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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (363) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,551 87,650 28
Proteins 18,820 42,561 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000002411 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002573 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.0419 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.004558 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000000028 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000000004133 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000000005766 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0000000000002086 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000003403 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000001641 Moderately Informative Direct
Biological Process (BP) system development 0.000000112 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000001413 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000003539 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000733 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000001158 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000002106 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00007017 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9183 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3178 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2551 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.06325 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8487 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1166 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.009267 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03212 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.5891 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.3108 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.3913 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.626 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01081 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) circulatory system development 0.000000000000005614 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000000109 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000007388 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000000001343 Informative Direct
Biological Process (BP) growth 0.0000000000313 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000001062 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000004467 Informative Direct
Biological Process (BP) protein oligomerization 0.0000001427 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000003949 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000004251 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000005015 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000005712 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000006165 Informative Direct
Biological Process (BP) tissue development 0.0000008233 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000004599 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000006006 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000007739 Informative Direct
Biological Process (BP) cell-cell signaling 0.00001946 Informative Direct
Biological Process (BP) central nervous system development 0.00002476 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00003261 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00004246 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00004829 Informative Direct
Biological Process (BP) regulation of locomotion 0.00006071 Informative Direct
Biological Process (BP) regulation of growth 0.00007641 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0007029 Informative Direct
Biological Process (BP) negative regulation of transport 0.0007924 Informative Direct
Biological Process (BP) pigment metabolic process 0.0009586 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0009946 Informative Direct
Biological Process (BP) regulation of cellular localization 0.3785 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.001087 Informative Inherited
Biological Process (BP) intracellular protein transport 0.133 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8258 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.4359 Informative Inherited
Biological Process (BP) cell development 0.7498 Informative Inherited
Biological Process (BP) organelle assembly 0.01604 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2996 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.002828 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01539 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.2992 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.002573 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.08658 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05863 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01257 Informative Inherited
Biological Process (BP) membrane organization 0.3235 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.3423 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9496 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1231 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) immune effector process 0.1956 Informative Inherited
Biological Process (BP) secondary metabolic process 0.03592 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.04129 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4185 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.4718 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.002069 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.2905 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3669 Informative Inherited
Biological Process (BP) embryo development 0.1937 Informative Inherited
Biological Process (BP) generation of neurons 0.4161 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.06303 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.6324 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) lipid localization 0.9009 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.008694 Informative Inherited
Biological Process (BP) sensory organ development 0.03458 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.002311 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.3925 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cell activation 0.08692 Informative Inherited
Biological Process (BP) immune response 0.8049 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regeneration 0.0000000000009326 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000000006823 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000000001409 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.000000002092 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.000000002706 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000007484 Highly Informative Direct
Biological Process (BP) appendage development 0.000000007809 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.00000001667 Highly Informative Direct
Biological Process (BP) protein maturation 0.00000006736 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000008687 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001159 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000001797 Highly Informative Direct
Biological Process (BP) neuron development 0.000002783 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.000003387 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.000006678 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000007488 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.000008874 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000009476 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000009669 Highly Informative Direct
Biological Process (BP) renal system process 0.00001275 Highly Informative Direct
Biological Process (BP) kidney development 0.00001477 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.00001537 Highly Informative Direct
Biological Process (BP) viral process 0.00002018 Highly Informative Direct
Biological Process (BP) negative regulation of peptide secretion 0.00002146 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00002743 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00003123 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00004623 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.00005224 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00006504 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00008268 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0001016 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0001059 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0001632 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001954 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0002172 Highly Informative Direct
Biological Process (BP) wound healing 0.0002282 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002509 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0003567 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0003786 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0004282 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0005253 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0007979 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.07895 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.4024 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.3291 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01846 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.8642 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.1055 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.3392 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.002953 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.4788 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.5815 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.7344 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2572 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.7261 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.2031 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.02898 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.3165 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.2494 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.004913 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.01549 Highly Informative Inherited
Biological Process (BP) inner ear development 0.001559 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.04276 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.001788 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.01605 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9586 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.437 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6273 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.457 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.03189 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.3655 Highly Informative Inherited
Biological Process (BP) brain development 0.005488 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.05465 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.05881 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.03491 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.3197 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.3514 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1187 Highly Informative Inherited
Biological Process (BP) protein import 0.04553 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.2961 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.005119 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.2058 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.03987 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.0546 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000000802 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.002369 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.008637 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1281 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.0398 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.004334 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2313 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000000005828 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000002335 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000009616 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00002239 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00038 Informative Direct
Molecular Function (MF) enzyme activator activity 0.01443 Informative Inherited
Molecular Function (MF) amide binding 0.02292 Informative Inherited
Molecular Function (MF) enzyme binding 0.5856 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.1022 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.1888 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.01086 Informative Inherited
Molecular Function (MF) phospholipid binding 0.09819 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000000135 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000004847 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000000001738 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.000000002212 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.00000001125 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000004325 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000001771 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000007412 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00001121 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00001557 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0004216 Highly Informative Direct
Molecular Function (MF) kinase binding 0.06139 Highly Informative Inherited
Molecular Function (MF) phosphatase regulator activity 0.02398 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.09872 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.02528 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000001481 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00001124 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.08107 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.001394 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.01315 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000001153 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000002481 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000004062 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000001354 Informative Direct
Cellular Component (CC) endosome 0.00002509 Informative Direct
Cellular Component (CC) membrane region 0.0001086 Informative Direct
Cellular Component (CC) neuron projection 0.5273 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.4346 Informative Inherited
Cellular Component (CC) lytic vacuole 0.001213 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.1948 Informative Inherited
Cellular Component (CC) extracellular matrix component 0.00000000008259 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000000005341 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000007518 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000004749 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.01804 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.05259 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06344Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004246Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00839Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1097Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1178Moderately InformativeInherited
Disease Ontology (DO)kidney cancer0.000000346InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002229InformativeDirect
Disease Ontology (DO)malignant glioma0.0003857InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.0758InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.339InformativeInherited
Disease Ontology (DO)neurofibroma0.000001151Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.00000823Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001009Highly InformativeDirect
Disease Ontology (DO)colorectal cancer0.00008733Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.07008Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08679Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4656Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.01122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.06454Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.07091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.1393Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.2217Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4465Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.0009199InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0.009813InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.0666InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.1689InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.1819InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3466InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.8141InformativeInherited
Phenotypic Abnormality (PA)Narrow palpebral fissure0.00003375Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.0003859Highly InformativeDirect
Phenotypic Abnormality (PA)Overgrowth0.0009535Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic dilatation0.07776Highly InformativeInherited
Phenotypic Abnormality (PA)Aneurysm0.1049Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.269Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000004042Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.008624Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08646Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1305Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2104Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2264Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.598Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000006436Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.00003975Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005239Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0002031Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.000532Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0006483Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001176Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003763Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005883Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.04645Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2069Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2326Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.239Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2613Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3925Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009536InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0000696InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002534InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.008891InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03189InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.133InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2497InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3796InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3982InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4076InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4344InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4844InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5843InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007425Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002229Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001167Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001839Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002719Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0003378Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0004947Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0006142Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.000629Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.05669Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.1006Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.101Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.221Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6112Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6359Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0001747Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0006837Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002065Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02013Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1345Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4682Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7819Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0001467Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.1574Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1651Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00008551InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001531InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001863InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0002889InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003418InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.003188InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000004613Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001489Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003518Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.000009114Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000009241Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002164Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00002915Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00008029Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0001585InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.09365Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1931Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2324Least InformativeInherited
Fly Anatomy (FA)nervous system0.2801Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3098Least InformativeInherited
Fly Anatomy (FA)somatic cell0.575Least InformativeInherited
Fly Anatomy (FA)integumentary system0.6196Least InformativeInherited
Fly Anatomy (FA)adult0.647Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02058Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.06231Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06786Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1065Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1115Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.116Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1532Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1738Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1848Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2073Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2156Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4024Moderately InformativeInherited
Fly Anatomy (FA)adult head0.4073Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.4425Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.7269Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.8108Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00003213InformativeDirect
Fly Anatomy (FA)tracheal system0.0007334InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0.007443InformativeInherited
Fly Anatomy (FA)adult external head0.009217InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.01546InformativeInherited
Fly Anatomy (FA)primordium0.0163InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval nervous system0.02741InformativeInherited
Fly Anatomy (FA)circulatory system0.0332InformativeInherited
Fly Anatomy (FA)prepupa0.03473InformativeInherited
Fly Anatomy (FA)muscle system0.03593InformativeInherited
Fly Anatomy (FA)male organism0.04271InformativeInherited
Fly Anatomy (FA)digestive system0.04564InformativeInherited
Fly Anatomy (FA)syncytium0.04788InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.06504InformativeInherited
Fly Anatomy (FA)interneuron0.06977InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1129InformativeInherited
Fly Anatomy (FA)imaginal precursor0.1373InformativeInherited
Fly Anatomy (FA)pupa0.2307InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.2362InformativeInherited
Fly Anatomy (FA)neuroblast0.768InformativeInherited
Fly Anatomy (FA)hub cell0.000001455Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.00001294Highly InformativeDirect
Fly Anatomy (FA)adult heart0.0001046Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001621Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001621Highly InformativeDirect
Fly Anatomy (FA)midline0.0001858Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.0007258Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.001049Highly InformativeInherited
Fly Anatomy (FA)pigment cell0.00119Highly InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.001448Highly InformativeInherited
Fly Anatomy (FA)acute muscle0.001449Highly InformativeInherited
Fly Anatomy (FA)hindgut0.004192Highly InformativeInherited
Fly Anatomy (FA)eye disc0.01088Highly InformativeInherited
Fly Anatomy (FA)germ layer derivative0.01972Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.5015Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9348Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03141Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.03605Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.881Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.04041InformativeInherited
Zebrafish Anatomy (ZA)anatomical space0.3602InformativeInherited
Zebrafish Anatomy (ZA)lateral line ganglion0.000126Highly InformativeDirect
Zebrafish Anatomy (ZA)intramembranous bone0.0005917Highly InformativeDirect
Zebrafish Anatomy (ZA)inner ear0.7074Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.3473Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.4792Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7101Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7288Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.09525Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.1629Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.6845Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.00000027InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.000002733InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00002103InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.00007579InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00008468InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0000914InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0002316InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0004227InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.01528InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.04442InformativeInherited
Xenopus ANatomical entity (XAN)tail0.282InformativeInherited
Xenopus ANatomical entity (XAN)duct1InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000001794Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.00004577Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0005036Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.001523Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.009852Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000004937Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.000002621Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000002526Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000004835InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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