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HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,235) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 90,547 405,420 77
Proteins 90,009 404,734 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.0022080.5544Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.024980.03003Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.45440.3102Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.99661Least InformativeInherited
Biological Process (BP)single-organism cellular process0.85280.3423Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.59491Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000015490.00000005974Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.90461Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.38791Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.75391Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.86591Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.37150.9323Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.79011Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.021210.01802Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.17351Moderately InformativeInherited
Biological Process (BP)lipid metabolic process10.01148Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.90331Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative biosynthetic process0.013880.07524Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.093750.0395Moderately InformativeInherited
Biological Process (BP)organelle organization0.6611Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00000005050.006256Moderately InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0000011210InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000015670.000001682InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.000044210.000001192InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000012590.00000000003585InformativeDirect
Biological Process (BP)single-organism membrane organization0.00019360InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00000017130.000005105InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.00068510.08279InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.064310.004058InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.0074310.08639InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0019521InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.27480.4885InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.0078780.02206InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.0029550.0007257InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00029790.001566InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.010920.1651InformativeInherited
Biological Process (BP)alcohol metabolic process0.15390.462InformativeInherited
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Biological Process (BP)nucleus organization0.000000000020030.00000002902Highly InformativeDirect
Biological Process (BP)serine family amino acid metabolic process0.0004820.00006498Highly InformativeDirect
Biological Process (BP)nucleotide catabolic process0.00012180.0009296Highly InformativeDirect
Biological Process (BP)endomembrane system organization0.0000005170.00003045Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000000053790.0001112Highly InformativeDirect
Biological Process (BP)L-methionine salvage0.0000000079420.000000001936Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.000098470.001471Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.0053740.02398Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0025360.0002221Highly InformativeInherited
Biological Process (BP)polyol metabolic process0.0014690.02178Highly InformativeInherited
Biological Process (BP)oligosaccharide metabolic process0.54160.000004125Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.00000031221Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.068481Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.1670Moderately InformativeInherited
Molecular Function (MF)metal ion binding00.001081Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)inorganic diphosphatase activity0.000000000013510.00002694Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.000000000069750.0000007165Highly InformativeDirect
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.39230.000000004861Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.0005219Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.031880Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.3750.000000162Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.075080.002333Moderately InformativeInherited
Cellular Component (CC)nuclear part0.23351Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.00000089960.0002052InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.00003750.0000003795InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000000000039920.00000002934Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000000053010.0000004694Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.3102 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.5544 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03003 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3423 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000005974 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9323 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.01148 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.07524 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0395 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.9515 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1301 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01802 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.006256 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9964 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000001682 Informative Direct
Biological Process (BP) metal ion transport 0.0003642 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.000001192 Informative Direct
Biological Process (BP) regulation of ion transport 0.000118 Informative Direct
Biological Process (BP) regulation of system process 0.0000000004946 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000000003585 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000005105 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00001565 Informative Direct
Biological Process (BP) ion homeostasis 0.000000000004179 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000009045 Informative Direct
Biological Process (BP) transmembrane transport 0.000000004931 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0007257 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.08279 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.006941 Informative Inherited
Biological Process (BP) system process 0.6637 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.004058 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.81 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development 0.7703 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.08639 Informative Inherited
Biological Process (BP) cell adhesion 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.4885 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.02206 Informative Inherited
Biological Process (BP) post-embryonic development 0.5397 Informative Inherited
Biological Process (BP) mitochondrion organization 0.1536 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.001566 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1651 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.462 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0002152 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0002804 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000002902 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.0002419 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00006498 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 0.0009296 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.000004125 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00003045 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00008148 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001112 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0002221 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000006938 Highly Informative Direct
Biological Process (BP) L-methionine salvage 0.000000001936 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000003014 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00000000000006928 Highly Informative Direct
Biological Process (BP) detoxification 0.0005153 Highly Informative Direct
Biological Process (BP) muscle system process 0.002728 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9874 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.00184 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.04769 Highly Informative Inherited
Biological Process (BP) inner ear development 0.008577 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.7705 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2456 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.2561 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.3867 Highly Informative Inherited
Biological Process (BP) brain development 0.6727 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.1455 Highly Informative Inherited
Biological Process (BP) lipopolysaccharide metabolic process 0.001471 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.02398 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9503 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3421 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.9395 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.9667 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.9418 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2005 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.02178 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.007885 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0004926 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.9825 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.01074 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.001081 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000000233 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.000000002271 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000001434 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.00000002176 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000002525 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000004021 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.00000000004216 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.08647 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic diphosphatase activity 0.00002694 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.00000000000000636 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000000001304 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.000693 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.0000007165 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.003212 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.008119 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0005219 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000004861 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0001251 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000487 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000000162 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.338 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.002333 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0002052 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0000003795 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000000005635 Informative Direct
Cellular Component (CC) organelle subcompartment 0.000008282 Informative Direct
Cellular Component (CC) vacuolar part 0.00003277 Informative Direct
Cellular Component (CC) transporter complex 0.004213 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.005348 Informative Inherited
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000002213 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000002934 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) myofibril 0.0002705 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000004694 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.004198 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005104InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.003958Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.08551Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0908Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.3037Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.01597InformativeInherited
Worm Phenotype (WP)plasma membrane composition variant0.0000000000001761Highly InformativeDirect
Worm Phenotype (WP)seam cell morphology variant0.0000000004526Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.000002816Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.0008711Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.5206Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5258Least InformativeInherited
Fly Anatomy (FA)nervous system0.5347Least InformativeInherited
Fly Anatomy (FA)adult0.6546Least InformativeInherited
Fly Anatomy (FA)cell0.6672Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1865Moderately InformativeInherited
Fly Anatomy (FA)adult head0.2542Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.3371Moderately InformativeInherited
Fly Anatomy (FA)neuron0.4069Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.4284Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.4792Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.8405Moderately InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.09035InformativeInherited
Fly Anatomy (FA)cell component0.2057InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00000009771Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002127Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02533Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1456Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1936Least InformativeInherited
Plant ANatomical entity (PAN)gamete0.00001678InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.000425InformativeDirect
Plant ANatomical entity (PAN)primordium0.002519InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006606InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell0.000002935Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.0000275Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.00003451Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.00008053Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000003214Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2196Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.05065InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.5885InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00006566Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0.00000000009784InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism9.591e-16Highly InformativeDirect
Biological processSodium transport0.00000000009072Highly InformativeDirect
Biological processTranslocation0.0000000009554Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0000001347Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000003607Moderately InformativeDirect
Cellular componentCell membrane0.00004428Moderately InformativeDirect
Cellular componentEndosome0.000951Moderately InformativeDirect
Cellular componentPeriplasm0.0005875InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000002779Least InformativeDirect
DiseaseDisease mutation0.0002588Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.001903Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionATP-binding0.00000000000005853Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride0.00000000002638Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase0.000000003343InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0001527InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2871Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0002926Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.03149Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.08904Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.1188Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.5331Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0003833InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.01198InformativeInherited
UniPathway (UP)phospholipid metabolism0.6454InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.000000000000001814Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.00000000000005222Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis0.0000000000006496Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis0.00000000000239Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0000000007128Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000002665Highly InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis0.000006524Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0.0004417Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]