SUPERFAMILY 1.75 HMM library and genome assignments server


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,358 144,985 147
Proteins 45,709 125,942 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 2.952e-10 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.717e-09 Least Informative Direct
Biological Process (BP) biosynthetic process 3.372e-09 Least Informative Direct
Biological Process (BP) regulation of metabolic process 3.741e-13 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0008768 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 3.638e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 2.955e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 3.87e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.034e-05 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0002662 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.208e-07 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organ development 6.652e-06 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.807e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.005e-12 Moderately Informative Direct
Biological Process (BP) tissue development 2.516e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 2.879e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.971e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 3.478e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 5.66e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.2242 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.008283 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3669 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8314 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6795 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4618 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.123 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.08112 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9427 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7709 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.002368 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 1.247e-09 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.569e-05 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 1.305e-13 Informative Direct
Biological Process (BP) localization of cell 9.643e-13 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1.457e-12 Informative Direct
Biological Process (BP) response to lipid 3.949e-12 Informative Direct
Biological Process (BP) tissue morphogenesis 2.214e-11 Informative Direct
Biological Process (BP) tube development 3.407e-11 Informative Direct
Biological Process (BP) cell projection organization 8.067e-11 Informative Direct
Biological Process (BP) gland development 5.657e-09 Informative Direct
Biological Process (BP) cytoskeleton organization 1.137e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 3.927e-07 Informative Direct
Biological Process (BP) growth 1.099e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.056e-05 Informative Direct
Biological Process (BP) embryonic organ development 1.206e-05 Informative Direct
Biological Process (BP) organ morphogenesis 3.899e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.315e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 7.455e-05 Informative Direct
Biological Process (BP) generation of neurons 0.000113 Informative Direct
Biological Process (BP) metal ion homeostasis 0.000418 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.9729 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.002103 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.006557 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003605 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7473 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.001933 Informative Inherited
Biological Process (BP) regulation of secretion 0.03147 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.85 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.05931 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5572 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2201 Informative Inherited
Biological Process (BP) response to oxidative stress 0.1153 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.09428 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001348 Informative Inherited
Biological Process (BP) response to inorganic substance 0.3572 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.01914 Informative Inherited
Biological Process (BP) reproductive system development 0.2796 Informative Inherited
Biological Process (BP) epithelium development 0.02656 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6526 Informative Inherited
Biological Process (BP) muscle structure development 0.1298 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.00541 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.05311 Informative Inherited
Biological Process (BP) muscle tissue development 0.5468 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.6907 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.6095 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.001684 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01549 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8171 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9376 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1861 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1417 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.3766 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) biological adhesion 0.005829 Informative Inherited
Biological Process (BP) central nervous system development 0.03262 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.02576 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) organic acid transport 0.1496 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.03425 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.00805 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.03056 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5737 Informative Inherited
Biological Process (BP) actin filament-based process 0.04707 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03318 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.008282 Informative Inherited
Biological Process (BP) single organism reproductive process 0.007505 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6674 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.008416 Informative Inherited
Biological Process (BP) DNA metabolic process 0.1506 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.5032 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9406 Informative Inherited
Biological Process (BP) leukocyte activation 0.6644 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.6514 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 3.306e-14 Highly Informative Direct
Biological Process (BP) placenta development 2.436e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 6.168e-10 Highly Informative Direct
Biological Process (BP) gonad development 7.299e-10 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.131e-09 Highly Informative Direct
Biological Process (BP) endocrine system development 2.789e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.87e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 1.529e-08 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 4.788e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 6.688e-08 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 8.051e-08 Highly Informative Direct
Biological Process (BP) actin filament organization 2.097e-07 Highly Informative Direct
Biological Process (BP) response to toxic substance 3.516e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside monophosphate metabolic process 3.965e-07 Highly Informative Direct
Biological Process (BP) ovulation cycle process 6.573e-07 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.667e-06 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.74e-06 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 2.456e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 3.234e-06 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 5.228e-06 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 5.789e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 2.467e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 2.583e-05 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 3.906e-05 Highly Informative Direct
Biological Process (BP) response to UV 4.98e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001704 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.0001804 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0002012 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002058 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0002205 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0002666 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0002901 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0005548 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007515 Highly Informative Direct
Biological Process (BP) regulation of organ morphogenesis 0.0007787 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0008665 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.835 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1871 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.8871 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.02275 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.8942 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.05242 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.8111 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.7798 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.9596 Highly Informative Inherited
Biological Process (BP) response to superoxide 0.003573 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.2527 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.0522 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.6188 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.6964 Highly Informative Inherited
Biological Process (BP) renal system development 0.2999 Highly Informative Inherited
Biological Process (BP) ear development 0.895 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1186 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.628 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.4649 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.7776 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.08923 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.8853 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.5358 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1641 Highly Informative Inherited
Biological Process (BP) digestion 0.1291 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.1985 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.4363 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.4619 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 1 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.01842 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.003261 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004313 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.2743 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.4562 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2761 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.00109 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.01786 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.173 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.04428 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.2821 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1458 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.1359 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.01056 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.6628 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.009393 Highly Informative Inherited
Biological Process (BP) neural tube development 0.1159 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.02196 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01078 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.9384 Highly Informative Inherited
Biological Process (BP) stem cell development 1 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.001543 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.134 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.006031 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.07087 Highly Informative Inherited
Biological Process (BP) axon development 0.004228 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.03186 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.01085 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5005 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7159 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.03475 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002262 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.1156 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.05552 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1005 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4254 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 4.413e-13 Moderately Informative Direct
Molecular Function (MF) cation binding 4.011e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.0872 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 1.518e-13 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 2.311e-10 Informative Direct
Molecular Function (MF) chromatin binding 5.317e-08 Informative Direct
Molecular Function (MF) carboxylic acid binding 3.001e-05 Informative Direct
Molecular Function (MF) receptor binding 0.5542 Informative Inherited
Molecular Function (MF) cofactor binding 0.3197 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.002236 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.9484 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.8358 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 1.521e-11 Highly Informative Direct
Molecular Function (MF) peptide binding 2.13e-09 Highly Informative Direct
Molecular Function (MF) actin binding 1.608e-05 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 2.132e-05 Highly Informative Direct
Molecular Function (MF) drug binding 0.0001172 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0002733 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.002868 Highly Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0.006829 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000634 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) small ribosomal subunit 0.2333 Informative Inherited
Cellular Component (CC) mitochondrial matrix 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.7291 Informative Inherited
Cellular Component (CC) cell-substrate junction 0 Highly Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 9.567e-09 Highly Informative Direct
Cellular Component (CC) chromatin 6.262e-05 Highly Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.007404 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4017Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.4487Moderately InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06254InformativeInherited
Disease Ontology (DO)physical disorder0.1166InformativeInherited
Disease Ontology (DO)kidney cancer0.9546InformativeInherited
Disease Ontology (DO)cholelithiasis2.738e-05Highly InformativeDirect
Disease Ontology (DO)hypospadias3.883e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5668Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1198Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.2196Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.6154InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.6296InformativeInherited
Phenotypic Abnormality (PA)Testicular neoplasm0.0003334Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype1.472e-05Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0007049Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.00126Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.002538Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1511Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3525Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.364Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0002699Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0006099Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.00122Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01328Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.01985Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.03452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0375Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.03859Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.04698Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.08878Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.131Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1859Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1881Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4227Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4371Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.8007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology2.789e-05InformativeDirect
Mammalian Phenotype (MP)abnormal pituitary hormone level0.0007419InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.002346InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.0027InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.0139InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.03925InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.0993InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.1104InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.1215InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2776InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.3453InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3493InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.5666InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.8135InformativeInherited
Mammalian Phenotype (MP)abnormal sublingual gland morphology6.014e-07Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus1.335e-06Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous1.097e-05Highly InformativeDirect
Mammalian Phenotype (MP)rudimentary Mullerian ducts2.573e-05Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis2.573e-05Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera2.573e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level2.855e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level3.229e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cricoid cartilage morphology0.0001606Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0002692Highly InformativeDirect
Mammalian Phenotype (MP)ectopic ureter0.0002973Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0003786Highly InformativeDirect
Mammalian Phenotype (MP)coloboma0.0006785Highly InformativeDirect
Mammalian Phenotype (MP)increased renin activity0.0007389Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.0008291Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0009951Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.001497Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ear development0.002463Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.02586Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02943Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.03283Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid aperture0.04089Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.05989Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.09031Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.1076Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.344Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.9862Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9976Moderately InformativeInherited
Worm Phenotype (WP)lipid metabolism variant5.276e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.05203InformativeInherited
Worm Phenotype (WP)failure to hatch5.39e-08Highly InformativeDirect
Worm Phenotype (WP)fat content increased3.469e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.003819Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.1464Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2529Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.3835Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4902Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1438Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2062Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.7698Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9384Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hematological system2.257e-05InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001739InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0002095InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0003505InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.002033InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.007684InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.01612InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.2034InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8403InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region1.565e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted ventral mesoderm1.825e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)diencephalon5.081e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0003311Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0003847Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0005293Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0006935Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.003752Highly InformativeInherited
Xenopus ANatomical entity (XAN)fused heart primordium0.02774Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5502InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation1.453e-07Moderately InformativeDirect
Biological processBiological rhythms6.43e-12InformativeDirect
Biological processCell adhesion0.0001771InformativeDirect
Biological processDNA synthesis0Highly InformativeDirect
Biological processNitrate assimilation1.017e-05Highly InformativeDirect
Biological processOsteogenesis0.0007751Highly InformativeDirect
Biological processRNA-mediated gene silencing0.000798Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton4.151e-13Moderately InformativeDirect
Coding sequence diversityAlternative splicing9.616e-07Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.000228Moderately InformativeDirect
DiseaseDisease mutation0.0002891Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionATP-binding1.629e-05Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionrRNA-binding0InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationRepressor4.131e-08Moderately InformativeDirect
Post-translational modificationKinase0.0002921Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationPhosphoprotein1.761e-09Least InformativeDirect
Post-translational modificationAcetylation0.0009805Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation1.603e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]