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Kringle-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Families:   Kringle modules [ 57441] (6)
  Fibronectin type II module [ 57459] (4)


Superfamily statistics
Genomes (187) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,878 10,330 59
Proteins 2,742 5,895 47


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.000000000001636 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000000348 Least Informative Direct
Biological Process (BP) response to stimulus 0.0003386 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.02448 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.8178 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02809 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.02043 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1143 Least Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000000004293 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000534 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000001207 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000007137 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0002241 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.3735 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4879 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.6456 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5946 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7668 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.481 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.6288 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.004111 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.004791 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2083 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3115 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.296 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9565 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.09478 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1822 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1584 Moderately Informative Inherited
Biological Process (BP) defense response 0.8847 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.01807 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.7781 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00239 Moderately Informative Inherited
Biological Process (BP) tissue development 0.04448 Moderately Informative Inherited
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) proteolysis 0.000000000000005563 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000000000003039 Informative Direct
Biological Process (BP) locomotion 0.000000000006386 Informative Direct
Biological Process (BP) response to wounding 0.00000000002553 Informative Direct
Biological Process (BP) secretion by cell 0.00000000002895 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000006244 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000000002503 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000003774 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000002707 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001199 Informative Direct
Biological Process (BP) circulatory system development 0.0001415 Informative Direct
Biological Process (BP) growth 0.000163 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000309 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0004935 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0005215 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0006378 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.03092 Informative Inherited
Biological Process (BP) regulation of locomotion 0.06135 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1039 Informative Inherited
Biological Process (BP) cellular response to lipid 0.002728 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008616 Informative Inherited
Biological Process (BP) response to bacterium 0.002845 Informative Inherited
Biological Process (BP) cell development 0.5049 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6904 Informative Inherited
Biological Process (BP) generation of neurons 0.9791 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.02339 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7354 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9105 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01399 Informative Inherited
Biological Process (BP) regulation of growth 0.0899 Informative Inherited
Biological Process (BP) central nervous system development 0.3034 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2519 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.02794 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.08939 Informative Inherited
Biological Process (BP) localization of cell 0.003353 Informative Inherited
Biological Process (BP) epithelium development 0.1752 Informative Inherited
Biological Process (BP) embryo development 0.2602 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.267 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.00341 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.04564 Informative Inherited
Biological Process (BP) protein maturation 0.00000000001859 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000001323 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.00000001156 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00000006475 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000002046 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.00000458 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.000006064 Highly Informative Direct
Biological Process (BP) regeneration 0.00001073 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00001122 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.00001125 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00002953 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.00006999 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00007995 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0001397 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0004612 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0005621 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0006214 Highly Informative Direct
Biological Process (BP) hemostasis 0.0008249 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.001196 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.021 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.135 Highly Informative Inherited
Biological Process (BP) neuron development 0.3625 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.6837 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.2859 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.04865 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01477 Highly Informative Inherited
Biological Process (BP) negative regulation of coagulation 0.01466 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.005709 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.3947 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.06655 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.0057 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.01057 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.8139 Highly Informative Inherited
Biological Process (BP) wound healing 0.05314 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.002122 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) heart development 0.004773 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.2615 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.5992 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.0713 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000004891 Least Informative Direct
Molecular Function (MF) binding 0.0004549 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.3537 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3593 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.1449 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.00002853 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0001934 Informative Direct
Molecular Function (MF) signal transducer activity 0.02929 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.001612 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0221 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.001257 Informative Inherited
Molecular Function (MF) kinase activity 0.04662 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.1155 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.00001445 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.002398 Highly Informative Inherited
Molecular Function (MF) cell adhesion molecule binding 0.003277 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.1227 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000000007544 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000001452 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00001554 Moderately Informative Direct
Cellular Component (CC) cell projection 0.03816 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.0000008572 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00009834 Informative Direct
Cellular Component (CC) extracellular organelle 0.0001439 Informative Direct
Cellular Component (CC) neuron projection 0.0006423 Informative Direct
Cellular Component (CC) plasma membrane region 0.1487 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001313Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000001212InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002463InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.000000000000002098Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B0.0000000001879Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.0000000001879Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHemostasis0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis0.00000000000002046InformativeDirect
Biological processEndocytosis0.00000000003052InformativeDirect
Biological processCell adhesion0.0000159InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processBlood coagulation0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0.000001161InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainKringle0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0.000000002855InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000001239Moderately InformativeDirect
Post-translational modificationKinase0.415Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationHeparin-binding0.0000000000001349InformativeDirect
Post-translational modificationGrowth factor0.0000001377Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0000004196Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.0000000000005361Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.000002912InformativeDirect
Post-translational modificationSulfation0.00002384InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.00000006808Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013806 SSF57440 Protein matches
Abstract

This entry represents proteins displaying a Kringle-like structure, which consists of a nearly all-beta, disulphide-rich fold. Proteins displaying this fold include both Kringle modules as well as fibronectin type II modules, the latter displaying a shorter two-disulphide version of the Kringle module.

Kringle modules occur in blood clotting and fibrinolytic proteins, such as plasminogen, prothrombin, meizothrombin, and urokinase-type plasminogen activator, as well as in apolipoprotein and hepatocyte growth factor. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [PubMed6373375, PubMed2157850].

Fibronectin type II modules occur in fibronectin, as well as in gelatinase A (MMP-2), gelatinase B (MMP-9), and the collagen-binding domain of PDC-109. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin [PubMed3780752]. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. Gelatinases A and B are members of the matrix metalloproteinase family that act as neutral proteinases in the breakdown and remodelling of the extracellular matrix. These gelatinases play important roles in the pathogenesis of inflammation, infection and in neoplastic diseases [PubMed16019990]. In gelatinase A, the three fibronectin-like modules are inserted within a catalytic domain, these modules acting to target the enzyme to matrix macromolecules [PubMed16085117].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Kringle-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]