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HIV-1 VPU cytoplasmic domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Other |
| Detailed category | Viral proteins |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR009032 SSF57647 Protein matches |
| Abstract | The human immunodeficiency virus type 1 Vpu transmembrane protein acts in the degradation of human CD4 receptor in the endoplasmic reticulum, and in the enhancement of virus particle release from the plasma membrane of infected cells. The cytoplasmic domain of Vpu is responsible for direct interaction with and degradation of the C4 receptor. The cytoplasmic domain encompasses the C-terminal half of the 81-residue protein, and is comprised of a few helical turns without an apparent hydrophobic core [ 9182993].
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a HIV-1 VPU cytoplasmic domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 1 hidden Markov models representing the HIV-1 VPU cytoplasmic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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