SUPERFAMILY 1.75 HMM library and genome assignments server


Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (311) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,200 35,099 28
Proteins 16,933 16,797 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process2.001e-060Least InformativeDirect
Biological Process (BP)multicellular organismal process5.49e-060Least InformativeDirect
Biological Process (BP)localization0.0035163.873e-10Least InformativeInherited
Biological Process (BP)single-organism cellular process0.047582.076e-15Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0076170.003181Least InformativeInherited
Biological Process (BP)response to stimulus0.015960Least InformativeInherited
Biological Process (BP)single-organism developmental process5.548e-070Moderately InformativeDirect
Biological Process (BP)signal transduction0.00027140Moderately InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway7.272e-084.008e-15InformativeDirect
Biological Process (BP)localization of cell4.277e-070InformativeDirect
Biological Process (BP)locomotion1.935e-060InformativeDirect
Biological Process (BP)cellular component movement5.535e-052.076e-15InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway2.168e-083.131e-05Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 3.873e-10 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.076e-15 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.008e-15 Least Informative Direct
Biological Process (BP) protein metabolic process 9.56e-12 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.003181 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3463 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 3.837e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 9.604e-10 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.076e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.141e-12 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 6.221e-11 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 2.662e-10 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 4.05e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 7.343e-06 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.264e-06 Moderately Informative Direct
Biological Process (BP) immune system process 1.938e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.03226 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05202 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.998 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4556 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00681 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.002192 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.04937 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4993 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7597 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3218 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.003228 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2871 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1025 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01764 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003959 Moderately Informative Inherited
Biological Process (BP) organ development 0.01805 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01312 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 4.008e-15 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 2.076e-15 Informative Direct
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) response to wounding 1.977e-12 Informative Direct
Biological Process (BP) regulation of cell proliferation 3.002e-12 Informative Direct
Biological Process (BP) regulation of apoptotic process 1.755e-11 Informative Direct
Biological Process (BP) cellular component morphogenesis 2.008e-10 Informative Direct
Biological Process (BP) response to external stimulus 6.068e-10 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 6.022e-09 Informative Direct
Biological Process (BP) positive regulation of developmental process 6.706e-09 Informative Direct
Biological Process (BP) negative regulation of developmental process 3.479e-08 Informative Direct
Biological Process (BP) negative regulation of signaling 5.559e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.205e-06 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.329e-06 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.837e-06 Informative Direct
Biological Process (BP) secretion 8.764e-06 Informative Direct
Biological Process (BP) growth 8.959e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.153e-05 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.206e-05 Informative Direct
Biological Process (BP) central nervous system development 1.234e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 1.277e-05 Informative Direct
Biological Process (BP) positive regulation of phosphorus metabolic process 1.584e-05 Informative Direct
Biological Process (BP) cardiovascular system development 3.371e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 4.012e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 6.543e-05 Informative Direct
Biological Process (BP) generation of neurons 6.922e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 9.988e-05 Informative Direct
Biological Process (BP) tube development 0.000119 Informative Direct
Biological Process (BP) protein oligomerization 0.0001262 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001317 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0001449 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001651 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004116 Informative Direct
Biological Process (BP) gland development 0.0005034 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0006114 Informative Direct
Biological Process (BP) regulation of system process 0.9898 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.2569 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cellular membrane organization 0.691 Informative Inherited
Biological Process (BP) protein transport 0.003856 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1963 Informative Inherited
Biological Process (BP) sensory organ development 0.01988 Informative Inherited
Biological Process (BP) regulation of growth 0.02668 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.3303 Informative Inherited
Biological Process (BP) regulation of cell development 0.9164 Informative Inherited
Biological Process (BP) regulation of secretion 0.1516 Informative Inherited
Biological Process (BP) response to lipid 0.8049 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.003474 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1946 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.2232 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.6894 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.3169 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.7678 Informative Inherited
Biological Process (BP) cell proliferation 0.006849 Informative Inherited
Biological Process (BP) apoptotic process 0.1821 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.6515 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.6622 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.1539 Informative Inherited
Biological Process (BP) defense response 0.053 Informative Inherited
Biological Process (BP) immune response 0.3773 Informative Inherited
Biological Process (BP) immune effector process 0.796 Informative Inherited
Biological Process (BP) regulation of protein localization 0.02088 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.5495 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.5531 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.9083 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5587 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.6665 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3586 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5203 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.4092 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2048 Informative Inherited
Biological Process (BP) steroid metabolic process 0.005045 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.06786 Informative Inherited
Biological Process (BP) lipid transport 0.003155 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.2974 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.002687 Informative Inherited
Biological Process (BP) organ morphogenesis 0.00462 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002505 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) epithelium development 0.08462 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.001196 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1287 Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 3.131e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine phosphorylation 1.51e-12 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 3.286e-11 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 4.11e-10 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 4.16e-10 Highly Informative Direct
Biological Process (BP) plasma membrane organization 9.258e-10 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 1.849e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.848e-08 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 2.169e-08 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 2.741e-08 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 7.868e-08 Highly Informative Direct
Biological Process (BP) protein localization to membrane 8.446e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 5.491e-07 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 7.305e-07 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling cascade 7.4e-07 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide catabolic process 2.971e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 5.35e-06 Highly Informative Direct
Biological Process (BP) phagocytosis 7.361e-06 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 1.369e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 1.655e-05 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 2.138e-05 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 2.694e-05 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 3.088e-05 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 3.247e-05 Highly Informative Direct
Biological Process (BP) hormone transport 3.49e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.695e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 4.046e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 5.137e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 6.152e-05 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 7.891e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000146 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0001605 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002311 Highly Informative Direct
Biological Process (BP) inner ear development 0.0003088 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0004781 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0005379 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0006158 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 0.0006486 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0008015 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00098 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.0009856 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.01905 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2934 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.003082 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.007242 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01556 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.2645 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.00402 Highly Informative Inherited
Biological Process (BP) developmental growth 0.01342 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.004153 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.9855 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 0.009454 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.9381 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.001832 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.9314 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.02871 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.7625 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.001342 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.005518 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.001933 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.7225 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1736 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.03353 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.02069 Highly Informative Inherited
Biological Process (BP) wound healing 0.01782 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.6669 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.2696 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.01193 Highly Informative Inherited
Biological Process (BP) innate immune response 0.0402 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002617 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.01549 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.07019 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.1037 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.3083 Highly Informative Inherited
Biological Process (BP) protein processing 0.002196 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001719 Highly Informative Inherited
Biological Process (BP) epidermis development 0.08151 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.01118 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.001233 Highly Informative Inherited
Biological Process (BP) nuclear import 0.02959 Highly Informative Inherited
Biological Process (BP) protein import 0.0433 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.0622 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.39 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1124 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 4.416e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.5979 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0002221 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5707 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.01439 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 3.433e-06 Informative Direct
Molecular Function (MF) enzyme activator activity 5.895e-05 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 6.349e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1716 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.00262 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.05846 Informative Inherited
Molecular Function (MF) lipid binding 0.2768 Informative Inherited
Molecular Function (MF) enzyme binding 0.8361 Informative Inherited
Molecular Function (MF) serine-type peptidase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 4.315e-13 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 1.24e-12 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.35e-11 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 4.442e-10 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1.67e-09 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 7.501e-09 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 2.404e-06 Highly Informative Direct
Molecular Function (MF) hormone binding 3.073e-06 Highly Informative Direct
Molecular Function (MF) peptide binding 9.496e-05 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.01348 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.0826 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.01675 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) vesicle 2.461e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001242 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.3241 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.05722 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) endosome 1.062e-14 Informative Direct
Cellular Component (CC) cell surface 1.01e-13 Informative Direct
Cellular Component (CC) Golgi apparatus 2.946e-06 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.01778 Informative Inherited
Cellular Component (CC) integral to membrane 0.5509 Informative Inherited
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 2.517e-13 Highly Informative Direct
Cellular Component (CC) endosomal part 2.806e-06 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 4.085e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 8.592e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)8.291e-07Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases6.22e-06Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1116Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4069Least InformativeInherited
Disease Ontology (DO)immune system disease0.6504Least InformativeInherited
Disease Ontology (DO)sensory system disease0.0007055Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.01553Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01569Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.0912Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1069Moderately InformativeInherited
Disease Ontology (DO)kidney cancer2.418e-07InformativeDirect
Disease Ontology (DO)malignant glioma0.0001535InformativeDirect
Disease Ontology (DO)large intestine cancer0.0004885InformativeDirect
Disease Ontology (DO)liver carcinoma0.0009812InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07467InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.4759InformativeInherited
Disease Ontology (DO)primary thrombocytopenia1.06e-05Highly InformativeDirect
Disease Ontology (DO)skin hemangioma1.124e-05Highly InformativeDirect
Disease Ontology (DO)neurofibroma2.718e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1694Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digits0.00794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.03841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1405Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1924Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.000642InformativeDirect
Phenotypic Abnormality (PA)Abnormality of toe0.02693InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.4579InformativeInherited
Phenotypic Abnormality (PA)Arachnodactyly0.0004695Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the ascending aorta0.0009Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0004004Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1723Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.9649Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype4.553e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology5.117e-05Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.00157Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.007247Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01503Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.07559Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07908Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.5559Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.6907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology4.463e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology7.912e-05InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.002168InformativeInherited
Mammalian Phenotype (MP)other phenotype0.003653InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.05182InformativeInherited
Mammalian Phenotype (MP)abnormal artery morphology0.1647InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.2989InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.331InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4636InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.4999InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.9732InformativeInherited
Mammalian Phenotype (MP)abnormal aorta morphology1.765e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0001838Highly InformativeDirect
Mammalian Phenotype (MP)other aberrant phenotype0.0006399Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.04372Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.04694Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2152Highly InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.6872Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.7945Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.4669Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.679e-06Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant1.627e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006497Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.2271Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant3.331e-05InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant4.042e-05InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001402InformativeDirect
Worm Phenotype (WP)body length variant0.0002221InformativeDirect
Worm Phenotype (WP)body width variant0.0003162InformativeDirect
Worm Phenotype (WP)activity level variant0.01925InformativeInherited
Worm Phenotype (WP)neuron development variant0.02399InformativeInherited
Worm Phenotype (WP)molt variant1.729e-07Highly InformativeDirect
Worm Phenotype (WP)myopodia present3.625e-07Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE4.27e-06Highly InformativeDirect
Worm Phenotype (WP)paralyzed1.734e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective2.228e-05Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant5.658e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005952Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.005357Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0001121InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.2Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2004Least InformativeInherited
Fly Anatomy (FA)larva0.3255Least InformativeInherited
Fly Anatomy (FA)organ system0.3694Least InformativeInherited
Fly Anatomy (FA)cell0.9816Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03623Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.07081Moderately InformativeInherited
Fly Anatomy (FA)anatomical group0.07163Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09602Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.14Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1678Moderately InformativeInherited
Fly Anatomy (FA)head0.2337Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.2431Moderately InformativeInherited
Fly Anatomy (FA)gonad0.2846Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.3024Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5492Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.000401InformativeDirect
Fly Anatomy (FA)germline stem cell0.000993InformativeDirect
Fly Anatomy (FA)tracheal system0.001802InformativeInherited
Fly Anatomy (FA)digestive system0.0155InformativeInherited
Fly Anatomy (FA)primordium0.04245InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.04518InformativeInherited
Fly Anatomy (FA)brain0.04995InformativeInherited
Fly Anatomy (FA)ganglion0.06904InformativeInherited
Fly Anatomy (FA)testis0.06955InformativeInherited
Fly Anatomy (FA)tract0.08635InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.09594InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1016InformativeInherited
Fly Anatomy (FA)labral segment0.109InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.1172InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1227InformativeInherited
Fly Anatomy (FA)neuromere0.1668InformativeInherited
Fly Anatomy (FA)pupa0.1696InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.234InformativeInherited
Fly Anatomy (FA)somatic stem cell0.6512InformativeInherited
Fly Anatomy (FA)ventral nervous system8.416e-06Highly InformativeDirect
Fly Anatomy (FA)adult heart1.883e-05Highly InformativeDirect
Fly Anatomy (FA)hub cell8.951e-05Highly InformativeDirect
Fly Anatomy (FA)embryonic cardioblast0.0001438Highly InformativeDirect
Fly Anatomy (FA)commissure0.0009452Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.002831Highly InformativeInherited
Fly Anatomy (FA)protocerebrum0.004552Highly InformativeInherited
Fly Anatomy (FA)hindgut0.01015Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.02441Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.02791Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.003759Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1148Least InformativeInherited
Zebrafish Anatomy (ZA)head0.6523Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.008226Moderately InformativeInherited
Zebrafish Anatomy (ZA)cranium0.0307Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.09976Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.2647Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.4001Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical surface0.000901InformativeDirect
Zebrafish Anatomy (ZA)endochondral bone0.02656InformativeInherited
Zebrafish Anatomy (ZA)dorsal hyoid arch0.0877InformativeInherited
Zebrafish Anatomy (ZA)symplectic5.139e-05Highly InformativeDirect
Zebrafish Anatomy (ZA)somite 20.0001824Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2026Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4279Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4374Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7419Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01518Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1691Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4351Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6193Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm4.424e-06InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0004066InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0006456InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0006879InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.001071InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.01736InformativeInherited
Xenopus ANatomical entity (XAN)fin4.558e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord6.009e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere9.355e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0001847Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0001943Highly InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal arch0.000741Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00519Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage6.341e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)3.333e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases6.32e-07InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis4.945e-07Moderately InformativeDirect
Biological processLipid metabolism0.4578Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSteroid metabolism9.105e-14InformativeDirect
Biological processSensory transduction3.032e-12InformativeDirect
Biological processLipid transport1.589e-11InformativeDirect
Biological processAngiogenesis8.002e-09InformativeDirect
Biological processCytolysis8.331e-06InformativeDirect
Biological processInnate immunity3.478e-05InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway3.055e-08Highly InformativeDirect
Biological processDNA synthesis3.393e-06Highly InformativeDirect
Biological processComplement pathway1.017e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome1.93e-12Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome0.0001116InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism3.002e-05Moderately InformativeDirect
DiseaseDisease mutation2.409e-05Least InformativeDirect
DiseaseDwarfism0.000944Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane5.449e-06Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainLaminin EGF-like domain1.03e-07Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionGrowth factor binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease2.461e-09Moderately InformativeDirect
Post-translational modificationActivator1.211e-07Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues8.882e-16Moderately InformativeDirect
Post-translational modificationHydroxylation4.498e-16InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid1.646e-13Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]