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Blood coagulation inhibitor (disintegrin) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Blood coagulation inhibitor (disintegrin) [ 57551]
Superfamily:   Blood coagulation inhibitor (disintegrin) [ 57552]
Families:   Blood coagulation inhibitor (disintegrin) [ 57553] (6)


Superfamily statistics
Genomes (305) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,612 6,789 13
Proteins 2,492 6,510 13


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.30360.6112Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0006120.0006335Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.0019030.001355Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0028470.001168Moderately InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.00002590.0001601InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.0000099410.1067InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.000031610.2418InformativeInherited
Biological Process (BP)negative regulation of response to external stimulus0.00000022310.00009318Highly InformativeDirect
Biological Process (BP)negative regulation of coagulation0.00000000047650.00000000006132Highly InformativeDirect
Biological Process (BP)negative regulation of hemostasis0.0000000002060.00000000003341Highly InformativeDirect
Biological Process (BP)regulation of response to wounding0.000000024830.0000001888Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000001077 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000134 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.07277 Least Informative Inherited
Biological Process (BP) biological regulation 0.6112 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8676 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8679 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.002955 Least Informative Inherited
Biological Process (BP) reproduction 0.000000002622 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000452 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0006335 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000001455 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.001355 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5089 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01125 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4154 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0499 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.06937 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2284 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001168 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.06802 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.755 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6536 Moderately Informative Inherited
Biological Process (BP) cell communication 0.00166 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.191 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.456 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8041 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1474 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000009744 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0001601 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000000000324 Informative Direct
Biological Process (BP) localization of cell 0.00007027 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.003035 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.006946 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.08139 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.002676 Informative Inherited
Biological Process (BP) behavior 0.01745 Informative Inherited
Biological Process (BP) circulatory system development 0.01175 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1457 Informative Inherited
Biological Process (BP) regulation of growth 0.002906 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0419 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.01848 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1304 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.1067 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2418 Informative Inherited
Biological Process (BP) generation of neurons 0.8378 Informative Inherited
Biological Process (BP) reproductive system development 0.002665 Informative Inherited
Biological Process (BP) central nervous system development 0.08049 Informative Inherited
Biological Process (BP) locomotion 0.0106 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.003278 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.00851 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.01644 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.05279 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5412 Informative Inherited
Biological Process (BP) epithelium development 0.3077 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of cell growth 0.00001374 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0006955 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0008355 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001846 Highly Informative Direct
Biological Process (BP) fertilization 0.00000398 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000004941 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0003547 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00009318 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00001452 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0002316 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.00000000006132 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.00000000003341 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.0000001888 Highly Informative Direct
Biological Process (BP) muscle organ development 0.01665 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001052 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.002371 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.001041 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02882 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.001642 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2409 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5774 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.005137 Highly Informative Inherited
Biological Process (BP) heart development 0.00827 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2536 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0002212 Moderately Informative Direct
Molecular Function (MF) receptor binding 0.000003136 Informative Direct
Molecular Function (MF) zinc ion binding 0.00000001222 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000003893 Informative Direct
Molecular Function (MF) enzyme binding 0.008635 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.001408 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00005724 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000000000001962 Highly Informative Direct
Cellular Component (CC) membrane 0.000000002798 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000001143 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.7098 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.01268 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1644 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.007054 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) membrane region 0.03966 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.006552 Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.000001658 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis4.848e-16Moderately InformativeDirect
Biological processDifferentiation0.0000001348Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processAngiogenesis0.000000000009654InformativeDirect
Biological processNotch signaling pathway0.00000000000008128Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0007977Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.07293Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0003926Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.0000000001495Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001762 SSF57552 Protein matches
Abstract

Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [PubMed15578957, PubMed15974889]. Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen [PubMed12050803]. The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant [PubMed16918409].

Disintegrins from different snake species have been characterised: albolabrin, applagin, barbourin, batroxostatin, bitistatin, obtustatin [PubMed12742023], schistatin [PubMed16101289], echistatin [PubMed15535803], elegantin, eristicophin, flavoridin [PubMed14499613], halysin, kistrin, tergeminin, salmosin [PubMed14661951] and triflavin.

Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain a disintegrin domain are:

  • Some snake venom zinc metalloproteinases [PubMed15962120] consist of an N-terminal catalytic domain fused to a disintegrin domain. Such is the case for trimerelysin I (HR1B), atrolysin-e (Ht-e) and trigramin. It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing.
  • The beta-subunit of guinea pig sperm surface protein PH30 [PubMed1552944]. PH30 is a protein involved in sperm-egg fusion. The beta subunit contains a disintegrin at the N-terminal extremity.
  • Mammalian epididymial apical protein 1 (EAP I) [PubMed1417724]. EAP I is associated with the sperm membrane and may play a role in sperm maturation. Structurally, EAP I consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Blood coagulation inhibitor (disintegrin) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Blood coagulation inhibitor (disintegrin) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]