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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,253) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 65,422 210,824 147
Proteins 46,430 165,366 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)structural molecule activity0.000074190.08766Moderately InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.01140.00001708Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.19081Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.65081Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.69831Least InformativeInherited
Cellular Component (CC)ribosome0.000076140.02967Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.089680.4683Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit0.0000011460.06012InformativeInherited
Cellular Component (CC)mitochondrial ribosome0.0000068350.0152InformativeInherited
Cellular Component (CC)mitochondrial small ribosomal subunit0.00000038550.000006567Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.04027 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.09738 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1585 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.1621 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.02212 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.05664 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02361 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000003037 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000000003042 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000000006093 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000000006546 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000002864 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000006855 Moderately Informative Direct
Biological Process (BP) tissue development 0.0000009153 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00001012 Moderately Informative Direct
Biological Process (BP) cell communication 0.00003346 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04988 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02296 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2291 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01608 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001016 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1643 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.595 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8096 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.116 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06285 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02848 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04253 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3174 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7071 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) behavior 0.00000000000003269 Informative Direct
Biological Process (BP) cellular response to lipid 0.000000000001227 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000000002169 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000000002433 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000000009292 Informative Direct
Biological Process (BP) localization of cell 0.00000002749 Informative Direct
Biological Process (BP) epithelium development 0.000002085 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000007802 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000007867 Informative Direct
Biological Process (BP) regulation of protein localization 0.000015 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00003014 Informative Direct
Biological Process (BP) single organism reproductive process 0.00003547 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00003675 Informative Direct
Biological Process (BP) central nervous system development 0.00005465 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0001334 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000248 Informative Direct
Biological Process (BP) regulation of peptide transport 0.0002751 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0004048 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0004673 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004829 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0006835 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0008019 Informative Direct
Biological Process (BP) negative regulation of cell death 0.07977 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8125 Informative Inherited
Biological Process (BP) regulation of secretion 0.001348 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.006748 Informative Inherited
Biological Process (BP) ATP metabolic process 0.8208 Informative Inherited
Biological Process (BP) generation of neurons 0.0567 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.03881 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) cell death 0.0679 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1096 Informative Inherited
Biological Process (BP) embryo development 0.0135 Informative Inherited
Biological Process (BP) response to radiation 0.005391 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2278 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1341 Informative Inherited
Biological Process (BP) growth 0.3168 Informative Inherited
Biological Process (BP) response to wounding 0.896 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.717 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.862 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.07094 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.004654 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01173 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.05714 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.7679 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4344 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3988 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.5165 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4644 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8343 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of system process 0.3893 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.2009 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) response to metal ion 0.01652 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1817 Informative Inherited
Biological Process (BP) reproductive system development 0.01138 Informative Inherited
Biological Process (BP) cell development 0.06277 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.858 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02781 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) DNA metabolic process 0.197 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) circulatory system development 0.001917 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) hemopoiesis 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.0259 Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000000000003734 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.00000000000001422 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000000000002753 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00000000002129 Highly Informative Direct
Biological Process (BP) forebrain development 0.00000000002893 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.00000000003653 Highly Informative Direct
Biological Process (BP) heart development 0.0000000003287 Highly Informative Direct
Biological Process (BP) response to estrogen 0.000000002365 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0000001287 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000001359 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.0000001494 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000005552 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00001018 Highly Informative Direct
Biological Process (BP) actin filament organization 0.00002571 Highly Informative Direct
Biological Process (BP) response to ketone 0.00004948 Highly Informative Direct
Biological Process (BP) response to heat 0.00009955 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0001612 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0002356 Highly Informative Direct
Biological Process (BP) response to UV 0.0002487 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.0003414 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0005192 Highly Informative Direct
Biological Process (BP) neuron development 0.0008432 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.001142 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.01322 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.8311 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.1144 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.9101 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1051 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.968 Highly Informative Inherited
Biological Process (BP) double-strand break repair 0.7446 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.01551 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.02769 Highly Informative Inherited
Biological Process (BP) gastrulation 0.09673 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.8712 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2354 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.214 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.5139 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.754 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.002674 Highly Informative Inherited
Biological Process (BP) regeneration 0.01928 Highly Informative Inherited
Biological Process (BP) wound healing 0.05281 Highly Informative Inherited
Biological Process (BP) kidney development 0.09619 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.5789 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.02259 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.001768 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.2322 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.02701 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01739 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.01122 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.003284 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.05768 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.07252 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.02188 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.2178 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.005862 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4772 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1468 Highly Informative Inherited
Biological Process (BP) ketone biosynthetic process 0.1512 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.01033 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.001537 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.09193 Highly Informative Inherited
Biological Process (BP) appendage development 0.261 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.2038 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001238 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.6164 Highly Informative Inherited
Biological Process (BP) digestion 0.1492 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.003349 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.001671 Highly Informative Inherited
Biological Process (BP) regulation of oxidoreductase activity 0.006586 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.7689 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.6397 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.0168 Highly Informative Inherited
Biological Process (BP) muscle system process 0.1813 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.1088 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.4218 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02121 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.03941 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.1238 Highly Informative Inherited
Biological Process (BP) steroid biosynthetic process 0.8339 Highly Informative Inherited
Biological Process (BP) secondary alcohol metabolic process 0.01664 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.03932 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.171 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.2443 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.3272 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.08076 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.9918 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2776 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.002099 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.8172 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1038 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00000000002688 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000003421 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.08766 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000322 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.8922 Informative Inherited
Molecular Function (MF) coenzyme binding 0.004205 Informative Inherited
Molecular Function (MF) receptor binding 0.3468 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.9065 Informative Inherited
Molecular Function (MF) amide binding 0.002919 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0000000000002791 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000000007909 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00001036 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00002845 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.00007639 Highly Informative Direct
Molecular Function (MF) drug binding 0.00009617 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0003294 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.002436 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.002535 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.01978 Highly Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0.009734 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.00001708 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00621 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4683 Moderately Informative Inherited
Cellular Component (CC) ribosome 0.02967 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.0000001586 Informative Direct
Cellular Component (CC) chromosome 0.8582 Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.06012 Informative Inherited
Cellular Component (CC) mitochondrial ribosome 0.0152 Informative Inherited
Cellular Component (CC) mitochondrial small ribosomal subunit 0.000006567 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000001991 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.000001271 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0.00008143 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.00000002276Moderately InformativeDirect
Biological processDNA repair0InformativeDirect
Biological processBiological rhythms4.846e-16InformativeDirect
Biological processCell adhesion0.0001162InformativeDirect
Biological processDNA synthesis0Highly InformativeDirect
Biological processNitrate assimilation0.00001251Highly InformativeDirect
Biological processPhagocytosis0.0002398Highly InformativeDirect
Biological processMyogenesis0.0005766Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000003149Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.00000006685Moderately InformativeDirect
DiseaseDisease mutation0.0001118Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationRepressor0.00000001893Moderately InformativeDirect
Post-translational modificationKinase0.000266Moderately InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationrRNA-binding0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationActin-binding0.00000000001797InformativeDirect
Post-translational modificationPhosphoprotein0.000000001026Least InformativeDirect
Post-translational modificationAcetylation0.000377Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationMethylation0.0009508Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000007879InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]