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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06419Least InformativeInherited
Disease Ontology (DO)cell type cancer0.00442Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.008813Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.113Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1199Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.00007101InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002286InformativeDirect
Disease Ontology (DO)malignant glioma0.0004293InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07546InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3371InformativeInherited
Disease Ontology (DO)neurofibroma0.000001168Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008276Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001012Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009452Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.05837Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2572Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.01378Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.03567Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.6546Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.006039InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.8326InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.3359Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001117Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01381Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08633Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.13Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2081Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2256Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6145Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.00000003528Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001946Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005106Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.00009849Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0001973Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001178Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.001294Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001315Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003723Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02945Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2601Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009774InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00007053InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002455InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.008984InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03186InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.134InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2449InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3824InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3995InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4207InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4635InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4833InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5876InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002251Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001175Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001624Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002613Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002728Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005483Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.0006313Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.05687Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08528Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1014Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6285Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6311Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0001882Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0007227Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002158Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0217Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1279Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1379Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4569Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7807Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0001555Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.02334Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1022Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1506Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1872Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000816InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001596InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002323InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0003209InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003611InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0009639InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.003132InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.11InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000004657Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001662Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003554Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000009353Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.000009359Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002191Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00003069Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00008658Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0002221InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0002367InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0.00347Least InformativeInherited
Fly Anatomy (FA)larva0.13Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2141Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2556Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2944Least InformativeInherited
Fly Anatomy (FA)nervous system0.3345Least InformativeInherited
Fly Anatomy (FA)integumentary system0.4883Least InformativeInherited
Fly Anatomy (FA)adult0.5514Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6618Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)non-connected developing system0.004298Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01351Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.01799Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.03975Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.06796Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.07133Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.08525Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0967Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.102Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1424Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1527Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2478Moderately InformativeInherited
Fly Anatomy (FA)adult head0.2674Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.295Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.3676Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3759Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.7046Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7476Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00002285InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0.00022InformativeDirect
Fly Anatomy (FA)endocuticle0.0004975InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0.004868InformativeInherited
Fly Anatomy (FA)adult external head0.007525InformativeInherited
Fly Anatomy (FA)anatomical space0.007682InformativeInherited
Fly Anatomy (FA)primordium0.008101InformativeInherited
Fly Anatomy (FA)circulatory system0.02167InformativeInherited
Fly Anatomy (FA)muscle system0.02754InformativeInherited
Fly Anatomy (FA)male organism0.03534InformativeInherited
Fly Anatomy (FA)interneuron0.03685InformativeInherited
Fly Anatomy (FA)digestive system0.03931InformativeInherited
Fly Anatomy (FA)syncytium0.04237InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.05859InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.07875InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.0825InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.2269InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.6677InformativeInherited
Fly Anatomy (FA)neuroblast0.7379InformativeInherited
Fly Anatomy (FA)hub cell0.0000009989Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.000007194Highly InformativeDirect
Fly Anatomy (FA)adult heart0.00007797Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001041Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001103Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001616Highly InformativeDirect
Fly Anatomy (FA)embryonic cardioblast0.0003014Highly InformativeDirect
Fly Anatomy (FA)pigment cell0.0007327Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.0007989Highly InformativeDirect
Fly Anatomy (FA)fascicle0.0009475Highly InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.0009481Highly InformativeDirect
Fly Anatomy (FA)acute muscle0.00111Highly InformativeInherited
Fly Anatomy (FA)hindgut0.002818Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.1004Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.006923Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5456Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8343Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.01228Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03334Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7396Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.05186InformativeInherited
Zebrafish Anatomy (ZA)intramembranous bone0.0005594Highly InformativeDirect
Zebrafish Anatomy (ZA)lymph vessel0.0008975Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.006698Highly InformativeInherited
Zebrafish Anatomy (ZA)ganglion0.02364Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.007758Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.08932Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2021Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5543Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6921Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000008427Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.007837Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.6681Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.000001837InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000001858InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000003689InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002058InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00006859InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0001693InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.01422InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.01528InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.2297InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3044InformativeInherited
Xenopus ANatomical entity (XAN)tail tip0.00002308Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0001371Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0001642Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0007187Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00357Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.01384Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0003372Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000002641Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007359InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis0.000001009Moderately InformativeDirect
Biological processImmunity0.00001977Moderately InformativeDirect
Biological processLipid metabolism0.4221Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSteroid metabolism0.00000000000004363InformativeDirect
Biological processSensory transduction0.000000000000511InformativeDirect
Biological processLipid transport0.00000000003122InformativeDirect
Biological processCytolysis0.00001528InformativeDirect
Biological processInnate immunity0.0502InformativeInherited
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway0.00000004599Highly InformativeDirect
Biological processDNA synthesis0.00000383Highly InformativeDirect
Biological processComplement pathway0.00001909Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000198Moderately InformativeDirect
Cellular componentCell junction0.0004753Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome0.0000004901InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000003424Moderately InformativeDirect
DiseaseDisease mutation0.000009753Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.000000005277Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainANK repeat0.00007166InformativeDirect
DomainLaminin EGF-like domain0.0000000535Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationActivator0.00000001323Moderately InformativeDirect
Post-translational modificationProtease0.00000002559Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationGrowth factor binding0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0.000000000000006685InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0000000000007606Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]