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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (281) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 76,348 214,533 117
Proteins 23,656 69,342 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.02251Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03204Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1463Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6974Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0003032InformativeDirect
Disease Ontology (DO)atherosclerosis0.0009571InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0002263Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0004228Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.02632Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.298Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.7116Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.03606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.04187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.07985Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1139Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.6517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.0007073InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.4771InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.4941InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.5132InformativeInherited
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.1373Highly InformativeInherited
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.4023Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00000008308Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.01155Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02281Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02906Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1302Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5282Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8258Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.00001462Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0000994Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0001112Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001334Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002169Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001185Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.003967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03681Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3811Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.000000303InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0001883InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0006699InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.006702InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.03637InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03781InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.06229InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1024InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1285InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1706InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1787InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2298InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2415InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4675InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.588InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.595InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7463InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000000005164Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002198Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002198Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.00008209Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00008846Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0001155Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0005125Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.0005641Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland duct morphology0.0006494Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0008856Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0009397Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.008616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01289Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.317Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9274Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0000008309Least InformativeDirect
Worm Phenotype (WP)larval lethal0.002898Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006024Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.00719Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01574Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.7194Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0004161Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.002613Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.05855Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1227Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1448Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6011Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.0000001094InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.000564InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.001749InformativeInherited
Worm Phenotype (WP)VPC competence variant0.003023InformativeInherited
Worm Phenotype (WP)neurite morphology variant0.004183InformativeInherited
Worm Phenotype (WP)vulva development variant0.01848InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000003715Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001778Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0001951Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0002682Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.0003099Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0003254Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000524Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.0009035Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.01384Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.01692Highly InformativeInherited
Worm Phenotype (WP)neuropil development variant0.02085Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.3037Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.5366Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.4367Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.00125Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0000003625InformativeDirect
Fly Phenotype (FP)planar polarity defective0.00005173InformativeDirect
Fly Phenotype (FP)cell migration defective0.0003781InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0005186InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.00000008683Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000001622Highly InformativeDirect
Fly Phenotype (FP)immune response defective0.00004595Highly InformativeDirect
Fly Phenotype (FP)increased occurrence of cell division0.0008747Highly InformativeDirect
Fly Phenotype (FP)cell adhesion defective0.0009088Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.07374Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.07679Least InformativeInherited
Fly Anatomy (FA)adult0.07816Least InformativeInherited
Fly Anatomy (FA)larva0.08165Least InformativeInherited
Fly Anatomy (FA)anatomical group0.08958Least InformativeInherited
Fly Anatomy (FA)nervous system0.226Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4786Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00002044Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.005849Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.01127Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01499Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01757Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.01941Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.03161Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0349Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.05987Moderately InformativeInherited
Fly Anatomy (FA)appendage0.06998Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09436Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1431Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1957Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2245Moderately InformativeInherited
Fly Anatomy (FA)head0.2404Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.3107Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3339Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7278Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.8733Moderately InformativeInherited
Fly Anatomy (FA)procuticle0.000008964InformativeDirect
Fly Anatomy (FA)primordium0.0001199InformativeDirect
Fly Anatomy (FA)wing blade0.0003912InformativeDirect
Fly Anatomy (FA)syncytium0.0007791InformativeDirect
Fly Anatomy (FA)muscle system0.0008135InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.001893InformativeInherited
Fly Anatomy (FA)larval segment0.002424InformativeInherited
Fly Anatomy (FA)gut section0.002604InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.002894InformativeInherited
Fly Anatomy (FA)tracheal system0.002904InformativeInherited
Fly Anatomy (FA)abdominal segment0.003231InformativeInherited
Fly Anatomy (FA)hemocyte0.003283InformativeInherited
Fly Anatomy (FA)prepupa0.006419InformativeInherited
Fly Anatomy (FA)larval abdomen0.006658InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007077InformativeInherited
Fly Anatomy (FA)adult external head0.01044InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.02347InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.03519InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.05757InformativeInherited
Fly Anatomy (FA)cell component0.06573InformativeInherited
Fly Anatomy (FA)gastrula embryo0.1477InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.1679InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.2206InformativeInherited
Fly Anatomy (FA)male organism0.2216InformativeInherited
Fly Anatomy (FA)proventriculus0.000012Highly InformativeDirect
Fly Anatomy (FA)hub cell0.00005052Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001741Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0005218Highly InformativeDirect
Fly Anatomy (FA)ocellus0.0008527Highly InformativeDirect
Fly Anatomy (FA)pigment cell0.0008616Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.0009677Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.002107Highly InformativeInherited
Fly Anatomy (FA)early extended germ band embryo0.0209Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.06524Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.07599Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.1106Highly InformativeInherited
Fly Anatomy (FA)longitudinal muscle0.16Highly InformativeInherited
Fly Anatomy (FA)acute muscle0.2709Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0001167Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.9673Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.008985Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.02841Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5625Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.9885Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.0001627InformativeDirect
Zebrafish Anatomy (ZA)lymphatic system0.00003509Highly InformativeDirect
Zebrafish Anatomy (ZA)ganglion0.06052Highly InformativeInherited
Zebrafish Anatomy (ZA)inner ear0.08776Highly InformativeInherited
Zebrafish Anatomy (ZA)lateral line system0.1519Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.6996Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9267Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01219Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1787Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.4564Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002431InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.001054InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.009219InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.01121InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.00001122Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00001548Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000338Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0006529Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0008824Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001863Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.9906InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0002511Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0001128Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0003328InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.1375InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 64 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 64 hidden Markov models representing the EGF/Laminin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]