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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2387Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06561Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4688Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05921InformativeInherited
Disease Ontology (DO)physical disorder0.1518InformativeInherited
Disease Ontology (DO)viral infectious disease0.3116InformativeInherited
Disease Ontology (DO)gallbladder disease0.0000667Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001493Highly InformativeDirect
Disease Ontology (DO)rubella0.0001844Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2967Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9049Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.07942Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2889Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.2912Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1131InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.1907InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.5201InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0007273Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas morphology0.004955Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000000136Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002467Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007017Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003825Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005399Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3799Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4157Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4614Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002481Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004782Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004979Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005094Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.002974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.004348Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006108Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008577Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03369Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09279Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005571InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001552InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00105InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001135InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007977InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03754InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03992InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0472InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06107InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.364InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3844InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4376InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5036InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6584InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9326InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004719Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007106Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002226Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002226Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000004432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004747Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007302Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002044Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004413Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003106Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.000324Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003647Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004467Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007431Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007667Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002352Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003423Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01575Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02197Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02426Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03478Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03842Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0758Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1337Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3551Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.008626Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.000000004105Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.6306Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.7805Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000006376InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.03813InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.07544InformativeInherited
Worm Phenotype (WP)fat content increased0.000005938Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00005514Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002034Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0008861Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.001855Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01767Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000006048InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.000908Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.005638Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.000005182Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001421Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0002042Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.1067Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.06942Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.3546Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.09199Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1641Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.267Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.66Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2356InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.3664InformativeInherited
Zebrafish Anatomy (ZA)heart0.06655Highly InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.3157Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.073Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3014Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4646Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.7531Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8355Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9479Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000002273Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0005736Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.6718Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.8851Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8911Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.000000716InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000003139InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00002218InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002588InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0001185InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0005694InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.006683InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.008229InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.009989InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.00002385Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00008974Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002128Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0003295Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0006425Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric kidney0.3866Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0001962InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5757InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0000000000000136Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]