SUPERFAMILY 1.75 HMM library and genome assignments server


Acetyl-CoA synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acetyl-CoA synthetase-like [ 56800]
Superfamily:   Acetyl-CoA synthetase-like [ 56801]
Families:   Acetyl-CoA synthetase-like [ 56802] (6)


Superfamily statistics
Genomes (2,941) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 53,343 104,905 7
Proteins 46,381 93,602 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.11340.01175Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.96691Least InformativeInherited
Biological Process (BP)ion transport0.00030257.164e-05Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00028160Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.28970.2214Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.59690.002902Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.76211.885e-05Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.21861Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)organic substance transport0.01480.007421Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00029480.0109Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.14161Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.66611Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.66730.8782Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.74471Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.6430.6506Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0043390.000242Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process1.362e-120InformativeDirect
Biological Process (BP)anion transport9.947e-076.366e-14InformativeDirect
Biological Process (BP)lipid localization8.221e-130InformativeDirect
Biological Process (BP)organic acid transport2.239e-090InformativeDirect
Biological Process (BP)secondary metabolic process1.266e-050InformativeDirect
Biological Process (BP)cellular amide metabolic process0.00060840InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.48260.01622InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.032720.01034InformativeInherited
Biological Process (BP)lipid catabolic process0.00390.1118InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.059810.007876InformativeInherited
Biological Process (BP)response to cytokine stimulus0.076150.4755InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.098541InformativeInherited
Biological Process (BP)acyl-CoA metabolic process6.503e-140Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process2.747e-053.429e-05Highly InformativeDirect
Biological Process (BP)phenylpropanoid metabolic process6.038e-070.0001485Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00025935.151e-07Highly InformativeDirect
Biological Process (BP)thioester biosynthetic process4.371e-100Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.00034860.0009132Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process1.113e-074.448e-07Highly InformativeDirect
Biological Process (BP)amide biosynthetic process2.009e-050Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process2.171e-050.0003703Highly InformativeDirect
Biological Process (BP)fatty acid catabolic process0.50661Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.0020710.08774Highly InformativeInherited
Molecular Function (MF)transporter activity0.16450.8748Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.062180.03215InformativeInherited
Molecular Function (MF)lipid transporter activity7.983e-130Highly InformativeDirect
Molecular Function (MF)C-acyltransferase activity4.953e-073.307e-09Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.20851Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.083660.03356Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum2.389e-051.104e-08Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.83661Moderately InformativeInherited
Cellular Component (CC)microbody00InformativeDirect
Cellular Component (CC)microbody membrane0.00024420.0004036Highly InformativeDirect
Cellular Component (CC)microbody part0.00010710.0003951Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01175 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) ion transport 7.164e-05 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.000242 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 1.885e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.8782 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.02265 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2214 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.002902 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.8646 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.007421 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.0109 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.6506 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 6.366e-14 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) transmembrane transport 0.9358 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01622 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01034 Informative Inherited
Biological Process (BP) lipid catabolic process 0.1118 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.007876 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4755 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.6912 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.004282 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.003114 Informative Inherited
Biological Process (BP) generation of neurons 0.7963 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 9.831e-08 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 3.429e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0001485 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0002794 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 5.151e-07 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0009132 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 4.448e-07 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 8.495e-05 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0003703 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.08951 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.08774 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.007405 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.8748 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.6609 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.1961 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.03215 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) C-acyltransferase activity 3.307e-09 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.001495 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.03356 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 1.104e-08 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) lipid particle 0.0004921 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.0004036 Highly Informative Direct
Cellular Component (CC) microbody part 0.0003951 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.07519 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1.62e-08Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0.00973Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1432Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.6517Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.7567InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.009986InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4955InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01008InformativeInherited
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)2.79e-13Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen1.123e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases5.652e-06Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.006848InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.0118InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.09775InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.5548InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.7423InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen2.06e-09Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.002743Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid transport9.479e-10InformativeDirect
Biological processVirulence5.361e-09InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processLuminescence4.231e-08Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum4.354e-14Moderately InformativeDirect
Cellular componentMitochondrion7.951e-12Moderately InformativeDirect
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane6.117e-09InformativeDirect
Cellular componentCell inner membrane0.0006688InformativeDirect
Cellular componentMicrosome6.1e-09Highly InformativeDirect
DomainTransmembrane0.0712Least InformativeInherited
DomainTransit peptide3.542e-10Moderately InformativeDirect
DomainSignal-anchor0.000529InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase3.035e-12InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.03939Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism5.109e-06Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.004499Moderately InformativeInherited
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)cell wall biogenesis0InformativeDirect
UniPathway (UP)siderophore metabolism4.412e-15InformativeDirect
UniPathway (UP)fatty acid biosynthesis1.849e-07InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.0004736InformativeDirect
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0003089Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.0005019Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acetyl-CoA synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Acetyl-CoA synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]