SUPERFAMILY 1.75 HMM library and genome assignments server


Blood coagulation inhibitor (disintegrin) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Blood coagulation inhibitor (disintegrin) [ 57551]
Superfamily:   Blood coagulation inhibitor (disintegrin) [ 57552]
Families:   Blood coagulation inhibitor (disintegrin) [ 57553] (6)


Superfamily statistics
Genomes (296) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,582 3,448 13
Proteins 2,463 3,353 13


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.015180.01178Least InformativeInherited
Biological Process (BP)reproduction2.081e-056.537e-10Moderately InformativeDirect
Biological Process (BP)biological adhesion8.764e-071.085e-14InformativeDirect
Biological Process (BP)single organism reproductive process1.399e-061.936e-15InformativeDirect
Biological Process (BP)cell adhesion7.783e-061.208e-13Highly InformativeDirect
Molecular Function (MF)binding0.0029470.0005421Least InformativeInherited
Molecular Function (MF)receptor binding0.0011641.474e-08InformativeInherited
Molecular Function (MF)protein complex binding5.686e-061.044e-14Highly InformativeDirect
Cellular Component (CC)cell surface1.974e-060InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0002273 Least Informative Direct
Biological Process (BP) protein metabolic process 9.463e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.4318 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01178 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09816 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.507 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 6.537e-10 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.4909 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1601 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07762 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5049 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02356 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3202 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.436 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5689 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9182 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5132 Moderately Informative Inherited
Biological Process (BP) organ development 0.7411 Moderately Informative Inherited
Biological Process (BP) tissue development 0.112 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.01643 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5914 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.696 Moderately Informative Inherited
Biological Process (BP) biological adhesion 1.085e-14 Informative Direct
Biological Process (BP) single organism reproductive process 1.936e-15 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.657e-09 Informative Direct
Biological Process (BP) sexual reproduction 6.584e-07 Informative Direct
Biological Process (BP) cardiovascular system development 0.000125 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.006024 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.06636 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0802 Informative Inherited
Biological Process (BP) regulation of cell development 0.1989 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.005109 Informative Inherited
Biological Process (BP) gland development 0.007571 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9988 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) regulation of growth 0.004075 Informative Inherited
Biological Process (BP) muscle structure development 0.01911 Informative Inherited
Biological Process (BP) muscle tissue development 0.006096 Informative Inherited
Biological Process (BP) localization of cell 0.005528 Informative Inherited
Biological Process (BP) locomotion 0.08865 Informative Inherited
Biological Process (BP) cellular component movement 0.2863 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1167 Informative Inherited
Biological Process (BP) cell adhesion 1.208e-13 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.023e-09 Highly Informative Direct
Biological Process (BP) fertilization 2.371e-08 Highly Informative Direct
Biological Process (BP) heart morphogenesis 4.415e-06 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 4.229e-05 Highly Informative Direct
Biological Process (BP) adult behavior 4.24e-05 Highly Informative Direct
Biological Process (BP) regulation of cell size 6.041e-05 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0004628 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0005322 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0006764 Highly Informative Direct
Biological Process (BP) renal system development 0.003673 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.002096 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.02883 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.001531 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001817 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.001483 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5664 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.7545 Highly Informative Inherited
Molecular Function (MF) binding 0.0005421 Least Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) cation binding 0.0001377 Moderately Informative Direct
Molecular Function (MF) receptor binding 1.474e-08 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.02765 Informative Inherited
Molecular Function (MF) transition metal ion binding 0.002821 Informative Inherited
Molecular Function (MF) protein complex binding 1.044e-14 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 5.632e-05 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 4.814e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 7.025e-08 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.2068 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01215 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01277 Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 2.583e-08 Highly Informative Direct
Cellular Component (CC) membrane raft 9.237e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.009476Least InformativeInherited
Disease Ontology (DO)artery disease0.00143Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis9.069e-05InformativeDirect
Disease Ontology (DO)breast carcinoma0.0002382InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.3706Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.2311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2613Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.003741InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.08539InformativeInherited
Mammalian Phenotype (MP)abnormal semilunar valve morphology9.253e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology1.197e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology1.931e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology5.787e-05Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0002065Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart and great vessel attachment0.007536Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.1896Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.2166Least InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.0007707InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis4.713e-16Moderately InformativeDirect
Biological processDifferentiation4.177e-08Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processAngiogenesis6.248e-12InformativeDirect
Biological processNotch signaling pathway7.458e-14Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1355Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0004079Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues8.066e-09Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001762 SSF57552 Protein matches
Abstract

Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [PubMed15578957, PubMed15974889]. Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen [PubMed12050803]. The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant [PubMed16918409].

Disintegrins from different snake species have been characterised: albolabrin, applagin, barbourin, batroxostatin, bitistatin, obtustatin [PubMed12742023], schistatin [PubMed16101289], echistatin [PubMed15535803], elegantin, eristicophin, flavoridin [PubMed14499613], halysin, kistrin, tergeminin, salmosin [PubMed14661951] and triflavin.

Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain a disintegrin domain are:

  • Some snake venom zinc metalloproteinases [PubMed15962120] consist of an N-terminal catalytic domain fused to a disintegrin domain. Such is the case for trimerelysin I (HR1B), atrolysin-e (Ht-e) and trigramin. It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing.
  • The beta-subunit of guinea pig sperm surface protein PH30 [PubMed1552944]. PH30 is a protein involved in sperm-egg fusion. The beta subunit contains a disintegrin at the N-terminal extremity.
  • Mammalian epididymial apical protein 1 (EAP I) [PubMed1417724]. EAP I is associated with the sperm membrane and may play a role in sperm maturation. Structurally, EAP I consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Blood coagulation inhibitor (disintegrin) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Blood coagulation inhibitor (disintegrin) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]