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Cystine-knot cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Families:   Platelet-derived growth factor-like [ 57502] (3)
  Transforming growth factor (TGF)-beta [ 57507] (7)
  Noggin [ 82904]
  Neurotrophin [ 57520] (4)
  Gonadodropin/Follitropin [ 57528] (3)
  Interleukin 17F, IL-17F [ 69955]
  Coagulogen [ 57531]


Superfamily statistics
Genomes (146) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,332 25,794 40
Proteins 6,300 25,668 40


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00000065570Least InformativeDirect
Biological Process (BP)response to stimulus0.0000003530Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.9210.000000000004988Least InformativeInherited
Biological Process (BP)primary metabolic process10.006889Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.00000000000001079Least InformativeInherited
Biological Process (BP)single-organism cellular process10.000000001644Least InformativeInherited
Biological Process (BP)reproduction0.000000099590.000000000007793Moderately InformativeDirect
Biological Process (BP)cell communication0.000012980Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.0000000051320Moderately InformativeDirect
Biological Process (BP)response to organic substance0.0000000022820Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.000062050Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000010970Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000004310Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.000082650Moderately InformativeDirect
Biological Process (BP)single organism signaling0.00012540Moderately InformativeDirect
Biological Process (BP)animal organ development0.00080660Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.00000052480Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000000000032780Moderately InformativeDirect
Biological Process (BP)multi-organism process0.000042690.00000008585Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.95810Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000024230.001533Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus10Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.074210Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.50310.08421Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.1450Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.69140.00204Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.14560Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0028340Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.000011321Moderately InformativeInherited
Biological Process (BP)gene expression0.013721Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.0091Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0052380Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0018890Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00039830.006613Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.000025681Moderately InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.00000000000069840.000000000000003734InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00000000012250InformativeDirect
Biological Process (BP)regulation of hormone levels00InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00033520.00000000000003926InformativeDirect
Biological Process (BP)regulation of system process0.0000000023290.00000000002407InformativeDirect
Biological Process (BP)single organism reproductive process0.00000029960.0003165InformativeDirect
Biological Process (BP)regulation of secretion0.000000062240.00000001805InformativeDirect
Biological Process (BP)positive regulation of transport0.0000000099090InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000000000018230InformativeDirect
Biological Process (BP)cellular response to lipid0.48630.0779InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.79630.4402InformativeInherited
Biological Process (BP)response to bacterium0.50060.000000003191InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.45561InformativeInherited
Biological Process (BP)multi-organism reproductive process0.0035051InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.0015710.5686InformativeInherited
Biological Process (BP)multicellular organism reproduction0.000064380.796InformativeInherited
Biological Process (BP)proteolysis0.0075461InformativeInherited
Biological Process (BP)lipid localization0.0000000000017270.06318InformativeInherited
Biological Process (BP)cell development0.53261InformativeInherited
Biological Process (BP)reproductive system development0.000010340.05414InformativeInherited
Biological Process (BP)cell-cell signaling0.00000051820Highly InformativeDirect
Biological Process (BP)sex differentiation00Highly InformativeDirect
Biological Process (BP)ovulation cycle process0.000053160Highly InformativeDirect
Biological Process (BP)regulation of endocrine process00Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0000000000016490.000000000005935Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.00026680Highly InformativeDirect
Biological Process (BP)anatomical structure maturation0.0000060350.00000000001236Highly InformativeDirect
Biological Process (BP)regulation of transmembrane receptor protein serine/threonine kinase signaling pathway0.00000098750Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.00013250Highly InformativeDirect
Biological Process (BP)response to ketone0.000050040Highly InformativeDirect
Biological Process (BP)positive regulation of secretion by cell0.000000000000033280Highly InformativeDirect
Biological Process (BP)regulation of lipid localization00.0003463Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.053230.0000000004746Highly InformativeInherited
Biological Process (BP)female gamete generation0.0055960.0003171Highly InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.000000000000064630.05926Highly InformativeInherited
Biological Process (BP)protein maturation0.000010660.03001Highly InformativeInherited
Biological Process (BP)germ cell development0.052760.4811Highly InformativeInherited
Biological Process (BP)cell maturation0.000047790.789Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)molecular function regulator0.35660Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)protein dimerization activity00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.039190.000000005594InformativeInherited
Molecular Function (MF)peptidase regulator activity0.017910.000000000000002411InformativeInherited
Molecular Function (MF)G-protein coupled receptor binding0.0053111Highly InformativeInherited
Cellular Component (CC)extracellular region part0.00000000110Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0005042 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000000004988 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000001644 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000000000001079 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.006889 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000000000007793 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) tissue development 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000000005175 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000001641 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000000004875 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00004805 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00000000002879 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000004774 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000002275 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000008585 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000000005784 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000001899 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0002491 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001533 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.006613 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002438 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.08421 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9451 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.00204 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.005906 Moderately Informative Inherited
Biological Process (BP) defense response 0.2555 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000007007 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000000000003734 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) cell death 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) response to bacterium 0.000000003191 Informative Direct
Biological Process (BP) embryo development 0.0003377 Informative Direct
Biological Process (BP) animal organ morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.0000000001412 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0006261 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.0000000002721 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000000003926 Informative Direct
Biological Process (BP) regulation of protein modification process 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0008577 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) regulation of protein localization 0.00000000001051 Informative Direct
Biological Process (BP) protein localization to organelle 0 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.0007067 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0000000000002588 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0 Informative Direct
Biological Process (BP) regulation of system process 0.00000000002407 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000003421 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.00000000003469 Informative Direct
Biological Process (BP) single organism reproductive process 0.0003165 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0 Informative Direct
Biological Process (BP) intracellular transport 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.00008343 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of secretion 0.00000001805 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) circulatory system development 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of peptide transport 0.00000000003551 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000000000000007296 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0 Informative Direct
Biological Process (BP) regulation of cellular localization 0.501 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006074 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9355 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4402 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2226 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5686 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.111 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.796 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.1776 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1636 Informative Inherited
Biological Process (BP) lipid localization 0.06318 Informative Inherited
Biological Process (BP) secretion by cell 0.01705 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) cellular response to lipid 0.0779 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.154 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) reproductive system development 0.05414 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) hemopoiesis 0.02402 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.0000000000003084 Highly Informative Direct
Biological Process (BP) angiogenesis 0.000000000005205 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0 Highly Informative Direct
Biological Process (BP) kidney development 0.000000492 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.0000000004746 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.0000572 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0003171 Highly Informative Direct
Biological Process (BP) gastrulation 0.00005625 Highly Informative Direct
Biological Process (BP) heart development 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00001901 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0 Highly Informative Direct
Biological Process (BP) viral process 0 Highly Informative Direct
Biological Process (BP) protein import 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0 Highly Informative Direct
Biological Process (BP) forebrain development 0.0008271 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.000003271 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.000007334 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) gliogenesis 0 Highly Informative Direct
Biological Process (BP) response to drug 0.00000000003673 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.000000009277 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0 Highly Informative Direct
Biological Process (BP) regulation of endocrine process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0001988 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00000000001516 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000000000005935 Highly Informative Direct
Biological Process (BP) embryonic organ development 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00000000000002606 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.0005664 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0001065 Highly Informative Direct
Biological Process (BP) cell chemotaxis 0.000002946 Highly Informative Direct
Biological Process (BP) muscle tissue development 0.00000000000001079 Highly Informative Direct
Biological Process (BP) response to growth factor 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.00000000001236 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000000004389 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000101 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.0002077 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) response to ketone 0 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0 Highly Informative Direct
Biological Process (BP) regulation of protein import 0.000000006988 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.0003463 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000004681 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.1094 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.6718 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 0.1998 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.4943 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 1 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.001394 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.3131 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.5382 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.6512 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.5015 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.001088 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.007418 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) regulation of RNA stability 0.2198 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.004776 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.05926 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.1088 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0299 Highly Informative Inherited
Biological Process (BP) regulation of oxidoreductase activity 0.1842 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.5554 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.1759 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.03966 Highly Informative Inherited
Biological Process (BP) negative regulation of coagulation 0.8997 Highly Informative Inherited
Biological Process (BP) protein maturation 0.03001 Highly Informative Inherited
Biological Process (BP) muscle system process 0.5301 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.02084 Highly Informative Inherited
Biological Process (BP) neuron development 0.4679 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.09006 Highly Informative Inherited
Biological Process (BP) nuclear export 0.6027 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.007001 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.1521 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.5342 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.4811 Highly Informative Inherited
Biological Process (BP) cell maturation 0.789 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.9592 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00006721 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6675 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.000000005594 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0.0000002115 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000004894 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) identical protein binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000000000002411 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000008482 Informative Direct
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) protein kinase activity 0.000000004516 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.000214 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.001168 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2781 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5827 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) secretory granule 0 Informative Direct
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.6447 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.000004401 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00001393 Highly Informative Direct
Cellular Component (CC) blood microparticle 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.000008743InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cystine-knot cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Cystine-knot cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]