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beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (571) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 281,511 589,218 212
Proteins 82,748 206,349 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0029570Least InformativeInherited
Biological Process (BP)regulation of gene expression0.000034580Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000045430Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.000098770Moderately InformativeDirect
Biological Process (BP)system development0.00044750.0001135Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0099140Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.011540.275Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.26490.04367Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.11610.004648Moderately InformativeInherited
Biological Process (BP)animal organ morphogenesis0.00083080.00000202InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00063940.04219InformativeInherited
Molecular Function (MF)binding0.53260.0000000000000244Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000087220Moderately InformativeDirect
Molecular Function (MF)DNA binding0.0000011710InformativeDirect
Molecular Function (MF)chromatin binding0.0000000041790Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) system development 0.0001135 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000001022 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004126 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.2375 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.77 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2351 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.004648 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.04367 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.9776 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.275 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9368 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1471 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.00000202 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000000000008098 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00000002385 Informative Direct
Biological Process (BP) post-embryonic development 0.000006501 Informative Direct
Biological Process (BP) single organism reproductive process 0.0005988 Informative Direct
Biological Process (BP) chromosome organization 0.0007341 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.9622 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6827 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8911 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) response to metal ion 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09872 Informative Inherited
Biological Process (BP) cellular response to lipid 0.1067 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.9218 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.8515 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) sensory organ development 0.01965 Informative Inherited
Biological Process (BP) growth 0.9198 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4482 Informative Inherited
Biological Process (BP) central nervous system development 0.8196 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6101 Informative Inherited
Biological Process (BP) reproductive system development 0.1573 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.07429 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) ribosome biogenesis 1 Informative Inherited
Biological Process (BP) cell activation 0.0396 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00334 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1115 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.04219 Informative Inherited
Biological Process (BP) behavior 0.9672 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5171 Informative Inherited
Biological Process (BP) embryo development 0.005897 Informative Inherited
Biological Process (BP) generation of neurons 0.2085 Informative Inherited
Biological Process (BP) DNA metabolic process 0.852 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.96 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.999 Informative Inherited
Biological Process (BP) tissue development 0.002539 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.9776 Informative Inherited
Biological Process (BP) locomotion 0.827 Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) appendage development 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000000002206 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000000002042 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000000002124 Highly Informative Direct
Biological Process (BP) kidney development 0.00000001618 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000003042 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000002008 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.000001772 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000003577 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.000007752 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00005364 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0000545 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0001354 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0003597 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0004509 Highly Informative Direct
Biological Process (BP) protein alkylation 0.0008505 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9501 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.158 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1793 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.004718 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.7013 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 1 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.02329 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.8132 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.6227 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.8101 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.07107 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.5528 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.02241 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.0658 Highly Informative Inherited
Biological Process (BP) gene silencing 0.8722 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.03022 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.07224 Highly Informative Inherited
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.6097 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3564 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.9435 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.2906 Highly Informative Inherited
Biological Process (BP) cell division 0.7012 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.193 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2492 Highly Informative Inherited
Biological Process (BP) brain development 0.4736 Highly Informative Inherited
Biological Process (BP) neuron development 0.4112 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.005481 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.5728 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.05297 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.09258 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.03796 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.5368 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001954 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.3541 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.8358 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01342 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9842 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.9874 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.6894 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.06876 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.8225 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.6282 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.03517 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.003377 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.05841 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.862 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000000244 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1549 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00000003056 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00004208 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.5683 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.006819 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.05862 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.2637 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0003779 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.000000000004933 Informative Direct
Cellular Component (CC) cilium 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 0.00000001104 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.0009975 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.9269Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0009234Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.183InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00002298Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001431Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001064Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006866Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.01061Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9498Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.00000004074InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0002233InformativeDirect
Worm Phenotype (WP)male morphology variant0.0003763InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004032InformativeDirect
Worm Phenotype (WP)egg laying variant0.2865InformativeInherited
Worm Phenotype (WP)drug resistant0.3436InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.3874InformativeInherited
Worm Phenotype (WP)neuron migration variant1InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.00000666Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.006461Highly InformativeInherited
Worm Phenotype (WP)sex determination variant0.0265Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.000000000000003402Least InformativeDirect
Fly Anatomy (FA)adult0.000000000375Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000001261Least InformativeDirect
Fly Anatomy (FA)nervous system1Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)appendage0.000000000000005099Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0000000000009403Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.000000000001771Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.000000000525Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0.0000005183Moderately InformativeDirect
Fly Anatomy (FA)central nervous system1Moderately InformativeInherited
Fly Anatomy (FA)neuron1Moderately InformativeInherited
Fly Anatomy (FA)ganglion1Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.5718Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6502Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7483Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3742Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.9763Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.2709InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.6236Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0885Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2913Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.04041InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.09735InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.0001999Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0006155Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0006442Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.00122Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7782Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003757InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002404Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004575Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.0000004916Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0141Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.04218Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.407e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.000000000148InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.00000000000001914Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0004495InformativeDirect
Biological processSporulation0.03133InformativeInherited
Biological processAbscisic acid signaling pathway0.0000003947Highly InformativeDirect
Biological processGrowth regulation0.000197Highly InformativeDirect
Biological processFlowering0.0004311Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.0000002208InformativeDirect
Cellular componentSpliceosome0.00002727InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseMental retardation0.0002882InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.0000000000000249InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0.000000002465Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]