SUPERFAMILY 1.75 HMM library and genome assignments server

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HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,233) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 90,353 405,420 77
Proteins 89,822 404,734 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.70661Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000041530.0003373Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.37411Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.84941Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.097810.2877Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0037010.0305Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.72280.648Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.51421Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.037150.001212Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.89090.01293Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.1340.0004598Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.020470.000002363Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.77790.008177Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.57011Moderately InformativeInherited
Biological Process (BP)organelle organization0.57470.9005Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.74990.9624Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00086610.4101Moderately InformativeInherited
Biological Process (BP)cellular membrane organization0.000034490InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000013350.0000000002181InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000027640.0000005381InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.00018450.0000119InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle0.00055220.5934InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0017280.8774InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.0091450.03203InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.0089810.01498InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00094750.01085InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.011351InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.36390.008239InformativeInherited
Biological Process (BP)organophosphate catabolic process0.0015860.000002136InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.2730.0002069InformativeInherited
Biological Process (BP)cellular carbohydrate metabolic process0.0012680.00007079InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.032340.1879InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.0024580.106InformativeInherited
Biological Process (BP)protein dephosphorylation0.00078990.00000000003667Highly InformativeDirect
Biological Process (BP)nucleus organization0.000000000010810.00000001398Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.0000065350.0001772Highly InformativeDirect
Biological Process (BP)amino acid salvage0.000000005740.000000003695Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.000000000052510.00001696Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process0.000000020410.000000006752Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.0022520.1483Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.00018270.004591Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.0023920.02862Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.00095010.004356Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.0018940.0004229Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.00001770.8221Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.057181Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.00000000023440.000002239Highly InformativeDirect
Cellular Component (CC)cytoplasmic part10.0000000005963Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.04455Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)organelle membrane0.53640.000000001031Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.07420.001007Moderately InformativeInherited
Cellular Component (CC)nuclear part0.54961Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.02580Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.03930Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.0000021080.00008321InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane0.000025010.0000000114InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000000000056770.00000002732Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000000081170.0000002745Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0003373 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0004598 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000002363 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9005 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.6953 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.008177 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.01293 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8672 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.2877 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.648 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.8259 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001212 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02639 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9624 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4101 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.0305 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1136 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.000097 Informative Direct
Biological Process (BP) blood circulation 0.0001445 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0002926 Informative Direct
Biological Process (BP) lipid localization 0.00000000000002119 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000000002181 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000005381 Informative Direct
Biological Process (BP) metal ion transport 0.000000002241 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.0000119 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000003996 Informative Direct
Biological Process (BP) regulation of system process 0.000000009222 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00007079 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000002136 Informative Direct
Biological Process (BP) cation homeostasis 0.0004384 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002069 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.5482 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5934 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8774 Informative Inherited
Biological Process (BP) apoptotic process 0.9597 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.2154 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.03203 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.01498 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.01085 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.6854 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.3643 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.8106 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.001345 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.06202 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.6348 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.4918 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.01296 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.008239 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1879 Informative Inherited
Biological Process (BP) response to light stimulus 0.2912 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.0338 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) gland development 0.5862 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.006017 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.106 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2386 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.005808 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 0.00000000003667 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0006608 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000001398 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00001595 Highly Informative Direct
Biological Process (BP) lactation 0.0000004317 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000008922 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0001772 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.0004229 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.00000124 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0.00000000000001086 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.000001083 Highly Informative Direct
Biological Process (BP) amino acid salvage 0.000000003695 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00001696 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 0.00003433 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00002316 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 0.000000006752 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1483 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.004591 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.5211 Highly Informative Inherited
Biological Process (BP) extrinsic apoptotic signaling pathway 0.01255 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.8205 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.9141 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.343 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1335 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01101 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1373 Highly Informative Inherited
Biological Process (BP) sensory perception 0.1737 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.001817 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.02892 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1553 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9675 Highly Informative Inherited
Biological Process (BP) glycolipid biosynthetic process 0.1031 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.0871 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.008515 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.02862 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.004356 Highly Informative Inherited
Biological Process (BP) learning or memory 0.5909 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2281 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.7243 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7322 Highly Informative Inherited
Biological Process (BP) ear development 0.07237 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 1 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.8221 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00001441 Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0000000002128 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000005732 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000001366 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.4422 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1819 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0373 Informative Inherited
Molecular Function (MF) ATP binding 0.00000000000001905 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.0001615 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0004223 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.000002239 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.000113 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.002553 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.1829 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.4332 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.001663 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.06113 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000005963 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.04455 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000006803 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000000001031 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.001007 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.2225 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.00008321 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0000000114 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000000007288 Informative Direct
Cellular Component (CC) vacuolar part 0.0001348 Informative Direct
Cellular Component (CC) contractile fiber part 0.01011 Informative Inherited
Cellular Component (CC) integral to membrane 0.003148 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1773 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.000000003336 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000002732 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0001991 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.0000000003258 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0007686 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0000002745 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00009662 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005104InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002368Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08705Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1511Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.02052InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.08308InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.00000001197Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.000001923Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.00003424Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00000009694Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002097Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02505Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1446Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1922Least InformativeInherited
Plant ANatomical entity (PAN)gamete0.00001662InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004188InformativeDirect
Plant ANatomical entity (PAN)primordium0.002516InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006588InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell0.000002926Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex0.00002743Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium0.00003442Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0000799Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000000000000991Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2018Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.0375InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.4825InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005729Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0.0000000000177InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism7.057e-16Highly InformativeDirect
Biological processSodium transport0.00000000005253Highly InformativeDirect
Biological processTranslocation0.0000000004858Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.000001648Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0003848Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000002131Moderately InformativeDirect
Cellular componentCell membrane0.0001294Moderately InformativeDirect
Cellular componentPeriplasm0.0003962InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000003159Least InformativeDirect
DiseaseDisease mutation0.00003916Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.000000005188Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionATP-binding0.0000000000009963Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride0.000000000005446Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase0.000000006532InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00007594InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2069Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0004232Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.0236Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.1234Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.1643Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.4585Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0003077InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.022InformativeInherited
UniPathway (UP)phospholipid metabolism0.5996InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis0.000000000000378Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis0.0000000000004149Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis0.000000000000598Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism0.0000000005606Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis0.0000002697Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.000002994Highly InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis0.000005547Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis0.0005019Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]