SUPERFAMILY 1.75 HMM library and genome assignments server


beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (513) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 252,628 246,363 212
Proteins 74,011 75,020 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)developmental process0.0061250Least InformativeInherited
Biological Process (BP)multicellular organismal process0.019921.483e-12Least InformativeInherited
Biological Process (BP)regulation of cellular process0.1250Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.18080Least InformativeInherited
Biological Process (BP)response to stimulus0.94981Least InformativeInherited
Biological Process (BP)regulation of gene expression6.75e-070Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process3.384e-060Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process5.809e-060Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.00012311.429e-08Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00037460Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0047780Moderately InformativeInherited
Biological Process (BP)organ development0.0046968.256e-11Moderately InformativeInherited
Biological Process (BP)tissue development0.063380.000264Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.13736.894e-10Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.022130.00255Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.071571Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.11023.746e-15Moderately InformativeInherited
Biological Process (BP)immune system process0.007610.6194Moderately InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process4.155e-057.973e-06InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00030483.346e-05InformativeDirect
Biological Process (BP)regulation of immune effector process5.008e-061InformativeInherited
Biological Process (BP)negative regulation of developmental process0.003960.0006921InformativeInherited
Biological Process (BP)regulation of immune response0.001041InformativeInherited
Biological Process (BP)sensory organ development0.020691.048e-07InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0078851InformativeInherited
Biological Process (BP)response to wounding0.00063311InformativeInherited
Biological Process (BP)immune response0.0018971InformativeInherited
Biological Process (BP)defense response0.011551InformativeInherited
Biological Process (BP)mesenchyme development4.905e-065.56e-06Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation5.359e-050Highly InformativeDirect
Biological Process (BP)negative regulation of cell differentiation0.0047110.00717Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process9.235e-051Highly InformativeInherited
Biological Process (BP)regulation of T cell activation8.658e-070.1299Highly InformativeInherited
Biological Process (BP)inflammatory response1.259e-050.3171Highly InformativeInherited
Molecular Function (MF)binding0.12937.725e-13Least InformativeInherited
Molecular Function (MF)nucleic acid binding1.006e-080Moderately InformativeDirect
Molecular Function (MF)DNA binding1.107e-110InformativeDirect
Molecular Function (MF)chromatin binding1.513e-050InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.483e-12 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.429e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 5.182e-06 Moderately Informative Direct
Biological Process (BP) organ development 8.256e-11 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 3.98e-07 Moderately Informative Direct
Biological Process (BP) tissue development 0.000264 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.746e-15 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 6.894e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 8.737e-05 Moderately Informative Direct
Biological Process (BP) gene expression 0.000926 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.4595 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1722 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4085 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6194 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.00255 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8957 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.518 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6121 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01365 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.02745 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.04178 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.2071 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.6207 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6728 Moderately Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 7.973e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 3.346e-05 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.0006921 Informative Direct
Biological Process (BP) organ morphogenesis 3.853e-08 Informative Direct
Biological Process (BP) sensory organ development 1.048e-07 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 3.746e-15 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 6.356e-05 Informative Direct
Biological Process (BP) sexual reproduction 6.966e-05 Informative Direct
Biological Process (BP) embryonic organ development 9.298e-05 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.0001829 Informative Direct
Biological Process (BP) cell activation 0.00021 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008268 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.1394 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01778 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4873 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.009138 Informative Inherited
Biological Process (BP) growth 0.2414 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3733 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.9049 Informative Inherited
Biological Process (BP) muscle structure development 0.5022 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) gland development 0.01787 Informative Inherited
Biological Process (BP) response to lipid 0.7607 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001276 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001782 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.04132 Informative Inherited
Biological Process (BP) locomotion 0.7406 Informative Inherited
Biological Process (BP) single-organism behavior 0.6444 Informative Inherited
Biological Process (BP) response to nutrient levels 0.9141 Informative Inherited
Biological Process (BP) central nervous system development 0.05119 Informative Inherited
Biological Process (BP) reproductive structure development 0.7263 Informative Inherited
Biological Process (BP) cell projection organization 0.2835 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) chromosome organization 0.005864 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1899 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) generation of neurons 0.9314 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) localization of cell 0.5773 Informative Inherited
Biological Process (BP) cellular component movement 0.9065 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2111 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.06367 Informative Inherited
Biological Process (BP) mesenchyme development 5.56e-06 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) renal system development 5.806e-11 Highly Informative Direct
Biological Process (BP) pattern specification process 1.726e-08 Highly Informative Direct
Biological Process (BP) stem cell development 5.422e-08 Highly Informative Direct
Biological Process (BP) neural tube development 5.869e-07 Highly Informative Direct
Biological Process (BP) interaction with symbiont 1.164e-06 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 2.27e-06 Highly Informative Direct
Biological Process (BP) gonad development 9.056e-06 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 2.421e-05 Highly Informative Direct
Biological Process (BP) myeloid cell development 2.711e-05 Highly Informative Direct
Biological Process (BP) T cell differentiation 5.151e-05 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0001635 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0003546 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0003898 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0007384 Highly Informative Direct
Biological Process (BP) RNA splicing 0.0007758 Highly Informative Direct
Biological Process (BP) B cell activation 0.0008985 Highly Informative Direct
Biological Process (BP) connective tissue development 0.0009511 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.7077 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.01285 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.7786 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.01443 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.3372 Highly Informative Inherited
Biological Process (BP) inner ear development 0.9408 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.02875 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.001335 Highly Informative Inherited
Biological Process (BP) epithelial cell development 1 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3694 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.02684 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1147 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.05336 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.5123 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1165 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.004065 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.7616 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001347 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.07782 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.9475 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.2339 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.3432 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.586 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.3998 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.6576 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.4469 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion 0.5017 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.3777 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.00717 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1299 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.04648 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1571 Highly Informative Inherited
Biological Process (BP) developmental maturation 1 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.007911 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.03602 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6928 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 1 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.9876 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of hormone metabolic process 0.06713 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.2066 Highly Informative Inherited
Biological Process (BP) fruiting body development 1 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.01432 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.001145 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.03909 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.02187 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3171 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.00352 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1592 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 7.725e-13 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.1393 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 3.308e-07 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.1741 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription factor binding 1.418e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000468 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.03476 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.2311 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1.369e-12 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.6308 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 1.079e-07 Informative Direct
Cellular Component (CC) nucleoplasm part 0.009424 Informative Inherited
Cellular Component (CC) small nuclear ribonucleoprotein complex 1.406e-05 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0003868 Highly Informative Direct
Cellular Component (CC) chromatin 0.02299 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases3.713e-10Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase1.404e-15InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0006854Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.5564Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6032Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.8868Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.2939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.5411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.7528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.8166InformativeInherited
Mammalian Phenotype (MP)abnormal splenocyte number0.0008267Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.1246Highly InformativeInherited
Mammalian Phenotype (MP)abnormal adrenal gland morphology0.3141Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001305Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant6.849e-06Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant1.901e-05Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8802Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant1.549e-05InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001141InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004198InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.1617InformativeInherited
Worm Phenotype (WP)drug resistant0.2286InformativeInherited
Worm Phenotype (WP)egg laying variant0.3289InformativeInherited
Worm Phenotype (WP)cell migration variant0.3294InformativeInherited
Worm Phenotype (WP)protein expression variant0.4563InformativeInherited
Worm Phenotype (WP)lineage variant0.0001944Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0005854Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.01225Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.05746Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.06336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.07016Least InformativeInherited
Fly Anatomy (FA)cell0.7737Least InformativeInherited
Fly Anatomy (FA)neuron0.4127Moderately InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.6982Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3435Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.01227InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.0001228Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0006036Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

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AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7764Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003645InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002397Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004564Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

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EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.001663Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.002212Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.06205Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase9.573e-16InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase9.573e-16Highly InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase1.95e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0002841InformativeDirect
Biological processGrowth regulation0.0006612Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome5.893e-06InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseTumor suppressor0.000575Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator3.995e-13InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.018e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]