regulation of system process 0.000000002428 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000000009982 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00003444 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000006141 Informative Direct
Biological Process (BP) ion homeostasis 0.000000000002552 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000000001235 Informative Direct
Biological Process (BP) transmembrane transport 0.0000003479 Informative Direct
Biological Process (BP) membrane organization 0 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0006636 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) system process 0.4866 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.05618 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.007236 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.3017 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.5364 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.01886 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.001941 Informative Inherited
Biological Process (BP) post-embryonic development 0.5166 Informative Inherited
Biological Process (BP) mitochondrion organization 0.008584 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1704 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4497 Informative Inherited
Biological Process (BP) embryo development 0.8383 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.000000008412 Highly Informative Direct
Biological Process (BP) nucleus organization 0.0000000336 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.0005345 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00006391 Highly Informative Direct
Biological Process (BP) oligosaccharide biosynthetic process 0.000217 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00003733 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.0002022 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001509 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0002239 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000006283 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.0001072 Highly Informative Direct
Biological Process (BP) L-methionine salvage 0.000000002 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.0000000000005202 Highly Informative Direct
Biological Process (BP) muscle system process 0.003291 Highly Informative Inherited
Biological Process (BP) detoxification 0.008249 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9154 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001403 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.01881 Highly Informative Inherited
Biological Process (BP) inner ear development 0.01019 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.05304 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.8121 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.2006 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2772 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2963 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.4336 Highly Informative Inherited
Biological Process (BP) brain development 0.7189 Highly Informative Inherited
Biological Process (BP) neutral lipid metabolic process 0.001419 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.02499 Highly Informative Inherited
Biological Process (BP) biological adhesion 1 Highly Informative Inherited
Biological Process (BP) proton transport 0.1412 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.001872 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2158 Highly Informative Inherited
Biological Process (BP) lipopolysaccharide metabolic process 0.001426 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.02585 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.8861 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9555 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.8704 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.009525 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.2737 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0005874 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.02784 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.0000006281 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000151 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000002753 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000003837 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000000001468 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.09237 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic diphosphatase activity 0.00002101 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.00000000000000324 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000000001033 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.0008479 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.000000837 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.009053 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.3394 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.003241 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0004931 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000003604 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9404 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000000007082 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.3905 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.4421 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.005023 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0009338 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000000244 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000000003065 Informative Direct
Cellular Component (CC) vacuolar part 0.00003422 Informative Direct
Cellular Component (CC) supramolecular polymer 0.744 Informative Inherited
Cellular Component (CC) transporter complex 0.007533 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.006303 Informative Inherited
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000003833 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.0000000261 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000001444 Highly Informative Direct
Cellular Component (CC) myofibril 0.002704 Highly Informative Inherited
Cellular Component (CC) contractile fiber part 0.02546 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.9802 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005104InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00369Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.004238Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.06868Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.092Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.008662Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2799Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.0144InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.1756InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.0000000000001334Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.0000000003977Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.000002357Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.0008432Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.4544Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.467Least InformativeInherited
Fly Anatomy (FA)anatomical group0.6392Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6692Least InformativeInherited
Fly Anatomy (FA)adult0.772Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1237Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3443Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.4181Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.5174Moderately InformativeInherited
Fly Anatomy (FA)neuron0.5459Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.5734Moderately InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.1117InformativeInherited
Fly Anatomy (FA)cell component0.117InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00000009771Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002127Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02533Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1456Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1936Least InformativeInherited
Plant ANatomical entity (PAN)gamete0.00001678InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.000425InformativeDirect
Plant ANatomical entity (PAN)primordium0.002519InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006606InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell0.000002935Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.0000275Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.00003451Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.00008053Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000001084Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2256Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.09175InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.5996InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00006513Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0.0000000001948InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism9.633e-16Highly InformativeDirect
Biological processSodium transport0.0000000002453Highly InformativeDirect
Biological processTranslocation0.000000001119Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0000001484Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000004153Moderately InformativeDirect
Cellular componentCell membrane0.00003136Moderately InformativeDirect
Cellular componentPeriplasm0.0006567InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000000186Least InformativeDirect
DiseaseDisease mutation0.0005314Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium0.0000000000001606Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionChloride0.0000000006677InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0.000000000000008306Highly InformativeDirect
Molecular functionZinc transport0.00002595Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.000000001774InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0001599InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2037Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0003058Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.03973Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.09272Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.1208Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.2675Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0000218InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.01228InformativeInherited
UniPathway (UP)phospholipid metabolism0.647InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.000000000000002048Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.00000000000004836Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis0.0000000000006356Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis0.000000000002396Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0000000007212Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000004048Highly InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis0.000006573Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0.0004355Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]