SUPERFAMILY 1.75 HMM library and genome assignments server

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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (274) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,365 77,955 117
Proteins 22,871 26,553 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) system development 0.0000000000249 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000003543 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000001531 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000001077 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000002703 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000007468 Moderately Informative Direct
Biological Process (BP) cell communication 0.000001849 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00008066 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.06279 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.00147 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7537 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8559 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001153 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001779 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7532 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.383 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1421 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6448 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9504 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.8001 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9133 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6238 Moderately Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) circulatory system development 0.000000000000005508 Informative Direct
Biological Process (BP) growth 0.000000000004716 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000000000005717 Informative Direct
Biological Process (BP) cell development 0.000000000006554 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000000000094 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000003103 Informative Direct
Biological Process (BP) regulation of growth 0.0000000009554 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000008189 Informative Direct
Biological Process (BP) behavior 0.00000003321 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000004748 Informative Direct
Biological Process (BP) generation of neurons 0.00000006544 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000001242 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000144 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000001603 Informative Direct
Biological Process (BP) regulation of transferase activity 0.00001753 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001214 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0001259 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0002752 Informative Direct
Biological Process (BP) central nervous system development 0.0003898 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0004446 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0006577 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0006938 Informative Direct
Biological Process (BP) negative regulation of cell death 0.1564 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) cell adhesion 0.3127 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.3106 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.576 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.01741 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003729 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04563 Informative Inherited
Biological Process (BP) protein oligomerization 0.006866 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1402 Informative Inherited
Biological Process (BP) regulation of secretion 0.6583 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8232 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.3613 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.001425 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.001302 Informative Inherited
Biological Process (BP) multi-organism cellular process 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.161 Informative Inherited
Biological Process (BP) response to cytokine 0.7404 Informative Inherited
Biological Process (BP) pigment metabolic process 0.2871 Informative Inherited
Biological Process (BP) secondary metabolic process 0.8325 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001106 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.00749 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.03116 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3764 Informative Inherited
Biological Process (BP) proteolysis 0.1217 Informative Inherited
Biological Process (BP) embryo development 0.00106 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) epithelium development 0.001961 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) protein targeting 0.01683 Informative Inherited
Biological Process (BP) nucleocytoplasmic transport 0.2427 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.2334 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) secretion 0.3516 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.02517 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03667 Informative Inherited
Biological Process (BP) immune response 0.6643 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.5534 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.9305 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.2158 Informative Inherited
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) cell junction assembly 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) appendage development 0.00000000000008346 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000000000001191 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0000000000007636 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.000000000007814 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000001086 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000000003248 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000000753 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000001326 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000000001961 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000000003482 Highly Informative Direct
Biological Process (BP) neuron development 0.000000004376 Highly Informative Direct
Biological Process (BP) protein maturation 0.000000005854 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000001051 Highly Informative Direct
Biological Process (BP) coagulation 0.00000002125 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000002177 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00000003282 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000004433 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000002322 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000004802 Highly Informative Direct
Biological Process (BP) wound healing 0.0000006483 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0000007481 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00000177 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000002472 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.000002957 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000003623 Highly Informative Direct
Biological Process (BP) cell migration 0.000007548 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00001254 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.00001883 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00004344 Highly Informative Direct
Biological Process (BP) brain development 0.00008152 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0001603 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0001685 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0002616 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0002753 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0002925 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.0003056 Highly Informative Direct
Biological Process (BP) gliogenesis 0.0003095 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0003799 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0006979 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000953 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.05337 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular protein localization 0.102 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.3014 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.0194 Highly Informative Inherited
Biological Process (BP) response to drug 0.00111 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.5936 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.01376 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.002361 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1289 Highly Informative Inherited
Biological Process (BP) inner ear development 0.001931 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.8992 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.01903 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.008522 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.002925 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.00196 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.00109 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.6962 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.5335 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.8058 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.005084 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 1 Highly Informative Inherited
Biological Process (BP) regeneration 0.001639 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2253 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00198 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.02442 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2419 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.3945 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.01239 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.1435 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.4969 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.4475 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.8956 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.003941 Highly Informative Inherited
Biological Process (BP) viral life cycle 0.01323 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.144 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.01609 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.05706 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 0.7906 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.1311 Highly Informative Inherited
Biological Process (BP) protein import 0.2855 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.2949 Highly Informative Inherited
Biological Process (BP) endocytosis 0.00655 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.3545 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001143 Highly Informative Inherited
Biological Process (BP) renal system process 0.01382 Highly Informative Inherited
Biological Process (BP) regulated exocytosis 0.02056 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.04299 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.4146 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.4783 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4031 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1694 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.06492 Highly Informative Inherited
Biological Process (BP) gastrulation 0.05533 Highly Informative Inherited
Biological Process (BP) ovulation cycle process 0.007708 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.002067 Highly Informative Inherited
Biological Process (BP) diterpenoid metabolic process 0.003696 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.0000000000002766 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000119 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0005699 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.2887 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.8092 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000000000000636 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0000000004177 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000003857 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0004522 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0006748 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.01277 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.2356 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.09857 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.8268 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.9648 Informative Inherited
Molecular Function (MF) peptidase regulator activity 0.009536 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.6263 Informative Inherited
Molecular Function (MF) enzyme binding 0.6426 Informative Inherited
Molecular Function (MF) phospholipid binding 0.5038 Informative Inherited
Molecular Function (MF) calcium ion binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000000000003685 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00001455 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.00001456 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.00008665 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0001176 Highly Informative Direct
Molecular Function (MF) heme binding 0.0003011 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0006558 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0009565 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.08503 Highly Informative Inherited
Molecular Function (MF) protein kinase regulator activity 0.3754 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.1108 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.5067 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.8295 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1144 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000007908 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.5283 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.001372 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1548 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.4565 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.6036 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.09108 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.000000000000003057 Informative Direct
Cellular Component (CC) lipid particle 0.000000000000003057 Informative Direct
Cellular Component (CC) apical part of cell 0.0000000000001033 Informative Direct
Cellular Component (CC) extracellular organelle 0.000000000006064 Informative Direct
Cellular Component (CC) side of membrane 0.0000000129 Informative Direct
Cellular Component (CC) cell projection part 0.000002226 Informative Direct
Cellular Component (CC) synapse 0.00005505 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.00006887 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00007879 Informative Direct
Cellular Component (CC) membrane region 0.0008014 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.01443 Informative Inherited
Cellular Component (CC) neuron projection 0.05571 Informative Inherited
Cellular Component (CC) vacuolar part 0.003874 Informative Inherited
Cellular Component (CC) lytic vacuole 0.002199 Informative Inherited
Cellular Component (CC) secretory vesicle 0.5842 Informative Inherited
Cellular Component (CC) extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.000000000000214 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00000000000109 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0000002942 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.0000003905 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0000009275 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.000004135 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.000007747 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 0.0000129 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0003892 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.0004656 Highly Informative Direct
Cellular Component (CC) membrane raft 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.416Least InformativeInherited
Disease Ontology (DO)blood coagulation disease0.000009605Moderately InformativeDirect
Disease Ontology (DO)artery disease0.0229Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1561Moderately InformativeInherited
Disease Ontology (DO)skin disease0.7207Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.0007724InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.000397Highly InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.006346Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.004488Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1227Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2714Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5652Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.5881Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.07947Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.111Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2499Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.3248Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.5511Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.5523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa0.7054Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.8056Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.9304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of oral mucosa0.02372InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.2097InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.2383InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.3572InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower urinary tract0.3676InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.6075InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size1InformativeInherited
Phenotypic Abnormality (PA)Overgrowth0.000465Highly InformativeDirect
Phenotypic Abnormality (PA)Palmar hyperhidrosis0.0008709Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow palpebral fissure0.0008789Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the bladder0.1253Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.1918Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of dental morphology0.2756Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000000327Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.01309Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01938Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.0284Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.134Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4164Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7817Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.000008078Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.00005693Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002208Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0002721Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001148Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.00783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.02635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3687Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.4049Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5076Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6698Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.7965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000003491InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0001819InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0006945InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.006891InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0345InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.08744InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1023InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1452InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1699InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.2008InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2127InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2556InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4688InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.5439InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.5826InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.6079InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7368InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.9601InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000000005403Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002229Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002229Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.00008314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00009006Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0001227Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.0004761Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.0005814Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland duct morphology0.0006658Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0008969Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.008656Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01111Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.3245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3601Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9272Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0000007436Least InformativeDirect
Worm Phenotype (WP)larval lethal0.002692Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.0028Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.008452Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01804Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1414Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6481Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0004358Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00221Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.09046Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1231Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1316Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3651Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.6268Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.0000001093InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0006986InformativeDirect
Worm Phenotype (WP)VPC competence variant0.003086InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.00655InformativeInherited
Worm Phenotype (WP)muscle system morphology variant0.009182InformativeInherited
Worm Phenotype (WP)vulva development variant0.009252InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.02343InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000003473Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00006266Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001458Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0001842Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000225Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.0003158Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.0004547Highly InformativeDirect
Worm Phenotype (WP)early larval lethal0.000958Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.00125Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.005355Highly InformativeInherited
Worm Phenotype (WP)germline proliferation variant0.01728Highly InformativeInherited
Worm Phenotype (WP)neuropil development variant0.02552Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.2881Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.5159Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.3311Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.002343Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0000004484InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.0000001176Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000003267Highly InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0004646Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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