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Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)

Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,243 0 29
Proteins 1,236 0 29

Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0006339Least InformativeDirect
Disease Ontology (DO)nervous system disease0.505Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.002923Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.003187Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.005053Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.006509Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001952InformativeDirect
Disease Ontology (DO)carcinoma0.0002355InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.04328InformativeInherited
Disease Ontology (DO)viral infectious disease0.08964InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.000005684Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.0001436Highly InformativeDirect
Disease Ontology (DO)osteosarcoma0.0002921Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.007377Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.008175Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05457Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1096Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0003893Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.002902Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.003411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.006456Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.02852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0306Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.0396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.05397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.06368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.1167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2152Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.00009675InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0001461InformativeDirect
Mammalian Phenotype (MP)abnormal T cell physiology0.0008019InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.0009608InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.003623InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.00439InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.005606InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.04608InformativeInherited
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.000007972Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.00002863Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.000214Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0006087Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.0126Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction0.000000000002543Moderately InformativeDirect
Biological processDifferentiation0.0003131Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0000002515Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCell junction0.0000005635Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000002433Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00005225Moderately InformativeDirect
Cellular componentSynapse0.0000000008789InformativeDirect
Cellular componentMitochondrion outer membrane0.000000004199InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0008725Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00007735Least InformativeDirect
Post-translational modificationUbl conjugation0.00000001089Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]