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Zn2/Cys6 DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Zn2/Cys6 DNA-binding domain [ 57700]
Superfamily:   Zn2/Cys6 DNA-binding domain [ 57701]
Families:   Zn2/Cys6 DNA-binding domain [ 57702] (6)


Superfamily statistics
Genomes (235) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,677 37,897 12
Proteins 23,353 37,468 12


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.01909 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8439 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3687 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.832 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.0000000000006277 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000000000007693 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.00000000002192 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000000007712 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000008015 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00004982 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000156 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.2908 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.002842 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.006085 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.187 Moderately Informative Inherited
Biological Process (BP) cell communication 0.2673 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4766 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.000000001537 Informative Direct
Biological Process (BP) growth 0.000000004067 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000003176 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.00001331 Informative Direct
Biological Process (BP) multi-organism cellular process 0.0001604 Informative Direct
Biological Process (BP) secondary metabolic process 0.0001937 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0002271 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000306 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0003834 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0003903 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0007164 Informative Direct
Biological Process (BP) regulation of growth 0.01193 Informative Inherited
Biological Process (BP) biofilm formation 0.000000000000003692 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.00000000001142 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0000000002274 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.000000001095 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.000000007246 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000008858 Highly Informative Direct
Biological Process (BP) response to drug 0.000004255 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0008806 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.02251 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1545 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.02893 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.004571 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.03102 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.03468 Highly Informative Inherited
Molecular Function (MF) binding 0.00001259 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00000002331 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00005191 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000275 Least Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processVirulence0.0000462Moderately InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0.000000008924Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001138 SSF57701 Protein matches
Abstract

The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [PubMed2107541, PubMed1557122]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism; amide and GABA catabolism; leucine biosynthesis and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn2/Cys6 DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Zn2/Cys6 DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]