SUPERFAMILY 1.73 HMM library and genome assignments server


C2H2 and C2HC zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (85)
  Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold:   C2H2 and C2HC zinc fingers [ 57666]
  alpha+beta metal(zinc)-bound fold: beta-hairpin + alpha-helix
Superfamily:   C2H2 and C2HC zinc fingers [ 57667] (6)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  Spliceosomal protein U1C [ 111436]
  variant C2H2 finger [ 118273]
  contains extra C-terminal, alpha-helical subdomain
  BED zinc finger [ 144157]
  Pfam 02892; contains extra N-terminal and C-terminal helices bundled together with the core helix


Superfamily statistics
Genomes (266) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 155,332 53,033 80
Proteins 41,694 19,851 61


Functional annotation
General category Regulation
Detailed category DNA-binding

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C2H2 and C2HC zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 83 hidden Markov models representing the C2H2 and C2HC zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]