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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06457Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004444Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.008881Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1135Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1203Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.0000722InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002318InformativeDirect
Disease Ontology (DO)malignant glioma0.0004367InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07568InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3373InformativeInherited
Disease Ontology (DO)neurofibroma0.000001181Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008421Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001028Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009598Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01487Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.02313Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1419Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.2626Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.6374Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.002082InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.3933InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.8041InformativeInherited
Phenotypic Abnormality (PA)Abnormal choroid morphology0.002563Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.3026Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal macular morphology0.5322Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001078Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01378Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08636Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.128Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2088Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.225Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6148Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001995Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005057Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001021Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0001986Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001187Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.001301Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001317Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001317Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003782Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005917Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2602Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.0000000958InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00006869InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002436InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.009076InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0319InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1349InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2458InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3824InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3988InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.418InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4637InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4833InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5877InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007441Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002233Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001614Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002612Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002725Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005478Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.0006292Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0567Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.0854Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1012Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6286Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6314Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0003116Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0004397Least InformativeDirect
Worm Phenotype (WP)cell development variant0.003106Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.005774Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0356Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4019Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7867Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0002054Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0002122Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.1457Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1977Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000006343InformativeDirect
Worm Phenotype (WP)egg laying variant0.00004643InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00009313InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002562InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0007654InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.03513InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000005079Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001634Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00001267Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002148Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001275Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0005288Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00133Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.006607Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0003939InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0004466InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1218Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1544Least InformativeInherited
Fly Anatomy (FA)nervous system0.1909Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2265Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.3041Least InformativeInherited
Fly Anatomy (FA)adult0.3972Least InformativeInherited
Fly Anatomy (FA)cell0.7074Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.007224Moderately InformativeInherited
Fly Anatomy (FA)embryo0.02463Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.04317Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.06547Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.08652Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1062Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1087Moderately InformativeInherited
Fly Anatomy (FA)gonad0.2167Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2945Moderately InformativeInherited
Fly Anatomy (FA)head0.3291Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.339Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4604Moderately InformativeInherited
Fly Anatomy (FA)thorax0.468Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4771Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.514Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5494Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.633Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.8706Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00004802InformativeDirect
Fly Anatomy (FA)chemosensory system0.000281InformativeDirect
Fly Anatomy (FA)adult heart0.000366InformativeDirect
Fly Anatomy (FA)tracheal system0.0006598InformativeDirect
Fly Anatomy (FA)head capsule0.004665InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.007345InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.01042InformativeInherited
Fly Anatomy (FA)primordium0.01318InformativeInherited
Fly Anatomy (FA)anatomical space0.01342InformativeInherited
Fly Anatomy (FA)muscle system0.01464InformativeInherited
Fly Anatomy (FA)syncytium0.02327InformativeInherited
Fly Anatomy (FA)sensory organ cell0.02519InformativeInherited
Fly Anatomy (FA)interneuron0.02928InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.0316InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.04409InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.0509InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.07693InformativeInherited
Fly Anatomy (FA)cuticular specialization0.1153InformativeInherited
Fly Anatomy (FA)adult head sensillum0.1206InformativeInherited
Fly Anatomy (FA)gut section0.1218InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.1289InformativeInherited
Fly Anatomy (FA)imaginal disc0.1589InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1826InformativeInherited
Fly Anatomy (FA)wing0.1922InformativeInherited
Fly Anatomy (FA)retina0.1995InformativeInherited
Fly Anatomy (FA)tract0.4683InformativeInherited
Fly Anatomy (FA)neuroblast0.7482InformativeInherited
Fly Anatomy (FA)somatic cell of testis0.000001104Highly InformativeDirect
Fly Anatomy (FA)germinal proliferation center hub0.00001308Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.00001329Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00006499Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001659Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001691Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002442Highly InformativeDirect
Fly Anatomy (FA)dorsal acute muscle0.000598Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.0008825Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0009943Highly InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.004059Highly InformativeInherited
Fly Anatomy (FA)ventral nerve cord primordium0.004442Highly InformativeInherited
Fly Anatomy (FA)embryonic neuroblast0.00918Highly InformativeInherited
Fly Anatomy (FA)embryonic midline of ventral nerve cord0.013Highly InformativeInherited
Fly Anatomy (FA)CNS glial cell0.0541Highly InformativeInherited
Fly Anatomy (FA)wing vein0.06652Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.006245Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.0989Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7189Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.002629Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.007244Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.5605Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.0006117InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.01883InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.2767InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.0008384Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.01246Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.07704Highly InformativeInherited
Zebrafish Anatomy (ZA)blood0.7408Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.8044Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.008148Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1183Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2229Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.655Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7972Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.9202Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0002381Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.01244Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7394Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00002218InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002836InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00005461InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00008974InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001305InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0005668InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.002417InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.03393InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.06919InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3166InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3791InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural ridge0.0001485Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0006007Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0008101Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.02241Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7947Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0005434Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.7458Moderately InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00001163Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.08017Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007236InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.00003047InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]