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HAD-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   HAD-like [ 56783]
Superfamily:   HAD-like [ 56784] (25)
Families:   Probable phosphatase YrbI [ 69467]
  HAD-related [ 56785] (2)
  beta-Phosphoglucomutase-like [ 75173] (9)
  YihX-like [ 56789] (2)
  Phosphonoacetaldehyde hydrolase-like [ 56792] (2)
  Phosphoserine phosphatase [ 64511]
  5'(3')-deoxyribonucleotidase (dNT-2) [ 82382]
  Homoserine kinase ThrH [ 102304]
  Class B acid phosphatase, AphA [ 102307]
  Hypothetical protein MW1667 (SA1546) [ 102310]
  phosphatase domain of polynucleotide kinase [ 82385] (2)
  Predicted hydrolases Cof [ 82388] (11)
  NagD-like [ 102317] (6)
  Meta-cation ATPase, catalytic domain P [ 81656] (2)
  Trehalose-phosphatase [ 110506]
  NLI interacting factor-like phosphatase [ 110509]
  Magnesium-dependent phosphatase-1, Mdp1 [ 117509]
  Hypothetical protein VC0232 [ 117512]
  Histidinol phosphatase-like [ 142177] (3)
  MtnX-like [ 142180]
  Pyrimidine 5'-nucleotidase (UMPH-1) [ 142183]
  Enolase-phosphatase E1 [ 142186] (2)
  5' nucleotidase-like [ 142191]
  AF1437-like [ 159537]
  BT0820-like [ 159540]


Superfamily statistics
Genomes (3,242) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 91,203 433,110 77
Proteins 90,654 431,535 77


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process0.0067440.8604Least InformativeInherited
Biological Process (BP)biosynthetic process0.33640.1383Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.69721Least InformativeInherited
Biological Process (BP)single-organism cellular process0.69110.01644Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.36111Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.03970.03569Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000032780.00000008105Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.82841Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.32880.8937Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.057850.06718Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.50651Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.20981Moderately InformativeInherited
Biological Process (BP)lipid metabolic process10.0016Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.85071Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.079410.09192Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.075720.07022Moderately InformativeInherited
Biological Process (BP)organelle organization0.83131Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00000020840.02403Moderately InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.0000018040.00000000000001422InformativeDirect
Biological Process (BP)regulation of lipid metabolic process0.00000030830.00000002711InformativeDirect
Biological Process (BP)cellular metabolic compound salvage0.000024660.000001081InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000013010.0000000002106InformativeDirect
Biological Process (BP)single-organism membrane organization0.000081410InformativeDirect
Biological Process (BP)organophosphate catabolic process0.0000015040.00004193InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process0.0030560.0006831InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.007440.07708InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.086110.01116InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0032931InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.2710.5756InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.0063860.03248InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.010930.1718InformativeInherited
Biological Process (BP)alcohol metabolic process0.16150.4668InformativeInherited
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Biological Process (BP)nucleus organization0.000000000017170.00000006088Highly InformativeDirect
Biological Process (BP)serine family amino acid metabolic process0.00060060.00006404Highly InformativeDirect
Biological Process (BP)endomembrane system organization0.00000059610.00004984Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000000083370.0001359Highly InformativeDirect
Biological Process (BP)L-methionine salvage0.0000000083130.000000002477Highly InformativeDirect
Biological Process (BP)polyol metabolic process0.001490.02723Highly InformativeInherited
Biological Process (BP)lipopolysaccharide metabolic process0.00007010.002059Highly InformativeInherited
Biological Process (BP)cellular polysaccharide biosynthetic process0.0062650.03219Highly InformativeInherited
Biological Process (BP)alcohol biosynthetic process0.0021550.0002738Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.000017541Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)metal ion binding00.000338Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.086531Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.16330Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)inorganic diphosphatase activity0.000000000012020.00003642Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity0.000000000066740.0000009514Highly InformativeDirect
Molecular Function (MF)sugar-phosphatase activity11Highly InformativeInherited
Cellular Component (CC)membrane10Least InformativeInherited
Cellular Component (CC)intracellular organelle part10.9629Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle10.0003Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.6260.0000005014Least InformativeInherited
Cellular Component (CC)endomembrane system10Moderately InformativeInherited
Cellular Component (CC)nuclear part0.18571Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000045910.0000003545InformativeDirect
Cellular Component (CC)nuclear envelope0.0000010090.001154InformativeInherited
Cellular Component (CC)protein serine/threonine phosphatase complex0.00000000000040720.00000004322Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.000000000090730.000002255Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01644 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8604 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1383 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03569 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000008105 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.06718 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.8937 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.0016 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8826 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.06235 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.09192 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.07022 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8939 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02403 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000000000001422 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00000002711 Informative Direct
Biological Process (BP) metal ion transport 0.0001987 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0.000001081 Informative Direct
Biological Process (BP) regulation of ion transport 0.000312 Informative Direct
Biological Process (BP) regulation of system process 0.000000002412 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000000002106 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00004193 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000007596 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000005898 Informative Direct
Biological Process (BP) transmembrane transport 0.00000258 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0006831 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) localization of cell 1 Informative Inherited
Biological Process (BP) response to metal ion 0.003142 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.07708 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01116 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9336 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.5756 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.03248 Informative Inherited
Biological Process (BP) system process 0.1134 Informative Inherited
Biological Process (BP) post-embryonic development 0.1786 Informative Inherited
Biological Process (BP) mitochondrion organization 0.009681 Informative Inherited
Biological Process (BP) cation homeostasis 0.002036 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.009517 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1718 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4668 Informative Inherited
Biological Process (BP) embryo development 0.8657 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7463 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.000000000004597 Highly Informative Direct
Biological Process (BP) nucleus organization 0.00000006088 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.0008921 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00006404 Highly Informative Direct
Biological Process (BP) oligosaccharide biosynthetic process 0.0001762 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00004984 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.0001359 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0002738 Highly Informative Direct
Biological Process (BP) response to copper ion 0.000006027 Highly Informative Direct
Biological Process (BP) L-methionine salvage 0.000000002477 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000001916 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.000000000001683 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.03172 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01262 Highly Informative Inherited
Biological Process (BP) detoxification 0.009228 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.001583 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02102 Highly Informative Inherited
Biological Process (BP) nervous system process 0.6833 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.009554 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.02723 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.1735 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.6334 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.2073 Highly Informative Inherited
Biological Process (BP) heart development 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01297 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8923 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 0.04585 Highly Informative Inherited
Biological Process (BP) biological adhesion 1 Highly Informative Inherited
Biological Process (BP) proton transport 0.1129 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.001952 Highly Informative Inherited
Biological Process (BP) lipopolysaccharide metabolic process 0.002059 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.03219 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.02639 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1901 Highly Informative Inherited
Biological Process (BP) appendage development 0.4457 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2061 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2674 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.05734 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.4714 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000338 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0003121 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.03781 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.0000001148 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000002294 Informative Direct
Molecular Function (MF) active ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0000004177 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000005594 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000000002818 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1157 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic diphosphatase activity 0.00003642 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000000000001686 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.0004321 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0.0000009514 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.01303 Highly Informative Inherited
Molecular Function (MF) UDP-glycosyltransferase activity 0.001278 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.4309 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) sugar-phosphatase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1857 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000005014 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.9629 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0001654 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000000008904 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.5469 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.4411 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle inner membrane 0.1159 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.03294 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.0000003545 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000000000096 Informative Direct
Cellular Component (CC) vacuolar part 0.00003318 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.001154 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.8608 Informative Inherited
Cellular Component (CC) plasma membrane region 0.392 Informative Inherited
Cellular Component (CC) transporter complex 0.01114 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0091 Informative Inherited
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000000004654 Highly Informative Direct
Cellular Component (CC) protein serine/threonine phosphatase complex 0.00000004322 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0002672 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000002255 Highly Informative Direct
Cellular Component (CC) dendrite 0.6144 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.002126 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.9402 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0001661Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0.00005104InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Inorganic diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processLipid transport0.0000000006875InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processNucleotide metabolism9.645e-16Highly InformativeDirect
Biological processSodium transport0.0000000003524Highly InformativeDirect
Biological processTranslocation0.000000001157Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0000001562Highly InformativeDirect
Biological processDetoxification0.0007051Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000003817Moderately InformativeDirect
Cellular componentCell membrane0.00005092Moderately InformativeDirect
Cellular componentPeriplasm0.0006688InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000009919Least InformativeDirect
DiseaseDisease mutation0.0006068Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionZinc1Least InformativeInherited
Molecular functionCalcium0.0000000000002856Moderately InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionChloride0.000000001445InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Molecular functionSchiff base0.00000000000001023Highly InformativeDirect
Molecular functionZinc transport0.00002622Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.000000002191InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.000189InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 63 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HAD-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 63 hidden Markov models representing the HAD-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]