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Zn2/Cys6 DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Zn2/Cys6 DNA-binding domain [ 57700]
Superfamily:   Zn2/Cys6 DNA-binding domain [ 57701]
Families:   Zn2/Cys6 DNA-binding domain [ 57702] (6)


Superfamily statistics
Genomes (235) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,677 37,897 12
Proteins 23,353 37,468 12


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.808 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6245 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.008963 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.876 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000000109 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000000000001439 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000000003509 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000000000008046 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.00000000001418 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000003022 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000007746 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00005767 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00007618 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.5955 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.004559 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01311 Moderately Informative Inherited
Biological Process (BP) cell communication 0.564 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.152 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.1742 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000000001195 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.00000000149 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.00000009892 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000004731 Informative Direct
Biological Process (BP) growth 0.000005215 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.00002459 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001525 Informative Direct
Biological Process (BP) secondary metabolic process 0.0001676 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0002329 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.0003193 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0004139 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0004312 Informative Direct
Biological Process (BP) regulation of growth 0.09618 Informative Inherited
Biological Process (BP) chromosome organization 0.0867 Informative Inherited
Biological Process (BP) response to nutrient levels 0.0000000001498 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.000000000159 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.0000000002773 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.000000007525 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000002981 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000001098 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.000001578 Highly Informative Direct
Biological Process (BP) response to drug 0.00005547 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0006597 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.003118 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.07536 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5405 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.02473 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02417 Highly Informative Inherited
Molecular Function (MF) binding 0.00002766 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.00000003374 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.0000002887 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0002624 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000006359 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.002 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.0008622 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processVirulence0.00005375Moderately InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0.000000246Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001138 SSF57701 Protein matches
Abstract

The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [PubMed2107541, PubMed1557122]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism; amide and GABA catabolism; leucine biosynthesis and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn2/Cys6 DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Zn2/Cys6 DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]