SUPERFAMILY 1.75 HMM library and genome assignments server


EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (263) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 71,559 77,955 117
Proteins 22,535 26,553 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism developmental process00Moderately InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.43e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 2.201e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 1.426e-07 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 1.969e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.794e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.406e-05 Moderately Informative Direct
Biological Process (BP) reproduction 2.123e-05 Moderately Informative Direct
Biological Process (BP) immune system process 2.412e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 8.684e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000134 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0003299 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0007171 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6992 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.3985 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03014 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.963 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4789 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.009424 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.111 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5628 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4416 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.203 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1423 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5187 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.7502 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.9925 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 7.281e-15 Informative Direct
Biological Process (BP) growth 1.253e-14 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.924e-13 Informative Direct
Biological Process (BP) cardiovascular system development 1.011e-12 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 3.118e-12 Informative Direct
Biological Process (BP) organ morphogenesis 2.561e-09 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 7.084e-09 Informative Direct
Biological Process (BP) positive regulation of protein modification process 1.678e-08 Informative Direct
Biological Process (BP) generation of neurons 3.191e-08 Informative Direct
Biological Process (BP) vesicle-mediated transport 3.502e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure size 2.946e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.752e-06 Informative Direct
Biological Process (BP) tube development 3.603e-06 Informative Direct
Biological Process (BP) tissue morphogenesis 4.96e-06 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 5.076e-06 Informative Direct
Biological Process (BP) positive regulation of developmental process 8.532e-06 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.132e-05 Informative Direct
Biological Process (BP) regulation of growth 2.831e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 8.618e-05 Informative Direct
Biological Process (BP) cell-cell signaling 9.935e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000123 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001398 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0003038 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.0003597 Informative Direct
Biological Process (BP) defense response 0.000608 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0006229 Informative Direct
Biological Process (BP) gland development 0.0006545 Informative Direct
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.4943 Informative Inherited
Biological Process (BP) cellular membrane organization 0.006971 Informative Inherited
Biological Process (BP) protein transport 0.001857 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.3261 Informative Inherited
Biological Process (BP) muscle structure development 0.01039 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) sensory organ development 0.113 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.00201 Informative Inherited
Biological Process (BP) epithelium development 0.2956 Informative Inherited
Biological Process (BP) protein complex assembly 0.06332 Informative Inherited
Biological Process (BP) regulation of secretion 0.1284 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001231 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.947 Informative Inherited
Biological Process (BP) single-organism behavior 0.01634 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.1196 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01536 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.009449 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.00392 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.008354 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3455 Informative Inherited
Biological Process (BP) regulation of cell development 0.2065 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.009855 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4745 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8028 Informative Inherited
Biological Process (BP) programmed cell death 0.3869 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.6566 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.001349 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.03309 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.5504 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01454 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01385 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.04493 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.502 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.49 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.8411 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0746 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1245 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.1065 Informative Inherited
Biological Process (BP) central nervous system development 0.1689 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1625 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1357 Informative Inherited
Biological Process (BP) lipid localization 0.9804 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.9378 Informative Inherited
Biological Process (BP) response to nutrient levels 0.1895 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1856 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.3329 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.354 Informative Inherited
Biological Process (BP) cytoplasmic transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) blood circulation 1 Informative Inherited
Biological Process (BP) secretion by cell 0.2672 Informative Inherited
Biological Process (BP) immune response 0.7466 Informative Inherited
Biological Process (BP) immune effector process 0.8293 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 2.099e-14 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 2.29e-13 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 1.374e-11 Highly Informative Direct
Biological Process (BP) cell junction organization 2.055e-11 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 5.432e-11 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 8.505e-11 Highly Informative Direct
Biological Process (BP) regulation of cell growth 3.495e-10 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 4.636e-10 Highly Informative Direct
Biological Process (BP) regulation of wound healing 9.26e-10 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 1.51e-09 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 3.637e-08 Highly Informative Direct
Biological Process (BP) regulation of mitosis 4.607e-08 Highly Informative Direct
Biological Process (BP) pattern specification process 6.701e-08 Highly Informative Direct
Biological Process (BP) skeletal system development 1.064e-07 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 1.215e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 1.509e-07 Highly Informative Direct
Biological Process (BP) telencephalon development 2.086e-07 Highly Informative Direct
Biological Process (BP) protein activation cascade 2.745e-07 Highly Informative Direct
Biological Process (BP) regulation of cell size 3.73e-07 Highly Informative Direct
Biological Process (BP) regulation of behavior 1.552e-06 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 2.318e-06 Highly Informative Direct
Biological Process (BP) humoral immune response 2.389e-06 Highly Informative Direct
Biological Process (BP) female gamete generation 2.947e-06 Highly Informative Direct
Biological Process (BP) coagulation 4.203e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.611e-06 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 4.667e-06 Highly Informative Direct
Biological Process (BP) sterol metabolic process 1.377e-05 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 1.885e-05 Highly Informative Direct
Biological Process (BP) regulation of coagulation 3.287e-05 Highly Informative Direct
Biological Process (BP) female pregnancy 3.656e-05 Highly Informative Direct
Biological Process (BP) hormone transport 4.145e-05 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 6.291e-05 Highly Informative Direct
Biological Process (BP) plasma membrane organization 9.647e-05 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0001055 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0001334 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0.0001372 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0001669 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0001978 Highly Informative Direct
Biological Process (BP) developmental growth 0.0002505 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0002963 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0004292 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0005017 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.000647 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0006931 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0007387 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007991 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0008248 Highly Informative Direct
Biological Process (BP) respiratory system development 0.000878 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.12 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.3535 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.9243 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.01849 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) response to drug 0.003366 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.4616 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.001081 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.1429 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.03834 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.1298 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.1051 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.01142 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.01557 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.0789 Highly Informative Inherited
Biological Process (BP) protein tetramerization 0.5842 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.2339 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.00241 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1048 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.003107 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.01083 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.00739 Highly Informative Inherited
Biological Process (BP) signal release 0.4871 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.008112 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.7497 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.013 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6287 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.007296 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.9888 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.03876 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.5634 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01928 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.8291 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.006069 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.2864 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.001042 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.05836 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.01615 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.01345 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3627 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02711 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.799 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 0.002164 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.005688 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.004335 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2719 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.07109 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1323 Highly Informative Inherited
Biological Process (BP) axon development 0.003685 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.5232 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.6477 Highly Informative Inherited
Biological Process (BP) protein import 0.0419 Highly Informative Inherited
Biological Process (BP) nuclear import 0.0584 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1298 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.4077 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.01127 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.6425 Highly Informative Inherited
Biological Process (BP) exocytosis 0.915 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.2942 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1145 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 1 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 5.247e-14 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5323 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.2588 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.4358 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.558e-15 Informative Direct
Molecular Function (MF) sulfur compound binding 7.239e-13 Informative Direct
Molecular Function (MF) carboxylic acid binding 3.44e-05 Informative Direct
Molecular Function (MF) tetrapyrrole binding 9.833e-05 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0001603 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0003401 Informative Direct
Molecular Function (MF) molecular transducer activity 0.01759 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.003829 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.7309 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.004915 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) lipid binding 0.001222 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 8.97e-15 Highly Informative Direct
Molecular Function (MF) heparin binding 9.864e-14 Highly Informative Direct
Molecular Function (MF) protein complex binding 1.159e-11 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 4.224e-06 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 4.052e-05 Highly Informative Direct
Molecular Function (MF) heme binding 6.481e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0001161 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on peroxide as acceptor 0.0004989 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0009498 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.3403 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.2352 Highly Informative Inherited
Molecular Function (MF) calcium ion transmembrane transporter activity 0.03946 Highly Informative Inherited
Molecular Function (MF) cation channel activity 0.458 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.5147 Highly Informative Inherited
Molecular Function (MF) growth factor receptor binding 0.001565 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) antioxidant activity 0.01305 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.4023 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.06e-14 Moderately Informative Direct
Cellular Component (CC) cell projection 5.279e-14 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1194 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.004335 Moderately Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cell leading edge 1.542e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 1.201e-05 Informative Direct
Cellular Component (CC) endosome 0.0002154 Informative Direct
Cellular Component (CC) vacuolar part 0.003602 Informative Inherited
Cellular Component (CC) lytic vacuole 0.002041 Informative Inherited
Cellular Component (CC) secretory granule 0.05209 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.0196 Informative Inherited
Cellular Component (CC) integral to membrane 0.4134 Informative Inherited
Cellular Component (CC) proteinaceous extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 6.161e-15 Highly Informative Direct
Cellular Component (CC) lipid particle 7.498e-11 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 1.869e-06 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 2.022e-06 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 2.903e-06 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 1.112e-05 Highly Informative Direct
Cellular Component (CC) adherens junction 1.396e-05 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.428e-05 Highly Informative Direct
Cellular Component (CC) lysosome 0.0002782 Highly Informative Direct
Cellular Component (CC) neuromuscular junction 0.0003184 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.000999 Highly Informative Direct
Cellular Component (CC) ion channel complex 1 Highly Informative Inherited
Cellular Component (CC) membrane raft 0.187 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases6.591e-06InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa2.266e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r2.421e-10Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)1.46e-08Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa1.257e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.367Least InformativeInherited
Disease Ontology (DO)artery disease0.02163Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05579Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1526Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6388Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0001822InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0003434Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0004026Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the globe0.02617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1101Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3713Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.5395Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.01075InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.308InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.5734InformativeInherited
Phenotypic Abnormality (PA)Palmar hyperhidrosis2.437e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Milia0.0003789Highly InformativeDirect
Phenotypic Abnormality (PA)Laryngeal cyst0.0005331Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior chamber0.000542Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary bladder inflammation0.0007932Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.02657Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.257Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype2.021e-07Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.09128Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1438Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3883Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.532Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5985Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype6.271e-05Moderately InformativeDirect
Mammalian Phenotype (MP)muscle phenotype6.358e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology9.504e-05Moderately InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0001808Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.001841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.006443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.0163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.04183Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5583Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.644Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.6611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8914Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.9809Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.9906Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.9957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation2.433e-06InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0009397InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02547InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.112InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1271InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3193InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.5131InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.5414InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.5426InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.6473InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.678InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.7893InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology9.515e-08Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation1.08e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.00012Highly InformativeDirect
Mammalian Phenotype (MP)absent sebaceous gland0.000311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0003854Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0006266Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0007912Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0008547Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0009557Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01825Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.03194Highly InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.0769Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3574Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.8568Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.5332Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7574Least InformativeInherited
Worm Phenotype (WP)organ system development variant1.406e-09Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant4.904e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0004116Moderately InformativeDirect
Worm Phenotype (WP)larval lethal0.002104Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.1289Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2636Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.5176Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6654Moderately InformativeInherited
Worm Phenotype (WP)muscle cell morphology variant9.269e-06InformativeDirect
Worm Phenotype (WP)body length variant0.0001052InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002273InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0003895InformativeDirect
Worm Phenotype (WP)activity level variant0.0005193InformativeDirect
Worm Phenotype (WP)body wall muscle morphology variant0.001095InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.001646InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003412InformativeInherited
Worm Phenotype (WP)cell corpse number variant0.005543InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.01059InformativeInherited
Worm Phenotype (WP)vulva development variant0.01957InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.06792InformativeInherited
Worm Phenotype (WP)copulation variant0.06917InformativeInherited
Worm Phenotype (WP)protein expression variant0.07409InformativeInherited
Worm Phenotype (WP)neuron development variant0.3556InformativeInherited
Worm Phenotype (WP)male behavior variant1InformativeInherited
Worm Phenotype (WP)muscle arm development defective3.587e-06Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0002093Highly InformativeDirect
Worm Phenotype (WP)roller0.0002282Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003415Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0004667Highly InformativeDirect
Worm Phenotype (WP)loss of asymmetry ASE0.000484Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0006188Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.0006954Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0007544Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.01557Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.01712Highly InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.01733Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.4559Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.001147Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of embryonic stage2.578e-08Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage8.312e-07Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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