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Acetyl-CoA synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acetyl-CoA synthetase-like [ 56800]
Superfamily:   Acetyl-CoA synthetase-like [ 56801]
Families:   Acetyl-CoA synthetase-like [ 56802] (6)


Superfamily statistics
Genomes (2,989) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 55,592 317,948 7
Proteins 48,419 278,012 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000000009490.0008922Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.016540.00003151Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000000000010560Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.000023140Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.46621Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.13311Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0033660.00000000001586Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process11Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.022560.000000000144Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.007260.000000000000007296Moderately InformativeInherited
Biological Process (BP)organic substance transport0.69130.1648Moderately InformativeInherited
Biological Process (BP)ion transport0.25270.008955Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.19861Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.34391Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.27770.2216Moderately InformativeInherited
Biological Process (BP)single-organism transport0.95320.9066Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.000000000078670InformativeDirect
Biological Process (BP)lipid localization0.000028460InformativeDirect
Biological Process (BP)secondary metabolic process0.0000072440InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.00049990.00000000001861InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.022110.00003545InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.0085630.000309InformativeInherited
Biological Process (BP)organic acid transport0.0017980.000000000000003734InformativeInherited
Biological Process (BP)anion transport0.0230.00000001174InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.072271InformativeInherited
Biological Process (BP)xenobiotic metabolic process0.0000075160.00006495Highly InformativeDirect
Biological Process (BP)phenylpropanoid metabolic process0.00000039920.000008798Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.00000015910Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00037810.00000000648Highly InformativeDirect
Biological Process (BP)nonribosomal peptide biosynthetic process0.0000026820Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process0.000000083340.000000047Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.00095660.00000000002794Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.000071290.0000000002458Highly InformativeDirect
Biological Process (BP)acyl-CoA biosynthetic process0.0000000037860.0000000000001233Highly InformativeDirect
Biological Process (BP)lipid modification0.27411Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.53741Moderately InformativeInherited
Molecular Function (MF)small molecule binding0.20390.2945Moderately InformativeInherited
Molecular Function (MF)anion binding0.22990.6193Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.059770.3567Moderately InformativeInherited
Molecular Function (MF)transporter activity0.59421Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.00031810.00001407InformativeDirect
Molecular Function (MF)ligase activity00InformativeDirect
Molecular Function (MF)purine nucleotide binding0.0084590.0503InformativeInherited
Molecular Function (MF)ribonucleotide binding0.013290.05915InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.037030.002631InformativeInherited
Molecular Function (MF)lipid transporter activity0.000000080280.00000000143Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.65271Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.6520.848Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)whole membrane0.24521Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.53791Moderately InformativeInherited
Cellular Component (CC)microbody0.0000000000024050InformativeDirect
Cellular Component (CC)microbody membrane0.00082010.0004687Highly InformativeDirect
Cellular Component (CC)peroxisomal part0.50261Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00003151 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0008922 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.000000000144 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000000001586 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1648 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.8037 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.008955 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9066 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2216 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.00000001174 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000309 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0.000000000000003734 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00000000001861 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00003545 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.9541 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.2718 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.02299 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0.00006495 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000008798 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000000648 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.000000047 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00000000002794 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000000002458 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.0000000000001233 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000000005511 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.0001314 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.2487 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.3059 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6934 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01554 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.03072 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.00773 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.1911 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.004653 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.2945 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6193 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3567 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.00001407 Informative Direct
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.002631 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.0503 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.05915 Informative Inherited
Molecular Function (MF) lipid transporter activity 0.00000000143 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.001517 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.848 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1778 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) lipid droplet 0.00004745 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.0004687 Highly Informative Direct
Cellular Component (CC) peroxisomal part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.0000000162Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0.00973Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1432Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.6517Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.7567InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.009986InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4955InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01008InformativeInherited
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000001123Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000000000006824Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid transport0.00000002717InformativeDirect
Biological processSteroid metabolism1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processLuminescence0.00000007605Highly InformativeDirect
Biological processCholesterol metabolism0.00001294Highly InformativeDirect
Cellular componentEndoplasmic reticulum0.000000000004932Moderately InformativeDirect
Cellular componentMitochondrion0.0000000005769Moderately InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.00000002517InformativeDirect
Cellular componentMicrosome0.000000001798Highly InformativeDirect
DomainTransmembrane0.3055Least InformativeInherited
DomainTransit peptide0.000000006953Moderately InformativeDirect
DomainSignal-anchor0.0006InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationAcyltransferase0.000000000009956InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acetyl-CoA synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Acetyl-CoA synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]