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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2383Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06535Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4683Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05914InformativeInherited
Disease Ontology (DO)physical disorder0.1517InformativeInherited
Disease Ontology (DO)viral infectious disease0.3116InformativeInherited
Disease Ontology (DO)gallbladder disease0.0000667Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001491Highly InformativeDirect
Disease Ontology (DO)rubella0.0001847Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1945Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.4654Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8494Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.002505Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.09433Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2732Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3126Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3339Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1767InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.1953InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.2934InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.6114InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0007032Highly InformativeDirect
Phenotypic Abnormality (PA)Hypothyroidism0.0009062Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000001366Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0000248Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00006979Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003802Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005364Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3799Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.416Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4618Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002489Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004783Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.000499Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005109Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.004348Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006056Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03383Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05095Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.13Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005573InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001534InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.001051InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001145InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007974InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03755InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03992InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.04739InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06107InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.364InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3844InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4377InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5047InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6585InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9326InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004718Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007111Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002227Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002227Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000004435Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004752Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007305Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002046Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004415Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001688Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003108Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.000324Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003649Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000447Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007437Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007675Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002353Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003422Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01575Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02196Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02426Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03478Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03841Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07582Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1337Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3551Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.008702Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.000000003867Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.6303Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.7791Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000005865InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.03605InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.07467InformativeInherited
Worm Phenotype (WP)fat content increased0.000005919Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0000519Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002147Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0008602Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.001914Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01741Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000012InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.0009693Least InformativeDirect
Fly Anatomy (FA)adult0.001241Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02201Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.00001124Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.000237Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0003282Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.1069Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.05455Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.2685Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.3584Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9966Least InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1014Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.4737Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5391Moderately InformativeInherited
Zebrafish Anatomy (ZA)coelom0.1107InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.4192InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)heart0.09627Highly InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.2962Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02663Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.19Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3531Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7331Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7828Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8184Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000003124Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0002314Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0004737Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.6375Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.8212Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9692Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0000004874InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000002146InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000002377InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00001371InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.00004977InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.008561InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0116InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.01298InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.000002131Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00001673Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00007828Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001323Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0001413Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0002178Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002522Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0004274Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.03146Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0001594InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5803InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000008427Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]