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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,248) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,385 144,985 147
Proteins 45,761 125,942 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)structural molecule activity0.00036620.09112Moderately InformativeInherited
Molecular Function (MF)structural constituent of ribosome0.000079330.0007874InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02015 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006055 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02708 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.06192 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.02226 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.02018 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.06985 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000000158 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000000000476 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000007063 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000003142 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000005551 Moderately Informative Direct
Biological Process (BP) signaling 0.00000039 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.58 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03859 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.009727 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01507 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.07553 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05098 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1232 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.04026 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.07059 Moderately Informative Inherited
Biological Process (BP) system development 0.02146 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0473 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9496 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.1163 Moderately Informative Inherited
Biological Process (BP) cell communication 0.001346 Moderately Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) behavior 0.00000000000006928 Informative Direct
Biological Process (BP) cellular response to lipid 0.00000000000008188 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000000004809 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000004669 Informative Direct
Biological Process (BP) cytoskeleton organization 0.000000000892 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000009768 Informative Direct
Biological Process (BP) regulation of protein localization 0.000005533 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000189 Informative Direct
Biological Process (BP) single organism reproductive process 0.00004814 Informative Direct
Biological Process (BP) actin filament-based process 0.00005286 Informative Direct
Biological Process (BP) central nervous system development 0.00007163 Informative Direct
Biological Process (BP) response to radiation 0.00008601 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0001273 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001572 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001621 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0001708 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0002152 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0002718 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0003309 Informative Direct
Biological Process (BP) generation of neurons 0.0006765 Informative Direct
Biological Process (BP) epithelium development 0.0008833 Informative Direct
Biological Process (BP) circulatory system development 0.0009284 Informative Direct
Biological Process (BP) negative regulation of cell death 0.08142 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.001328 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.005755 Informative Inherited
Biological Process (BP) ATP metabolic process 0.7073 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9909 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.02441 Informative Inherited
Biological Process (BP) cell death 0.03033 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.9618 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4681 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) embryo development 0.001879 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.8226 Informative Inherited
Biological Process (BP) regulation of defense response 0.03437 Informative Inherited
Biological Process (BP) growth 0.2634 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1563 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.00631 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002612 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.1178 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6759 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4587 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1015 Informative Inherited
Biological Process (BP) post-embryonic development 0.8884 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) reproductive system development 0.0201 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3305 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.4369 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2629 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9744 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.6985 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.1383 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.08402 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8007 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.08788 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.7876 Informative Inherited
Biological Process (BP) DNA metabolic process 0.2297 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) cell adhesion 0.009515 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) cell development 0.02674 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0000000000001283 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000000000002296 Highly Informative Direct
Biological Process (BP) cell projection organization 0.000000000002831 Highly Informative Direct
Biological Process (BP) response to estrogen 0.0000000006 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000000002058 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000003142 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.00000002765 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.00000003434 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0000001387 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000002915 Highly Informative Direct
Biological Process (BP) brain development 0.0000003196 Highly Informative Direct
Biological Process (BP) sex differentiation 0.000002546 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.000003868 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.000009914 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0000102 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.00002033 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.00004674 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0001307 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0001905 Highly Informative Direct
Biological Process (BP) muscle structure development 0.0005838 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0007174 Highly Informative Direct
Biological Process (BP) response to UV 0.0009254 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.008961 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.02827 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.2584 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.05245 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.5932 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.2421 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.05654 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01077 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.153 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.8627 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.7213 Highly Informative Inherited
Biological Process (BP) response to glucocorticoid 0.2603 Highly Informative Inherited
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.09683 Highly Informative Inherited
Biological Process (BP) response to fungus 0.001861 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.0202 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.03349 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2223 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.0225 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.4736 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.8195 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.001321 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.687 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.392 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001727 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.8643 Highly Informative Inherited
Biological Process (BP) digestion 0.12 Highly Informative Inherited
Biological Process (BP) appendage development 0.4064 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.001647 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.007463 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.351 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.4223 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.002777 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.5144 Highly Informative Inherited
Biological Process (BP) muscle system process 0.0542 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.007618 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.05993 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.006696 Highly Informative Inherited
Biological Process (BP) neuron development 0.001078 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.02612 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.05634 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.07945 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.02051 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1189 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.02787 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.1488 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.2172 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.04075 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.9118 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.9485 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.01641 Highly Informative Inherited
Biological Process (BP) hemopoiesis 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2668 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.04137 Highly Informative Inherited
Biological Process (BP) cell migration 0.001864 Highly Informative Inherited
Biological Process (BP) gastrulation 0.06027 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.9479 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.2717 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000000000004354 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00000512 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09112 Moderately Informative Inherited
Molecular Function (MF) structural constituent of ribosome 0.0007874 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000001998 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000005323 Informative Direct
Molecular Function (MF) coenzyme binding 0.001538 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.5048 Informative Inherited
Molecular Function (MF) receptor binding 0.5671 Informative Inherited
Molecular Function (MF) amide binding 0.002572 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.9311 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) nuclease activity 0.9435 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.5692 Informative Inherited
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0000000000003811 Highly Informative Direct
Molecular Function (MF) peptide binding 0.000000002853 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.000000003991 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00006101 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0001207 Highly Informative Direct
Molecular Function (MF) drug binding 0.0001997 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0005033 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0.0009279 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.00578 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.008391 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.02424 Highly Informative Inherited
Molecular Function (MF) deoxyribonuclease activity 0.04775 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.03586 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3144 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3695 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2923 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) chromosome 0.1967 Informative Inherited
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) anchoring junction 0 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.000000000001956 Highly Informative Direct
Cellular Component (CC) chromatin 0.00000002582 Highly Informative Direct
Cellular Component (CC) nuclear chromosome 0.1943 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.266Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.08597Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4653Moderately InformativeInherited
Disease Ontology (DO)endometrial cancer0.0002549InformativeDirect
Disease Ontology (DO)physical disorder0.1479InformativeInherited
Disease Ontology (DO)viral infectious disease0.3596InformativeInherited
Disease Ontology (DO)gallbladder disease0.00007015Highly InformativeDirect
Disease Ontology (DO)rubella0.000107Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001474Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0007366Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3242Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3323Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8531Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.003796Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.02974Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2872Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.3666Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.02647InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the heart valves0.03482InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1171InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.1211InformativeInherited
Phenotypic Abnormality (PA)Atrioventricular block0.00003012Highly InformativeDirect
Phenotypic Abnormality (PA)Tricuspid regurgitation0.0001638Highly InformativeDirect
Phenotypic Abnormality (PA)Left ventricular hypertrophy0.000551Highly InformativeDirect
Phenotypic Abnormality (PA)Lipoatrophy0.0008927Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.00000004874Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00004765Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0001706Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0008639Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.006455Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3295Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3582Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4466Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0002389Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0003029Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0006562Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.003005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00538Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.007427Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.007932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03228Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.05315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.09831Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4189Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.0001112InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0002394InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.000981InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.00101InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.01199InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.05171InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.05636InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.05918InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.07551InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3862InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.4044InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.4253InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.434InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4638InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6384InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.935InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9611InformativeInherited
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007777Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.000001121Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002406Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000004798Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.00000552Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007733Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000008557Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002168Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.0000861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001724Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0002931Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003907Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004684Highly InformativeDirect
Mammalian Phenotype (MP)increased trabecular bone volume0.0005027Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0005343Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007949Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0008105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.001713Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003234Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01937Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02444Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02486Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.039Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04596Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.08637Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3239Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.3672Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.01762Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0000000008185Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.7493Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8986Moderately InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.06807InformativeInherited
Worm Phenotype (WP)cell migration variant0.5674InformativeInherited
Worm Phenotype (WP)fat content variant0.9174InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000004165Highly InformativeDirect
Worm Phenotype (WP)fat content increased0.000006654Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0001289Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.002836Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01293Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000002241Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.0007776Least InformativeDirect
Fly Anatomy (FA)adult0.0007947Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.005871Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.000008335Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001719Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0008628Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.03406Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9291Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1537Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3883Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.1643InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.3219Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02959Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.08504Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.102Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.311Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5068Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.9298Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.0001655Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.02363Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7922Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0000001262InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000001326InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000168InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00008156InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0001012InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.001719InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.004495InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01556InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8659InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.000005596Highly InformativeDirect
Xenopus ANatomical entity (XAN)hypothalamus0.00005116Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm0.00006863Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.00008771Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0004247Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.0009296Highly InformativeDirect
Xenopus ANatomical entity (XAN)telencephalon0.00221Highly InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.03335Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5035InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.0001646Least InformativeDirect
Drugbank ATC_code (DB)alimentary tract and metabolism0.01905Least InformativeInherited
Drugbank ATC_code (DB)cardiovascular system0.02542Least InformativeInherited
Drugbank ATC_code (DB)systemic hormonal preparations, excl. sex hormones and insulins0.00006768Moderately InformativeDirect
Drugbank ATC_code (DB)dermatologicals0.000245Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.0002594Moderately InformativeDirect
Drugbank ATC_code (DB)other antineoplastic agents0.01595Moderately InformativeInherited
Drugbank ATC_code (DB)musculo-skeletal system0.02368Moderately InformativeInherited
Drugbank ATC_code (DB)drugs used in diabetes0.04062Moderately InformativeInherited
Drugbank ATC_code (DB)nasal preparations0.1558Moderately InformativeInherited
Drugbank ATC_code (DB)antiinflammatory and antirheumatic products, non-steroids0.000292InformativeDirect
Drugbank ATC_code (DB)aldosterone antagonists0.0003078InformativeDirect
Drugbank ATC_code (DB)corticosteroids for systemic use0.0008295InformativeDirect
Drugbank ATC_code (DB)retinoids for topical use in acne0.01356InformativeInherited
Drugbank ATC_code (DB)drugs for obstructive airway diseases0.05143InformativeInherited
Drugbank ATC_code (DB)other dermatological preparations1InformativeInherited
Drugbank ATC_code (DB)etretinate0.0000000003233Highly InformativeDirect
Drugbank ATC_code (DB)adapalene0.0000000003233Highly InformativeDirect
Drugbank ATC_code (DB)alitretinoin0.0000000003233Highly InformativeDirect
Drugbank ATC_code (DB)estrogens0.0000001304Highly InformativeDirect
Drugbank ATC_code (DB)bezafibrate0.000002229Highly InformativeDirect
Drugbank ATC_code (DB)mineralocorticoids0.000002229Highly InformativeDirect
Drugbank ATC_code (DB)alitretinoin0.000002981Highly InformativeDirect
Drugbank ATC_code (DB)fluticasone0.000006306Highly InformativeDirect
Drugbank ATC_code (DB)3-oxoandrosten (4) derivatives0.000006306Highly InformativeDirect
Drugbank ATC_code (DB)fluticasone0.000006306Highly InformativeDirect
Drugbank ATC_code (DB)glucocorticoids0.000006306Highly InformativeDirect
Drugbank ATC_code (DB)thiazolidinediones0.00002715Highly InformativeDirect
Drugbank ATC_code (DB)bexarotene0.0007488Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)