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Bcl-2 inhibitors of programmed cell death superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Toxins' membrane translocation domains [ 56836] (5)
Superfamily:   Bcl-2 inhibitors of programmed cell death [ 56854]
Families:   Bcl-2 inhibitors of programmed cell death [ 56855] (10)


Superfamily statistics
Genomes (146) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,243 2,910 29
Proteins 1,236 2,883 29


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0000015220.0000008424Least InformativeDirect
Biological Process (BP)response to stimulus0.00000000018660.0000001325Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0000000000000046850.00000004636Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00000000016610.002056Least InformativeInherited
Biological Process (BP)reproduction0.00000010170.0000009233Moderately InformativeDirect
Biological Process (BP)organelle organization00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000010970.0002535Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.00000049280.0000005629Moderately InformativeDirect
Biological Process (BP)single organism signaling00.000000000001517Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00074220.000263Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization0.0000081880.0003622Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000000014860Moderately InformativeDirect
Biological Process (BP)cellular localization0.000016650.00004547Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000015570.000007103Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000000000000036080Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.0003790.01423Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.014050.165Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization10.6046Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.75341Moderately InformativeInherited
Biological Process (BP)regulation of localization0.54850.852Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0012130.0001995Moderately InformativeInherited
Biological Process (BP)immune system process0.0056580.09344Moderately InformativeInherited
Biological Process (BP)ion transport0.0017720.002911Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.0031410.05484Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0035620.004396Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.24620.2661Moderately InformativeInherited
Biological Process (BP)animal organ development0.03460.9181Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000031810.005024Moderately InformativeInherited
Biological Process (BP)mitochondrion organization00InformativeDirect
Biological Process (BP)central nervous system development0.000003240.00001995InformativeDirect
Biological Process (BP)cell death00InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00010570.000009406InformativeDirect
Biological Process (BP)regulation of proteolysis0.000000000000060660InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.0000023320.00002575InformativeDirect
Biological Process (BP)regulation of organelle organization0.00000006240.0000000007922InformativeDirect
Biological Process (BP)intracellular signal transduction0.00030740.0001693InformativeDirect
Biological Process (BP)regulation of apoptotic process00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00000069430.0003767InformativeDirect
Biological Process (BP)single-organism membrane organization00InformativeDirect
Biological Process (BP)intracellular transport0.00000063790.0000001574InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.0000010040.0003532InformativeDirect
Biological Process (BP)protein oligomerization0.00000030990.000001182InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.000000014380.000000000001954InformativeDirect
Biological Process (BP)cation homeostasis0.00000000046820.00000009357InformativeDirect
Biological Process (BP)transmembrane transport0.0000000043670.0000001199InformativeDirect
Biological Process (BP)regulation of cellular localization0.00000000000001780.0000000004522InformativeDirect
Biological Process (BP)negative regulation of cell death0.00000006520InformativeDirect
Biological Process (BP)reproductive system development0.00014830.00003295InformativeDirect
Biological Process (BP)inorganic ion homeostasis0.00000000049390.0000001112InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.0029390.002983InformativeInherited
Biological Process (BP)mitotic cell cycle0.0000090590.002128InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.85210.9985InformativeInherited
Biological Process (BP)negative regulation of molecular function0.0096210.0006095InformativeInherited
Biological Process (BP)cell activation0.0042670.03712InformativeInherited
Biological Process (BP)regulation of cell cycle0.0021350.001003InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.014870.001562InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0023270.02574InformativeInherited
Biological Process (BP)embryo development0.018110.005336InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.0022440.1138InformativeInherited
Biological Process (BP)positive regulation of transport0.18850.2389InformativeInherited
Biological Process (BP)multicellular organism reproduction0.052890.09737InformativeInherited
Biological Process (BP)regulation of ion transport0.042110.04253InformativeInherited
Biological Process (BP)response to radiation0.0012140.0000977InformativeInherited
Biological Process (BP)hemopoiesis0.000035060.003861InformativeInherited
Biological Process (BP)single organism reproductive process0.00012010.001049InformativeInherited
Biological Process (BP)cell cycle process0.0029520.108InformativeInherited
Biological Process (BP)cell cycle checkpoint0.0000002130.00005671Highly InformativeDirect
Biological Process (BP)cytokinesis0.0008940.0001048Highly InformativeDirect
Biological Process (BP)leukocyte differentiation0.000059260.0005369Highly InformativeDirect
Biological Process (BP)mitochondrial transport0.0000000000000076730Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis0.000000028630.000005785Highly InformativeDirect
Biological Process (BP)apoptotic process00Highly InformativeDirect
Biological Process (BP)mitochondrial membrane organization0.000000000000006150Highly InformativeDirect
Biological Process (BP)sex differentiation0.00000029440.0008355Highly InformativeDirect
Biological Process (BP)response to UV0.000000093520.000005782Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.0000053160.000007352Highly InformativeDirect
Biological Process (BP)regulation of mitochondrion organization0.0000000000003360Highly InformativeDirect
Biological Process (BP)ovulation cycle process0.00000056820.000003139Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.000048960.00007433Highly InformativeDirect
Biological Process (BP)negative regulation of homeostatic process0.000054660.0002688Highly InformativeDirect
Biological Process (BP)response to endoplasmic reticulum stress00.0000000001486Highly InformativeDirect
Biological Process (BP)regulation of membrane potential00Highly InformativeDirect
Biological Process (BP)positive regulation of cellular component biogenesis0.00000000052770.0000007506Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.0000000000000031440.0000000000008319Highly InformativeDirect
Biological Process (BP)negative regulation of mitotic cell cycle0.0000077280.0000002501Highly InformativeDirect
Biological Process (BP)lymphocyte activation0.0000000060850.00000515Highly InformativeDirect
Biological Process (BP)organelle fusion0.0000000001090.000000000000341Highly InformativeDirect
Biological Process (BP)regulation of binding0.00000045280.00009899Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.00000058570.00001445Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH0.000000026890.00000002066Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport0.0000000025350.0000001308Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.000000000016510.000000002737Highly InformativeDirect
Biological Process (BP)regulation of membrane permeability00Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis00.0000000000001279Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity00Highly InformativeDirect
Biological Process (BP)regulation of apoptotic signaling pathway0.000000000000031880.00000000000004577Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.00046010.01855Highly InformativeInherited
Biological Process (BP)regulation of neuron apoptotic process0.031390.006716Highly InformativeInherited
Biological Process (BP)forebrain development0.000012590.00109Highly InformativeInherited
Biological Process (BP)single-organism membrane fusion0.0051570.0007322Highly InformativeInherited
Molecular Function (MF)binding00.000000000007215Least InformativeDirect
Molecular Function (MF)transporter activity0.00000027710.000005311Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.010620.006489Moderately InformativeInherited
Molecular Function (MF)passive transmembrane transporter activity00.00000000000004665InformativeDirect
Molecular Function (MF)protein dimerization activity0.00000000000022480InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00035620.0003335InformativeDirect
Molecular Function (MF)protein domain specific binding00Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.0000002990.0000001218Highly InformativeDirect
Molecular Function (MF)protein heterodimerization activity0.00000000000066860.00000000001073Highly InformativeDirect
Cellular Component (CC)membrane0.00000000000019990.000000000000104Least InformativeDirect
Cellular Component (CC)protein complex0.0000000013560.000001275Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00039820.000000007344Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00000068780.0003899Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.007170.007481Least InformativeInherited
Cellular Component (CC)mitochondrial envelope0.00000010850.000000000006813Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.00000025680.000008754Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.000025840.0005028Moderately InformativeDirect
Cellular Component (CC)membrane protein complex0.000000053160.0000000002403Moderately InformativeDirect
Cellular Component (CC)mitochondrial protein complex0.0000009270.0000000193Moderately InformativeDirect
Cellular Component (CC)whole membrane0.000000092320.00000007801Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0046120.1501Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.0036150.01383Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.0000000000054330.000000001912InformativeDirect
Cellular Component (CC)outer membrane0.000000000000017710InformativeDirect
Cellular Component (CC)microtubule cytoskeleton0.00029490.01585InformativeInherited
Cellular Component (CC)mitochondrial outer membrane0.00000000020540.00000000005519Highly InformativeDirect
Cellular Component (CC)microtubule organizing center0.0000068130.0007168Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0000008424 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000001325 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000004636 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.002056 Least Informative Inherited
Biological Process (BP) reproduction 0.0000009233 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0002535 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000005629 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000000001517 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000263 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0003622 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00004547 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000007103 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0001995 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.01423 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.165 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.6046 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8496 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.852 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.09344 Moderately Informative Inherited
Biological Process (BP) ion transport 0.002911 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.05484 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.004396 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.005024 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2661 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.9181 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2475 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) central nervous system development 0.00001995 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) response to radiation 0.0000977 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000009406 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00002575 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000007922 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001693 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0003767 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0006095 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) intracellular transport 0.0000001574 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0003532 Informative Direct
Biological Process (BP) protein oligomerization 0.000001182 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000000000001954 Informative Direct
Biological Process (BP) cation homeostasis 0.00000009357 Informative Direct
Biological Process (BP) transmembrane transport 0.0000001199 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0000000004522 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0.00003295 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.0000001112 Informative Direct
Biological Process (BP) mitotic cell cycle 0.002128 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.002983 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.9985 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1804 Informative Inherited
Biological Process (BP) cell activation 0.03712 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.001003 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.001562 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.02574 Informative Inherited
Biological Process (BP) embryo development 0.005336 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001049 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1138 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2389 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.002575 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.09737 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.04253 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.001244 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.765 Informative Inherited
Biological Process (BP) hemopoiesis 0.003861 Informative Inherited
Biological Process (BP) cell cycle process 0.108 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.00005671 Highly Informative Direct
Biological Process (BP) cytokinesis 0.0001048 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0005369 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.000005785 Highly Informative Direct
Biological Process (BP) autophagy 0.000004428 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0008355 Highly Informative Direct
Biological Process (BP) response to UV 0.000005782 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0007476 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.00001147 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000007352 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000003139 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.00002641 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00007433 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.0002688 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000001486 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.0000007506 Highly Informative Direct
Biological Process (BP) single-organism membrane fusion 0.0007322 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000000000008319 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.0000002501 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000515 Highly Informative Direct
Biological Process (BP) organelle fusion 0.000000000000341 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0006147 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00009899 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00001445 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.00000002066 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0000001308 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000000002737 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000000001279 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00000000000004577 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.01855 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.01073 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.006716 Highly Informative Inherited
Biological Process (BP) forebrain development 0.00109 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.02356 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000007215 Least Informative Direct
Molecular Function (MF) transporter activity 0.000005311 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.006489 Moderately Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.00000000000004665 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003335 Informative Direct
Molecular Function (MF) protein domain specific binding 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001218 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000001073 Highly Informative Direct
Cellular Component (CC) membrane 0.000000000000104 Least Informative Direct
Cellular Component (CC) protein complex 0.000001275 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000007344 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003899 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.007481 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.000000000006813 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000008754 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0005028 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0000000002403 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.0000000193 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00000007801 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.1501 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01383 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000001912 Informative Direct
Cellular Component (CC) outer membrane 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.01585 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.00000000005519 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.0007168 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction0.0000000004033Moderately InformativeDirect
Biological processDifferentiation0.0002504Moderately InformativeDirect
Biological processModulation of host cell apoptosis by virus0.00000000000002046Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000007433Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentCell junction0.0000003045Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.000001237Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00003586Moderately InformativeDirect
Cellular componentSynapse0.0000000005136InformativeDirect
Cellular componentMitochondrion outer membrane0.000000003019InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationDevelopmental protein0.0007136Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00003404Least InformativeDirect
Post-translational modificationUbl conjugation0.000000005395Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bcl-2 inhibitors of programmed cell death domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Bcl-2 inhibitors of programmed cell death superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]