SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2383Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06535Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4683Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05914InformativeInherited
Disease Ontology (DO)physical disorder0.1517InformativeInherited
Disease Ontology (DO)viral infectious disease0.3116InformativeInherited
Disease Ontology (DO)gallbladder disease0.0000667Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001491Highly InformativeDirect
Disease Ontology (DO)rubella0.0001847Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2574Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.5427Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8979Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.06906Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2927Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1179InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.1946InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.3324InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.573InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0007244Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas morphology0.004268Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000000136Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002467Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007017Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003825Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005399Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3799Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4157Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4614Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002481Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004782Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004979Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005094Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.002974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.004348Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.006108Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.008577Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03369Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.06881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09279Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005571InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001552InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00105InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001135InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007977InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03754InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03992InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0472InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06107InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.364InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3844InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4376InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5036InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6584InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9326InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004719Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007106Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002226Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002226Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000004432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004747Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007302Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002044Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004413Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003106Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.000324Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003647Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004467Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007431Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007667Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002352Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003423Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01575Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02197Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02426Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03478Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03842Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0758Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1337Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3551Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.009014Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.000000003809Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.6286Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.7798Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000006089InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.03579InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.07493InformativeInherited
Worm Phenotype (WP)fat content increased0.000005924Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00005193Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002156Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0008625Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.001797Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01745Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000004644InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.0008544Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.01716Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.00000551Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001456Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0002216Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.1061Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.042Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.2898Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.2642Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6199Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.5513InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.3124Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2089Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.355Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7338Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7827Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.8214Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000007362Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0002642Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0005209Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.6346Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.829Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9683Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0000002496InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000001181InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000221InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000002823InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002058InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.00005713InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0002618InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.007326InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.009732InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.02821InformativeInherited
Xenopus ANatomical entity (XAN)tail0.9152InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.000008172Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00008965Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.0001381Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0002051Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0002779Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0003876Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0007069Highly InformativeDirect
Xenopus ANatomical entity (XAN)proximal tubule0.006578Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0001715InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5776InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.000000000002408Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]