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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (363) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,551 87,650 28
Proteins 18,820 42,561 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004084 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000004084 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.2324 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.04685 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.00000164 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000001296 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000005041 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000007711 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000000008092 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000001058 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0007291 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00005825 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.00001284 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000002409 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000002271 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000000000538 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000251 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000006479 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2773 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2538 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.0731 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.7617 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.6466 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01123 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01353 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.521 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.073 Moderately Informative Inherited
Biological Process (BP) reproduction 0.8061 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.00000000000001422 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) central nervous system development 0.00002699 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000009978 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000515 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000000002289 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000007688 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000364 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000009916 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00001587 Informative Direct
Biological Process (BP) growth 0.00000000006754 Informative Direct
Biological Process (BP) regulation of growth 0.00017 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001371 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0006837 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000008858 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.000000000000003734 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00001954 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0005525 Informative Direct
Biological Process (BP) negative regulation of transport 0.00054 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000007516 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000001458 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000001584 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000001763 Informative Direct
Biological Process (BP) protein oligomerization 0.0000006594 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000879 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) circulatory system development 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0000000000002694 Informative Direct
Biological Process (BP) negative regulation of cell death 0.1884 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.3033 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.06184 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8005 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.4861 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.003766 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.3847 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.44 Informative Inherited
Biological Process (BP) organelle assembly 0.01023 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.02104 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.2115 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03874 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.004052 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1692 Informative Inherited
Biological Process (BP) regulation of secretion 0.5264 Informative Inherited
Biological Process (BP) positive regulation of transport 0.004449 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.8571 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.008736 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001584 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1918 Informative Inherited
Biological Process (BP) proteolysis 0.9945 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.6441 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6109 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3083 Informative Inherited
Biological Process (BP) cell development 0.6215 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.001706 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.258 Informative Inherited
Biological Process (BP) generation of neurons 0.4279 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1571 Informative Inherited
Biological Process (BP) lipid localization 0.7637 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.007015 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.3964 Informative Inherited
Biological Process (BP) epithelium development 0.1889 Informative Inherited
Biological Process (BP) embryo development 0.2142 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) protein transport 0.6533 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.008818 Informative Inherited
Biological Process (BP) secondary metabolic process 0.04949 Informative Inherited
Biological Process (BP) system process 0.8755 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.7663 Informative Inherited
Biological Process (BP) hemopoiesis 0.1257 Informative Inherited
Biological Process (BP) cell activation 0.08453 Informative Inherited
Biological Process (BP) immune response 0.8552 Informative Inherited
Biological Process (BP) immune effector process 0.164 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001149 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000000000001756 Highly Informative Direct
Biological Process (BP) kidney development 0.00001079 Highly Informative Direct
Biological Process (BP) negative regulation of peptide secretion 0.00005623 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00000001274 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000006733 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.0001024 Highly Informative Direct
Biological Process (BP) heart development 0.0001722 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0001594 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000377 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000001624 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0008006 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000016 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.00000000003474 Highly Informative Direct
Biological Process (BP) viral process 0.00008078 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0003009 Highly Informative Direct
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regeneration 0.0000000000002331 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0006508 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.0000000189 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.00004904 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00000000017 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000001936 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0001002 Highly Informative Direct
Biological Process (BP) wound healing 0.0001472 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000141 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0002379 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0006723 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0004484 Highly Informative Direct
Biological Process (BP) neuron development 0.000001935 Highly Informative Direct
Biological Process (BP) appendage development 0.00000003576 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0007474 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0001278 Highly Informative Direct
Biological Process (BP) protein maturation 0.000000272 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.0001211 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.0000004209 Highly Informative Direct
Biological Process (BP) cell chemotaxis 0.000000001923 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0004101 Highly Informative Direct
Biological Process (BP) response to growth factor 0.00002364 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00002609 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0001055 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000000005809 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.00006477 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0000002339 Highly Informative Direct
Biological Process (BP) regulation of protein import 0.00001653 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0002897 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.06188 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.5937 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.09062 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1011 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.4405 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.05213 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.2975 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.561 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.6157 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.001945 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.6945 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.4433 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.004782 Highly Informative Inherited
Biological Process (BP) phagocytosis 0.05477 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.277 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.02448 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.001889 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.02897 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9334 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.04049 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.4527 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6224 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.0267 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.00197 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.07888 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.006762 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.003611 Highly Informative Inherited
Biological Process (BP) positive regulation of supramolecular fiber organization 0.4823 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.03674 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.001027 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.3752 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.009595 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.09904 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.5972 Highly Informative Inherited
Biological Process (BP) forebrain development 0.01069 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.003288 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.01745 Highly Informative Inherited
Biological Process (BP) muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.7166 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.5641 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001884 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.08449 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.3967 Highly Informative Inherited
Biological Process (BP) protein import 0.03976 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.05066 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.01976 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.5003 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.255 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.03928 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000001852 Least Informative Direct
Molecular Function (MF) transferase activity 0.01644 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.007671 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.05233 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1794 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1715 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.2925 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.000294 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000000000004824 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000001459 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00001832 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000003704 Informative Direct
Molecular Function (MF) enzyme binding 0.6371 Informative Inherited
Molecular Function (MF) amide binding 0.008682 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.03862 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.4137 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.02161 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.27 Informative Inherited
Molecular Function (MF) phospholipid binding 0.1738 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.000007707 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.000000001575 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00004657 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000000000003209 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000000005022 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0005493 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001359 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00003019 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000003653 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000002469 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.000003564 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.2623 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.105 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.0561 Highly Informative Inherited
Molecular Function (MF) phosphatase regulator activity 0.0238 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000003724 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000002226 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0000506 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.08594 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.06836 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.001603 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000122 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000586 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000001314 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.000001839 Informative Direct
Cellular Component (CC) apical part of cell 0 Informative Direct
Cellular Component (CC) membrane region 0.00006217 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000001014 Informative Direct
Cellular Component (CC) neuron projection 0.6961 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) lytic vacuole 0.001021 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.4637 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.3297 Informative Inherited
Cellular Component (CC) apical plasma membrane 0.00000002761 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000009687 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00001965 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0.00000000005886 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.006717 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.09331 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis0.000001103Moderately InformativeDirect
Biological processImmunity0.000008528Moderately InformativeDirect
Biological processLipid metabolism0.4214Moderately InformativeInherited
Biological processEndocytosis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processSteroid metabolism0.00000000000003669InformativeDirect
Biological processSensory transduction0.0000000000005705InformativeDirect
Biological processLipid transport0.0000000000192InformativeDirect
Biological processCytolysis0.00001566InformativeDirect
Biological processInnate immunity0.04693InformativeInherited
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processComplement alternate pathway0.00000008689Highly InformativeDirect
Biological processDNA synthesis0.00000392Highly InformativeDirect
Biological processComplement pathway0.00003554Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell projection0.000000000000002596Moderately InformativeDirect
Cellular componentGolgi apparatus0.000001939Moderately InformativeDirect
Cellular componentCell junction0.0003437Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome0.0000004269InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000003781Moderately InformativeDirect
DiseaseDisease mutation0.000005473Least InformativeDirect
DiseaseDwarfism0.0008441InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000000521Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainANK repeat0.00007398InformativeDirect
DomainLaminin EGF-like domain0.00000005627Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationActivator0.000000008763Moderately InformativeDirect
Post-translational modificationProtease0.000000009657Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationGrowth factor binding0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0000000000008157Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]