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Dehydroquinate synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Dehydroquinate synthase-like [ 56795]
Superfamily:   Dehydroquinate synthase-like [ 56796] (2)
Families:   Dehydroquinate synthase, DHQS [ 56797]
  Iron-containing alcohol dehydrogenase [ 69892] (5)


Superfamily statistics
Genomes (3,033) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,594 62,125 10
Proteins 10,573 62,047 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.000050740.000000005577Least InformativeDirect
Biological Process (BP)single-organism cellular process0.18120.7579Least InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.0000004390.0000001012Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00000032450.00004237Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.042680.005263Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00000077310.0000000001869InformativeDirect
Biological Process (BP)fermentation00Highly InformativeDirect
Molecular Function (MF)binding0.07891Least InformativeInherited
Molecular Function (MF)oxidoreductase activity0.000000000000057750Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.0000017520.000002473Moderately InformativeDirect
Molecular Function (MF)lyase activity0.16860.05973Moderately InformativeInherited
Molecular Function (MF)coenzyme binding0.0000023670.00001082InformativeDirect
Molecular Function (MF)carbon-oxygen lyase activity, acting on phosphates0.00000013540.000000000002196Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor01Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000005577 Least Informative Direct
Biological Process (BP) biosynthetic process 0.7233 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7579 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.0000001012 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000009613 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00004237 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.1634 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01892 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.005263 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02045 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0000000001869 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.0000006727 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0004019 Informative Direct
Biological Process (BP) fermentation 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.00007056 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.000000001287 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000002473 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.05973 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0.00001082 Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity, acting on phosphates 0.000000000002196 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.3372 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.732 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.05463 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000000002126Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.6488Moderately InformativeInherited
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000005439Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000000438Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.03268InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processLipid metabolism0.000000000003393Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000008094Highly InformativeDirect
Biological processGlycerol metabolism0.0004798Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationKinase0.00000004862Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.9759Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0.000000007613Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00008941Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.04343Moderately InformativeInherited
UniPathway (UP)fermentation0.009973InformativeInherited
UniPathway (UP)alcohol biosynthesis0.0498InformativeInherited
UniPathway (UP)glycerol metabolism0.4641InformativeInherited
UniPathway (UP)alcohol degradation0.6929InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)glycerol fermentation0.000000000008675Highly InformativeDirect
UniPathway (UP)3-chlorocatechol degradation0.0000000006207Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis0.00000006681Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis0.0001881Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dehydroquinate synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Dehydroquinate synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]