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Elafin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Elafin-like [ 57256]
Families:   Elafin-like [ 57257] (2)


Superfamily statistics
Genomes (133) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,386 2,087 2
Proteins 1,287 1,432 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.2210.00252Least InformativeInherited
Biological Process (BP)response to external stimulus0.0022120.0000005655Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0072750.000001316Moderately InformativeInherited
Biological Process (BP)response to bacterium0.000038760.000000000001859InformativeDirect
Molecular Function (MF)molecular function regulator0.000035820.000000000947Moderately InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.14020.000008173InformativeInherited
Molecular Function (MF)peptidase regulator activity0.051440.00000008894InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity0.00000019940Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.6741 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5145 Least Informative Inherited
Biological Process (BP) response to stimulus 0.00252 Least Informative Inherited
Biological Process (BP) response to external stimulus 0.0000005655 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001316 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0506 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2808 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.001007 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1762 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.09055 Moderately Informative Inherited
Biological Process (BP) system development 0.1955 Moderately Informative Inherited
Biological Process (BP) response to stress 0.1789 Moderately Informative Inherited
Biological Process (BP) response to bacterium 0.000000000001859 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.000000921 Informative Direct
Biological Process (BP) defense response to other organism 0.00002671 Informative Direct
Biological Process (BP) cell development 0.005391 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.004186 Informative Inherited
Biological Process (BP) generation of neurons 0.01868 Informative Inherited
Biological Process (BP) defense response to bacterium 0.00008793 Highly Informative Direct
Biological Process (BP) neuron development 0.05603 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.00245 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.0029 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.01609 Highly Informative Inherited
Molecular Function (MF) molecular function regulator 0.000000000947 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000008173 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00000008894 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.0000000006829 Moderately Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0.00000000000000464Highly InformativeDirect
Post-translational modificationAntibiotic0.000000000008131Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008197 SSF57256 Protein matches
Abstract

Whey acidic protein (WAP) is a major component of the whey fraction of milk, which contains a significant number of different proteins. WAP proteins share limited sequence identity, except for their conserved cysteine-rich regions, known as 4-disulphide core (4-DSC) domains, and the positional conservation of specific residues [PubMed12751894]. Several non-milk proteins also contain 4-DSC patterns, such as certain serine protease inhibitors. WAP itself appears to have a protease-inhibitor function, as seen with its inhibitory effect on the progression of cancer cells [PubMed17215074].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Elafin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Elafin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]