SUPERFAMILY 1.75 HMM library and genome assignments server


Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (169) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 32,098 33,806 82
Proteins 6,894 7,758 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 5.685e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.1174 Least Informative Inherited
Biological Process (BP) developmental process 0.5058 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.002415 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 2.545e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 1.883e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.994e-08 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002131 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0003936 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.5572 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.001572 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8258 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.731 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7146 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8996 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9729 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5629 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.08231 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5237 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3118 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 1.257e-09 Informative Direct
Biological Process (BP) response to other organism 4.363e-08 Informative Direct
Biological Process (BP) regulation of immune effector process 2.015e-06 Informative Direct
Biological Process (BP) biological adhesion 2.245e-06 Informative Direct
Biological Process (BP) regulation of defense response 5.336e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.592e-05 Informative Direct
Biological Process (BP) immune effector process 4.347e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0004489 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.004462 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7906 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01046 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1242 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.003133 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.2775 Informative Inherited
Biological Process (BP) synaptic transmission 0.001506 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3321 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5143 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.481 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.05684 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07724 Informative Inherited
Biological Process (BP) response to lipid 0.05059 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02072 Informative Inherited
Biological Process (BP) central nervous system development 0.1227 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0028 Informative Inherited
Biological Process (BP) regulation of cell development 0.09708 Informative Inherited
Biological Process (BP) generation of neurons 0.3188 Informative Inherited
Biological Process (BP) single-organism behavior 0.006546 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.02062 Informative Inherited
Biological Process (BP) response to wounding 0.7076 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6276 Informative Inherited
Biological Process (BP) sexual reproduction 0.1819 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9183 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9348 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1676 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) humoral immune response 8.503e-10 Highly Informative Direct
Biological Process (BP) cell adhesion 1.2e-07 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 7.476e-07 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 2.7e-06 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.802e-06 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 4.629e-06 Highly Informative Direct
Biological Process (BP) regulation of coagulation 5.538e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 6.19e-06 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 2.785e-05 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 5.077e-05 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.624e-05 Highly Informative Direct
Biological Process (BP) fertilization 6.061e-05 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 9.261e-05 Highly Informative Direct
Biological Process (BP) hemostasis 9.356e-05 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 9.418e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0001261 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001821 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002872 Highly Informative Direct
Biological Process (BP) B cell activation 0.0003196 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0007657 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.03173 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.00181 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.002022 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2435 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.01524 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01223 Highly Informative Inherited
Biological Process (BP) coagulation 0.001542 Highly Informative Inherited
Biological Process (BP) wound healing 0.4789 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.598 Highly Informative Inherited
Biological Process (BP) innate immune response 0.05077 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 1 Highly Informative Inherited
Molecular Function (MF) binding 6.909e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.2811 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.347e-08 Informative Direct
Molecular Function (MF) peptidase activity 1.773e-05 Informative Direct
Molecular Function (MF) sulfur compound binding 4.082e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0004643 Informative Direct
Molecular Function (MF) serine hydrolase activity 2.685e-07 Highly Informative Direct
Molecular Function (MF) heparin binding 5.181e-07 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.009035 Highly Informative Inherited
Cellular Component (CC) membrane 9.638e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 3.543e-09 Moderately Informative Direct
Cellular Component (CC) plasma membrane 3.271e-08 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 5.516e-10 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 5.894e-10 Informative Direct
Cellular Component (CC) vacuolar part 1.893e-05 Informative Direct
Cellular Component (CC) secretory granule 6.52e-05 Informative Direct
Cellular Component (CC) synapse part 0.000299 Informative Direct
Cellular Component (CC) extracellular space 0.005787 Informative Inherited
Cellular Component (CC) neuron projection 0.6833 Informative Inherited
Cellular Component (CC) sperm part 1.498e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 2.155e-07 Highly Informative Direct
Cellular Component (CC) cell body 8.395e-07 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0002408 Highly Informative Direct
Cellular Component (CC) dendrite 0.01118 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases2.461e-14Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases1.466e-07InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s1.393e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r1.393e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease2.708e-05Least InformativeDirect
Disease Ontology (DO)nervous system disease0.08121Least InformativeInherited
Disease Ontology (DO)syndrome0.0004593Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.000481Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.001566Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02697Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.05705Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.09965Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.02027InformativeInherited
Disease Ontology (DO)nephritis0.02732InformativeInherited
Disease Ontology (DO)retinal disease0.07554InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.9841InformativeInherited
Disease Ontology (DO)normocytic anemia7.802e-14Highly InformativeDirect
Disease Ontology (DO)degeneration of macula and posterior pole2.12e-10Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.1703Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.221InformativeInherited
Phenotypic Abnormality (PA)Recurrent meningococcal disease5.095e-07Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.03254Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2066Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6002Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.867Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.006417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1295Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.7866Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8902Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.004914InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005221InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.01541InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1161InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1611InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.2187InformativeInherited
Mammalian Phenotype (MP)abnormal complement pathway9.465e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.0001919Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level0.0003045Highly InformativeDirect
Mammalian Phenotype (MP)abnormal excitatory postsynaptic currents0.02162Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.03484Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.04913Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.1029Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.4234Least InformativeInherited
Xenopus ANatomical entity (XAN)adipose tissue0.0001614Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.987e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5044Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.776e-14InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor1.208e-07InformativeDirect
Enzyme Commission (EC)Peroxidases1.159e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processCytolysis4.353e-12InformativeDirect
Biological processInnate immunity8.229e-08InformativeDirect
Biological processAngiogenesis7.854e-07InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway1.996e-05Highly InformativeDirect
Cellular componentMembrane1.597e-13Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.79e-12Moderately InformativeDirect
Cellular componentCell junction1.877e-06Moderately InformativeDirect
Cellular componentExtracellular matrix1.84e-05InformativeDirect
Cellular componentGPI-anchor0.0006059InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.08193Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain6.153e-08InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionHeparin-binding1.07e-11InformativeDirect
Post-translational modificationHydrolase0.1971Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor4.421e-10Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001555Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation1.353e-15InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]