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BPTI-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   BPTI-like [ 57361]
Superfamily:   BPTI-like [ 57362] (3)
Families:   Small Kunitz-type inhibitors & BPTI-like toxins [ 57363] (12)
  Soft tick anticoagulant proteins [ 57386] (2)
  Tick tryptase inhibitor-like [ 161132]


Superfamily statistics
Genomes (155) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,070 9,169 59
Proteins 3,001 5,015 57


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multi-organism process0.00000010820.000001424Moderately InformativeDirect
Biological Process (BP)reproduction0.000000110.00000002231Moderately InformativeDirect
Biological Process (BP)behavior0.00000000069510InformativeDirect
Biological Process (BP)multicellular organism reproduction0.00000011060.0000006861InformativeDirect
Biological Process (BP)multi-organism behavior0.0000000005540.00000885Highly InformativeDirect
Molecular Function (MF)molecular function regulator00.00000000000001095Moderately InformativeDirect
Molecular Function (MF)peptidase regulator activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity00.000000000308InformativeDirect
Molecular Function (MF)serine-type endopeptidase inhibitor activity00.0000001015Highly InformativeDirect
Cellular Component (CC)extracellular region part0.00000017660Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000001155 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002321 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.009538 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7602 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9254 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8739 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.7425 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.000001424 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000002231 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000005274 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0001072 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000111 Moderately Informative Direct
Biological Process (BP) cellular localization 0.007835 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.05786 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1997 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1201 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04807 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.001185 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8233 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04955 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.007162 Moderately Informative Inherited
Biological Process (BP) signaling 0.0179 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8628 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03575 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2328 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9508 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1148 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1155 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1547 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.7013 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.00141 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.8362 Moderately Informative Inherited
Biological Process (BP) gene expression 0.08445 Moderately Informative Inherited
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0000006861 Informative Direct
Biological Process (BP) growth 0.0000001666 Informative Direct
Biological Process (BP) generation of neurons 0.0000005881 Informative Direct
Biological Process (BP) locomotion 0.0000006141 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000001431 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000001504 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000001689 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000004929 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000005629 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00001093 Informative Direct
Biological Process (BP) ion homeostasis 0.00001514 Informative Direct
Biological Process (BP) microtubule-based process 0.0002027 Informative Direct
Biological Process (BP) regulation of growth 0.0002725 Informative Direct
Biological Process (BP) response to bacterium 0.0004731 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00075 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0009979 Informative Direct
Biological Process (BP) regulation of protein modification process 0.4585 Informative Inherited
Biological Process (BP) cell development 0.002954 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.001146 Informative Inherited
Biological Process (BP) response to radiation 0.2272 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.3892 Informative Inherited
Biological Process (BP) system process 0.006946 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.004202 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.05462 Informative Inherited
Biological Process (BP) multi-organism behavior 0.00000885 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) cell growth 0.0000000000003022 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.000000000006735 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00000000001903 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.00000000004687 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00000000007686 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.00000004609 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0000002716 Highly Informative Direct
Biological Process (BP) cell maturation 0.000001892 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.000002093 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000002363 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.000008481 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00003347 Highly Informative Direct
Biological Process (BP) neuron development 0.0002543 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0005352 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.6229 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.00000000000001095 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase regulator activity 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000000000308 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.0000000007195 Informative Direct
Molecular Function (MF) identical protein binding 0.0001095 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.001116 Informative Inherited
Molecular Function (MF) serine-type endopeptidase inhibitor activity 0.0000001015 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000000002689 Highly Informative Direct
Cellular Component (CC) membrane 0.001648 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.5337 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0008589 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02552 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.0002653 Informative Direct
Cellular Component (CC) neuron projection 0.0003125 Informative Direct
Cellular Component (CC) extracellular matrix 0.003219 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.05595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.05696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.000001351Highly InformativeDirect
Mammalian Phenotype (MP)abnormal muscle weight0.000006931Highly InformativeDirect
Mammalian Phenotype (MP)decreased skeletal muscle size0.00002767Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect
Worm Phenotype (WP)cell number increased0.0458InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.0002346Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00008242Moderately InformativeDirect
Biological processHemostasis0.000000000003805InformativeDirect
Biological processCell adhesion0.000000000007667InformativeDirect
Biological processEndocytosis0.00000001353InformativeDirect
Biological processNotch signaling pathway0.0000000000001734Highly InformativeDirect
Biological processBlood coagulation0.00000000000355Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix1InformativeInherited
Cellular componentCoated pit0.000000000002396Highly InformativeDirect
Cellular componentBasement membrane0.00005143Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainCollagen0.000007949Highly InformativeDirect
Molecular functionHeparin-binding0.0000000001455InformativeDirect
Molecular functionCopper0.00000006674InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationIon channel impairing toxin0.000000001618Highly InformativeDirect
Post-translational modificationNeurotoxin1Highly InformativeInherited
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein1Least InformativeInherited
Post-translational modificationProteoglycan0.00000002049InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.00000003701InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002223 SSF57362 Protein matches
Abstract

The majority of the sequences having this domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family [PubMed14705960] and are restricted to the metazoa with a single exception: Amsacta moorei entomopoxvirus. They are short (~50 residue) alpha/beta proteins with few secondary structures. The fold is constrained by 3 disulphide bonds. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [PubMed1714504] (or basic protease inhibitor), but the family includes numerous other members [PubMed1703675, PubMed1593645, PubMed8159751, PubMed1304909], such as snake venom basic protease; mammalian inter-alpha-trypsin inhibitors; trypstatin, a rat mast cell inhibitor of trypsin; a domain found in an alternatively-spliced form of Alzheimer's amyloid beta-protein; domains at the C-termini of the alpha(1) and alpha(3) chains of type VII and type VI collagens; and tissue factor pathway inhibitor precursor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BPTI-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the BPTI-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]