SUPERFAMILY 1.75 HMM library and genome assignments server


Dehydroquinate synthase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Dehydroquinate synthase-like [ 56795]
Superfamily:   Dehydroquinate synthase-like [ 56796] (2)
Families:   Dehydroquinate synthase, DHQS [ 56797]
  Iron-containing alcohol dehydrogenase [ 69892] (5)


Superfamily statistics
Genomes (2,325) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 8,177 31,462 10
Proteins 8,157 31,438 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.001181.828e-07Least InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.00012551.65e-07Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00170.006338Moderately InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds8.658e-096.467e-09InformativeDirect
Molecular Function (MF)oxidoreductase activity4.331e-060Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors1.966e-150InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor1.314e-151Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.828e-07 Least Informative Direct
Biological Process (BP) localization 0.0003885 Least Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.65e-07 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.006338 Moderately Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 6.467e-09 Informative Direct
Biological Process (BP) hydrogen transport 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 8.621e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.02645 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep2.126e-13Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.6488Moderately InformativeInherited
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors5.439e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor2.386e-13Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.02848InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.5436InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processLipid metabolism7.33e-13Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processPhospholipid biosynthesis0Highly InformativeDirect
Biological processAntibiotic biosynthesis2.743e-08Highly InformativeDirect
Biological processGlycerol metabolism0.0003323Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionZinc1.161e-08Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionCobalt0.0001002InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationKinase1.702e-08Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.9913Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism1.38e-08Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.003542Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.03256Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis1.125e-05InformativeDirect
UniPathway (UP)alcohol biosynthesis0.05682InformativeInherited
UniPathway (UP)glycerol metabolism0.5119InformativeInherited
UniPathway (UP)alcohol degradation0.7917InformativeInherited
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)3-chlorocatechol degradation1.246e-09Highly InformativeDirect
UniPathway (UP)aminoglycoside antibiotic biosynthesis2.558e-07Highly InformativeDirect
UniPathway (UP)2-deoxystreptamine biosynthesis0.0001791Highly InformativeDirect
UniPathway (UP)fermentation0.008308Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dehydroquinate synthase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Dehydroquinate synthase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]