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Heparin-binding domain from vascular endothelial growth factor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Heparin-binding domain from vascular endothelial growth factor [ 57592]
Superfamily:   Heparin-binding domain from vascular endothelial growth factor [ 57593]
Families:   Heparin-binding domain from vascular endothelial growth factor [ 57594]


Superfamily statistics
Genomes (57) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 138 355 1
Proteins 138 355 1


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0000004829 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001233 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0112 Least Informative Inherited
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) immune system process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000000000178 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000000007694 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00000000002741 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00000000007482 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000000006971 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000000103 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000003267 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000001052 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000003437 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000005828 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000002568 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000006998 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00001324 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0001097 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001796 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.6493 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.005037 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8979 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5705 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.3243 Moderately Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hemopoiesis 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0 Informative Direct
Biological Process (BP) regulation of protein modification process 0 Informative Direct
Biological Process (BP) circulatory system development 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.00000000000001763 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0000000000009054 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000005003 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000001713 Informative Direct
Biological Process (BP) positive regulation of transport 0.00000000254 Informative Direct
Biological Process (BP) generation of neurons 0.00000004703 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000004091 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000136 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00376 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.002341 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001135 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.003105 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6324 Informative Inherited
Biological Process (BP) cell chemotaxis 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) response to growth factor 0.000000000000001925 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000000001982 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.00000008055 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.000004548 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00005452 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.000155 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.007087 Highly Informative Inherited
Molecular Function (MF) binding 0.00008948 Least Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0 Informative Direct
Molecular Function (MF) heparin binding 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000000000001864 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000818 Least Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000000000005254 Moderately Informative Direct
Cellular Component (CC) secretory granule 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00000005845Least InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heparin-binding domain from vascular endothelial growth factor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Heparin-binding domain from vascular endothelial growth factor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]