SUPERFAMILY 1.75 HMM library and genome assignments server

beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (565) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 277,575 297,723 212
Proteins 81,595 97,219 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.20040Least InformativeInherited
Biological Process (BP)regulation of cellular process0.15640.0000000000001132Least InformativeInherited
Biological Process (BP)developmental process0.0094720Least InformativeInherited
Biological Process (BP)multicellular organismal process0.024060Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.44860.0008559Least InformativeInherited
Biological Process (BP)response to stimulus0.98831Least InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0000049940Moderately InformativeDirect
Biological Process (BP)regulation of gene expression0.0000071240Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.0000088970Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0016520Moderately InformativeInherited
Biological Process (BP)tissue development0.05740.00001128Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.13950Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.056970.8905Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.022130.001674Moderately InformativeInherited
Biological Process (BP)organ development0.0050530.000000000006797Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.19560.0000001374Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0013440.02076Moderately InformativeInherited
Biological Process (BP)immune system process0.011130.7015Moderately InformativeInherited
Biological Process (BP)defense response0.013971Moderately InformativeInherited
Biological Process (BP)positive regulation of RNA metabolic process0.000020.000000221InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00005470.0000148InformativeDirect
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.000061040.0001449InformativeDirect
Biological Process (BP)regulation of cell activation0.00041820.07931InformativeInherited
Biological Process (BP)negative regulation of immune system process0.00037881InformativeInherited
Biological Process (BP)regulation of immune effector process0.0000071841InformativeInherited
Biological Process (BP)negative regulation of developmental process0.0050210.00006448InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.011910.7447InformativeInherited
Biological Process (BP)regulation of immune response0.0012851InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.011831InformativeInherited
Biological Process (BP)sensory organ development0.012440.0000001346InformativeInherited
Biological Process (BP)immune response0.0023661InformativeInherited
Biological Process (BP)mesenchyme development0.0000074440.0002447Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.000043130.000000000000001913Highly InformativeDirect
Biological Process (BP)negative regulation of immune effector process0.000000056760.06063Highly InformativeInherited
Biological Process (BP)regulation of T cell activation0.0000010250.1296Highly InformativeInherited
Biological Process (BP)negative regulation of leukocyte activation0.0000000820.1082Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.0046920.009546Highly InformativeInherited
Biological Process (BP)negative regulation of immune response0.00000048770.2632Highly InformativeInherited
Biological Process (BP)inflammatory response0.000013980.3702Highly InformativeInherited
Molecular Function (MF)binding0.18140.00000000001446Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000000040790Moderately InformativeDirect
Molecular Function (MF)DNA binding0.00000000002570InformativeDirect
Molecular Function (MF)chromatin binding0.000014250InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000000000001132 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.0008559 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.00004793 Moderately Informative Direct
Biological Process (BP) organ development 0.000000000006797 Moderately Informative Direct
Biological Process (BP) tissue development 0.00001128 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0000003301 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000001374 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0005339 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07221 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.01246 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8905 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9268 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001674 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7015 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8221 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1721 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.14 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.02076 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2042 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7794 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4873 Moderately Informative Inherited
Biological Process (BP) gene expression 0.02943 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.876 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.000000221 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000148 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001449 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00006448 Informative Direct
Biological Process (BP) organ morphogenesis 0.00000002702 Informative Direct
Biological Process (BP) sensory organ development 0.0000001346 Informative Direct
Biological Process (BP) tube development 0.000007211 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0000000000003613 Informative Direct
Biological Process (BP) leukocyte activation 0.000002857 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001551 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0002342 Informative Direct
Biological Process (BP) embryonic organ development 0.0003811 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.5475 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.7111 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1123 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cell proliferation 0.001271 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.5926 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3364 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7447 Informative Inherited
Biological Process (BP) response to inorganic substance 0.6902 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cell activation 0.07931 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1588 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) growth 0.4201 Informative Inherited
Biological Process (BP) muscle structure development 0.2727 Informative Inherited
Biological Process (BP) response to lipid 0.8448 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.2781 Informative Inherited
Biological Process (BP) response to nutrient levels 0.6875 Informative Inherited
Biological Process (BP) gland development 0.01948 Informative Inherited
Biological Process (BP) central nervous system development 0.1623 Informative Inherited
Biological Process (BP) generation of neurons 0.7854 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.005988 Informative Inherited
Biological Process (BP) cell projection organization 0.304 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) chromosome organization 0.001277 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) locomotion 0.5062 Informative Inherited
Biological Process (BP) cellular component movement 0.6268 Informative Inherited
Biological Process (BP) sexual reproduction 0.002508 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01597 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1259 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) localization of cell 0.1842 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.0185 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02745 Informative Inherited
Biological Process (BP) mesenchyme development 0.0002447 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000000000000001913 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) stem cell development 0.000000002284 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0000001306 Highly Informative Direct
Biological Process (BP) kidney development 0.0000001567 Highly Informative Direct
Biological Process (BP) neural tube development 0.000001106 Highly Informative Direct
Biological Process (BP) erythrocyte differentiation 0.000001996 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.000005568 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.000007433 Highly Informative Direct
Biological Process (BP) gonad development 0.0000206 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.00002177 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00002385 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0000251 Highly Informative Direct
Biological Process (BP) T cell differentiation 0.00003477 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00004497 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0002106 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.0003484 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0003617 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.1204 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.009546 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.01128 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.8893 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.005266 Highly Informative Inherited
Biological Process (BP) regulation of hematopoietic progenitor cell differentiation 0.03249 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01382 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.7109 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) response to cold 0.6838 Highly Informative Inherited
Biological Process (BP) ear development 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.07181 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.001749 Highly Informative Inherited
Biological Process (BP) developmental growth 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6463 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.4175 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.07484 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.6002 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.8216 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.05337 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.3408 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.002864 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1969 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.1082 Highly Informative Inherited
Biological Process (BP) response to transition metal nanoparticle 0.1857 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.8178 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 0.3792 Highly Informative Inherited
Biological Process (BP) negative regulation of secretion by cell 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response 0.4755 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1296 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.4054 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.2463 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.094 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.004947 Highly Informative Inherited
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.8583 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1361 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.2632 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine production involved in immune response 0.07708 Highly Informative Inherited
Biological Process (BP) regulation of alcohol biosynthetic process 0.3489 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) negative regulation of hormone metabolic process 0.04634 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.842 Highly Informative Inherited
Biological Process (BP) B cell activation 0.001068 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 1 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.0107 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01367 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 1 Highly Informative Inherited
Biological Process (BP) endocrine system development 0.02176 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.06063 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.3702 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.6753 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.004173 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000001446 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.3713 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.2654 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) transcription factor binding 0.00000002573 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0007825 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.6232 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) cation channel activity 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.02753 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000000000819 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9169 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0000002261 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 0.0000000003838 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000005952 Highly Informative Direct
Cellular Component (CC) chromosome, centromeric region 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.001264Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.8679Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.004648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.04826Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.02271InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology/development0.3983InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001305Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.000006849Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00001901Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.8802Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.00001549InformativeDirect
Worm Phenotype (WP)male morphology variant0.0001141InformativeDirect
Worm Phenotype (WP)protruding vulva0.0004198InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.1617InformativeInherited
Worm Phenotype (WP)drug resistant0.2286InformativeInherited
Worm Phenotype (WP)egg laying variant0.3289InformativeInherited
Worm Phenotype (WP)cell migration variant0.3294InformativeInherited
Worm Phenotype (WP)protein expression variant0.4563InformativeInherited
Worm Phenotype (WP)lineage variant0.0001944Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.0005854Highly InformativeDirect
Worm Phenotype (WP)neuron migration variant0.01225Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.05746Highly InformativeInherited
Worm Phenotype (WP)antibody staining variant0.06336Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.04828Least InformativeInherited
Fly Anatomy (FA)cell0.7327Least InformativeInherited
Fly Anatomy (FA)neuron0.4724Moderately InformativeInherited

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.726Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.3763Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.0268InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.00006361Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7764Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003645InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002397Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004564Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.001545Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.002064Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.05697Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase7.245e-16InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00000000002011InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase9.63e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processWnt signaling pathway0.0002975InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome0.0000119InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DiseaseTumor suppressor0.0004936Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationChromatin regulator0.000000000000002202InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00001605Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0.000000002983Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 91 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 91 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]