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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (358) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,066 43,726 28
Proteins 18,547 21,271 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000001484 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002164 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.02669 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000000000003478 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000000004825 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000000346 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000001395 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000001845 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000002302 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000004982 Moderately Informative Direct
Biological Process (BP) system development 0.0000001021 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000002962 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000003536 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000004159 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002062 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0005632 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.08575 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02947 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1657 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8529 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1437 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.8228 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.203 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.822 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06684 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.5963 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.2313 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2972 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) circulatory system development 0.000000000000001902 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000000000000005508 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000000000000009009 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000000000208 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000001222 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000001019 Informative Direct
Biological Process (BP) growth 0.00000000002066 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000003314 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00000009203 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000002132 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000004937 Informative Direct
Biological Process (BP) protein oligomerization 0.000002123 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000002274 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000003473 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000004939 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000009071 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000009215 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00001104 Informative Direct
Biological Process (BP) central nervous system development 0.00001114 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00004632 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000555 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00006594 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001066 Informative Direct
Biological Process (BP) regulation of growth 0.0001697 Informative Direct
Biological Process (BP) generation of neurons 0.0002163 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0003529 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0004784 Informative Direct
Biological Process (BP) pigment metabolic process 0.0007639 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0008743 Informative Direct
Biological Process (BP) negative regulation of cell death 0.1048 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.2886 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cell adhesion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.02607 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8613 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3935 Informative Inherited
Biological Process (BP) organelle assembly 0.06011 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.3237 Informative Inherited
Biological Process (BP) regulation of secretion 0.3026 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cell development 0.5595 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001487 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1828 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.4581 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.005666 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.005034 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.007031 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.03191 Informative Inherited
Biological Process (BP) immune response 0.74 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1099 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.4036 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.8447 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.4856 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.001647 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.5838 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.4481 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.09307 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.002501 Informative Inherited
Biological Process (BP) lipid localization 0.8917 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9013 Informative Inherited
Biological Process (BP) epithelium development 0.3303 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.6386 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.09563 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.09179 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.0138 Informative Inherited
Biological Process (BP) protein targeting 0.00302 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05204 Informative Inherited
Biological Process (BP) embryo development 0.08957 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cell migration 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000000002864 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000000009074 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.0000000001812 Highly Informative Direct
Biological Process (BP) regeneration 0.0000000007197 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000003463 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000004601 Highly Informative Direct
Biological Process (BP) protein maturation 0.0000001939 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000002475 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000002491 Highly Informative Direct
Biological Process (BP) appendage development 0.0000002616 Highly Informative Direct
Biological Process (BP) endocytosis 0.000001209 Highly Informative Direct
Biological Process (BP) viral life cycle 0.000001246 Highly Informative Direct
Biological Process (BP) neuron development 0.000001276 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.000001397 Highly Informative Direct
Biological Process (BP) renal system process 0.00000167 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000002226 Highly Informative Direct
Biological Process (BP) negative regulation of cellular protein localization 0.000002608 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.000006883 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.00000693 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000009715 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00002671 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0000303 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.0000345 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000469 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00004881 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00005793 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00006225 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00008082 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00008675 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0001041 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0001061 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0001122 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000114 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0002052 Highly Informative Direct
Biological Process (BP) wound healing 0.0002675 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0004185 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.79 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.3815 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.2699 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.06645 Highly Informative Inherited
Biological Process (BP) inner ear development 0.001093 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.5818 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.7527 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.002688 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.7122 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.004135 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.02533 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.2211 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.2642 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.0136 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.05766 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9579 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5228 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.02702 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.006916 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.01544 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1756 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.004385 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.9376 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.04135 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.3108 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.008598 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.131 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6301 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4073 Highly Informative Inherited
Biological Process (BP) brain development 0.00251 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.05562 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.7289 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.1934 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.549 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.002681 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.4513 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.2776 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1334 Highly Informative Inherited
Biological Process (BP) protein import 0.1365 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.2642 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.2949 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.002922 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.1521 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.068 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.09487 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.0603 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0005856 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.0000000000002069 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.002538 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01325 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.07672 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.0137 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3868 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000000002875 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000007691 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00002344 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0001678 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0003678 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.1672 Informative Inherited
Molecular Function (MF) enzyme binding 0.6362 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.01345 Informative Inherited
Molecular Function (MF) amide binding 0.04428 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.0822 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.007166 Informative Inherited
Molecular Function (MF) phospholipid binding 0.1301 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000000000004013 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000004585 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000000001794 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0000000002452 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000000006564 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0000004327 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000006675 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000007163 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00001517 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0009435 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.01632 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.04538 Highly Informative Inherited
Molecular Function (MF) phosphatase regulator activity 0.03135 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.08323 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000001565 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0653 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.05512 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.03479 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000001486 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000004543 Informative Direct
Cellular Component (CC) cell junction 0.000000282 Informative Direct
Cellular Component (CC) endosome 0.0000004089 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0000006569 Informative Direct
Cellular Component (CC) membrane region 0.00001701 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00005114 Informative Direct
Cellular Component (CC) lytic vacuole 0.0003614 Informative Direct
Cellular Component (CC) neuron projection 0.2729 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.6897 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000000000000866 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000003125 Highly Informative Direct
Cellular Component (CC) dendrite 0.0002041 Highly Informative Direct
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.06299 Highly Informative Inherited
Cellular Component (CC) spindle 0.1911 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.07517Least InformativeInherited
Disease Ontology (DO)immune system disease0.8554Least InformativeInherited
Disease Ontology (DO)cell type cancer0.005375Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.006994Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.09871Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1082Moderately InformativeInherited
Disease Ontology (DO)kidney cancer0.0000003174InformativeDirect
Disease Ontology (DO)malignant glioma0.0002889InformativeDirect
Disease Ontology (DO)liver carcinoma0.0004382InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07481InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3438InformativeInherited
Disease Ontology (DO)neurofibroma0.000001153Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008242Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001004Highly InformativeDirect
Disease Ontology (DO)colorectal cancer0.00006448Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.07031Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.105Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.476Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4837Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.008192Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01153Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.0511Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.0595Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.1617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.1637Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4068Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.0009128InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the thorax0.0106InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.1518InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.2216InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.3163InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3637InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.8055InformativeInherited
Phenotypic Abnormality (PA)Narrow palpebral fissure0.00003492Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.0002813Highly InformativeDirect
Phenotypic Abnormality (PA)Overgrowth0.0009763Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pulmonary artery0.2649Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000006937Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01189Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1136Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1388Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2331Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2476Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5741Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001875Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00008682Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001017Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0002068Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001199Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.002209Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.002833Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.003741Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.003764Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.006015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2027Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5121Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.0000004406InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00006791InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002582InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.008511InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.02517InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03055InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1587InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.1909InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3807InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.4049InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4255InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4614InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.484InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.6005InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007867Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002343Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.000122Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001664Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000264Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002787Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005457Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.000645Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.04985Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08526Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1029Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.1922Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6303Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0004662Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0006137Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002009Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.04068Least InformativeInherited
Worm Phenotype (WP)larval lethal0.47Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7845Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00014Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.1596Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.0001636InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001746InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.000222InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000004537Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001628Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003466Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000007727Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.000009309Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00001969Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00002529Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00006923Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0002406InformativeDirect
Fly Phenotype (FP)size defective0.0006181InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.07612Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1353Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.175Least InformativeInherited
Fly Anatomy (FA)nervous system0.2051Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2476Least InformativeInherited
Fly Anatomy (FA)integumentary system0.5621Least InformativeInherited
Fly Anatomy (FA)adult0.5705Least InformativeInherited
Fly Anatomy (FA)cell0.6797Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.007695Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.01832Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.03521Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.03955Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.06771Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0686Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.07176Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1035Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1073Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1314Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1376Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.156Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3124Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3632Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.6751Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.793Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00005885InformativeDirect
Fly Anatomy (FA)adult circulatory system0.000129InformativeDirect
Fly Anatomy (FA)procuticle0.001019InformativeInherited
Fly Anatomy (FA)adult external head0.002694InformativeInherited
Fly Anatomy (FA)primordium0.006473InformativeInherited
Fly Anatomy (FA)male organism0.01469InformativeInherited
Fly Anatomy (FA)prepupa0.01478InformativeInherited
Fly Anatomy (FA)larval segment0.01551InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.01556InformativeInherited
Fly Anatomy (FA)digestive system0.01992InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.04265InformativeInherited
Fly Anatomy (FA)muscle system0.04334InformativeInherited
Fly Anatomy (FA)syncytium0.05367InformativeInherited
Fly Anatomy (FA)muscle cell0.06577InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.07018InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.07261InformativeInherited
Fly Anatomy (FA)interneuron0.1049InformativeInherited
Fly Anatomy (FA)labral segment0.1204InformativeInherited
Fly Anatomy (FA)germline cell0.153InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.16InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1949InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.2048InformativeInherited
Fly Anatomy (FA)tract0.2128InformativeInherited
Fly Anatomy (FA)neuromere0.2319InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.3558InformativeInherited
Fly Anatomy (FA)somatic stem cell0.5469InformativeInherited
Fly Anatomy (FA)hub cell0.000001809Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.000005548Highly InformativeDirect
Fly Anatomy (FA)embryonic cardioblast0.0001507Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.0001762Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002429Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0002728Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.001444Highly InformativeInherited
Fly Anatomy (FA)acute muscle0.001993Highly InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.002218Highly InformativeInherited
Fly Anatomy (FA)hindgut0.005981Highly InformativeInherited
Fly Anatomy (FA)germ layer derivative0.007179Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.01854Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.02337Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.003089Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.4984Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9523Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.04948Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.0704Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08023Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.3264Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.8985Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.04048InformativeInherited
Zebrafish Anatomy (ZA)muscle0.1945InformativeInherited
Zebrafish Anatomy (ZA)coelom1InformativeInherited
Zebrafish Anatomy (ZA)lateral line ganglion0.0001555Highly InformativeDirect
Zebrafish Anatomy (ZA)intramembranous bone0.0006193Highly InformativeDirect
Zebrafish Anatomy (ZA)epithelium0.06404Highly InformativeInherited
Zebrafish Anatomy (ZA)inner ear0.6795Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3917Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.5741Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7428Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7447Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.157Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6766Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.719Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0000007205InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000005658InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000007616InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00002849InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0000497InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00005373InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0001978InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.008421InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.03903InformativeInherited
Xenopus ANatomical entity (XAN)tail0.2313InformativeInherited
Xenopus ANatomical entity (XAN)duct1InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0000009869Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.000004102Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.00001656Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric duct0.00003151Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00003804Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.000442Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.001272Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.008181Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000001449Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.000007123Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000002531Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000005499InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.01095Least InformativeInherited
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.08798Least InformativeInherited
Drugbank ATC_code (DB)protein kinase inhibitors0.0007357Moderately InformativeDirect
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.002442Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)pituitary and hypothalamic hormones and analogues0.0002566InformativeDirect
Drugbank ATC_code (DB)mecasermin0.0000005603Highly InformativeDirect
Drugbank ATC_code (DB)afatinib0.00002828Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis0.000001043Moderately InformativeDirect
Biological processImmunity0.000004516Moderately InformativeDirect
Biological processLipid metabolism0.5362Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSensory transduction0.00000000000005469InformativeDirect
Biological processSteroid metabolism0.0000000000004723InformativeDirect
Biological processLipid transport0.0000000001501InformativeDirect
Biological processCytolysis0.00001121InformativeDirect
Biological processInnate immunity0.06638InformativeInherited
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway0.00000009785Highly InformativeDirect
Biological processDNA synthesis0.000003952Highly InformativeDirect
Biological processComplement pathway0.00003993Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection6.533e-16Moderately InformativeDirect
Cellular componentEndosome0.0000000000002218Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000194Moderately InformativeDirect
Cellular componentCell junction0.0002956Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome0.000001547InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000003665Moderately InformativeDirect
DiseaseDisease mutation0.00000704Least InformativeDirect
DiseaseDwarfism0.0006126InformativeDirect
DomainRepeat0Least InformativeDirect