SUPERFAMILY 1.75 HMM library and genome assignments server


HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,233) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 90,370 405,420 77
Proteins 89,837 404,734 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.9322Least InformativeInherited
Biological Process (BP)protein metabolic process0.79391Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process2.945e-050.0004368Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.32791Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.80331Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.53811Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.84070.004522Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.088490.2595Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0023930.02897Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.7070.634Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.038730.001331Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.10268.811e-05Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.65560.01149Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.014312.176e-06Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process10.8157Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.058180.03978Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.5561Moderately InformativeInherited
Biological Process (BP)organelle organization0.56120.9075Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.71570.936Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0015640.4387Moderately InformativeInherited
Biological Process (BP)cellular membrane organization3.473e-050InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process1.451e-065.522e-10InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of lipid metabolic process2.712e-074.273e-07InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.00019771.094e-05InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00096310.0001245InformativeDirect
Biological Process (BP)organophosphate catabolic process0.00089561.875e-07InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle0.0005590.5711InformativeInherited
Biological Process (BP)regulation of cell cycle process0.0017420.8597InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.0081950.02727InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process0.007280.01254InformativeInherited
Biological Process (BP)sulfur amino acid metabolic process0.00080780.009333InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0091691InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.31770.002137InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.25340.0003763InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.028830.1749InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.0022120.09847InformativeInherited
Biological Process (BP)protein dephosphorylation0.0005451.881e-11Highly InformativeDirect
Biological Process (BP)nucleus organization1.066e-111.212e-08Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process7.382e-060.0001646Highly InformativeDirect
Biological Process (BP)amino acid salvage7.847e-094.61e-09Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process5.169e-111.619e-05Highly InformativeDirect
Biological Process (BP)L-methionine biosynthetic process1.483e-084.956e-09Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle phase transition0.0023190.1393Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.0001810.004376Highly InformativeInherited
Biological Process (BP)deoxyribonucleotide metabolic process0.0022580.02537Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.00089710.00385Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.0018370.0004501Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding7.224e-060.7456Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)cation binding00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.052511Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.47750Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity1.362e-101.587e-06Highly InformativeDirect
Cellular Component (CC)cytoplasmic part12.374e-10Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.03636Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)organelle membrane0.52757.864e-10Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0720.001023Moderately InformativeInherited
Cellular Component (CC)nuclear part0.54791Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.018063.128e-15Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.037250Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.965e-062.649e-05InformativeDirect
Cellular Component (CC)endoplasmic reticulum membrane2.536e-052.192e-08InformativeDirect
Cellular Component (CC)protein serine/threonine phosphatase complex5.626e-132.186e-08Highly InformativeDirect
Cellular Component (CC)nuclear membrane6.945e-112.672e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9322 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0004368 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 2.8e-14 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 8.811e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 2.176e-06 Moderately Informative Direct
Biological Process (BP) cellular localization 0.9945 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9075 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.9808 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.8157 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9366 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.2595 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.634 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.03978 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9391 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 0.01149 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.004522 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001331 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.05853 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01847 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.936 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4387 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.02897 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.09945 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 8.525e-05 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0001529 Informative Direct
Biological Process (BP) lipid localization 1.439e-14 Informative Direct
Biological Process (BP) cellular membrane organization 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 5.522e-10 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 4.273e-07 Informative Direct
Biological Process (BP) metal ion transport 1.279e-09 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.0009771 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 1.094e-05 Informative Direct
Biological Process (BP) regulation of ion transport 8.049e-07 Informative Direct
Biological Process (BP) regulation of system process 3.217e-08 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0001245 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0002289 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.875e-07 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0003763 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 0.0002332 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.4979 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.5711 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.8597 Informative Inherited
Biological Process (BP) apoptotic process 0.9456 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02727 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.01254 Informative Inherited
Biological Process (BP) sulfur amino acid metabolic process 0.009333 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.6754 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.7652 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.05658 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.02642 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.007023 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9952 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 0.6354 Informative Inherited
Biological Process (BP) biological adhesion 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.407 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.04317 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.2633 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.002137 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.1749 Informative Inherited
Biological Process (BP) response to light stimulus 0.2746 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) gland development 0.5731 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.005385 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.09847 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2679 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.005538 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 1.881e-11 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0006228 Highly Informative Direct
Biological Process (BP) nucleus organization 1.212e-08 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 1.354e-05 Highly Informative Direct
Biological Process (BP) lactation 4.145e-07 Highly Informative Direct
Biological Process (BP) locomotory behavior 5.193e-06 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0001646 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.0004501 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 3.444e-06 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 1.269e-14 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 1.051e-06 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0 Highly Informative Direct
Biological Process (BP) amino acid salvage 4.61e-09 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 1.619e-05 Highly Informative Direct
Biological Process (BP) ATP metabolic process 5.8e-05 Highly Informative Direct
Biological Process (BP) negative regulation of lipid biosynthetic process 2.478e-05 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.777e-05 Highly Informative Direct
Biological Process (BP) L-methionine biosynthetic process 4.956e-09 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1393 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.004376 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.5285 Highly Informative Inherited
Biological Process (BP) extrinsic apoptotic signaling pathway 0.01227 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.8459 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.8984 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.3439 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1313 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01456 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1436 Highly Informative Inherited
Biological Process (BP) sensory perception 0.253 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.03226 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1352 Highly Informative Inherited
Biological Process (BP) cellular transition metal ion homeostasis 0.534 Highly Informative Inherited
Biological Process (BP) glycolipid biosynthetic process 0.09399 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.06576 Highly Informative Inherited
Biological Process (BP) response to toxic substance 0.006205 Highly Informative Inherited
Biological Process (BP) deoxyribonucleotide metabolic process 0.02537 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00385 Highly Informative Inherited
Biological Process (BP) learning or memory 0.5981 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1758 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.7272 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.04477 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7152 Highly Informative Inherited
Biological Process (BP) ear development 0.06906 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9936 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.7456 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 1.072e-05 Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.566e-10 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 5.691e-09 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 1.365e-09 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.3955 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1811 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.03151 Informative Inherited
Molecular Function (MF) ATP binding 1.839e-14 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0.0001386 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0005804 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 1.587e-06 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 6.342e-05 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.002147 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.1732 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.3955 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.001601 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0583 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 2.374e-10 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.03636 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.171e-11 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.128e-15 Moderately Informative Direct
Cellular Component (CC) organelle membrane 7.864e-10 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.001023 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1601 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 2.649e-05 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 2.192e-08 Informative Direct
Cellular Component (CC) Golgi apparatus 7.541e-10 Informative Direct
Cellular Component (CC) vacuolar part 0.0001341 Informative Direct
Cellular Component (CC) contractile fiber part 0.01026 Informative Inherited
Cellular Component (CC) integral to membrane 0.00227 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 0.1951 Informative Inherited
Cellular Component (CC) trans-Golgi network 5.807e-10 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 2.186e-08 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0007537 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0001713 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 2.441e-10 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0007332 Highly Informative Direct
Cellular Component (CC) nuclear membrane 2.672e-07 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0002858 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)5.104e-05InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase6.865e-12Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase4.443e-10Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase7.143e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002368Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08705Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1511Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1597Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.02052InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.08308InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant1.197e-08Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive1.923e-06Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant3.424e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium9.694e-08Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.002097Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.02505Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1446Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1922Least InformativeInherited
Plant ANatomical entity (PAN)gamete1.662e-05InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.0004188InformativeDirect
Plant ANatomical entity (PAN)primordium0.002516InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.006588InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell2.926e-06Highly InformativeDirect
Plant ANatomical entity (PAN)vegetative shoot apex2.743e-05Highly InformativeDirect
Plant ANatomical entity (PAN)phyllome primordium3.442e-05Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage7.99e-05Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.36e-14Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.1989Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.03278InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.4748InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)5.707e-05Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport1.817e-11InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism7.056e-16Highly InformativeDirect
Biological processSodium transport5.506e-11Highly InformativeDirect
Biological processTranslocation4.959e-10Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis1.672e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0003614Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus1.892e-12Moderately InformativeDirect
Cellular componentCell membrane0.0001077Moderately InformativeDirect
Cellular componentPeriplasm0.0003834InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing2.438e-09Least InformativeDirect
DiseaseDisease mutation3.484e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding7.085e-09Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionATP-binding9.823e-13Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0Highly InformativeDirect
Molecular functionChloride5.064e-12Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase7.466e-09InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration7.673e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.2078Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.000414Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis0.02362Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis0.1241Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism0.1646Moderately InformativeInherited
UniPathway (UP)amine and polyamine metabolism0.4577Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)amino-sugar metabolism0.0003078InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.02215InformativeInherited
UniPathway (UP)phospholipid metabolism0.6003InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)trehalose metabolism0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)LPS core biosynthesis3.77e-13Highly InformativeDirect
UniPathway (UP)sucrose biosynthesis4.138e-13Highly InformativeDirect
UniPathway (UP)GDP-alpha-D-mannose biosynthesis5.96e-13Highly InformativeDirect
UniPathway (UP)Lipooligosaccharide metabolism5.612e-10Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis2.695e-07Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis2.599e-06Highly InformativeDirect
UniPathway (UP)phosphatidylglycerol biosynthesis5.552e-06Highly InformativeDirect
UniPathway (UP)ADP-L-glycero-beta-D-manno-heptose biosynthesis0.0005006Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]