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Acetyl-CoA synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acetyl-CoA synthetase-like [ 56800]
Superfamily:   Acetyl-CoA synthetase-like [ 56801]
Families:   Acetyl-CoA synthetase-like [ 56802] (6)


Superfamily statistics
Genomes (2,984) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,212 210,149 7
Proteins 48,122 188,911 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biosynthetic process0.022130.0004174Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0000037990.2103Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000000000031880Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.000031140Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.34681Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.97131Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.030490.0000000003409Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.010350.00000000000001409Moderately InformativeInherited
Biological Process (BP)single-organism transport0.96010.8276Moderately InformativeInherited
Biological Process (BP)ion transport0.27310.006582Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.28530.211Moderately InformativeInherited
Biological Process (BP)organic substance transport0.73290.1822Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.12891Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.20121Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.45471Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0039140.0000000002356Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00000000012520InformativeDirect
Biological Process (BP)lipid localization0.000044720InformativeDirect
Biological Process (BP)secondary metabolic process0.0000057240InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0001380.00000000003404InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.04680.0001088InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0035760.0008266InformativeInherited
Biological Process (BP)anion transport0.025550.000000007188InformativeInherited
Biological Process (BP)organic acid transport0.0024360.000000000000007239InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.089441InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process0.00000021810.000004134Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.0000002440Highly InformativeDirect
Biological Process (BP)nonribosomal peptide biosynthetic process0.0000029640Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process0.00000011620.00000004776Highly InformativeDirect
Biological Process (BP)lipid homeostasis0.000088450.0009023Highly InformativeDirect
Biological Process (BP)cellular response to xenobiotic stimulus0.00000044140.000006289Highly InformativeDirect
Biological Process (BP)acyl-CoA biosynthetic process0.0000000011720.000000000006849Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.0021950.0000003349Highly InformativeInherited
Biological Process (BP)cell wall biogenesis0.0071760.00000002154Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.56231Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.13540.2212Moderately InformativeInherited
Molecular Function (MF)anion binding0.24160.5872Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.065060.4449Moderately InformativeInherited
Molecular Function (MF)transporter activity0.66661Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.00035440.00001586InformativeDirect
Molecular Function (MF)ligase activity00InformativeDirect
Molecular Function (MF)purine nucleoside binding0.0083720.03239InformativeInherited
Molecular Function (MF)purine nucleotide binding0.0097770.05348InformativeInherited
Molecular Function (MF)ribonucleoside binding0.0077660.03176InformativeInherited
Molecular Function (MF)ribonucleotide binding0.014920.06231InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.039980.002791InformativeInherited
Molecular Function (MF)lipid transporter activity0.000000092410.000000001072Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.7411Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.59890.7871Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)organelle membrane0.9821Moderately InformativeInherited
Cellular Component (CC)whole membrane0.23941Moderately InformativeInherited
Cellular Component (CC)microbody0.0000000000041430InformativeDirect
Cellular Component (CC)microbody membrane0.0010950.0003426Highly InformativeInherited
Cellular Component (CC)peroxisomal part0.45250.9362Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0004174 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2103 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.0000000003409 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000002356 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000000000001409 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.006582 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.211 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.8897 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8276 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1822 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.000000007188 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.0008266 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0.000000000000007239 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00000000003404 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001088 Informative Direct
Biological Process (BP) drug metabolic process 0.004359 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) phenylpropanoid metabolic process 0.000004134 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0000003349 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.00000004776 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00000002154 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.0009023 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0.000006289 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.000000000006849 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.1812 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.007194 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.001522 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.2212 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.5872 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.4449 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.00001586 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.002791 Informative Inherited
Molecular Function (MF) purine nucleoside binding 0.03239 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.05348 Informative Inherited
Molecular Function (MF) ribonucleoside binding 0.03176 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.06231 Informative Inherited
Molecular Function (MF) lipid transporter activity 0.000000001072 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.0005619 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7871 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000004396 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.0000268 Informative Direct
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) microbody membrane 0.0003426 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.9362 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.0000000162Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0.00973Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1432Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.6517Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.7567InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.009986InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4955InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01008InformativeInherited
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000001123Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.2092Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0005603Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.03275Least InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0002599Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.0056InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated0.0138InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1075InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.2767InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.5522InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase0.000000002643Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.003325Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.000000002071Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid transport0.000000009594InformativeDirect
Biological processSteroid metabolism0.9837InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processLuminescence0.00000005691Highly InformativeDirect
Biological processCholesterol metabolism0.000007751Highly InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000000007174Moderately InformativeDirect
Cellular componentMitochondrion0.00000000009726Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.00000002049InformativeDirect
Cellular componentMicrosome0.000000002879Highly InformativeDirect
DomainTransmembrane0.1638Least InformativeInherited
DomainTransit peptide0.000000005473Moderately InformativeDirect
DomainSignal-anchor0.0005942InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0.000000000001862InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.0007054Least InformativeDirect
UniPathway (UP)cofactor metabolism0.4353Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.00000001145Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.00001506Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.00000001138InformativeDirect
UniPathway (UP)steroid metabolism0.02839InformativeInherited
UniPathway (UP)L-lysine biosynthesis0.3995InformativeInherited
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway0.00000004728Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.00009448Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.000185Highly InformativeDirect
UniPathway (UP)tyrocidine biosynthesis0.000185Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acetyl-CoA synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Acetyl-CoA synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]