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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,249) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,938 144,985 147
Proteins 46,152 125,942 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)structural molecule activity0.000085230.05096Moderately InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.010740.001293Least InformativeInherited
Cellular Component (CC)macromolecular complex0.19431Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.19651Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.65640.3827Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.71141Least InformativeInherited
Cellular Component (CC)ribosome0.000087420.01759Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.090670.1132Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit0.0000013010.05818InformativeInherited
Cellular Component (CC)mitochondrial ribosome0.0000078050.01094InformativeInherited
Cellular Component (CC)mitochondrial small ribosomal subunit0.00000043580.000004045Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.0294 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.046 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01017 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.0308 Least Informative Inherited
Biological Process (BP) cellular biosynthetic process 0.00955 Least Informative Inherited
Biological Process (BP) organic substance biosynthetic process 0.02209 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.08639 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02027 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000000002312 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000004108 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000000001467 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000007315 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000001381 Moderately Informative Direct
Biological Process (BP) cell communication 0.00001186 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02518 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04106 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02956 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1459 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1964 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1668 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 0.006393 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1635 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4115 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01252 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03226 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.7198 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.06201 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.4676 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) locomotion 0.000000000000003705 Informative Direct
Biological Process (BP) behavior 0.0000000000002129 Informative Direct
Biological Process (BP) cellular response to lipid 0.0000000000009735 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00000000001415 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000005382 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000004597 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000001023 Informative Direct
Biological Process (BP) regulation of protein localization 0.00001098 Informative Direct
Biological Process (BP) epithelium development 0.00001152 Informative Direct
Biological Process (BP) response to radiation 0.00001761 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00001991 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002196 Informative Direct
Biological Process (BP) actin filament-based process 0.00004188 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000766 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0000845 Informative Direct
Biological Process (BP) central nervous system development 0.0001283 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0002433 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0003107 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003121 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0004193 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004456 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004625 Informative Direct
Biological Process (BP) regulation of peptide transport 0.0005148 Informative Direct
Biological Process (BP) sensory organ development 0.0009706 Informative Direct
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.001374 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01504 Informative Inherited
Biological Process (BP) ATP metabolic process 0.7504 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.02656 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.08081 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.4879 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1093 Informative Inherited
Biological Process (BP) cell death 0.0712 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6767 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.8985 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3017 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.004748 Informative Inherited
Biological Process (BP) circulatory system development 0.002414 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.1395 Informative Inherited
Biological Process (BP) defense response to other organism 0.92 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.5489 Informative Inherited
Biological Process (BP) regulation of defense response 0.05024 Informative Inherited
Biological Process (BP) post-embryonic development 0.8655 Informative Inherited
Biological Process (BP) growth 0.2174 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1086 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.9309 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.06346 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4733 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1192 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.5073 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) embryo development 0.008026 Informative Inherited
Biological Process (BP) reproductive system development 0.01417 Informative Inherited
Biological Process (BP) cell-cell signaling 0.002825 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.679 Informative Inherited
Biological Process (BP) generation of neurons 0.07767 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.3574 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to metal ion 0.0164 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.006228 Informative Inherited
Biological Process (BP) cell development 0.03307 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1281 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.02019 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0000000000001292 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000000000004133 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.00000000001751 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00000000002878 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000000003368 Highly Informative Direct
Biological Process (BP) response to estrogen 0.0000000005591 Highly Informative Direct
Biological Process (BP) heart development 0.000000002363 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.00000002989 Highly Informative Direct
Biological Process (BP) brain development 0.0000002113 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0000003647 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000003765 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00000382 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000007037 Highly Informative Direct
Biological Process (BP) pattern specification process 0.00002313 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00004092 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.00007371 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0001066 Highly Informative Direct
Biological Process (BP) response to UV 0.0003328 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0005016 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0007075 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0007945 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0135 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7394 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.02475 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.06366 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.8369 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.8999 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.6105 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1184 Highly Informative Inherited
Biological Process (BP) regeneration 0.02058 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.1899 Highly Informative Inherited
Biological Process (BP) neuron development 0.002731 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.02083 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.02156 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.8026 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.02766 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.2528 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.8506 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2362 Highly Informative Inherited
Biological Process (BP) kidney development 0.1118 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.2241 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.8441 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02579 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.001972 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.5573 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001324 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.2741 Highly Informative Inherited
Biological Process (BP) regulation of oxidoreductase activity 0.004811 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01508 Highly Informative Inherited
Biological Process (BP) response to fungus 0.002949 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.007469 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.004783 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.06062 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8631 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4678 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 1 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.142 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.004304 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1394 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001898 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.8654 Highly Informative Inherited
Biological Process (BP) digestion 0.1298 Highly Informative Inherited
Biological Process (BP) appendage development 0.1942 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.001423 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.0397 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.598 Highly Informative Inherited
Biological Process (BP) muscle system process 0.1279 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.1079 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.3102 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.06546 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.08133 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1036 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.02624 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.114 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.009672 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.1299 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.3051 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.05616 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.9417 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.211 Highly Informative Inherited
Biological Process (BP) gastrulation 0.06689 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0000000000002015 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000002257 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.05096 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000000000004513 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000003032 Informative Direct
Molecular Function (MF) amide binding 0.0006723 Informative Direct
Molecular Function (MF) coenzyme binding 0.002019 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.5224 Informative Inherited
Molecular Function (MF) receptor binding 0.2583 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.9645 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8021 Informative Inherited
Molecular Function (MF) nuclease activity 0.9829 Informative Inherited
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.00000000000007511 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0000000002584 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00000107 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.000008593 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00008879 Highly Informative Direct
Molecular Function (MF) drug binding 0.0001498 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0002288 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.0006478 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0009747 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.006677 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.008969 Highly Informative Inherited
Molecular Function (MF) deoxyribonuclease activity 0.05127 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3827 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.001293 Least Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.43 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1132 Moderately Informative Inherited
Cellular Component (CC) ribosome 0.01759 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0000002107 Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.01094 Informative Inherited
Cellular Component (CC) chromosome 0.006488 Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.05818 Informative Inherited
Cellular Component (CC) mitochondrial small ribosomal subunit 0.000004045 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.00000000000007255 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.00000000000262 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000001491 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.0000006548 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2873Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.07071Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4606Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06071InformativeInherited
Disease Ontology (DO)physical disorder0.155InformativeInherited
Disease Ontology (DO)viral infectious disease0.311InformativeInherited
Disease Ontology (DO)gallbladder disease0.00006727Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001548Highly InformativeDirect
Disease Ontology (DO)rubella0.0001825Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0007598Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.322Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3724Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.05308Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2126Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3668Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4134Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.01733InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the heart valves0.02179InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.09468InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1239InformativeInherited
Phenotypic Abnormality (PA)Atrioventricular block0.00003359Highly InformativeDirect
Phenotypic Abnormality (PA)Tricuspid regurgitation0.0001802Highly InformativeDirect
Phenotypic Abnormality (PA)Left ventricular hypertrophy0.0006007Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000000152Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0000253Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0000732Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003978Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005402Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.382Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4178Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4634Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002492Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004821Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005189Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0005272Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.003046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00461Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006202Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008868Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03417Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04799Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2943Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005796InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001537InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.001023InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001152InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007721InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0373InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03966InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.04797InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06132InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.367InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3788InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4349InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4771InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5097InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6582InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9361InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.964InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000005275Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007062Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002222Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000004411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000005316Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007276Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000007924Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002038Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00008156Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001641Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003104Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003642Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004195Highly InformativeDirect
Mammalian Phenotype (MP)increased trabecular bone volume0.0004617Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0005721Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007411Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007658Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002268Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.00342Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01575Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02169Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02408Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03461Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03828Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07903Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3045Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3608Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01393Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0000000004281Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.7466Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9164Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000004476InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.09332InformativeInherited
Worm Phenotype (WP)fat content variant0.913InformativeInherited
Worm Phenotype (WP)fat content increased0.000004693Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0001435Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.003043Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01297Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000001282Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.0006708Least InformativeDirect
Fly Anatomy (FA)adult0.001112Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01014Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.000005559Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001206Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0001558Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.1799Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.02145Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2752Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9772Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1187Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1232Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.3978Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3985Moderately InformativeInherited
Zebrafish Anatomy (ZA)coelom0.06598InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.0955InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.1508InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)endocrine pancreas0.0005975Highly InformativeDirect
Zebrafish Anatomy (ZA)spinal cord0.2107Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.0215Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.07421Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.09138Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.3195Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5006Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.883Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.00009011Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.01633Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7714Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.9753Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0000001449InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000004807InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000002478InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.00000437InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0000182InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.00003184InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.002948InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.008927InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01811InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.7676InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8717InformativeInherited
Xenopus ANatomical entity (XAN)diencephalon0.000001112Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.000001463Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.00007821Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0001014Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0001107Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0001191Highly InformativeDirect
Xenopus ANatomical entity (XAN)non-neural ectoderm0.0005892Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0008972Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0009799Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.001548Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited