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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06438Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004473Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00888Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1137Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1205Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.00007226InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002314InformativeDirect
Disease Ontology (DO)malignant glioma0.0004364InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07571InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3373InformativeInherited
Disease Ontology (DO)neurofibroma0.000001181Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008409Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001027Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009588Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.0535Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.003258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.008231Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.112Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.7961Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.004156InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.7657InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pulmonary vasculature0.0001858Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.2867Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001081Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01383Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08653Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1287Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2085Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2246Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.615Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000002004Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005061Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001024Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0001964Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001191Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.001306Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001323Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003793Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005953Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1162Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2601Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009607InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00006919InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002447InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.009093InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03189InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.135InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2451InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3824InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3989InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4181InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4637InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4833InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5877InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007465Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000224Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001614Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002609Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002725Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005495Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.0006307Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.05673Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08538Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1012Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6285Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6312Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0001663Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000202Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002275Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02349Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1253Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1379Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4183Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7656Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0001471Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.02735Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1977Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2686Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00007014InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00007812InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002254InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0003939InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0006179InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.003114InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000004643Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001378Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003539Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000009305Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00001018Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002181Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00003453Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00009469Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000472Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0003557InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0004056InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.08306Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3084Least InformativeInherited
Fly Anatomy (FA)nervous system0.3622Least InformativeInherited
Fly Anatomy (FA)adult0.3817Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4293Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5414Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02275Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06483Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.07555Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.07567Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1538Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.1935Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.21Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2103Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.2212Moderately InformativeInherited
Fly Anatomy (FA)gonad0.2332Moderately InformativeInherited
Fly Anatomy (FA)head0.331Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.3653Moderately InformativeInherited
Fly Anatomy (FA)thorax0.4733Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4779Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5501Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.6635Moderately InformativeInherited
Fly Anatomy (FA)appendage0.7056Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.8902Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00005701InformativeDirect
Fly Anatomy (FA)adult heart0.0002034InformativeDirect
Fly Anatomy (FA)tracheal system0.0008697InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0.009551InformativeInherited
Fly Anatomy (FA)muscle system0.01313InformativeInherited
Fly Anatomy (FA)interneuron0.01315InformativeInherited
Fly Anatomy (FA)adult external head0.01331InformativeInherited
Fly Anatomy (FA)anatomical space0.01405InformativeInherited
Fly Anatomy (FA)primordium0.01444InformativeInherited
Fly Anatomy (FA)wing blade0.01736InformativeInherited
Fly Anatomy (FA)syncytium0.01871InformativeInherited
Fly Anatomy (FA)male organism0.05808InformativeInherited
Fly Anatomy (FA)gut section0.08912InformativeInherited
Fly Anatomy (FA)cuticular specialization0.1183InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1289InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.139InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.1628InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1835InformativeInherited
Fly Anatomy (FA)tract0.3071InformativeInherited
Fly Anatomy (FA)neuroblast0.7573InformativeInherited
Fly Anatomy (FA)hub cell0.000001761Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.000008911Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.0000422Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001722Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.000194Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002562Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0006268Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.0009285Highly InformativeDirect
Fly Anatomy (FA)acute muscle0.001603Highly InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.00193Highly InformativeInherited
Fly Anatomy (FA)ventral nerve cord primordium0.006031Highly InformativeInherited
Fly Anatomy (FA)embryonic neuroblast0.02018Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.1124Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0006108Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0.1872Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8235Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001928Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.04055Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7716Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.01711InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.0009795Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.006843Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.07495Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.7897Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.008542Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2215Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6344Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7702Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001575Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.008472Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.1549Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7151Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000007746InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000009366InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00002016InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00008086InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.000587InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0006927InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.000863InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.02544InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.05924InformativeInherited
Xenopus ANatomical entity (XAN)tail0.2723InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3075InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.00007242Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0001475Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0001723Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0004547Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0007127Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuromere0.0008473Highly InformativeDirect
Xenopus ANatomical entity (XAN)proximal tubule0.0009802Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.02141Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.8037Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000487Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.7544Moderately InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000002576Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007324InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]