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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (173) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30,717 33,806 82
Proteins 6,585 7,758 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0000000001794 Least Informative Direct
Biological Process (BP) biological regulation 0.02108 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3823 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.765 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000000000007388 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000001291 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000001042 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000001101 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00001957 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1351 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7767 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1942 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.03035 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3623 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.004686 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.06177 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7465 Moderately Informative Inherited
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000000007367 Informative Direct
Biological Process (BP) regulation of defense response 0.00000003501 Informative Direct
Biological Process (BP) positive regulation of immune response 0.000001989 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.7697 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8586 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3518 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.2038 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.05888 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2548 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4395 Informative Inherited
Biological Process (BP) defense response to other organism 0.02553 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.008047 Informative Inherited
Biological Process (BP) locomotion 0.0327 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05085 Informative Inherited
Biological Process (BP) response to oxidative stress 0.9088 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6913 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.01137 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002803 Informative Inherited
Biological Process (BP) immune effector process 0.001966 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.06876 Informative Inherited
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00001903 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00002176 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0003335 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0003787 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0006735 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.02221 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.07208 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.2921 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.1349 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.006883 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.8133 Least Informative Inherited
Molecular Function (MF) binding 0.002245 Least Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.04732 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.0000001106 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.001274 Highly Informative Inherited
Cellular Component (CC) membrane 0.004611 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000002609 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000003992 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.4442 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5855 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.00000000000001208 Informative Direct
Cellular Component (CC) extracellular organelle 0.000000001438 Informative Direct
Cellular Component (CC) secretory granule 0.00001009 Informative Direct
Cellular Component (CC) synapse 0.00002167 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0005819 Informative Direct
Cellular Component (CC) extracellular space 0.1201 Informative Inherited
Cellular Component (CC) sperm part 0.000000008732 Highly Informative Direct
Cellular Component (CC) blood microparticle 0.00001793 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 0.00004472 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.4082 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06678Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0000001038Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0006063Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0006223Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.02008Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02945Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.0792Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.01402InformativeInherited
Disease Ontology (DO)nephritis0.02948InformativeInherited
Disease Ontology (DO)degeneration of macula and posterior pole0.0000000001821Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.01033Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.03063Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.089Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1598Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.625Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8276Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9456Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.000000000003884Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.006615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.02616Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.0276Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.06323Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2732Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5032Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5213Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.6899Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.7816Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8407Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.9378Moderately InformativeInherited
Phenotypic Abnormality (PA)Complement deficiency0InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.00002747InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.00003144InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.00004175InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glomerulus0.0000446InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.000204InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.01066InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.01663InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.03079InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.03927InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.08063InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.1284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.1984InformativeInherited
Phenotypic Abnormality (PA)Renal insufficiency0.37InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.4087InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.4352InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.7287InformativeInherited
Phenotypic Abnormality (PA)Elevated serum creatinine0.000000007896Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent Neisserial infections0.00001336Highly InformativeDirect
Phenotypic Abnormality (PA)Chronic active hepatitis0.00001963Highly InformativeDirect
Phenotypic Abnormality (PA)Discoid lupus rash0.00005039Highly InformativeDirect
Phenotypic Abnormality (PA)Diarrhea0.00007734Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.00008386Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombocytopenia0.0004576Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent bronchitis0.0005058Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0006758Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous hemorrhage0.001374Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07275Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2666Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7397Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7545Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005218InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.006179InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.02367InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.05835InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1003InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1446InformativeInherited
Mammalian Phenotype (MP)biphasic excitatory postsynaptic current amplitude0.0000000728Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.000000531Highly InformativeDirect
Mammalian Phenotype (MP)short excitatory postsynaptic current rise time0.0000144Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0001702Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.000211Highly InformativeDirect
Mammalian Phenotype (MP)lymph node hypoplasia0.0006309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.02645Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.04082Highly InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.04911Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.09525Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.000001215Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000799Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4846Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000001155InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000001071InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processCytolysis0.000000000005972InformativeDirect
Biological processAngiogenesis0.0000009599InformativeDirect
Biological processInnate immunity0.00005653InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway0.000004126Highly InformativeDirect
Cellular componentMembrane0.0000000000003699Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000001729Moderately InformativeDirect
Cellular componentCell junction0.0000014Moderately InformativeDirect
Cellular componentExtracellular matrix0.00001475InformativeDirect
Cellular componentGPI-anchor0.000746InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.06796Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain0.00000003715InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationHydrolase0.2329Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000003069Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationHeparin-binding0.00000000001404InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001655Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation9.536e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]