SUPERFAMILY 1.75 HMM library and genome assignments server

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Elafin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Elafin-like [ 57256]
Families:   Elafin-like [ 57257] (2)


Superfamily statistics
Genomes (139) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,419 6,676 2
Proteins 1,315 3,881 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.2650.001456Least InformativeInherited
Biological Process (BP)response to biotic stimulus0.00058810.000000459Moderately InformativeDirect
Biological Process (BP)response to external stimulus0.0039230.0000003089Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0098380.000003206Moderately InformativeInherited
Molecular Function (MF)molecular function regulator0.0000026020.000000000001578Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity0.025440.00000001772InformativeInherited
Molecular Function (MF)enzyme inhibitor activity0.084180.000002462InformativeInherited
Molecular Function (MF)serine-type endopeptidase inhibitor activity0.0000000023090Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.001456 Least Informative Inherited
Biological Process (BP) biological regulation 0.5692 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5243 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8371 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5004 Least Informative Inherited
Biological Process (BP) defense response 0.00000002602 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0000003089 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.000000459 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000003206 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.3036 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.00198 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2296 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1892 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01261 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01677 Moderately Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.000001744 Informative Direct
Biological Process (BP) defense response to other organism 0.0002885 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.005525 Informative Inherited
Biological Process (BP) locomotion 0.009383 Informative Inherited
Biological Process (BP) generation of neurons 0.01018 Informative Inherited
Biological Process (BP) cell development 0.003611 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001848 Informative Inherited
Biological Process (BP) response to bacterium 0.003055 Informative Inherited
Biological Process (BP) immune response 0.004166 Informative Inherited
Biological Process (BP) antimicrobial humoral response 0.00002307 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.001195 Highly Informative Inherited
Biological Process (BP) neuron development 0.0308 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.006936 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.00511 Highly Informative Inherited
Molecular Function (MF) molecular function regulator 0.000000000001578 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000002462 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.00000001772 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.00000000001561 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0.00000000000000284Highly InformativeDirect
Post-translational modificationAntibiotic0.000000000007533Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008197 SSF57256 Protein matches
Abstract

Whey acidic protein (WAP) is a major component of the whey fraction of milk, which contains a significant number of different proteins. WAP proteins share limited sequence identity, except for their conserved cysteine-rich regions, known as 4-disulphide core (4-DSC) domains, and the positional conservation of specific residues [PubMed12751894]. Several non-milk proteins also contain 4-DSC patterns, such as certain serine protease inhibitors. WAP itself appears to have a protease-inhibitor function, as seen with its inhibitory effect on the progression of cancer cells [PubMed17215074].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Elafin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Elafin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]