SUPERFAMILY 1.75 HMM library and genome assignments server

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Thyroglobulin type-1 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Thyroglobulin type-1 domain [ 57609]
Superfamily:   Thyroglobulin type-1 domain [ 57610]
Families:   Thyroglobulin type-1 domain [ 57611] (4)


Superfamily statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,349 13,614 5
Proteins 1,846 6,094 5


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2041Least InformativeInherited
Disease Ontology (DO)endocrine system disease0.03275Moderately InformativeInherited
Disease Ontology (DO)urinary system cancer0.002036InformativeInherited
Disease Ontology (DO)renal cell carcinoma0.00004827Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00005447Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8158Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.07868Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.002003InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.1242InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2572InformativeInherited
Mammalian Phenotype (MP)decreased quadriceps weight0.0000006695Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0008346Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.002786Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.003866Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.009792Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.00004882Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00002108InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR000716 SSF57610 Protein matches
Abstract

Thyroglobulin (Tg) is a large glycoprotein specific to the thyroid gland and is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The N-terminal section of Tg contains 10 repeats of a domain of about 65 amino acids which is known as the Tg type-1 repeat [PubMed3595599, PubMed8797845]. Such a domain has also been found as a single or repeated sequence in the HLA class II associated invariant chain [PubMed3038530]; human pancreatic carcinoma marker proteins GA733-1 and GA733-2 [PubMed2333300]; nidogen (entactin), a sulphated glycoprotein which is widely distributed in basement membranes and that is tightly associated with laminin; insulin-like growth factor binding proteins (IGFBP) [PubMed1709161]; saxiphilin, a transferrin-like protein from Rana catesbeiana (Bull frog) that binds specifically to the neurotoxin saxitoxin [PubMed8146142]; chum salmon egg cysteine proteinase inhibitor, and equistatin, a thiol-protease inhibitor from Actinia equina (sea anemone) [PubMed9153250]. The existence of Thyr-1 domains in such a wide variety of proteins raises questions about their activity and function, and their interactions with neighbouring domains. The Thyr-1 and related domains belong to MEROPS proteinase inhibitor family I31, clan IX.

Equistatin from A. equina is composed of three Thyr-1 domains; as with other proteins that contains Thyr-1 domains, the thyropins, they bind reversibly and tightly to cysteine proteases (inhibitor family C1). In equistatin inhibition of papain is a function of domain-1. Unusually domain-2 inhibits cathepsin D, an aspartic protease (inhibitor family A1) and has no activity against papain. Domain-3, does not inhibit either papain or cathepsin D, and its function or its target peptidase has yet to be determined [PubMed9153250, PubMed12650938].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thyroglobulin type-1 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Thyroglobulin type-1 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Internal database links ]