SUPERFAMILY 1.75 HMM library and genome assignments server


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (2,485) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 56,059 81,820 147
Proteins 39,364 66,584 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.141e-11 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.392e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.531e-07 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 7.522e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.849e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 0.002477 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.004309 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.5483 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 9.227e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.158e-14 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.705e-08 Moderately Informative Direct
Biological Process (BP) tissue development 2.27e-08 Moderately Informative Direct
Biological Process (BP) cell differentiation 5.308e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.05352 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3375 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.9461 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5274 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002096 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.9119 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.007622 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2831 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.445 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.2109 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1713 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.3976 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1979 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) localization of cell 1.268e-12 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.553e-12 Informative Direct
Biological Process (BP) response to lipid 1.063e-11 Informative Direct
Biological Process (BP) gland development 3.822e-10 Informative Direct
Biological Process (BP) tissue morphogenesis 7.009e-10 Informative Direct
Biological Process (BP) cell projection organization 1.817e-09 Informative Direct
Biological Process (BP) regulation of cell proliferation 7.038e-08 Informative Direct
Biological Process (BP) tube development 9.383e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 7.981e-07 Informative Direct
Biological Process (BP) cytoskeleton organization 1.078e-06 Informative Direct
Biological Process (BP) regulation of protein localization 1.094e-05 Informative Direct
Biological Process (BP) growth 2.684e-05 Informative Direct
Biological Process (BP) steroid metabolic process 6.645e-05 Informative Direct
Biological Process (BP) response to external stimulus 0.0001165 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0001483 Informative Direct
Biological Process (BP) generation of neurons 0.0002194 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0002345 Informative Direct
Biological Process (BP) organ morphogenesis 0.000333 Informative Direct
Biological Process (BP) embryonic organ development 0.0004802 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.6595 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.04449 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1025 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.03968 Informative Inherited
Biological Process (BP) regulation of secretion 0.06062 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.09055 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) apoptotic process 0.8537 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.9812 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.05321 Informative Inherited
Biological Process (BP) protein localization to organelle 0.6152 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.09654 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.147 Informative Inherited
Biological Process (BP) response to inorganic substance 0.7077 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.7627 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.6727 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02478 Informative Inherited
Biological Process (BP) reproductive system development 0.05309 Informative Inherited
Biological Process (BP) epithelium development 0.1635 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.1396 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) muscle structure development 0.09531 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00121 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8761 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.4123 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1885 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.2506 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3067 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4921 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.6047 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.3753 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.3812 Informative Inherited
Biological Process (BP) muscle system process 0.3943 Informative Inherited
Biological Process (BP) cellular component disassembly 0.03395 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6879 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.004451 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3495 Informative Inherited
Biological Process (BP) cell proliferation 0.00919 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4149 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3283 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) biological adhesion 0.04089 Informative Inherited
Biological Process (BP) central nervous system development 0.04023 Informative Inherited
Biological Process (BP) chordate embryonic development 0.1189 Informative Inherited
Biological Process (BP) cellular component movement 0.00686 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) organic acid transport 0.238 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) lipid transport 0.009504 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.01838 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2071 Informative Inherited
Biological Process (BP) actin filament-based process 0.09784 Informative Inherited
Biological Process (BP) single organism reproductive process 0.003727 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.07353 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.09882 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.3917 Informative Inherited
Biological Process (BP) DNA metabolic process 0.05129 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.738 Informative Inherited
Biological Process (BP) cell activation 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.914 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002719 Informative Inherited
Biological Process (BP) gonad development 1.743e-11 Highly Informative Direct
Biological Process (BP) cellular protein complex disassembly 2.065e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 1.836e-09 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 2.114e-09 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 2.79e-09 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 5.97e-09 Highly Informative Direct
Biological Process (BP) endocrine system development 2.558e-08 Highly Informative Direct
Biological Process (BP) diol metabolic process 3.573e-08 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 7.017e-08 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 8.56e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.727e-07 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 2.263e-07 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.035e-06 Highly Informative Direct
Biological Process (BP) apoptotic signaling pathway 1.037e-06 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.439e-06 Highly Informative Direct
Biological Process (BP) response to UV 1.549e-05 Highly Informative Direct
Biological Process (BP) actin filament organization 2.389e-05 Highly Informative Direct
Biological Process (BP) maintenance of location 2.459e-05 Highly Informative Direct
Biological Process (BP) axonogenesis 2.812e-05 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 3.585e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 6.046e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 6.493e-05 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 8.376e-05 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 9.536e-05 Highly Informative Direct
Biological Process (BP) regulation of binding 0.000239 Highly Informative Direct
Biological Process (BP) regulation of lipid storage 0.0002514 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0003768 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0007902 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.01403 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.04835 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.04046 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.09894 Highly Informative Inherited
Biological Process (BP) regulation of protein secretion 0.02997 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.8727 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.01746 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.6756 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.9107 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.03497 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.7663 Highly Informative Inherited
Biological Process (BP) lipid homeostasis 0.001498 Highly Informative Inherited
Biological Process (BP) kidney development 0.2209 Highly Informative Inherited
Biological Process (BP) inner ear development 0.8109 Highly Informative Inherited
Biological Process (BP) developmental growth 0.256 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) tube formation 0.2535 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6765 Highly Informative Inherited
Biological Process (BP) morphogenesis of a branching epithelium 1 Highly Informative Inherited
Biological Process (BP) lung development 1 Highly Informative Inherited
Biological Process (BP) connective tissue development 1 Highly Informative Inherited
Biological Process (BP) skeletal system development 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.4201 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 0.9124 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.05935 Highly Informative Inherited
Biological Process (BP) digestion 0.1084 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.7021 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.005056 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 0.01021 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.4814 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.725 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) T cell activation 0.05261 Highly Informative Inherited
Biological Process (BP) lymphocyte differentiation 0.4775 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.001409 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.0857 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.7807 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.9412 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.2599 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02017 Highly Informative Inherited
Biological Process (BP) feeding behavior 0.5594 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.6359 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7725 Highly Informative Inherited
Biological Process (BP) regulation of cellular amine metabolic process 0.002196 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.173 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.2956 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.6239 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.692 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.04352 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.1098 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.001032 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.00773 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.02294 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.2375 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.6468 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.02754 Highly Informative Inherited
Biological Process (BP) DNA repair 0.001447 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.4772 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.003918 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.2864 Highly Informative Inherited
Biological Process (BP) gastrulation 0.01557 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0 Moderately Informative Direct
Molecular Function (MF) cation binding 1.83e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.2181 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 3.472e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0001434 Informative Direct
Molecular Function (MF) lipid binding 0.0002522 Informative Direct
Molecular Function (MF) receptor binding 0.6171 Informative Inherited
Molecular Function (MF) cofactor binding 0.2832 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.7268 Informative Inherited
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) zinc ion binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 2.336e-11 Highly Informative Direct
Molecular Function (MF) steroid binding 2.698e-10 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 4.745e-10 Highly Informative Direct
Molecular Function (MF) hormone binding 2.429e-06 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 3.186e-05 Highly Informative Direct
Molecular Function (MF) chromatin binding 4.505e-05 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.000359 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.003034 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.9267 Highly Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0.00442 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 7.748e-06 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1.201e-13 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.8645 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.959 Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.339 Informative Inherited
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 4.919e-07 Highly Informative Direct
Cellular Component (CC) transcription factor complex 1.761e-06 Highly Informative Direct
Cellular Component (CC) chromatin 1.799e-05 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) mitochondrial ribosome 0.009641 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3983Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.439Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06001InformativeInherited
Disease Ontology (DO)physical disorder0.2075InformativeInherited
Disease Ontology (DO)cholelithiasis3.407e-05Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0006427Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6267Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.2372Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.5171InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.608InformativeInherited
Phenotypic Abnormality (PA)Testicular neoplasm0.0004122Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0004198Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.04147Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3565Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6447Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0003667Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.00358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.006053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.0136Moderately InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.0231Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.04247Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.06977Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.08475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1323Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1392Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.247Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.3314Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.6186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.6785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology4.81e-05InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology5.657e-05InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0.0005687InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.00499InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.009843InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0171InformativeInherited
Mammalian Phenotype (MP)abnormal circulating hormone level0.02606InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.084InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.08511InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.1911InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.1948InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3738InformativeInherited
Mammalian Phenotype (MP)abnormal hindbrain morphology0.6107InformativeInherited
Mammalian Phenotype (MP)abnormal sublingual gland morphology7.323e-07Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus1.564e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myocardium layer morphology1.745e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level2.4e-05Highly InformativeDirect
Mammalian Phenotype (MP)rudimentary Mullerian ducts2.893e-05Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis2.893e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level3.097e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cricoid cartilage morphology0.0001046Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.0001956Highly InformativeDirect
Mammalian Phenotype (MP)increased renin activity0.0006164Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pituitary hormone level0.0007828Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal development0.001584Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ear development0.002413Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.002889Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid aperture0.01476Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.01494Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.0219Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.04443Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.09406Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.1269Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.179Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.187Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.2795Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle/choroid plexus morphology0.3913Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart and great artery attachment1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.9862Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9976Moderately InformativeInherited
Worm Phenotype (WP)lipid metabolism variant5.276e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.05203InformativeInherited
Worm Phenotype (WP)failure to hatch5.39e-08Highly InformativeDirect
Worm Phenotype (WP)fat content increased3.469e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.003819Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)portion of organism substance0.0005557Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.2064Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4651Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.5069Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.5736Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.4959Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.7016Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.7116Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.01154InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.02657InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0621InformativeInherited
Xenopus ANatomical entity (XAN)dorsal lateral plate region8.915e-06Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.001869Highly InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.003828Highly InformativeInherited
Xenopus ANatomical entity (XAN)circumblastoporal collar0.01036Highly InformativeInherited
Xenopus ANatomical entity (XAN)retina0.02662Highly InformativeInherited
Xenopus ANatomical entity (XAN)fused heart primordium0.02933Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.6294InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)genito urinary system and sex hormones0.001187Moderately InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.01186Moderately InformativeInherited
Drugbank ATC_code (DB)other antipsoriatics for topical use6.634e-08InformativeDirect
Drugbank ATC_code (DB)sex hormones and modulators of the genital system2.985e-06InformativeDirect
Drugbank ATC_code (DB)endocrine therapy0.0002569InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation3.083e-06Moderately InformativeDirect
Biological processDNA synthesis0Highly InformativeDirect
Biological processNitrate assimilation8.327e-06Highly InformativeDirect
Biological processPhagocytosis1.171e-05Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0002983Highly InformativeDirect
Biological processOsteogenesis0.0005531Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentPlastid0.0007668Moderately InformativeDirect
Coding sequence diversityAlternative splicing4.025e-08Least InformativeDirect
DiseaseDisease mutation0.0003827Least InformativeDirect
DiseaseCardiomyopathy6.318e-05Highly InformativeDirect
DomainRepeat2.371e-13Least InformativeDirect
DomainHomeobox0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionrRNA-binding0InformativeDirect
Molecular functionActin-binding0.0007932InformativeDirect
Molecular functionLIM domain0Highly InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.225e-16Moderately InformativeDirect
Post-translational modificationRepressor4.033e-05Moderately InformativeDirect
Post-translational modificationKinase0.0001835Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationPhosphoprotein1.068e-06Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation9.337e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]