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BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (159) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,270 28,450 59
Proteins 3,076 12,145 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00026180.00000001972Least InformativeDirect
Biological Process (BP)reproduction0.00000012910.00000005446Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00000026480.00001073Moderately InformativeDirect
Biological Process (BP)behavior0.0000000006950InformativeDirect
Biological Process (BP)multicellular organism reproduction0.00000017360.000004407InformativeDirect
Biological Process (BP)multi-organism behavior0.00000000023690.0000044Highly InformativeDirect
Molecular Function (MF)molecular function regulator00Moderately InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.0000000000784InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.00000006079Highly InformativeDirect
Cellular Component (CC)extracellular region part0.0000002080Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00000001972 Least Informative Direct
Biological Process (BP) response to stimulus 0.0008107 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000512 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8986 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.9578 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7835 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9443 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.03748 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.7645 Least Informative Inherited
Biological Process (BP) reproduction 0.00000005446 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000000001534 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000218 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00001073 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00005535 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.08881 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0994 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1003 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1965 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5574 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.02109 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9092 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6767 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03954 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001108 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.03684 Moderately Informative Inherited
Biological Process (BP) cell communication 0.02476 Moderately Informative Inherited
Biological Process (BP) gene expression 0.04767 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03604 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04058 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.009857 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.009513 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.242 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.2646 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01025 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8286 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9335 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001063 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.000002467 Informative Direct
Biological Process (BP) microtubule-based process 0.000037 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) response to bacterium 0.0009048 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000009073 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001687 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000004407 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000007106 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000003314 Informative Direct
Biological Process (BP) growth 0.0000006017 Informative Direct
Biological Process (BP) regulation of growth 0.0004576 Informative Direct
Biological Process (BP) locomotion 0.000002571 Informative Direct
Biological Process (BP) generation of neurons 0.000002041 Informative Direct
Biological Process (BP) cation homeostasis 0.00001594 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00001432 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.00001846 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000061 Informative Direct
Biological Process (BP) intracellular transport 0.001411 Informative Inherited
Biological Process (BP) epithelium development 0.5226 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.06292 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.8168 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1039 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.6159 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.05523 Informative Inherited
Biological Process (BP) cell development 0.01313 Informative Inherited
Biological Process (BP) system process 0.001333 Informative Inherited
Biological Process (BP) response to radiation 0.2465 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.3282 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.001742 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001922 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.09201 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.001049 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.000002509 Highly Informative Direct
Biological Process (BP) mRNA processing 0.0000005641 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00004075 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.000000004176 Highly Informative Direct
Biological Process (BP) cell growth 0.0000000000003232 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000001889 Highly Informative Direct
Biological Process (BP) cell maturation 0.000002374 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00001894 Highly Informative Direct
Biological Process (BP) neuron development 0.000283 Highly Informative Direct
Biological Process (BP) nervous system process 0.00000000004614 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0000044 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.0000000001321 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00000000006671 Highly Informative Direct
Biological Process (BP) response to growth factor 0.0001633 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.00000001853 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0000001143 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.1922 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5992 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0000000000784 Informative Direct
Molecular Function (MF) identical protein binding 0.0003837 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000009242 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000000003242 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0003843 Informative Direct
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.00000006079 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000000002678 Highly Informative Direct
Cellular Component (CC) membrane 0.000577 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.1926 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0001975 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.04091 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.04396 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0004125 Informative Direct
Cellular Component (CC) neuron projection 0.001468 Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.0001435Moderately InformativeDirect
Biological processHemostasis0.00000000000696InformativeDirect
Biological processCell adhesion0.00000000002347InformativeDirect
Biological processEndocytosis0.00000002544InformativeDirect
Biological processNotch signaling pathway0.0000000000003182Highly InformativeDirect
Biological processBlood coagulation0.000000000006486Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000004404Highly InformativeDirect
Cellular componentBasement membrane0.00004923Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.00001158Highly InformativeDirect
Molecular functionCopper0.000000196InformativeDirect
Molecular functionChromophore0.00004971InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHeparin-binding0.000000001633InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.00000000000007526Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.0000000001191InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.0000001106InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]