SUPERFAMILY 1.75 HMM library and genome assignments server

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Growth factor receptor domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Families:   Growth factor receptor domain [ 57185] (8)


Superfamily statistics
Genomes (356) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,781 43,726 28
Proteins 18,912 21,271 21


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.0000013350Least InformativeDirect
Biological Process (BP)multicellular organismal process0.0000034390Least InformativeDirect
Biological Process (BP)localization0.0027250.0000000000009384Least InformativeInherited
Biological Process (BP)single-organism cellular process0.049620Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0064570.04137Least InformativeInherited
Biological Process (BP)response to stimulus0.01320Least InformativeInherited
Biological Process (BP)signal transduction0.00019350Moderately InformativeDirect
Biological Process (BP)enzyme linked receptor protein signaling pathway0.000000047070InformativeDirect
Biological Process (BP)localization of cell0.00000035630InformativeDirect
Biological Process (BP)locomotion0.0000015510InformativeDirect
Biological Process (BP)cellular component movement0.000085540InformativeDirect
Biological Process (BP)transmembrane receptor protein tyrosine kinase signaling pathway0.000000012180.000006207Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0.0000000000009384 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.04137 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.003223 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000511 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000005052 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000000000001086 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.00000000000007357 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000008647 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000000009863 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000003927 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000008643 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000004743 Moderately Informative Direct
Biological Process (BP) immune system process 0.0001415 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000245 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05211 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8834 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2117 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2997 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.001301 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.0186 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1789 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.5577 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06789 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6839 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.009717 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6531 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.408 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5823 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2986 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2988 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02954 Moderately Informative Inherited
Biological Process (BP) tissue development 0.008898 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) response to wounding 0.0000000000001068 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000000001209 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0000000001076 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0000000008415 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000002434 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000044 Informative Direct
Biological Process (BP) protein oligomerization 0.00000002789 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000001059 Informative Direct
Biological Process (BP) growth 0.0000006486 Informative Direct
Biological Process (BP) cardiovascular system development 0.000001052 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.000001224 Informative Direct
Biological Process (BP) organ morphogenesis 0.000003717 Informative Direct
Biological Process (BP) central nervous system development 0.000004474 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000006547 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00002082 Informative Direct
Biological Process (BP) tube development 0.00002377 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00003634 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001163 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0001695 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0002508 Informative Direct
Biological Process (BP) generation of neurons 0.0004109 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0005428 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.2745 Informative Inherited
Biological Process (BP) cellular membrane organization 0.08664 Informative Inherited
Biological Process (BP) protein transport 0.002497 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) muscle structure development 0.6619 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07981 Informative Inherited
Biological Process (BP) regulation of growth 0.002836 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3042 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01891 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1448 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.02954 Informative Inherited
Biological Process (BP) negative regulation of transport 0.004032 Informative Inherited
Biological Process (BP) regulation of secretion 0.1139 Informative Inherited
Biological Process (BP) sensory organ development 0.01566 Informative Inherited
Biological Process (BP) embryonic organ development 0.04597 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.137 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) secretion by cell 0.0239 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.004255 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4562 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.08872 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.809 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4916 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.8672 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02303 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.67 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.001714 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001794 Informative Inherited
Biological Process (BP) apoptotic process 0.08706 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.7973 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.8851 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00106 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.3504 Informative Inherited
Biological Process (BP) defense response 0.03774 Informative Inherited
Biological Process (BP) immune response 0.5551 Informative Inherited
Biological Process (BP) immune effector process 0.736 Informative Inherited
Biological Process (BP) secondary metabolic process 0.09394 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.001062 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001806 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.7199 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.5728 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.6423 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of cell activation 0.00364 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to lipid 0.4102 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.5985 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.06754 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.2089 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1634 Informative Inherited
Biological Process (BP) gland development 0.001971 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5528 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2076 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1614 Informative Inherited
Biological Process (BP) lipid localization 0.3885 Informative Inherited
Biological Process (BP) regulation of cell development 0.8788 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.002689 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1816 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4222 Informative Inherited
Biological Process (BP) response to nutrient levels 0.001367 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.001738 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01208 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) epithelium development 0.3286 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01059 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2167 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6107 Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000006207 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.0000000004517 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.00000001443 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00000001604 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000000258 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0.00000006522 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00000009866 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.00000009991 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000001601 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0000002072 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0000002345 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0000007675 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000001478 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.000002211 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000003792 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.000005103 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000005326 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00001235 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00001402 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000147 Highly Informative Direct
Biological Process (BP) hormone transport 0.00002081 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00002272 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00003129 Highly Informative Direct
Biological Process (BP) respiratory system development 0.00005794 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.00006187 Highly Informative Direct
Biological Process (BP) telencephalon development 0.00009411 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0001016 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.0001053 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.0001152 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0001525 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0001929 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002199 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0002888 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0003256 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0004739 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.0005535 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0006048 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0007094 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0007147 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.008596 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.2044 Highly Informative Inherited
Biological Process (BP) stem cell development 0.3006 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.00858 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.01351 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.137 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.001008 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.3555 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.007238 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.01029 Highly Informative Inherited
Biological Process (BP) developmental growth 0.004789 Highly Informative Inherited
Biological Process (BP) mammary gland epithelium development 0.001717 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04915 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.001159 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.00131 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6927 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1491 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.03222 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.345 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.1547 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7673 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.002595 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.004184 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.7714 Highly Informative Inherited
Biological Process (BP) signal release 0.7193 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.4142 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.0432 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.07431 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.003608 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.09117 Highly Informative Inherited
Biological Process (BP) interaction with host 0.05146 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.007081 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.02612 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.4704 Highly Informative Inherited
Biological Process (BP) lipoprotein metabolic process 0.00117 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.9112 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3266 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1119 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.002945 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.01129 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.0317 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.001305 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3154 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.003417 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.002472 Highly Informative Inherited
Biological Process (BP) negative regulation of cell growth 0.01228 Highly Informative Inherited
Biological Process (BP) membrane fusion 0.02303 Highly Informative Inherited
Biological Process (BP) protein processing 0.001604 Highly Informative Inherited
Biological Process (BP) ear development 0.02152 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.46 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.9466 Highly Informative Inherited
Biological Process (BP) nuclear import 0.01327 Highly Informative Inherited
Biological Process (BP) protein import 0.02076 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.03523 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.3471 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.001115 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000000000002264 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.00002397 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1484 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.00988 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000007516 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000000007782 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0000004367 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.00001689 Informative Direct
Molecular Function (MF) enzyme activator activity 0.00007263 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.191 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.002724 Informative Inherited
Molecular Function (MF) amide binding 0.02133 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02994 Informative Inherited
Molecular Function (MF) peptidase activity 0.0476 Informative Inherited
Molecular Function (MF) lipid binding 0.4155 Informative Inherited
Molecular Function (MF) enzyme binding 0.9191 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00000000001599 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000000002779 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000000001771 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00000001353 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000001214 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000135 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00002509 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.00003284 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0001628 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.0006869 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.01354 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.002287 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.006347 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.008997 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.3986 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000008825 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.05712 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000000000003044 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0000006793 Informative Direct
Cellular Component (CC) lytic vacuole 0.0001238 Informative Direct
Cellular Component (CC) cell leading edge 0.0003831 Informative Direct
Cellular Component (CC) neuron projection 0.9454 Informative Inherited
Cellular Component (CC) cell junction 0.001036 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0.00000007138 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000007616 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00001428 Highly Informative Direct
Cellular Component (CC) lysosome 0.00001456 Highly Informative Direct
Cellular Component (CC) cell body 0.0001471 Highly Informative Direct
Cellular Component (CC) dendrite 0.0003646 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0009711 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000008291Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000622Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1054Least InformativeInherited
Disease Ontology (DO)immune system disease0.5237Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.006426Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.009087Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.09606Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.1308Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.0000299InformativeDirect
Disease Ontology (DO)malignant glioma0.0005069InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0.007013InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.0731InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.4001InformativeInherited
Disease Ontology (DO)skin hemangioma0.000009987Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0000125Highly InformativeDirect
Disease Ontology (DO)neurofibroma0.00002386Highly InformativeDirect
Disease Ontology (DO)colorectal cancer0.0002165Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1611Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.002181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.01302Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.01504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.3293Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.2913InformativeInherited
Phenotypic Abnormality (PA)Arachnodactyly0.0003168Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the ascending aorta0.0005323Highly InformativeDirect
Phenotypic Abnormality (PA)Emphysema0.000838Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00000284Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.1174Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1344Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1723Least InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.000001055Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.000003725Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001603Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype0.0002945Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.002625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.008171Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01782Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07711Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.08399Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1864Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4908Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7252Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.000001239InformativeDirect
Mammalian Phenotype (MP)abnormal cranium morphology0.0000237InformativeDirect
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.0008011InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0251InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02678InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.1258InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1982InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2348InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3063InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.3421InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.379InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.4962InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5215InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.7484InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.9542InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00003701Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0002161Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0005158Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0006032Highly InformativeDirect
Mammalian Phenotype (MP)small kidney0.0006221Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0008801Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.007258Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.02274Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.0523Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureteric bud morphology0.0898Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vein morphology0.1855Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.4787Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.7317Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.4669Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000003679Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00001627Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006497Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.2271Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00003331InformativeDirect
Worm Phenotype (WP)muscle cell morphology variant0.00004042InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001402InformativeDirect
Worm Phenotype (WP)body length variant0.0002221InformativeDirect
Worm Phenotype (WP)body width variant0.0003162InformativeDirect
Worm Phenotype (WP)activity level variant0.01925InformativeInherited
Worm Phenotype (WP)neuron development variant0.02399InformativeInherited
Worm Phenotype (WP)molt variant0.0000001729Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0000003625Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.00000427Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001734Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00002228Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00005658Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005952Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.005357Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective0.00007904InformativeDirect
Fly Phenotype (FP)cell polarity defective0.000167InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.09082Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1874Least InformativeInherited
Fly Anatomy (FA)larva0.192Least InformativeInherited
Fly Anatomy (FA)organ system0.208Least InformativeInherited
Fly Anatomy (FA)adult0.2926Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3718Least InformativeInherited
Fly Anatomy (FA)cell0.9866Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01379Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06358Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1027Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.1034Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.1306Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1522Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.1763Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1938Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.339Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.3521Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5005Moderately InformativeInherited
Fly Anatomy (FA)adult head0.5335Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0004148InformativeDirect
Fly Anatomy (FA)commissure0.000796InformativeDirect
Fly Anatomy (FA)germline stem cell0.0009078InformativeDirect
Fly Anatomy (FA)tracheal system0.002091InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.005879InformativeInherited
Fly Anatomy (FA)alimentary canal0.007395InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.009611InformativeInherited
Fly Anatomy (FA)primordium0.0102InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.04461InformativeInherited
Fly Anatomy (FA)interneuron0.04916InformativeInherited
Fly Anatomy (FA)ommatidium0.04931InformativeInherited
Fly Anatomy (FA)circulatory system0.05InformativeInherited
Fly Anatomy (FA)optic lobe neuron0.05325InformativeInherited
Fly Anatomy (FA)male reproductive system0.06327InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.08341InformativeInherited
Fly Anatomy (FA)sensory organ cell0.09409InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1054InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.1061InformativeInherited
Fly Anatomy (FA)labral segment0.1176InformativeInherited
Fly Anatomy (FA)pupa0.1573InformativeInherited
Fly Anatomy (FA)embryonic/larval central nervous system0.1675InformativeInherited
Fly Anatomy (FA)neuromere0.1874InformativeInherited
Fly Anatomy (FA)somatic stem cell0.637InformativeInherited
Fly Anatomy (FA)ventral nervous system0.000009876Highly InformativeDirect
Fly Anatomy (FA)hub cell0.00005668Highly InformativeDirect
Fly Anatomy (FA)adult heart0.0001526Highly InformativeDirect
Fly Anatomy (FA)adult gut0.0007103Highly InformativeDirect
Fly Anatomy (FA)neuroblast of ventral nerve cord primordium0.00216Highly InformativeInherited
Fly Anatomy (FA)hindgut0.008141Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.008556Highly InformativeInherited
Fly Anatomy (FA)larval procephalic segment0.01253Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval brain0.02427Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.02868Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of tissue0.1056Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1822Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.4166Least InformativeInherited
Zebrafish Anatomy (ZA)head0.7271Least InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.295Moderately InformativeInherited
Zebrafish Anatomy (ZA)suspensorium0.3082Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.776Moderately InformativeInherited
Zebrafish Anatomy (ZA)symplectic0.0003631InformativeDirect
Zebrafish Anatomy (ZA)somite 20.0004293InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2152Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4288Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4603Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.781Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01303Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.07558Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3496Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.9601Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000006274InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00001824InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001245InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0002911InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.0003153InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0004976InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0008226InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.003659InformativeInherited
Xenopus ANatomical entity (XAN)tail0.5933InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.0000164Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0004842Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0006659Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0007493Highly InformativeDirect
Xenopus ANatomical entity (XAN)floor plate0.0008947Highly InformativeDirect
Xenopus ANatomical entity (XAN)zygote0.001674Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.00006299Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.0001527Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.000003069Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000005714InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processApoptosis0.000000825Moderately InformativeDirect
Biological processLipid metabolism0.4943Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processHemostasis0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processSensory transduction0.00000000000005182InformativeDirect
Biological processSteroid metabolism0.00000000000013InformativeDirect
Biological processLipid transport0.00000000006962InformativeDirect
Biological processInnate immunity0.00000132InformativeDirect
Biological processCytolysis0.00001071InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processComplement alternate pathway0.0000002608Highly InformativeDirect
Biological processDNA synthesis0.000003566Highly InformativeDirect
Biological processComplement pathway0.00009516Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000000001013Moderately InformativeDirect
Cellular componentGolgi apparatus0.00009703Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentLysosome0.000003786InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
Coding sequence diversityPolymorphism0.000009892Moderately InformativeDirect
DiseaseDisease mutation0.000001796Least InformativeDirect
DiseaseDwarfism0.0009944Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000001214Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainANK repeat0.00007776InformativeDirect
DomainLaminin EGF-like domain0.00000006624Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHeparin-binding0InformativeDirect
Molecular functionGrowth factor binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationActivator0.000000002898Moderately InformativeDirect
Post-translational modificationProtease0.000000004541Moderately InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues9.055e-16Moderately InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.0000000000001299Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009030 SSF57184 Protein matches
Abstract

The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [PubMed11447105], the type-1 insulin-like growth-factor receptor (IGF-1R) [PubMed9690478], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) [PubMed12154198]. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides.

IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organization, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues.

IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain.

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Growth factor receptor domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]