SUPERFAMILY 1.73 HMM library and genome assignments server


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (85)
  Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
  alpha+beta metal(zinc)-bound fold
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (15)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  single zinc-binding motif
  Nuclear receptor [ 57721] (12)
  duplication: two zinc-binding motifs
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  duplication: contains two (sub)domains of this fold
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Zn-binding site is particularly similar to that of ribosomal protein L24e
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Pfam 00645
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Pfam 01258; Pfam coverage extends to the second helix of the upstream alpha-hairpin domain
  Type II thymidine kinase zinc finger [ 118276]
  C-terminal part of Pfam 00265
  A20-like zinc finger [ 144187]
  Pfam 01754


Superfamily statistics
Genomes (1,232) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 29,842 19,257 135
Proteins 21,096 15,440 99


Functional annotation
General category Regulation
Detailed category DNA-binding

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 104 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 104 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]