SUPERFAMILY 1.75 HMM library and genome assignments server


beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (564) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 277,547 297,723 212
Proteins 81,570 97,219 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.0092440Least InformativeInherited
Biological Process (BP)multicellular organismal process0.028768.605e-14Least InformativeInherited
Biological Process (BP)regulation of cellular process0.11150Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.16520Least InformativeInherited
Biological Process (BP)response to stimulus0.98691Least InformativeInherited
Biological Process (BP)regulation of gene expression1.104e-060Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process4.633e-060Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process7.975e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00012091.68e-09Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00052980Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0043820Moderately InformativeInherited
Biological Process (BP)organ development0.0055412.136e-11Moderately InformativeInherited
Biological Process (BP)tissue development0.067190.001259Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.14174.342e-11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.020760.0007642Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.074691Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.10450Moderately InformativeInherited
Biological Process (BP)immune system process0.011360.6637Moderately InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process4.726e-055.045e-06InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00034961.097e-05InformativeDirect
Biological Process (BP)regulation of immune effector process6.55e-061InformativeInherited
Biological Process (BP)negative regulation of developmental process0.0040560.0004224InformativeInherited
Biological Process (BP)regulation of immune response0.0012671InformativeInherited
Biological Process (BP)sensory organ development0.021041.202e-07InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0081481InformativeInherited
Biological Process (BP)response to wounding0.00069071InformativeInherited
Biological Process (BP)immune response0.0024011InformativeInherited
Biological Process (BP)defense response0.014421InformativeInherited
Biological Process (BP)mesenchyme development4.338e-061.813e-05Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation4.708e-051.931e-15Highly InformativeDirect
Biological Process (BP)negative regulation of cell activation9.306e-060.584Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.0039470.00324Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00010691Highly InformativeInherited
Biological Process (BP)regulation of T cell activation9.564e-070.1263Highly InformativeInherited
Biological Process (BP)inflammatory response1.354e-050.3429Highly InformativeInherited
Molecular Function (MF)binding0.17473.009e-12Least InformativeInherited
Molecular Function (MF)nucleic acid binding1.889e-080Moderately InformativeDirect
Molecular Function (MF)DNA binding2.396e-110InformativeDirect
Molecular Function (MF)chromatin binding1.342e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 8.605e-14 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.68e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 2.457e-05 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 2.136e-11 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0007642 Moderately Informative Direct
Biological Process (BP) cell differentiation 4.526e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 4.342e-11 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0002257 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001259 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3339 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.5443 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6637 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7222 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.8746 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.8007 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.02638 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0584 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.07676 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3018 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.003724 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8382 Moderately Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 5.045e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.097e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0004224 Informative Direct
Biological Process (BP) organ morphogenesis 1.971e-08 Informative Direct
Biological Process (BP) sensory organ development 1.202e-07 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 2.033e-13 Informative Direct
Biological Process (BP) leukocyte activation 2.528e-06 Informative Direct
Biological Process (BP) sexual reproduction 0.0001393 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0002279 Informative Direct
Biological Process (BP) embryonic organ development 0.0004003 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000408 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.07657 Informative Inherited
Biological Process (BP) response to lipid 0.7807 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1039 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.02156 Informative Inherited
Biological Process (BP) growth 0.8233 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.4982 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1525 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.9645 Informative Inherited
Biological Process (BP) muscle structure development 0.7119 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) gland development 0.02247 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.005192 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001346 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.03213 Informative Inherited
Biological Process (BP) locomotion 0.4318 Informative Inherited
Biological Process (BP) single-organism behavior 0.8251 Informative Inherited
Biological Process (BP) response to nutrient levels 0.8526 Informative Inherited
Biological Process (BP) central nervous system development 0.2193 Informative Inherited
Biological Process (BP) cell projection organization 0.248 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.9668 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.002093 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.003206 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1142 Informative Inherited
Biological Process (BP) epithelium development 0.8622 Informative Inherited
Biological Process (BP) cardiovascular system development 0.6146 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.7567 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) localization of cell 0.1599 Informative Inherited
Biological Process (BP) cellular component movement 0.5434 Informative Inherited
Biological Process (BP) tube development 0.003244 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.232 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02248 Informative Inherited
Biological Process (BP) mesenchyme development 1.813e-05 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.931e-15 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) renal system development 3.857e-10 Highly Informative Direct
Biological Process (BP) stem cell development 7.224e-09 Highly Informative Direct
Biological Process (BP) pattern specification process 1.87e-08 Highly Informative Direct
Biological Process (BP) neural tube development 1.037e-06 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 2.113e-06 Highly Informative Direct
Biological Process (BP) post-embryonic development 4.99e-06 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 6.364e-06 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 6.917e-06 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 2.733e-05 Highly Informative Direct
Biological Process (BP) gonad development 3.014e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 3.573e-05 Highly Informative Direct
Biological Process (BP) T cell differentiation 3.875e-05 Highly Informative Direct
Biological Process (BP) cell fate commitment 4.75e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0001733 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0001925 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.000547 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0005945 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.8144 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.07253 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.8878 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.001351 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3974 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.2954 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01836 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.9978 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6353 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.4558 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.07236 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.8233 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1146 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.4615 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.002326 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.6855 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.383 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.6441 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.584 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.4538 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7566 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.5445 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.554 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2334 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.00324 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1263 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.3908 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2588 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1727 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.008322 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.111 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.8799 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of hormone metabolic process 0.07984 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.2384 Highly Informative Inherited
Biological Process (BP) B cell activation 0.001048 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.2824 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01425 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01373 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.02116 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3429 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.9999 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.003495 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Molecular Function (MF) binding 3.009e-12 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2948 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.24 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.247e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0006561 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.5872 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) cation channel activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2895 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 1.739e-07 Informative Direct
Cellular Component (CC) nucleoplasm part 0.08534 Informative Inherited
Cellular Component (CC) nuclear body 0.0003182 Highly Informative Direct
Cellular Component (CC) chromatin 0.02497 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases3.713e-10Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.404e-15InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0007412Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.846Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.00267Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.05839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.6044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.4281InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.1464Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001305Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant6.849e-06Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant1.901e-05Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8802Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant1.549e-05InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001141InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004198InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.1617InformativeInherited
Worm Phenotype (WP)drug resistant0.2286InformativeInherited
Worm Phenotype (WP)egg laying variant0.3289InformativeInherited
Worm Phenotype (WP)cell migration variant0.3294InformativeInherited
Worm Phenotype (WP)protein expression variant0.4563InformativeInherited
Worm Phenotype (WP)lineage variant0.0001944Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0005854Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.01225Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.05746Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.06336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.04813Least InformativeInherited
Fly Anatomy (FA)cell0.7345Least InformativeInherited
Fly Anatomy (FA)neuron0.473Moderately InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.7183Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.366Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pre-chordal neural plate0.0001417InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.007172InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border4.441e-05Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7764Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003645InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002397Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004564Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.001567Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.002081Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.05715Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.222e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase2.027e-11InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase9.6e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0002951InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome1.181e-05InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseTumor suppressor0.0005127Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator6.212e-13InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.309e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]