SUPERFAMILY 1.75 HMM library and genome assignments server


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,205) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 59,860 81,820 147
Proteins 42,973 66,584 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.641e-09 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1.84e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 7.09e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 5.329e-12 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.951e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.864e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 4.027e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 8.843e-06 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001348 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0005106 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.727e-08 Moderately Informative Direct
Biological Process (BP) organ development 7.124e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 7.333e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 3.748e-12 Moderately Informative Direct
Biological Process (BP) tissue development 1.06e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.513e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000553 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0009707 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.003067 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3253 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.02834 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3812 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1332 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9115 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1248 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.146 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6496 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003122 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.001271 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 3.805e-09 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 9.348e-06 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to lipid 5.708e-13 Informative Direct
Biological Process (BP) localization of cell 9.801e-13 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.903e-12 Informative Direct
Biological Process (BP) cell projection organization 7.394e-11 Informative Direct
Biological Process (BP) tissue morphogenesis 2.403e-09 Informative Direct
Biological Process (BP) cytoskeleton organization 3.443e-08 Informative Direct
Biological Process (BP) gland development 4.241e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.706e-07 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 5.366e-07 Informative Direct
Biological Process (BP) growth 7.819e-07 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 3.72e-05 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0002699 Informative Direct
Biological Process (BP) steroid metabolic process 0.0002806 Informative Direct
Biological Process (BP) generation of neurons 0.0003209 Informative Direct
Biological Process (BP) organ morphogenesis 0.0004232 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0004774 Informative Direct
Biological Process (BP) embryonic organ development 0.0009816 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.9716 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.02163 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.04635 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.02541 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.1563 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.01703 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1901 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.267 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.5799 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) sensory organ development 0.1629 Informative Inherited
Biological Process (BP) reproductive structure development 0.05964 Informative Inherited
Biological Process (BP) epithelium development 0.1628 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00631 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.2239 Informative Inherited
Biological Process (BP) muscle structure development 0.08489 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.003133 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.03749 Informative Inherited
Biological Process (BP) muscle tissue development 0.4465 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.5755 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.001091 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01153 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.6212 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.8347 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.5268 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6401 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4358 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.05489 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2645 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) biological adhesion 0.009178 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.01053 Informative Inherited
Biological Process (BP) central nervous system development 0.07023 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) organic acid transport 0.1451 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.02924 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.008542 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 1 Informative Inherited
Biological Process (BP) cell death 0.7721 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.6122 Informative Inherited
Biological Process (BP) actin filament-based process 0.05506 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6622 Informative Inherited
Biological Process (BP) single organism reproductive process 0.005556 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.07779 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.4462 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1257 Informative Inherited
Biological Process (BP) DNA metabolic process 0.296 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.6075 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.6184 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 1.773e-14 Highly Informative Direct
Biological Process (BP) placenta development 1.85e-12 Highly Informative Direct
Biological Process (BP) gonad development 5.492e-10 Highly Informative Direct
Biological Process (BP) cellular response to radiation 9.799e-10 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 2.292e-09 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 8.477e-09 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 2.546e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 3.118e-08 Highly Informative Direct
Biological Process (BP) response to toxic substance 3.597e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 5.814e-08 Highly Informative Direct
Biological Process (BP) endocrine system development 7.462e-08 Highly Informative Direct
Biological Process (BP) actin filament organization 1.854e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside monophosphate metabolic process 3.495e-07 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 5.735e-07 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 1.835e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 2.051e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 2.228e-06 Highly Informative Direct
Biological Process (BP) cell fate commitment 3.288e-06 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 3.415e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 9.151e-06 Highly Informative Direct
Biological Process (BP) female pregnancy 1.094e-05 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 1.257e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 2.057e-05 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 3.124e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 5.563e-05 Highly Informative Direct
Biological Process (BP) response to UV 9.612e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0001373 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.0001484 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0002235 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.0003827 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0004047 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0008877 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0009796 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.03492 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1621 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.09734 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.1913 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.06331 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.2426 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.008115 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.008967 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.006303 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.1581 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.7895 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 1 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.001379 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.551 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.6988 Highly Informative Inherited
Biological Process (BP) renal system development 0.4444 Highly Informative Inherited
Biological Process (BP) inner ear development 0.7549 Highly Informative Inherited
Biological Process (BP) developmental growth 0.2994 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) tube formation 0.3431 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.7114 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.004035 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.2374 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.18 Highly Informative Inherited
Biological Process (BP) digestion 0.1267 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.8662 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.004533 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.5815 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.537 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.8794 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.01924 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.008976 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.4427 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.1869 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.01303 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1952 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.06178 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7969 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.3534 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.01514 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1215 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.152 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.01096 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.6358 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.06047 Highly Informative Inherited
Biological Process (BP) neural tube development 0.5934 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.07997 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.006123 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.0205 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.9572 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.001248 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.1474 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.6219 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.002909 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.005403 Highly Informative Inherited
Biological Process (BP) development of primary male sexual characteristics 0.1586 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.0669 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.01406 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4631 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.712 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.05328 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.1648 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.6928 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6203 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 1.354e-12 Moderately Informative Direct
Molecular Function (MF) cation binding 2.461e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2536 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 1.135e-13 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 3.897e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.421e-05 Informative Direct
Molecular Function (MF) chromatin binding 3.248e-05 Informative Direct
Molecular Function (MF) amide binding 0.0005354 Informative Direct
Molecular Function (MF) receptor binding 0.6044 Informative Inherited
Molecular Function (MF) cofactor binding 0.2796 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.9412 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 1.214e-11 Highly Informative Direct
Molecular Function (MF) peptide binding 1.189e-10 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 1.663e-05 Highly Informative Direct
Molecular Function (MF) drug binding 0.0004048 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.002279 Highly Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0.005216 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0006764 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.1343 Informative Inherited
Cellular Component (CC) mitochondrial matrix 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) transcription factor complex 2.51e-07 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 7.371e-07 Highly Informative Direct
Cellular Component (CC) chromatin 4.349e-05 Highly Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.006904 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4598Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4587Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05795InformativeInherited
Disease Ontology (DO)physical disorder0.1215InformativeInherited
Disease Ontology (DO)cholelithiasis2.944e-05Highly InformativeDirect
Disease Ontology (DO)hypospadias4.189e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.1364Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.9863Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.5323InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.613InformativeInherited
Phenotypic Abnormality (PA)Testicular neoplasm0.0003878Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0001233Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0007514Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00317Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1359Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3448Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4253Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0002007Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0005788Moderately InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.005284Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01976Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.04264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.05479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.05514Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.08566Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1878Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3725Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4673Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology2.143e-05InformativeDirect
Mammalian Phenotype (MP)abnormal pituitary hormone level0.0008327InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0.003053InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.005052InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.01367InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01957InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.02847InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.06834InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.09602InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.1394InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue morphology0.2243InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2537InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.3509InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.4173InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.8105InformativeInherited
Mammalian Phenotype (MP)abnormal sublingual gland morphology6.062e-07Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus1.353e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myocardium layer morphology5.987e-06Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous1.109e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level2.58e-05Highly InformativeDirect
Mammalian Phenotype (MP)rudimentary Mullerian ducts2.58e-05Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis2.58e-05Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera2.58e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level3.492e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cricoid cartilage morphology0.0001632Highly InformativeDirect
Mammalian Phenotype (MP)ectopic ureter0.0003472Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0008199Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.002639Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.002869Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02997Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.03212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid aperture0.0371Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.08016Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.08674Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.1067Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.1561Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.3411Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9123Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.9862Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9976Moderately InformativeInherited
Worm Phenotype (WP)lipid metabolism variant5.276e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.05203InformativeInherited
Worm Phenotype (WP)failure to hatch5.39e-08Highly InformativeDirect
Worm Phenotype (WP)fat content increased3.469e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.003819Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.1406Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3267Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.4828Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4902Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1708Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3239Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.6784Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.7654Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hematological system1.728e-05InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.001734InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01328InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.03204InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8367InformativeInherited
Xenopus ANatomical entity (XAN)lateral plate mesoderm9.716e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm1.16e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0003519Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0003711Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0004489Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.002053Highly InformativeInherited
Xenopus ANatomical entity (XAN)fused heart primordium0.02724Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5573InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation1.121e-07Moderately InformativeDirect
Biological processCell adhesion0.0001608InformativeDirect
Biological processDNA synthesis0Highly InformativeDirect
Biological processNitrate assimilation8.19e-06Highly InformativeDirect
Biological processBiological rhythms0.0006409Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0007074Highly InformativeDirect
Biological processOsteogenesis0.000788Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton2.52e-15Moderately InformativeDirect
Cellular componentPlastid0.0009794Moderately InformativeDirect
Coding sequence diversityAlternative splicing2.721e-09Least InformativeDirect
DiseaseDisease mutation0.0005585Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainLIM domain0Highly InformativeDirect
DomainHomeobox1.011e-06Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionrRNA-binding0InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationRepressor5.134e-08Moderately InformativeDirect
Post-translational modificationKinase0.0002635Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationPhosphoprotein1.16e-09Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation1.531e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]