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Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,243 3,727 29
Proteins 1,236 3,700 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0006342Least InformativeDirect
Disease Ontology (DO)nervous system disease0.5055Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.002925Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.003196Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00506Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.006525Moderately InformativeInherited
Disease Ontology (DO)connective tissue cancer0.0001952InformativeDirect
Disease Ontology (DO)carcinoma0.0002363InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.04328InformativeInherited
Disease Ontology (DO)viral infectious disease0.08967InformativeInherited
Disease Ontology (DO)chronic lymphocytic leukemia0.000005686Highly InformativeDirect
Disease Ontology (DO)Graves' disease0.0001438Highly InformativeDirect
Disease Ontology (DO)osteosarcoma0.0002925Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.007366Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.008166Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.05451Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1096Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.0003885Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.002898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.003407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.006471Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.01218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.02853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.03057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.05394Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.06361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.1167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.00009665InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.0001458InformativeDirect
Mammalian Phenotype (MP)abnormal T cell physiology0.0008008InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.0009599InformativeDirect
Mammalian Phenotype (MP)abnormal germ cell morphology0.003619InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.004385InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.005603InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.04608InformativeInherited
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.000007963Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.00002859Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0002137Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.0006076Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.01261Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]