SUPERFAMILY 1.75 HMM library and genome assignments server


Acetyl-CoA synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acetyl-CoA synthetase-like [ 56800]
Superfamily:   Acetyl-CoA synthetase-like [ 56801]
Families:   Acetyl-CoA synthetase-like [ 56802] (6)


Superfamily statistics
Genomes (2,982) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,154 210,149 7
Proteins 48,065 188,911 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.083030.006275Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.96831Least InformativeInherited
Biological Process (BP)ion transport0.00027520.0001964Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.00010090Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.29840.2105Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.64640.003165Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.80232.993e-05Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.2191Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.9431Moderately InformativeInherited
Biological Process (BP)organic substance transport0.015280.01358Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00036220.02178Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.13621Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.64931Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.7060.879Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.7731Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.67380.6412Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.002528.434e-05Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process7.524e-130InformativeDirect
Biological Process (BP)anion transport7.598e-073.517e-13InformativeDirect
Biological Process (BP)lipid localization8.188e-130InformativeDirect
Biological Process (BP)organic acid transport1.402e-090InformativeDirect
Biological Process (BP)secondary metabolic process1.33e-050InformativeDirect
Biological Process (BP)cellular amide metabolic process0.00073410InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.40630.01298InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.040110.01241InformativeInherited
Biological Process (BP)lipid catabolic process0.0036530.1124InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.020130.002345InformativeInherited
Biological Process (BP)response to cytokine stimulus0.074970.4737InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.089951InformativeInherited
Biological Process (BP)acyl-CoA metabolic process5.44e-140Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process2.615e-052.902e-05Highly InformativeDirect
Biological Process (BP)phenylpropanoid metabolic process5.456e-070.0001447Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00022465.094e-07Highly InformativeDirect
Biological Process (BP)thioester biosynthetic process4.494e-100Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process4.861e-050.0002236Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process1.01e-074.363e-07Highly InformativeDirect
Biological Process (BP)peptide biosynthetic process9.012e-070Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process3.189e-050.0003882Highly InformativeDirect
Biological Process (BP)fatty acid catabolic process0.50221Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.0020050.08666Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.16170.9718Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.040420.08648InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.061950.0336InformativeInherited
Molecular Function (MF)lipid transporter activity6.468e-130Highly InformativeDirect
Molecular Function (MF)C-acyltransferase activity4.447e-072.456e-09Highly InformativeDirect
Molecular Function (MF)adenylyltransferase activity0.00038650.0002103Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.31991Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.07570.04106Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum3.478e-052.38e-08Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.86251Moderately InformativeInherited
Cellular Component (CC)microbody00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.006275 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0001964 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 8.434e-05 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 2.993e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.879 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.01567 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2105 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.003165 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.8532 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01358 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02178 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.6412 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8832 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 3.517e-13 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) transmembrane transport 0.9721 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01298 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01241 Informative Inherited
Biological Process (BP) lipid catabolic process 0.1124 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.002345 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4737 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.6908 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.003958 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.003544 Informative Inherited
Biological Process (BP) generation of neurons 0.8562 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 0.6199 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 9.633e-08 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 2.902e-05 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0001447 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0003634 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 5.094e-07 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.0002236 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 4.363e-07 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 1.665e-05 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0003882 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 2.826e-11 Highly Informative Direct
Biological Process (BP) stem cell proliferation 1.6e-10 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.08666 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.007988 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.9718 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.08648 Informative Inherited
Molecular Function (MF) nucleotide binding 0.7074 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.2358 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.0336 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) C-acyltransferase activity 2.456e-09 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 0.0002103 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.001701 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04106 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 2.38e-08 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.08615 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1.62e-08Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0.00973Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1432Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.6517Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.7567InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.009986InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4955InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01008InformativeInherited
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)2.79e-13Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen1.123e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases4.912e-06Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.00591InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.01159InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.09456InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.5471InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.7982InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen2.308e-09Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.002628Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid transport2.814e-09InformativeDirect
Biological processVirulence8.29e-09InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processLuminescence4.507e-08Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum8.348e-14Moderately InformativeDirect
Cellular componentMitochondrion9.788e-12Moderately InformativeDirect
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane6.333e-09InformativeDirect
Cellular componentCell inner membrane0.0006781InformativeDirect
Cellular componentMicrosome4.141e-09Highly InformativeDirect
DomainTransmembrane0.07523Least InformativeInherited
DomainTransit peptide4.83e-10Moderately InformativeDirect
DomainSignal-anchor0.0005337InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase3.761e-12InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0.002215Least InformativeInherited
UniPathway (UP)cofactor metabolism0.4767Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis1.079e-08Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation1.461e-05Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.2414Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)fatty acid biosynthesis2.892e-10InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0004537InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.4066InformativeInherited
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)L-lysine biosynthesis via AAA pathway5.167e-08Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis1.082e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acetyl-CoA synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Acetyl-CoA synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]