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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (176) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 31,786 0 82
Proteins 6,968 0 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06685Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0000001027Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0006283Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0006393Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.02053Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02983Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.07958Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.01415InformativeInherited
Disease Ontology (DO)nephritis0.03024InformativeInherited
Disease Ontology (DO)degeneration of macula and posterior pole0.0000000002166Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.003838Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1705InformativeInherited
Phenotypic Abnormality (PA)Recurrent Neisserial infections0.0000007904Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.07256Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.266Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7396Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01888Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005218InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.006063InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.02345InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1007InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1444InformativeInherited
Mammalian Phenotype (MP)biphasic excitatory postsynaptic current amplitude0.00000007303Highly InformativeDirect
Mammalian Phenotype (MP)abnormal complement pathway0.0000005428Highly InformativeDirect
Mammalian Phenotype (MP)short excitatory postsynaptic current rise time0.00001439Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0001709Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.0002134Highly InformativeDirect
Mammalian Phenotype (MP)lymph node hypoplasia0.0006335Highly InformativeDirect
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.02646Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.04155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.05005Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.09605Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6507Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.00913Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4904Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000003163InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000001335InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0.0005713Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processCytolysis0.000000000007956InformativeDirect
Biological processAngiogenesis0.000001066InformativeDirect
Biological processInnate immunity0.00001552InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway0.000001134Highly InformativeDirect
Cellular componentMembrane0.0000000000005721Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002353Moderately InformativeDirect
Cellular componentCell junction0.000001992Moderately InformativeDirect
Cellular componentExtracellular matrix0.00001279InformativeDirect
Cellular componentGPI-anchor0.0007169InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.06513Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain0.00000009049InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationHydrolase0.2431Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000004066Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationHeparin-binding0.00000000001749InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001914Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation0.00000000000002114InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]