SUPERFAMILY 1.75 HMM library and genome assignments server


Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (165) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30,400 0 82
Proteins 6,567 0 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 2.964e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) localization 0.09358 Least Informative Inherited
Biological Process (BP) developmental process 0.4205 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.003001 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1.194e-12 Moderately Informative Direct
Biological Process (BP) multi-organism process 6.52e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.457e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0001086 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003734 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0009314 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.554 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8215 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7415 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7148 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8992 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9748 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.5653 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.083 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.448 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3383 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 7.073e-10 Informative Direct
Biological Process (BP) response to other organism 4.3e-08 Informative Direct
Biological Process (BP) biological adhesion 1.459e-06 Informative Direct
Biological Process (BP) regulation of immune effector process 2.142e-06 Informative Direct
Biological Process (BP) regulation of response to stress 2.508e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 2.599e-05 Informative Direct
Biological Process (BP) immune effector process 4.493e-05 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 0.0003767 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.004397 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.8052 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01025 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.1185 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2107 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.01109 Informative Inherited
Biological Process (BP) cell-cell signaling 0.09889 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3318 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.514 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.4994 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.03568 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.04616 Informative Inherited
Biological Process (BP) response to lipid 0.03063 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.02179 Informative Inherited
Biological Process (BP) central nervous system development 0.121 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002673 Informative Inherited
Biological Process (BP) regulation of cell development 0.09794 Informative Inherited
Biological Process (BP) generation of neurons 0.3246 Informative Inherited
Biological Process (BP) single-organism behavior 0.005099 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.01802 Informative Inherited
Biological Process (BP) response to wounding 0.7098 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.5984 Informative Inherited
Biological Process (BP) sexual reproduction 0.1606 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8925 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8918 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1599 Informative Inherited
Biological Process (BP) regulation of humoral immune response 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) protein activation cascade 0 Highly Informative Direct
Biological Process (BP) activation of immune response 1.761e-14 Highly Informative Direct
Biological Process (BP) humoral immune response 1.084e-09 Highly Informative Direct
Biological Process (BP) cell adhesion 6.915e-08 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 7.388e-07 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 2.156e-06 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 3.717e-06 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 3.861e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 5.182e-06 Highly Informative Direct
Biological Process (BP) regulation of coagulation 5.636e-06 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 2.447e-05 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 4.298e-05 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 4.585e-05 Highly Informative Direct
Biological Process (BP) fertilization 5.115e-05 Highly Informative Direct
Biological Process (BP) hemostasis 7.475e-05 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 8.64e-05 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 9.03e-05 Highly Informative Direct
Biological Process (BP) adult behavior 0.0001558 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0002539 Highly Informative Direct
Biological Process (BP) B cell activation 0.0002689 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0006605 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.03209 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.001764 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.001835 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2444 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01255 Highly Informative Inherited
Biological Process (BP) coagulation 0.001263 Highly Informative Inherited
Biological Process (BP) wound healing 0.4743 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.534 Highly Informative Inherited
Biological Process (BP) innate immune response 0.04924 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.1988 Highly Informative Inherited
Molecular Function (MF) binding 5.216e-08 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.9949 Least Informative Inherited
Molecular Function (MF) anion binding 0.2814 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1.172e-08 Informative Direct
Molecular Function (MF) peptidase activity 1.304e-05 Informative Direct
Molecular Function (MF) sulfur compound binding 3.704e-05 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000318 Informative Direct
Molecular Function (MF) heparin binding 5.337e-07 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 0.008741 Highly Informative Inherited
Cellular Component (CC) membrane 6.815e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.965e-08 Moderately Informative Direct
Cellular Component (CC) vesicle 1.437e-06 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 3.074e-10 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.365e-06 Informative Direct
Cellular Component (CC) vacuolar part 1.524e-05 Informative Direct
Cellular Component (CC) secretory granule 6.436e-05 Informative Direct
Cellular Component (CC) synapse part 0.000235 Informative Direct
Cellular Component (CC) neuron projection 0.6816 Informative Inherited
Cellular Component (CC) sperm part 1.173e-07 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 2.472e-07 Highly Informative Direct
Cellular Component (CC) cell body 6.388e-07 Highly Informative Direct
Cellular Component (CC) neuron spine 3.816e-05 Highly Informative Direct
Cellular Component (CC) blood microparticle 5.527e-05 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000208 Highly Informative Direct
Cellular Component (CC) dendrite 0.00956 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases2.461e-14Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases1.466e-07InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s1.393e-11Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r1.393e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease1.851e-05Least InformativeDirect
Disease Ontology (DO)nervous system disease0.08543Least InformativeInherited
Disease Ontology (DO)syndrome0.0004752Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.000505Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00148Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.02502Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.04684Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.05107Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.1939Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease5.547e-05InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.007027InformativeInherited
Disease Ontology (DO)nephritis0.02524InformativeInherited
Disease Ontology (DO)retinal disease0.07496InformativeInherited
Disease Ontology (DO)anemia0.1718InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.8482InformativeInherited
Disease Ontology (DO)normocytic anemia6.865e-14Highly InformativeDirect
Disease Ontology (DO)degeneration of macula and posterior pole2.373e-10Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.1708Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.2134InformativeInherited
Phenotypic Abnormality (PA)Recurrent meningococcal disease5.349e-07Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.02235Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1705Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5493Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8906Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.004747Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.1211Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.7856Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.004378InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.005121InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.01387InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1141InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1624InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.1859InformativeInherited
Mammalian Phenotype (MP)abnormal complement pathway9.371e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Purkinje cell innervation0.000193Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating alanine transaminase level0.0002728Highly InformativeDirect
Mammalian Phenotype (MP)abnormal excitatory postsynaptic currents0.02178Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.03383Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cellular extravasation0.0491Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.1035Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.4232Least InformativeInherited
Xenopus ANatomical entity (XAN)adipose tissue0.0001613Highly InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage1.989e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.5038Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.776e-14InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor1.188e-07InformativeDirect
Enzyme Commission (EC)Peroxidases1.14e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processCytolysis4.33e-12InformativeDirect
Biological processInnate immunity8.218e-08InformativeDirect
Biological processAngiogenesis7.915e-07InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway1.993e-05Highly InformativeDirect
Cellular componentMembrane1.453e-13Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle8.92e-12Moderately InformativeDirect
Cellular componentCell junction1.897e-06Moderately InformativeDirect
Cellular componentExtracellular matrix1.891e-05InformativeDirect
Cellular componentGPI-anchor0.0006138InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.07928Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain6.329e-08InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionHeparin-binding1.084e-11InformativeDirect
Post-translational modificationHydrolase0.1962Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor4.556e-10Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001536Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation1.788e-15InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]