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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (169) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,098 33,806 82
Proteins 6,894 7,758 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000007182 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.1395 Least Informative Inherited
Biological Process (BP) developmental process 0.5386 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003131 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000004562 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000005965 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000004056 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002393 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0004364 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.5887 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002094 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8384 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7266 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7169 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9084 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9938 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5744 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.08557 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5371 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6912 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3214 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) response to bacterium 0.00000000006876 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000001796 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000000817 Informative Direct
Biological Process (BP) regulation of immune effector process 0.000001689 Informative Direct
Biological Process (BP) biological adhesion 0.000002565 Informative Direct
Biological Process (BP) regulation of defense response 0.000004518 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00003866 Informative Direct
Biological Process (BP) immune effector process 0.00003938 Informative Direct
Biological Process (BP) regulation of cell activation 0.0002765 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0005047 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.003632 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7904 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01009 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1288 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.003336 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2477 Informative Inherited
Biological Process (BP) synaptic transmission 0.00166 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3559 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5205 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4665 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.05435 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07389 Informative Inherited
Biological Process (BP) response to lipid 0.05303 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02128 Informative Inherited
Biological Process (BP) central nervous system development 0.1294 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002643 Informative Inherited
Biological Process (BP) regulation of cell development 0.1004 Informative Inherited
Biological Process (BP) generation of neurons 0.3223 Informative Inherited
Biological Process (BP) single-organism behavior 0.007733 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.02003 Informative Inherited
Biological Process (BP) response to wounding 0.6916 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6357 Informative Inherited
Biological Process (BP) sexual reproduction 0.1892 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9187 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9121 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1744 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000000000834 Highly Informative Direct
Biological Process (BP) cell adhesion 0.0000001256 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.000003108 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.000003386 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.000004949 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000006785 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00002816 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.00004372 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.00005291 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00005399 Highly Informative Direct
Biological Process (BP) fertilization 0.00007744 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.00008949 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.00009354 Highly Informative Direct
Biological Process (BP) hemostasis 0.00009838 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0001314 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001814 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002978 Highly Informative Direct
Biological Process (BP) B cell activation 0.0003354 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0009322 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.03189 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.002334 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02182 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2331 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.01569 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01326 Highly Informative Inherited
Biological Process (BP) coagulation 0.001552 Highly Informative Inherited
Biological Process (BP) wound healing 0.493 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.6008 Highly Informative Inherited
Biological Process (BP) innate immune response 0.04431 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001648 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.2696 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000001249 Informative Direct
Molecular Function (MF) peptidase activity 0.00002023 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00004215 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0005072 Informative Direct
Molecular Function (MF) serine hydrolase activity 0.0000002998 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000004531 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.008827 Highly Informative Inherited
Cellular Component (CC) membrane 0.0001234 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000004319 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000004916 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000000000641 Informative Direct
Cellular Component (CC) extracellular matrix 0.0000000007196 Informative Direct
Cellular Component (CC) vacuolar part 0.00001991 Informative Direct
Cellular Component (CC) secretory granule 0.00006528 Informative Direct
Cellular Component (CC) synapse part 0.0005307 Informative Direct
Cellular Component (CC) extracellular space 0.005944 Informative Inherited
Cellular Component (CC) neuron projection 0.6937 Informative Inherited
Cellular Component (CC) sperm part 0.0000001777 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000002087 Highly Informative Direct
Cellular Component (CC) cell body 0.0000009695 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0002449 Highly Informative Direct
Cellular Component (CC) dendrite 0.01262 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.00004059Least InformativeDirect
Disease Ontology (DO)nervous system disease0.07496Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.0006393Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0006892Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.001456Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.02657Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.03157Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.1414Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.00004343InformativeDirect
Disease Ontology (DO)eye disease0.0004412InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0227InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.9983InformativeInherited
Disease Ontology (DO)normocytic anemia0.0000000000000641Highly InformativeDirect
Disease Ontology (DO)degeneration of macula and posterior pole0.0000000003228Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.1096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.5853Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.006239InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.1338InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1725InformativeInherited
Phenotypic Abnormality (PA)Recurrent meningococcal disease0.0000007243Highly InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.00009751Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.03376Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2111Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6083Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8349Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.006379Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1303Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.7842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8887Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.004777InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005304InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.01619InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1164InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1607InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.4115InformativeInherited
Mammalian Phenotype (MP)abnormal complement pathway0.0000009145Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.000185Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level0.0003035Highly InformativeDirect
Mammalian Phenotype (MP)abnormal excitatory postsynaptic currents0.02132Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.03527Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.0506Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.1025Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.4265Least InformativeInherited
Xenopus ANatomical entity (XAN)adipose tissue0.0001614Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00001982Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5056Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000001736InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000001207InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001158Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processCytolysis0.000000000004495InformativeDirect
Biological processInnate immunity0.0000000672InformativeDirect
Biological processAngiogenesis0.0000007996InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway0.00001993Highly InformativeDirect
Cellular componentMembrane0.000000000000251Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000001022Moderately InformativeDirect
Cellular componentCell junction0.0000002951Moderately InformativeDirect
Cellular componentExtracellular matrix0.00002055InformativeDirect
Cellular componentGPI-anchor0.0006037InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.08917Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain0.00000006481InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionHeparin-binding0.000000000011InformativeDirect
Post-translational modificationHydrolase0.2112Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.0000000004746Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001584Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation0.000000000000001793InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]