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Acetyl-CoA synthetase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Acetyl-CoA synthetase-like [ 56800]
Superfamily:   Acetyl-CoA synthetase-like [ 56801]
Families:   Acetyl-CoA synthetase-like [ 56802] (6)


Superfamily statistics
Genomes (2,982) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 55,125 210,149 7
Proteins 48,038 188,911 7


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.10640.00469Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.9811Least InformativeInherited
Biological Process (BP)ion transport0.00031720.0002231Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.0001670Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.32880.1232Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.65350.002544Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.81370.00003556Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.23111Moderately InformativeInherited
Biological Process (BP)signal transduction11Moderately InformativeInherited
Biological Process (BP)response to organic substance0.98691Moderately InformativeInherited
Biological Process (BP)organic substance transport0.01720.01523Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.00043530.02432Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.14291Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.65551Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.71240.9176Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.77651Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.67960.7125Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.003640.0001067Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.00015440InformativeDirect
Biological Process (BP)fatty acid metabolic process0.00000000000039920InformativeDirect
Biological Process (BP)anion transport0.00000092080.0000000000004733InformativeDirect
Biological Process (BP)lipid localization0.00000000000072310InformativeDirect
Biological Process (BP)organic acid transport0.0000000015190InformativeDirect
Biological Process (BP)secondary metabolic process0.000014150InformativeDirect
Biological Process (BP)amide biosynthetic process0.000034970InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.41020.02131InformativeInherited
Biological Process (BP)organic hydroxy compound biosynthetic process0.037190.006829InformativeInherited
Biological Process (BP)lipid catabolic process0.0042920.1307InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.020270.002576InformativeInherited
Biological Process (BP)response to cytokine stimulus0.085180.4972InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.081281InformativeInherited
Biological Process (BP)acyl-CoA metabolic process0.000000000000093040Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process0.000029350.00003222Highly InformativeDirect
Biological Process (BP)phenylpropanoid metabolic process0.00000049320.0001573Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)phenol-containing compound metabolic process0.00023850.00000008413Highly InformativeDirect
Biological Process (BP)thioester biosynthetic process0.00000000037770Highly InformativeDirect
Biological Process (BP)benzene-containing compound metabolic process0.00000011620.0000004584Highly InformativeDirect
Biological Process (BP)peptide biosynthetic process0.0000013010Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.000030690.0002247Highly InformativeDirect
Biological Process (BP)fatty acid catabolic process0.5131Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.0028880.09329Highly InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups11Moderately InformativeInherited
Molecular Function (MF)transporter activity0.16980.9751Moderately InformativeInherited
Molecular Function (MF)nucleotidyltransferase activity0.044380.01536InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.026510.007522InformativeInherited
Molecular Function (MF)lipid transporter activity0.00000000000071430Highly InformativeDirect
Molecular Function (MF)C-acyltransferase activity0.000000021180.00000000003811Highly InformativeDirect
Molecular Function (MF)adenylyltransferase activity0.00047280.000004503Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.34331Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.087550.04959Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.000037690.00000002764Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.86941Moderately InformativeInherited
Cellular Component (CC)microbody00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.00469 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) ion transport 0.0002231 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0001067 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.00003556 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.9176 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.006872 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1232 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.002544 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.8929 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01523 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02432 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7125 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7788 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) anion transport 0.0000000000004733 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) organic acid transport 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) transmembrane transport 0.9796 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02131 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.006829 Informative Inherited
Biological Process (BP) lipid catabolic process 0.1307 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.002576 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.4972 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.004898 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.7149 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.002472 Informative Inherited
Biological Process (BP) generation of neurons 0.8649 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) response to other organism 0.5501 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.0000001113 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00003222 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0001573 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0004053 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00000008413 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0000004584 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.000005813 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0002247 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.00000000002381 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000000001456 Highly Informative Direct
Biological Process (BP) fatty acid catabolic process 1 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.09329 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.004057 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.9093 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.9751 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.01536 Informative Inherited
Molecular Function (MF) nucleotide binding 0.7565 Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0.1464 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.007522 Informative Inherited
Molecular Function (MF) lipid transporter activity 0 Highly Informative Direct
Molecular Function (MF) C-acyltransferase activity 0.00000000003811 Highly Informative Direct
Molecular Function (MF) adenylyltransferase activity 0.000004503 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.001846 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04959 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000002764 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.1012 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.0000000162Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0.00973Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.1432Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.6517Moderately InformativeInherited
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.7567InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.009986InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4955InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.01008InformativeInherited
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000001123Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.000004905Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0.005848InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen0.01156InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.09428InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.547InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.7982InformativeInherited
Enzyme Commission (EC)With incorporation of one atom of oxygen0.0000000023Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.002618Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid transport0.000000002814InformativeDirect
Biological processVirulence0.00000000829InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processLuminescence0.00000004507Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.00000000000008348Moderately InformativeDirect
Cellular componentMitochondrion0.000000000009788Moderately InformativeDirect
Cellular componentCell membrane1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.000000006333InformativeDirect
Cellular componentCell inner membrane0.0006781InformativeDirect
Cellular componentMicrosome0.000000004141Highly InformativeDirect
DomainTransmembrane0.07523Least InformativeInherited
DomainTransit peptide0.000000000483Moderately InformativeDirect
DomainSignal-anchor0.0005337InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0.000000000003761InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.000000000000281Moderately InformativeDirect
UniPathway (UP)carnitine metabolism0InformativeDirect
UniPathway (UP)cell wall biogenesis0InformativeDirect
UniPathway (UP)beta-lactam biosynthesis0.00001078InformativeDirect
UniPathway (UP)lipoteichoic acid biosynthesis0Highly InformativeDirect
UniPathway (UP)siderophore metabolism0.000000008526Highly InformativeDirect
UniPathway (UP)bacitracin biosynthesis0.0001695Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acetyl-CoA synthetase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Acetyl-CoA synthetase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]