SUPERFAMILY 1.75 HMM library and genome assignments server


Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (356) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,781 43,726 28
Proteins 18,912 21,271 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process1.281e-060Least InformativeDirect
Biological Process (BP)multicellular organismal process3.336e-060Least InformativeDirect
Biological Process (BP)localization0.0026322.466e-13Least InformativeInherited
Biological Process (BP)single-organism cellular process0.050380Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0060540.04284Least InformativeInherited
Biological Process (BP)response to stimulus0.012510Least InformativeInherited
Biological Process (BP)signal transduction0.00018790Moderately InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway4.572e-080InformativeDirect
Biological Process (BP)localization of cell3.586e-070InformativeDirect
Biological Process (BP)locomotion1.57e-060InformativeDirect
Biological Process (BP)cellular component movement8.963e-050InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway1.175e-086.501e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 2.466e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.04284 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.002218 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 8.894e-06 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 3.929e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.77e-15 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 2.8e-14 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 3.149e-11 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 2.123e-09 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 2.143e-09 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.99e-09 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 9.503e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.175e-06 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001091 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002515 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.04768 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8628 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1477 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3314 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.001095 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01391 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1884 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.04396 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.641 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.008065 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6226 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4489 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6083 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3104 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3173 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01731 Moderately Informative Inherited
Biological Process (BP) tissue development 0.007146 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) response to wounding 6.733e-14 Informative Direct
Biological Process (BP) negative regulation of developmental process 8.613e-11 Informative Direct
Biological Process (BP) positive regulation of developmental process 1.491e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.821e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 4.622e-09 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.05e-07 Informative Direct
Biological Process (BP) growth 1.171e-07 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 5.63e-07 Informative Direct
Biological Process (BP) cardiovascular system development 6.175e-07 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 1.275e-06 Informative Direct
Biological Process (BP) organ morphogenesis 2.638e-06 Informative Direct
Biological Process (BP) central nervous system development 3.586e-06 Informative Direct
Biological Process (BP) tube development 1.461e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.7e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 1.877e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 8.693e-05 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.000155 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001651 Informative Direct
Biological Process (BP) generation of neurons 0.0004192 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004831 Informative Direct
Biological Process (BP) response to nutrient levels 0.0007514 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0008263 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.2653 Informative Inherited
Biological Process (BP) cellular membrane organization 0.08691 Informative Inherited
Biological Process (BP) protein transport 0.002304 Informative Inherited
Biological Process (BP) muscle structure development 0.5757 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07632 Informative Inherited
Biological Process (BP) metal ion transport 0.6524 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) regulation of growth 0.002648 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2747 Informative Inherited
Biological Process (BP) protein complex assembly 0.004284 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.008222 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1569 Informative Inherited
Biological Process (BP) negative regulation of transport 0.007247 Informative Inherited
Biological Process (BP) regulation of secretion 0.1364 Informative Inherited
Biological Process (BP) sensory organ development 0.01725 Informative Inherited
Biological Process (BP) embryonic organ development 0.04799 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1526 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) secretion by cell 0.02306 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.003117 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4614 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.07903 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8074 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4986 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8624 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02193 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.6621 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001811 Informative Inherited
Biological Process (BP) regulation of locomotion 0.00193 Informative Inherited
Biological Process (BP) apoptotic process 0.0834 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8368 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9163 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.3382 Informative Inherited
Biological Process (BP) defense response 0.0414 Informative Inherited
Biological Process (BP) immune response 0.5776 Informative Inherited
Biological Process (BP) immune effector process 0.7435 Informative Inherited
Biological Process (BP) secondary metabolic process 0.08752 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.001312 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001737 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7342 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.5732 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6579 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to lipid 0.3952 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.6679 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.05048 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.1155 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2304 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1525 Informative Inherited
Biological Process (BP) gland development 0.002001 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.574 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2296 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1465 Informative Inherited
Biological Process (BP) lipid localization 0.3843 Informative Inherited
Biological Process (BP) regulation of cell development 0.8579 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.002742 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1796 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4132 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001741 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.009156 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) epithelium development 0.2904 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.006215 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2091 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5852 Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.501e-06 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 1.531e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 1.09e-08 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 2.251e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 2.73e-08 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.191e-07 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.491e-07 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 2.228e-07 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 2.952e-07 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 4.404e-07 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 5.153e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 1.01e-06 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.306e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.012e-06 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 5.063e-06 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 5.884e-06 Highly Informative Direct
Biological Process (BP) phagocytosis 1.363e-05 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.54e-05 Highly Informative Direct
Biological Process (BP) hormone transport 1.774e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 1.899e-05 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 2.442e-05 Highly Informative Direct
Biological Process (BP) respiratory system development 3.173e-05 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 3.31e-05 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 3.738e-05 Highly Informative Direct
Biological Process (BP) telencephalon development 8.699e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 9.801e-05 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0001077 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000152 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0001738 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002056 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0002462 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002493 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0003434 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0003655 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0004017 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0006258 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.0008443 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0008539 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0008834 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.0009583 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0009759 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.009051 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2002 Highly Informative Inherited
Biological Process (BP) stem cell development 0.3141 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.009046 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01488 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.1492 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.007615 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.02469 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.4181 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01501 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.003079 Highly Informative Inherited
Biological Process (BP) developmental growth 0.005835 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.002 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04728 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.001265 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6821 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1741 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.03131 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.363 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1719 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7891 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.00249 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.002903 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.7709 Highly Informative Inherited
Biological Process (BP) signal release 0.7138 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.3833 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.04302 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.08019 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.1002 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.007287 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.02307 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.4642 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.001207 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9125 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3364 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1204 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.001912 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01072 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.03176 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.001515 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.319 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.01409 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.02146 Highly Informative Inherited
Biological Process (BP) protein processing 0.00143 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01967 Highly Informative Inherited
Biological Process (BP) ear development 0.02041 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.512 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.9518 Highly Informative Inherited
Biological Process (BP) axon development 0.03935 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01247 Highly Informative Inherited
Biological Process (BP) protein import 0.0202 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.03269 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3443 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2421 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.3527 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001359 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 7.893e-14 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1.974e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1627 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.009636 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 6.858e-12 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 8.86e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 4.797e-07 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1.788e-05 Informative Direct
Molecular Function (MF) enzyme activator activity 6.456e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1838 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.002487 Informative Inherited
Molecular Function (MF) amide binding 0.0207 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02824 Informative Inherited
Molecular Function (MF) peptidase activity 0.043 Informative Inherited
Molecular Function (MF) lipid binding 0.4135 Informative Inherited
Molecular Function (MF) enzyme binding 0.8999 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 2.13e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 3.088e-11 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 1.527e-09 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.008e-08 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 1.009e-07 Highly Informative Direct
Molecular Function (MF) hormone binding 1.49e-05 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 2.329e-05 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 3.287e-05 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001365 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0006635 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.0126 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002419 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.006059 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.008549 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.3917 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 7.503e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.05843 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.03345 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 2.483e-12 Informative Direct
Cellular Component (CC) Golgi apparatus 5.989e-07 Informative Direct
Cellular Component (CC) lytic vacuole 0.0001037 Informative Direct
Cellular Component (CC) cell leading edge 0.000373 Informative Direct
Cellular Component (CC) neuron projection 0.9755 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.1041 Informative Inherited
Cellular Component (CC) integral to membrane 0.9537 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) endosomal part 6.894e-08 Highly Informative Direct
Cellular Component (CC) receptor complex 7.108e-08 Highly Informative Direct
Cellular Component (CC) lysosome 1.138e-05 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.287e-05 Highly Informative Direct
Cellular Component (CC) dendrite 0.0001685 Highly Informative Direct
Cellular Component (CC) cell body 0.0004153 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.0008026 Highly Informative Direct
Cellular Component (CC) adherens junction 0.000936 Highly Informative Direct
Cellular Component (CC) membrane raft 0.002759 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)8.291e-07Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases6.22e-06Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.09996Least InformativeInherited
Disease Ontology (DO)immune system disease0.6659Least InformativeInherited
Disease Ontology (DO)cell type cancer0.01157Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01283Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.09283Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.113Moderately InformativeInherited
Disease Ontology (DO)kidney cancer2.205e-07InformativeDirect
Disease Ontology (DO)malignant glioma0.0001756InformativeDirect
Disease Ontology (DO)colorectal cancer0.0004508InformativeDirect
Disease Ontology (DO)liver carcinoma0.0009232InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07211InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.4622InformativeInherited
Disease Ontology (DO)primary thrombocytopenia9.377e-06Highly InformativeDirect
Disease Ontology (DO)skin hemangioma1.001e-05Highly InformativeDirect
Disease Ontology (DO)neurofibroma1.587e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.002362Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.01924Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02557Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.3229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.3078InformativeInherited
Phenotypic Abnormality (PA)Arachnodactyly0.000357Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the ascending aorta0.0005872Highly InformativeDirect
Phenotypic Abnormality (PA)Emphysema0.000923Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype2.363e-06Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1112Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1301Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3814Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology8.61e-07Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype4.193e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.000149Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0002629Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.002287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.006781Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01647Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.03879Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.06661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0722Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.08589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.179Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1.087e-06InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology1.881e-05InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.0008087InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02104InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02504InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.1182InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1901InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2346InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.323InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3965InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.4756InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5206InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.5824InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.7464InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology3.196e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001014Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.000215Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0004012Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.0006245Highly InformativeDirect
Mammalian Phenotype (MP)small kidney0.000633Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01929Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.05659Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.07621Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory system development0.08289Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.08892Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.4977Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.7163Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.4669Least InformativeInherited
Worm Phenotype (WP)organ system development variant3.679e-06Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant1.627e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006497Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.2271Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant3.331e-05InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant4.042e-05InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001402InformativeDirect
Worm Phenotype (WP)body length variant0.0002221InformativeDirect
Worm Phenotype (WP)body width variant0.0003162InformativeDirect
Worm Phenotype (WP)activity level variant0.01925InformativeInherited
Worm Phenotype (WP)neuron development variant0.02399InformativeInherited
Worm Phenotype (WP)molt variant1.729e-07Highly InformativeDirect
Worm Phenotype (WP)myopodia present3.625e-07Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE4.27e-06Highly InformativeDirect
Worm Phenotype (WP)paralyzed1.734e-05Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective2.228e-05Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant5.658e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005952Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.005357Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective7.996e-05InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0001561InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.09315Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1856Least InformativeInherited
Fly Anatomy (FA)larva0.1924Least InformativeInherited
Fly Anatomy (FA)organ system0.2116Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3841Least InformativeInherited
Fly Anatomy (FA)cell0.9939Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01348Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06503Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1136Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1281Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1328Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1557Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.2028Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2395Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.3589Moderately InformativeInherited
Fly Anatomy (FA)head0.3853Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5088Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0004392InformativeDirect
Fly Anatomy (FA)commissure0.0007847InformativeDirect
Fly Anatomy (FA)germline stem cell0.0008996InformativeDirect
Fly Anatomy (FA)tracheal system0.002094InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.008434InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.009224InformativeInherited
Fly Anatomy (FA)primordium0.01014InformativeInherited
Fly Anatomy (FA)digestive system0.0199InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.04118InformativeInherited
Fly Anatomy (FA)interneuron0.04652InformativeInherited
Fly Anatomy (FA)ommatidium0.04848InformativeInherited
Fly Anatomy (FA)optic lobe neuron0.04916InformativeInherited
Fly Anatomy (FA)circulatory system0.05115InformativeInherited
Fly Anatomy (FA)male reproductive system0.06407InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.08472InformativeInherited
Fly Anatomy (FA)sensory organ cell0.09635InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.1051InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1065InformativeInherited
Fly Anatomy (FA)labral segment0.1134InformativeInherited
Fly Anatomy (FA)pupa0.1581InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1738InformativeInherited
Fly Anatomy (FA)neuromere0.185InformativeInherited
Fly Anatomy (FA)somatic stem cell0.6411InformativeInherited
Fly Anatomy (FA)ventral nervous system9.746e-06Highly InformativeDirect
Fly Anatomy (FA)hub cell5.656e-05Highly InformativeDirect
Fly Anatomy (FA)adult heart0.000154Highly InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.002012Highly InformativeInherited
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.002148Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.007393Highly InformativeInherited
Fly Anatomy (FA)hindgut0.008138Highly InformativeInherited
Fly Anatomy (FA)larval procephalic segment0.01322Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.02441Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.02803Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.08653Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1616Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.3642Least InformativeInherited
Zebrafish Anatomy (ZA)head0.7454Least InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.2894Moderately InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.3079Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.7789Moderately InformativeInherited
Zebrafish Anatomy (ZA)symplectic0.0003443InformativeDirect
Zebrafish Anatomy (ZA)somite 20.0004199InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2144Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4288Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4558Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7738Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01202Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1315Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3408Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.9586Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm1.69e-05InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme5.369e-05InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001136InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0003061InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00041InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.003253InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5912InformativeInherited
Xenopus ANatomical entity (XAN)hypochord1.645e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0004299Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0005478Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0006552Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.001469Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.01586Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage6.371e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0001532Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)3.125e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases5.748e-07InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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