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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06457Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004444Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.008881Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1135Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1203Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.0000722InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002318InformativeDirect
Disease Ontology (DO)malignant glioma0.0004367InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07568InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3373InformativeInherited
Disease Ontology (DO)neurofibroma0.000001181Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008421Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001028Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009598Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01479Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5058Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.02296Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.1414Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.2625Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.6361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.002081InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.3932InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.8034InformativeInherited
Phenotypic Abnormality (PA)Abnormal choroid morphology0.002562Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.3026Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal macular morphology0.5322Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001068Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01382Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08653Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1282Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2091Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2245Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6147Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.00000197Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005055Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001025Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0001991Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001187Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.001302Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001317Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003778Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02983Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4276Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009612InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00006876InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002437InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.009085InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0319InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1349InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2457InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3823InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3988InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4181InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4637InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4818InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5877InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007446Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002238Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001171Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001615Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002619Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002725Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.000629Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.0567Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08579Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1012Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6287Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6313Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00008021Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0003029Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002834Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.005592Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01883Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4005Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7915Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.000196Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0002025Moderately InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000001257InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00009235InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001381InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002543InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0007609InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.1147InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00000005023Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001613Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.00001057Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00001211Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002127Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00004183Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001228Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0005062Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0004058InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0004322InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1111Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1784Least InformativeInherited
Fly Anatomy (FA)nervous system0.2325Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2627Least InformativeInherited
Fly Anatomy (FA)adult0.4564Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5729Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.007877Moderately InformativeInherited
Fly Anatomy (FA)embryo0.01398Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.04288Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.07379Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.09959Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1036Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1072Moderately InformativeInherited
Fly Anatomy (FA)gonad0.234Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2895Moderately InformativeInherited
Fly Anatomy (FA)head0.3326Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.3382Moderately InformativeInherited
Fly Anatomy (FA)appendage0.4655Moderately InformativeInherited
Fly Anatomy (FA)thorax0.4729Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4953Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.5439Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5539Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.6614Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00005755InformativeDirect
Fly Anatomy (FA)adult heart0.0003725InformativeDirect
Fly Anatomy (FA)tracheal system0.0008839InformativeDirect
Fly Anatomy (FA)head capsule0.004703InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.007931InformativeInherited
Fly Anatomy (FA)embryonic/larval muscle system0.01331InformativeInherited
Fly Anatomy (FA)anatomical space0.01459InformativeInherited
Fly Anatomy (FA)primordium0.01481InformativeInherited
Fly Anatomy (FA)wing blade0.02023InformativeInherited
Fly Anatomy (FA)syncytium0.02264InformativeInherited
Fly Anatomy (FA)interneuron0.02848InformativeInherited
Fly Anatomy (FA)muscle cell0.03043InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.03623InformativeInherited
Fly Anatomy (FA)male organism0.0589InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1149InformativeInherited
Fly Anatomy (FA)cuticular specialization0.1176InformativeInherited
Fly Anatomy (FA)gut section0.1234InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.1417InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1757InformativeInherited
Fly Anatomy (FA)tract0.4703InformativeInherited
Fly Anatomy (FA)neuroblast0.7473InformativeInherited
Fly Anatomy (FA)hub cell0.000001712Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.00001343Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00006609Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001697Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001879Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002761Highly InformativeDirect
Fly Anatomy (FA)dorsal acute muscle0.0006496Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0009428Highly InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.003561Highly InformativeInherited
Fly Anatomy (FA)ventral nerve cord primordium0.006258Highly InformativeInherited
Fly Anatomy (FA)embryonic neuroblast0.009381Highly InformativeInherited
Fly Anatomy (FA)CNS glial cell0.05635Highly InformativeInherited
Fly Anatomy (FA)wing vein0.06728Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0009099Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.7573Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.9142Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001605Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.05543Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.6411Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.01563InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.0008276Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.0105Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.08029Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.7915Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.008219Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1115Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2284Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6618Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8023Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.9229Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00004387Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.007242Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7449Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00002194InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0000268InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00005255InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001309InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.000564InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.002352InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.03373InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.1002InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3143InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3825InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.00008664Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0001398Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0006018Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0007991Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.02207Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.8013Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0005118Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.7508Moderately InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00001163Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.07976Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007164InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.00003028InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]