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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 40,160 103,232 28
Proteins 19,122 50,551 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06457Least InformativeInherited
Disease Ontology (DO)cell type cancer0.004444Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.008881Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1135Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.1203Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.0000722InformativeDirect
Disease Ontology (DO)liver carcinoma0.0002318InformativeDirect
Disease Ontology (DO)malignant glioma0.0004367InformativeDirect
Disease Ontology (DO)organ system benign neoplasm0.07568InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.3373InformativeInherited
Disease Ontology (DO)neurofibroma0.000001181Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.000008421Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.00001028Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00009598Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04694Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.074Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.006532Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.06344Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.116Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.7334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.801InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic valve physiology0.2337Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001078Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.01381Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08606Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1287Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.2091Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2251Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6146Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001986Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.00005055Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001029Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0001973Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001189Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.001307Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.001324Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.001327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.003765Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.005949Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02982Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1162Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2594Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.00000009663InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.00006922InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002443InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.009106InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03189InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1355InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.2457InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.3824InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.3991InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4181InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.4637InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.4819InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.5878InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.000007472Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.00002243Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.0001174Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body wall morphology0.0001618Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0002618Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002729Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005509Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.0006298Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.05673Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08579Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.1012Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.2211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.6286Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.6312Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0002095Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000225Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0007898Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.004225Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.00424Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.005074Least InformativeInherited
Worm Phenotype (WP)larval lethal0.4149Least InformativeInherited
Worm Phenotype (WP)larval development variant0.7603Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.00003785Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00003785Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00003819Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00003852Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00004757Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.2309Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00005641InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00008096InformativeDirect
Worm Phenotype (WP)male morphology variant0.0002325InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0003905InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0006352InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.0000000483Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0000001439Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.000009647Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.00001056Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002254Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00003567Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00009787Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0003458InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0003943InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.08459Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1734Least InformativeInherited
Fly Anatomy (FA)nervous system0.2159Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2598Least InformativeInherited
Fly Anatomy (FA)adult0.3828Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5487Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.006824Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.04045Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.07502Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09866Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.09876Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.1001Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1545Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.22Moderately InformativeInherited
Fly Anatomy (FA)gonad0.2351Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.2798Moderately InformativeInherited
Fly Anatomy (FA)head0.3331Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.3665Moderately InformativeInherited
Fly Anatomy (FA)thorax0.4648Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.4833Moderately InformativeInherited
Fly Anatomy (FA)appendage0.5011Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5526Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.581Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.7342Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.00005908InformativeDirect
Fly Anatomy (FA)adult heart0.000322InformativeDirect
Fly Anatomy (FA)tracheal system0.0008605InformativeDirect
Fly Anatomy (FA)muscle system0.01326InformativeInherited
Fly Anatomy (FA)adult external head0.01405InformativeInherited
Fly Anatomy (FA)anatomical space0.01405InformativeInherited
Fly Anatomy (FA)primordium0.01445InformativeInherited
Fly Anatomy (FA)syncytium0.01899InformativeInherited
Fly Anatomy (FA)wing blade0.02096InformativeInherited
Fly Anatomy (FA)interneuron0.02633InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.03644InformativeInherited
Fly Anatomy (FA)male organism0.05915InformativeInherited
Fly Anatomy (FA)cuticular specialization0.118InformativeInherited
Fly Anatomy (FA)gut section0.1202InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1288InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.1386InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.1618InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.178InformativeInherited
Fly Anatomy (FA)tract0.4694InformativeInherited
Fly Anatomy (FA)neuroblast0.7596InformativeInherited
Fly Anatomy (FA)hub cell0.000001747Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.00001382Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00006806Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0001675Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001932Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002552Highly InformativeDirect
Fly Anatomy (FA)late extended germ band embryo0.0009544Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0009755Highly InformativeDirect
Fly Anatomy (FA)acute muscle0.001595Highly InformativeInherited
Fly Anatomy (FA)peptidergic neuron0.00302Highly InformativeInherited
Fly Anatomy (FA)ventral nerve cord primordium0.00595Highly InformativeInherited
Fly Anatomy (FA)embryonic neuroblast0.01998Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.1113Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0009316Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0.0645Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7562Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001673Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.05364Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.637Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.0004371InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.01565InformativeInherited
Zebrafish Anatomy (ZA)lymphatic system0.0008888Highly InformativeDirect
Zebrafish Anatomy (ZA)lateral line system0.006323Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.07525Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.7869Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.008625Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.2252Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6513Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7919Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002985Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.009886Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7337Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.00001525InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002172InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00004063InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001258InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0007728InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.001603InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.03043InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.08273InformativeInherited
Xenopus ANatomical entity (XAN)tail0.2958InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.3573InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.00009367Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0001471Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0004776Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypochord0.0006243Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.02229Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.8036Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000487Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.7532Moderately InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00000335Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000007402InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]