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Blood coagulation inhibitor (disintegrin) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Blood coagulation inhibitor (disintegrin) [ 57551]
Superfamily:   Blood coagulation inhibitor (disintegrin) [ 57552]
Families:   Blood coagulation inhibitor (disintegrin) [ 57553] (6)


Superfamily statistics
Genomes (303) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,595 6,789 13
Proteins 2,475 6,510 13


Functional annotation
General category Processes_EC
Detailed category Blood clotting

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.0000001631 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000001212 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7639 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7137 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.00312 Least Informative Inherited
Biological Process (BP) biological regulation 0.7604 Least Informative Inherited
Biological Process (BP) reproduction 0.00000001888 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001622 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0003934 Moderately Informative Direct
Biological Process (BP) cell communication 0.0009318 Moderately Informative Direct
Biological Process (BP) system development 0.4369 Moderately Informative Inherited
Biological Process (BP) immune system process 0.007342 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.3748 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.977 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.03811 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1293 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1322 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.09926 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2078 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.00522 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3824 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.009556 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3362 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.425 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8599 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1536 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000000008312 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0000009204 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0008324 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0009691 Informative Direct
Biological Process (BP) regulation of proteolysis 0.005969 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.07011 Informative Inherited
Biological Process (BP) behavior 0.01249 Informative Inherited
Biological Process (BP) circulatory system development 0.007712 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.07548 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002397 Informative Inherited
Biological Process (BP) regulation of locomotion 0.004333 Informative Inherited
Biological Process (BP) generation of neurons 0.8358 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.02811 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.06736 Informative Inherited
Biological Process (BP) reproductive system development 0.01034 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.07783 Informative Inherited
Biological Process (BP) locomotion 0.01522 Informative Inherited
Biological Process (BP) central nervous system development 0.06599 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.005023 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.01527 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01822 Informative Inherited
Biological Process (BP) tissue development 0.5813 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.0442 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4841 Informative Inherited
Biological Process (BP) cell development 0.9608 Informative Inherited
Biological Process (BP) regulation of growth 0.001443 Informative Inherited
Biological Process (BP) fertilization 0.000002831 Highly Informative Direct
Biological Process (BP) biological adhesion 0.000003319 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000008392 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000009097 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0001136 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0002011 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.0003059 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0005425 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0005494 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0006589 Highly Informative Direct
Biological Process (BP) muscle structure development 0.01634 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.006596 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.002072 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.01962 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1795 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5733 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.003971 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.269 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000154 Moderately Informative Direct
Molecular Function (MF) zinc ion binding 0.000000007545 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000002382 Informative Direct
Molecular Function (MF) receptor binding 0.000001802 Informative Direct
Molecular Function (MF) enzyme binding 0.006652 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.001903 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000000000001061 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00006338 Highly Informative Direct
Cellular Component (CC) membrane 0.000000003522 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000001953 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.6836 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.008891 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01423 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) membrane region 0.03699 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.004665 Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.000000003213 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.003295Least InformativeInherited
Disease Ontology (DO)artery disease0.0007251Moderately InformativeDirect
Disease Ontology (DO)atherosclerosis0.00001952InformativeDirect
Disease Ontology (DO)integumentary system cancer0.005231Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.4346Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.08123Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.3211Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.0716InformativeInherited
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.000001336Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.000001336Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.000002027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.000007486Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.00006732Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0002367Highly InformativeDirect
Mammalian Phenotype (MP)double outlet right ventricle0.0003109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid morphology0.003046Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis4.844e-16Moderately InformativeDirect
Biological processDifferentiation0.0000001026Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processAngiogenesis0.000000000007454InformativeDirect
Biological processNotch signaling pathway0.00000000000006949Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.0008549Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.1306Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000324Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0.000000001589Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001762 SSF57552 Protein matches
Abstract

Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [PubMed15578957, PubMed15974889]. Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen [PubMed12050803]. The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant [PubMed16918409].

Disintegrins from different snake species have been characterised: albolabrin, applagin, barbourin, batroxostatin, bitistatin, obtustatin [PubMed12742023], schistatin [PubMed16101289], echistatin [PubMed15535803], elegantin, eristicophin, flavoridin [PubMed14499613], halysin, kistrin, tergeminin, salmosin [PubMed14661951] and triflavin.

Disintegrin-like proteins are found in various species ranging from slime mold to humans. Some other proteins known to contain a disintegrin domain are:

  • Some snake venom zinc metalloproteinases [PubMed15962120] consist of an N-terminal catalytic domain fused to a disintegrin domain. Such is the case for trimerelysin I (HR1B), atrolysin-e (Ht-e) and trigramin. It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing.
  • The beta-subunit of guinea pig sperm surface protein PH30 [PubMed1552944]. PH30 is a protein involved in sperm-egg fusion. The beta subunit contains a disintegrin at the N-terminal extremity.
  • Mammalian epididymial apical protein 1 (EAP I) [PubMed1417724]. EAP I is associated with the sperm membrane and may play a role in sperm maturation. Structurally, EAP I consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Blood coagulation inhibitor (disintegrin) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Blood coagulation inhibitor (disintegrin) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]