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Dehydroquinate synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Dehydroquinate synthase-like [ 56795]
Superfamily:   Dehydroquinate synthase-like [ 56796] (2)
Families:   Dehydroquinate synthase, DHQS [ 56797]
  Iron-containing alcohol dehydrogenase [ 69892] (5)


Superfamily statistics
Genomes (3,029) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,577 72,224 10
Proteins 10,556 72,181 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0033110.000001006Least InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.0000001210.00000000001157Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.041440.1603Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00022310.0001434InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.00000046150.0004216InformativeDirect
Molecular Function (MF)oxidoreductase activity0.000000043350Moderately InformativeDirect
Molecular Function (MF)lyase activity0.028040.000617Moderately InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors00InformativeDirect
Molecular Function (MF)carbon-oxygen lyase activity, acting on phosphates0.000000041520Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor01Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000001006 Least Informative Direct
Biological Process (BP) biosynthetic process 0.05016 Least Informative Inherited
Biological Process (BP) localization 0.04287 Least Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.0000199 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000000001157 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.1603 Moderately Informative Inherited
Biological Process (BP) alcohol metabolic process 0.0001434 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0004216 Informative Direct
Biological Process (BP) hydrogen transport 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.000617 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity, acting on phosphates 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6876 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.07326 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000000002126Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.6488Moderately InformativeInherited
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000005439Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0000000000005581Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.02868InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.7017InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.00000226Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processLipid metabolism0.000000000001141Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processAntibiotic biosynthesis0.0000001559Highly InformativeDirect
Biological processGlycerol metabolism0.0003844Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionZinc0.000000007934Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionCobalt0.0000328InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationKinase0.00000003033Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0.0000000161Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.004377Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.03382Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.0000661InformativeDirect
UniPathway (UP)fermentation0.01021InformativeInherited
UniPathway (UP)alcohol biosynthesis0.05544InformativeInherited
UniPathway (UP)glycerol metabolism0.5225InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)polyol degradation1InformativeInherited
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)glycerol fermentation0.000000000009009Highly InformativeDirect
UniPathway (UP)3-chlorocatechol degradation0.00000000102Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis0.00000008104Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis0.000182Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dehydroquinate synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Dehydroquinate synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]