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Complement control module/SCR domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Families:   Complement control module/SCR domain [ 57536] (14)


Superfamily statistics
Genomes (176) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 31,786 66,077 82
Proteins 6,968 15,481 40


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000000005314 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.3844 Least Informative Inherited
Biological Process (BP) biological regulation 0.07576 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7746 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05169 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00003531 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000000000007148 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000001166 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000005263 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000006178 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.2139 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.03264 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.2257 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7712 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1945 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.002622 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.02251 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5683 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.5233 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7816 Moderately Informative Inherited
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000000001925 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) regulation of defense response 0.00000001076 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000000001925 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00000242 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.917 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4509 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8471 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4702 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.3803 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.09653 Informative Inherited
Biological Process (BP) defense response to other organism 0.0423 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1008 Informative Inherited
Biological Process (BP) response to oxidative stress 0.9015 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7843 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.05773 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.004576 Informative Inherited
Biological Process (BP) response to extracellular stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02587 Informative Inherited
Biological Process (BP) immune effector process 0.001154 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.005188 Informative Inherited
Biological Process (BP) locomotion 0.02612 Informative Inherited
Biological Process (BP) localization of cell 0.02 Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000009735 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000809 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00004566 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0005244 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0004759 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.01781 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.1327 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.3323 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.07441 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.02138 Highly Informative Inherited
Biological Process (BP) response to molecule of bacterial origin 0.005253 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.03988 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Molecular Function (MF) binding 0.03717 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.6486 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3579 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0.09606 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 1 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0.0000001641 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.002641 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.008345 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.000001211 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00001006 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.2756 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.5058 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.611 Moderately Informative Inherited
Cellular Component (CC) cell surface 0.00000000000008837 Informative Direct
Cellular Component (CC) secretory granule 0.00001344 Informative Direct
Cellular Component (CC) extracellular organelle 0.000000002537 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0009292 Informative Direct
Cellular Component (CC) extracellular space 0.0798 Informative Inherited
Cellular Component (CC) blood microparticle 0.00002016 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.4049 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4992Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00000000000002461Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001466InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001393Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001393Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processCytolysis0.000000000008217InformativeDirect
Biological processAngiogenesis0.0000009926InformativeDirect
Biological processInnate immunity0.00001098InformativeDirect
Biological processAcute phase0Highly InformativeDirect
Biological processComplement pathway0Highly InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processComplement alternate pathway0.00000368Highly InformativeDirect
Cellular componentMembrane0.000000000000484Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000001844Moderately InformativeDirect
Cellular componentCell junction0.000001436Moderately InformativeDirect
Cellular componentExtracellular matrix0.00001224InformativeDirect
Cellular componentGPI-anchor0.0007446InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.06461Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainImmunoglobulin domain0.00000006534InformativeDirect
DomainSushi0Highly InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationHydrolase0.2288Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor0.00000000000308Moderately InformativeDirect
Post-translational modificationOxidoreductase1Moderately InformativeInherited
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationHeparin-binding0.0000000000179InformativeDirect
Post-translational modificationAntibiotic0Highly InformativeDirect
Post-translational modificationPeroxidase0.0001952Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationHydroxylation9.634e-16InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the Complement control module/SCR domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]