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beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (566) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 279,770 297,723 212
Proteins 82,122 97,219 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0048170Least InformativeInherited
Biological Process (BP)regulation of gene expression0.0000086990Moderately InformativeDirect
Biological Process (BP)system development0.00038160.0002845Moderately InformativeDirect
Biological Process (BP)regulation of biosynthetic process0.018220Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.19130Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.020580Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.11590.00228Moderately InformativeInherited
Biological Process (BP)animal organ morphogenesis0.00085510.0000008883InformativeDirect
Molecular Function (MF)binding0.58470Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000035210Moderately InformativeDirect
Molecular Function (MF)DNA binding0.00000027340InformativeDirect
Molecular Function (MF)macromolecular complex binding0.0000093280.00000008555InformativeDirect
Molecular Function (MF)chromatin binding0.0000000032420Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) system development 0.0002845 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000001478 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.08733 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.09653 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2492 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.00228 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1368 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.1604 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.315 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.00139 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6429 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7469 Moderately Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.0000008883 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000004991 Informative Direct
Biological Process (BP) post-embryonic development 0.0000004245 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008508 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.5078 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.09636 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.2597 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7232 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1166 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.03024 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.986 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cell adhesion 0.447 Informative Inherited
Biological Process (BP) cellular response to lipid 0.03834 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.8862 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07194 Informative Inherited
Biological Process (BP) response to oxidative stress 0.7889 Informative Inherited
Biological Process (BP) epithelium development 0.2261 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3125 Informative Inherited
Biological Process (BP) embryo development 0.001505 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.8004 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01239 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.2276 Informative Inherited
Biological Process (BP) central nervous system development 0.7155 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.6019 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4395 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) locomotion 0.7743 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.9381 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.973 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.9049 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.951 Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0 Highly Informative Direct
Biological Process (BP) appendage development 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000000001644 Highly Informative Direct
Biological Process (BP) myeloid cell homeostasis 0.000000002017 Highly Informative Direct
Biological Process (BP) metamorphosis 0.00000001052 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.00000001517 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0000001121 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.0000009734 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000002489 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.00005044 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00006173 Highly Informative Direct
Biological Process (BP) cellular response to corticosteroid stimulus 0.0001111 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0003628 Highly Informative Direct
Biological Process (BP) RNA splicing 0.0006142 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0006268 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.8893 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.06809 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.1197 Highly Informative Inherited
Biological Process (BP) mRNA metabolic process 0.2864 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.6037 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.193 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.6946 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.06277 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.07805 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.02666 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.06312 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.001595 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.538 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8742 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.2634 Highly Informative Inherited
Biological Process (BP) maintenance of location in cell 0.1358 Highly Informative Inherited
Biological Process (BP) brain development 0.3971 Highly Informative Inherited
Biological Process (BP) neuron development 0.2331 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.003764 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.5502 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2934 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7561 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.455 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.1525 Highly Informative Inherited
Biological Process (BP) regulation of viral life cycle 0.00375 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.01428 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001513 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.3486 Highly Informative Inherited
Biological Process (BP) gastrulation 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9475 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.8653 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.7677 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01101 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.04799 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.8926 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.8049 Highly Informative Inherited
Biological Process (BP) chromosome organization 0.8155 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.8773 Highly Informative Inherited
Biological Process (BP) histone modification 0.0242 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.005518 Highly Informative Inherited
Biological Process (BP) cell division 1 Highly Informative Inherited
Biological Process (BP) cell migration 0.3609 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.8513 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.1579 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000008555 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000005126 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.000001143 Highly Informative Direct
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.006151 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00000000004083 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3342 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000002618 Informative Direct
Cellular Component (CC) cell projection part 1 Informative Inherited
Cellular Component (CC) cilium 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8341 Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.0001783 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8825Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.07296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.2633InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00002144Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00005778Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0003767Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.005799Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0005916Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.03343Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.06807Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9925Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.00000005068InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0001986InformativeDirect
Worm Phenotype (WP)male morphology variant0.0003407InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004107InformativeDirect
Worm Phenotype (WP)cell migration variant0.05893InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.2757InformativeInherited
Worm Phenotype (WP)egg laying variant0.2965InformativeInherited
Worm Phenotype (WP)drug resistant0.3218InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.000005451Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.006404Highly InformativeInherited
Worm Phenotype (WP)sex determination variant0.0264Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0Least InformativeDirect
Fly Anatomy (FA)adult0.0000000006487Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.0000002834Least InformativeDirect
Fly Anatomy (FA)nervous system1Least InformativeInherited
Fly Anatomy (FA)cell1Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.000000000000003601Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0000000000004095Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.000000000000777Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.00000000007426Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0.0000009573Moderately InformativeDirect
Fly Anatomy (FA)central nervous system1Moderately InformativeInherited
Fly Anatomy (FA)neuron1Moderately InformativeInherited
Fly Anatomy (FA)ganglion1Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.4618Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.5432Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.5814Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2495Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.9471Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.2327InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5833Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1242Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2383Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2744Moderately InformativeInherited
Xenopus ANatomical entity (XAN)circulatory system0.0003577InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.004994InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2686InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.0001054Highly InformativeDirect
Xenopus ANatomical entity (XAN)blood vessel0.0003251Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0004602Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0008175Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0009473Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7782Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003757InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002404Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004575Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.001194Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.001797Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.09954Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.353e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0000000000179InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.00000000000000146Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0004366InformativeDirect
Biological processSporulation0.03087InformativeInherited
Biological processFlowering0.000245Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0.000001478InformativeDirect
Cellular componentSpliceosome0.00002534InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseMental retardation0.0008756InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.000000000000001344InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0.000000002596Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]