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Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,141 266,876 147
Proteins 46,833 210,545 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2386Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.06609Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4676Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05941InformativeInherited
Disease Ontology (DO)physical disorder0.1519InformativeInherited
Disease Ontology (DO)viral infectious disease0.3131InformativeInherited
Disease Ontology (DO)gallbladder disease0.00006751Highly InformativeDirect
Disease Ontology (DO)hypospadias0.0001504Highly InformativeDirect
Disease Ontology (DO)rubella0.0001853Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2963Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9045Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.07953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.291Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.113InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.1905InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the testis0.5198InformativeInherited
Phenotypic Abnormality (PA)Testicular gonadoblastoma0.0007339Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pancreas morphology0.004978Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000001361Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002469Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00007023Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003827Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.005401Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3798Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4156Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4614Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.0002482Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0004784Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004981Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005097Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.002975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00435Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00611Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.00858Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.03369Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.05096Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0688Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.09278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1299Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.00005575InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0001552InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.001051InformativeInherited
Mammalian Phenotype (MP)abnormal eye development0.001135InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.007979InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.03754InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03992InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0472InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06106InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.364InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.3844InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.4376InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.4773InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5036InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.6584InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.9326InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0000004722Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sublingual gland morphology0.0000007111Highly InformativeDirect
Mammalian Phenotype (MP)absent Harderian gland0.000002227Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus0.000002227Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous0.000004436Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level0.000004751Highly InformativeDirect
Mammalian Phenotype (MP)fused bronchial cartilage rings0.000007307Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis0.00002046Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera0.00004416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesonephros morphology0.0001677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0003108Highly InformativeDirect
Mammalian Phenotype (MP)decreased ventral retina size0.0003242Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renin activity0.0003648Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0004468Highly InformativeDirect
Mammalian Phenotype (MP)decreased nephron number0.0007435Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0007671Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.002353Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.003425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01576Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.02197Highly InformativeInherited
Mammalian Phenotype (MP)abnormal larynx morphology0.02426Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.03478Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03843Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.07579Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1337Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.3058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.355Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.009178Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.000000003932Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.6581Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.78Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000006278InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.03708InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.07474InformativeInherited
Worm Phenotype (WP)fat content increased0.000005924Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00005199Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002157Highly InformativeDirect
Worm Phenotype (WP)cell fusion variant0.0008629Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.001798Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01744Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000008328InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.0008503Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.005819Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)appendage0.000005563Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.0001499Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.0002215Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0.107Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.0645Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.3165Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.3146Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6945Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2534InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.3245Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.0754Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3053Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4693Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.7528Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8357Least InformativeInherited
Xenopus ANatomical entity (XAN)cell0.8375Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9486Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002045Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0003254Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.6777Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8944Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.9468Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.0000008657InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000004539InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000008364InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002767InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004372InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0007761InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.004287InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.01212InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0243InformativeInherited
Xenopus ANatomical entity (XAN)neural nucleus0.00000001895Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuromere0.00001179Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00002573Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00004891Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0001378Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0004481Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0009131Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric kidney0.5062Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.4399Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001092Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0001973InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.5651InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000001085Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]