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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (170) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30,589 33,806 82
Proteins 6,550 7,758 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000000001223 Least Informative Direct
Biological Process (BP) biological regulation 0.09328 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.732 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000000001902 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000003237 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000009761 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00001038 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00006913 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.231 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2903 Moderately Informative Inherited
Biological Process (BP) response to stress 0.05185 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7906 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.09068 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1534 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6403 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.004774 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05684 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000000001179 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0000000002755 Informative Direct
Biological Process (BP) regulation of defense response 0.0000009576 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00002123 Informative Direct
Biological Process (BP) cell adhesion 0.00004107 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.7477 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.393 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8376 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1337 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2047 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3369 Informative Inherited
Biological Process (BP) defense response to other organism 0.04676 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.006677 Informative Inherited
Biological Process (BP) locomotion 0.03137 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.02609 Informative Inherited
Biological Process (BP) regulation of locomotion 0.03679 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8902 Informative Inherited
Biological Process (BP) response to inorganic substance 0.1509 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.6998 Informative Inherited
Biological Process (BP) behavior 0.2075 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002841 Informative Inherited
Biological Process (BP) system process 0.5263 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04839 Informative Inherited
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.000000000000003692 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000004497 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00002566 Highly Informative Direct
Biological Process (BP) endocytosis 0.0001637 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0003659 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0003659 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000413 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.02176 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.1306 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.03761 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.2569 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.001445 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.005734 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.01822 Highly Informative Inherited
Biological Process (BP) sensory perception 0.07702 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.7512 Least Informative Inherited
Molecular Function (MF) binding 0.008158 Least Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0.04297 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.00000001877 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.001192 Highly Informative Inherited
Cellular Component (CC) membrane 0.01544 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000002491 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00002327 Moderately Informative Direct
Cellular Component (CC) cell surface 0.00000000000001039 Informative Direct
Cellular Component (CC) extracellular organelle 0.000000002509 Informative Direct
Cellular Component (CC) synapse 0.00002026 Informative Direct
Cellular Component (CC) extracellular space 0.02822 Informative Inherited
Cellular Component (CC) secretory vesicle 0.001647 Informative Inherited
Cellular Component (CC) side of membrane 0.003456 Informative Inherited
Cellular Component (CC) sperm part 0.000000005185 Highly Informative Direct
Cellular Component (CC) blood microparticle 0.00001071 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0006492 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.00001669Least InformativeDirect
Disease Ontology (DO)nervous system disease0.07187Least InformativeInherited
Disease Ontology (DO)organ system cancer0.7776Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.0005723Moderately InformativeDirect
Disease Ontology (DO)syndrome0.00064Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.02134Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02977Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.08243Moderately InformativeInherited
Disease Ontology (DO)blood coagulation disease0.1635Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.9444Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.01511InformativeInherited
Disease Ontology (DO)nephritis0.02994InformativeInherited
Disease Ontology (DO)anemia0.03177InformativeInherited
Disease Ontology (DO)retinal disease0.04039InformativeInherited
Disease Ontology (DO)myeloma0.3286InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.9657InformativeInherited
Disease Ontology (DO)degeneration of macula and posterior pole0.0000000002391Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.01002Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0303Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.088Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1417Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4506Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.6311Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8258Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8782Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9211Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.000000000003547Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.006509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.02521Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.02642Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.02818Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.04645Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.2209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2713Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.4036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.5075Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.6818Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.8121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8381Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.9375Moderately InformativeInherited
Phenotypic Abnormality (PA)Complement deficiency0InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.00001408InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.00001705InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.00003003InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.00004169InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glomerulus0.00004759InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.01192InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.01665InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.03035InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.09741InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.1244InformativeInherited
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.195InformativeInherited
Phenotypic Abnormality (PA)Renal insufficiency0.3754InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.4029InformativeInherited
Phenotypic Abnormality (PA)Dermatological manifestations of systemic disorders0.4398InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.6227InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.7202InformativeInherited
Phenotypic Abnormality (PA)Elevated serum creatinine0.000000008508Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent Neisserial infections0.0000138Highly InformativeDirect
Phenotypic Abnormality (PA)Chronic active hepatitis0.00002032Highly InformativeDirect
Phenotypic Abnormality (PA)Discoid lupus erythematosus0.00005194Highly InformativeDirect
Phenotypic Abnormality (PA)Diarrhea0.00006495Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.00007495Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombocytopenia0.0004153Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent bronchitis0.0004864Highly InformativeDirect
Phenotypic Abnormality (PA)Arthritis0.000591Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0006534Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous hemorrhage0.00115Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.05262Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1286Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7118Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9647Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005067InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.005799InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.02249InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.04802InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.09896InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1481InformativeInherited
Mammalian Phenotype (MP)biphasic excitatory postsynaptic current amplitude0.00000006909Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0000005438Highly InformativeDirect
Mammalian Phenotype (MP)short excitatory postsynaptic current rise time0.00001455Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0001436Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.0002114Highly InformativeDirect
Mammalian Phenotype (MP)lymph node hypoplasia0.0006052Highly InformativeDirect
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.02817Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.04148Highly InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.04961Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.09552Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.000001176Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.000793Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4928Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000000157InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000001133InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.1711Least InformativeInherited
Drugbank ATC_code (DB)immunosuppressants0.00278Moderately InformativeInherited
Drugbank ATC_code (DB)interleukin inhibitors0.00004847InformativeDirect
Drugbank ATC_code (DB)basiliximab0.000007234Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processCytolysis0.000000000005151InformativeDirect
Biological processAngiogenesis0.0000009258InformativeDirect
Biological processInnate immunity0.00008121InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway0.000004697Highly InformativeDirect
Cellular componentMembrane0.0000000000002506Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000000981Moderately InformativeDirect
Cellular componentCell junction0.000001201Moderately InformativeDirect
Cellular componentExtracellular matrix0.00001371InformativeDirect
Cellular componentGPI-anchor0.0007123InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.06336Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain0.00000003606InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionHeparin-binding0.00000000001367InformativeDirect
Post-translational modificationHydrolase0.2323Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000003097Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001656Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation9.502e-16InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]