SUPERFAMILY 1.75 HMM library and genome assignments server


Glucocorticoid receptor-like (DNA-binding domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Families:   Erythroid transcription factor GATA-1 [ 57717]
  Nuclear receptor [ 57721] (12)
  Transcription factor grauzone Cg33133-Pa, zinc finger associated domain [ 103605]
  LIM domain [ 57736] (18)
  LASP-1 [ 57743]
  DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain [ 57746]
  Ribosomal protein L24e [ 57749]
  Hypothetical zinc finger protein YacG [ 82914]
  Ribosomal protein S14 [ 57752]
  C-terminal, Zn-finger domain of MutM-like DNA repair proteins [ 81627] (3)
  ClpX chaperone zinc binding domain [ 103608]
  PARP-type zinc finger [ 111445]
  Prokaryotic DksA/TraR C4-type zinc finger [ 111448]
  Type II thymidine kinase zinc finger [ 118276]
  A20-like zinc finger [ 144187]
  THAP domain [ 161163]
  TRASH domain [ 161166]
  FwdE C-terminal domain-like [ 161169]


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,354 144,985 147
Proteins 45,705 125,942 109


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.751e-10 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.632e-08 Least Informative Direct
Biological Process (BP) biosynthetic process 5.528e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0007363 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1.481e-12 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 5.424e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 3.425e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 4.336e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.431e-05 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0002555 Moderately Informative Direct
Biological Process (BP) cell differentiation 8.419e-08 Moderately Informative Direct
Biological Process (BP) organ development 8.184e-06 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0002998 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1.643e-13 Moderately Informative Direct
Biological Process (BP) tissue development 2.2e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 1.852e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 2.563e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 4.27e-05 Moderately Informative Direct
Biological Process (BP) multi-organism process 6.138e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.2878 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.3992 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8621 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6517 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4187 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1191 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.1167 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9835 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6905 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.04905 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component movement 1.848e-09 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 1.741e-05 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 1.068e-13 Informative Direct
Biological Process (BP) localization of cell 1.919e-12 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.458e-12 Informative Direct
Biological Process (BP) response to lipid 5.514e-12 Informative Direct
Biological Process (BP) tissue morphogenesis 2.307e-11 Informative Direct
Biological Process (BP) tube development 2.459e-11 Informative Direct
Biological Process (BP) cell projection organization 1.374e-10 Informative Direct
Biological Process (BP) regulation of cell proliferation 5.044e-09 Informative Direct
Biological Process (BP) gland development 1.207e-08 Informative Direct
Biological Process (BP) cytoskeleton organization 2.467e-08 Informative Direct
Biological Process (BP) response to DNA damage stimulus 8.455e-07 Informative Direct
Biological Process (BP) growth 5.876e-06 Informative Direct
Biological Process (BP) embryonic morphogenesis 6.902e-06 Informative Direct
Biological Process (BP) embryonic organ development 1.036e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 5.57e-05 Informative Direct
Biological Process (BP) organ morphogenesis 6.718e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0001011 Informative Direct
Biological Process (BP) generation of neurons 0.0001493 Informative Direct
Biological Process (BP) regulation of protein localization 0.000488 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0005183 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.9697 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.001801 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.005552 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003159 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.878 Informative Inherited
Biological Process (BP) regulation of secretion 0.0379 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.9085 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.06597 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4661 Informative Inherited
Biological Process (BP) protein localization to organelle 0.238 Informative Inherited
Biological Process (BP) response to oxidative stress 0.1389 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1062 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.001143 Informative Inherited
Biological Process (BP) response to inorganic substance 0.3229 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) sensory organ development 0.01667 Informative Inherited
Biological Process (BP) reproductive system development 0.2778 Informative Inherited
Biological Process (BP) epithelium development 0.02863 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.547 Informative Inherited
Biological Process (BP) muscle structure development 0.162 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.06755 Informative Inherited
Biological Process (BP) muscle tissue development 0.6422 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.6287 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.002211 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01133 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.91 Informative Inherited
Biological Process (BP) regulation of cell activation 0.7677 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9208 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.217 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1318 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7098 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.4139 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) biological adhesion 0.007052 Informative Inherited
Biological Process (BP) central nervous system development 0.06208 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.0227 Informative Inherited
Biological Process (BP) organic acid transport 0.1563 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.03823 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.007818 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 1 Informative Inherited
Biological Process (BP) apoptotic process 0.03232 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5652 Informative Inherited
Biological Process (BP) actin filament-based process 0.04741 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03193 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.008222 Informative Inherited
Biological Process (BP) single organism reproductive process 0.007754 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6601 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.4987 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.07039 Informative Inherited
Biological Process (BP) DNA metabolic process 0.1832 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) muscle system process 0.5096 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9337 Informative Inherited
Biological Process (BP) leukocyte activation 0.692 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.6711 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) intrinsic apoptotic signaling pathway 5.267e-14 Highly Informative Direct
Biological Process (BP) placenta development 6.154e-13 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 3.902e-10 Highly Informative Direct
Biological Process (BP) gonad development 6.586e-10 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 2.214e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 5.222e-09 Highly Informative Direct
Biological Process (BP) endocrine system development 6.967e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 2.079e-08 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 6.817e-08 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 7.209e-08 Highly Informative Direct
Biological Process (BP) chemotaxis 1.561e-07 Highly Informative Direct
Biological Process (BP) actin filament organization 1.841e-07 Highly Informative Direct
Biological Process (BP) ovulation cycle process 3.108e-07 Highly Informative Direct
Biological Process (BP) deoxyribonucleoside monophosphate metabolic process 4.236e-07 Highly Informative Direct
Biological Process (BP) response to toxic substance 6.86e-07 Highly Informative Direct
Biological Process (BP) cell fate commitment 1.799e-06 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 2.281e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 2.56e-06 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 3.083e-06 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 5.056e-06 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 6.678e-06 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 1.215e-05 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 2.936e-05 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 4.314e-05 Highly Informative Direct
Biological Process (BP) response to UV 4.789e-05 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 5.582e-05 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0001566 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.000173 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002232 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.0002582 Highly Informative Direct
Biological Process (BP) regulation of neural precursor cell proliferation 0.0002756 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.0005472 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0008133 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.0008228 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0008688 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0008986 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.8507 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.2276 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.9036 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.03255 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9362 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001155 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.05258 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.01275 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.01046 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.8163 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.8103 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.9984 Highly Informative Inherited
Biological Process (BP) response to superoxide 0.004677 Highly Informative Inherited
Biological Process (BP) cellular response to reactive oxygen species 0.2902 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.0508 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.5131 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.6682 Highly Informative Inherited
Biological Process (BP) renal system development 0.292 Highly Informative Inherited
Biological Process (BP) ear development 0.9039 Highly Informative Inherited
Biological Process (BP) developmental growth 0.2341 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 1 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.6366 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.4529 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.7583 Highly Informative Inherited
Biological Process (BP) connective tissue development 0.0951 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9715 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.4973 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.1702 Highly Informative Inherited
Biological Process (BP) digestion 0.1262 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.1997 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.452 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.4624 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.9682 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.01753 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.003788 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004051 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.2904 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.4828 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3723 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.001262 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02005 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.9763 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.182 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.04451 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.2963 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1601 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.1629 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.008522 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.6483 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.007356 Highly Informative Inherited
Biological Process (BP) neural tube development 0.1079 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.02127 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.8216 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01157 Highly Informative Inherited
Biological Process (BP) regulation of lipid storage 0.001606 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.1386 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.006225 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.07495 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5045 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation homeostasis 0.4859 Highly Informative Inherited
Biological Process (BP) protein glycosylation 0.7246 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.02403 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.005557 Highly Informative Inherited
Biological Process (BP) energy reserve metabolic process 0.1237 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.0686 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1074 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.3957 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 1.083e-13 Moderately Informative Direct
Molecular Function (MF) cation binding 5.883e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.09416 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) lipid binding 2.968e-13 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 2.252e-10 Informative Direct
Molecular Function (MF) chromatin binding 2.192e-07 Informative Direct
Molecular Function (MF) carboxylic acid binding 4.681e-05 Informative Direct
Molecular Function (MF) receptor binding 0.57 Informative Inherited
Molecular Function (MF) cofactor binding 0.4044 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.002775 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 0.8855 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.8497 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 2.222e-11 Highly Informative Direct
Molecular Function (MF) peptide binding 3.419e-09 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 3.61e-05 Highly Informative Direct
Molecular Function (MF) drug binding 0.0001475 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0003161 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.003835 Highly Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0.008349 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0006338 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) contractile fiber part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) small ribosomal subunit 0.2315 Informative Inherited
Cellular Component (CC) mitochondrial matrix 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 0.6926 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 6.97e-09 Highly Informative Direct
Cellular Component (CC) chromatin 3.48e-05 Highly Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.007781 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0Highly InformativeDirect
Enzyme Commission (EC)DNA-formamidopyrimidine glycosylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4426Least InformativeInherited
Disease Ontology (DO)endometrial cancer0.0002321InformativeDirect
Disease Ontology (DO)physical disorder0.1376InformativeInherited
Disease Ontology (DO)cholelithiasis3.303e-05Highly InformativeDirect
Disease Ontology (DO)hypospadias8.599e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0006356Least InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0826Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.9769Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.5206InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.585InformativeInherited
Phenotypic Abnormality (PA)Testicular neoplasm0.0005718Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype3.79e-06Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0008424Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0.0009727Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.001057Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.006496Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0979Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2717Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.474Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0003348Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0009645Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001456Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.0142Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.02951Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.04732Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.04915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.05953Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.07196Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.15Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1776Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1883Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.2965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3688Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4222Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.872Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology6.18e-06InformativeDirect
Mammalian Phenotype (MP)abnormal internal male genitalia morphology2.89e-05InformativeDirect
Mammalian Phenotype (MP)abnormal pituitary hormone level0.0006669InformativeDirect
Mammalian Phenotype (MP)abnormal sex gland morphology0.0008243InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.003017InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.06063InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.1191InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.1363InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.231InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2753InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.294InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3583InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.5656InformativeInherited
Mammalian Phenotype (MP)abnormal sublingual gland morphology6.225e-07Highly InformativeDirect
Mammalian Phenotype (MP)absent fetal ductus arteriosus1.375e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level9.336e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myocardium layer morphology1.114e-05Highly InformativeDirect
Mammalian Phenotype (MP)persistent hyperplastic primary vitreous1.144e-05Highly InformativeDirect
Mammalian Phenotype (MP)rudimentary Mullerian ducts2.678e-05Highly InformativeDirect
Mammalian Phenotype (MP)split cervical axis2.678e-05Highly InformativeDirect
Mammalian Phenotype (MP)absent sclera2.678e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating testosterone level3.032e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0001199Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0001565Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cricoid cartilage morphology0.0002162Highly InformativeDirect
Mammalian Phenotype (MP)decreased compact bone area0.0002773Highly InformativeDirect
Mammalian Phenotype (MP)ectopic ureter0.0002834Highly InformativeDirect
Mammalian Phenotype (MP)coloboma0.0006726Highly InformativeDirect
Mammalian Phenotype (MP)increased renin activity0.0007622Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal inner plexiform layer morphology0.0009145Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ear development0.002364Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.003799Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.03274Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vagina morphology0.03536Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04939Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.05214Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.05955Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.101Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.1065Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.3936Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.9862Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.9976Moderately InformativeInherited
Worm Phenotype (WP)lipid metabolism variant5.276e-05InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.05203InformativeInherited
Worm Phenotype (WP)failure to hatch5.39e-08Highly InformativeDirect
Worm Phenotype (WP)fat content increased3.469e-05Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.003819Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0.1469Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2622Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue0.3904Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4905Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1056Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2163Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.7735Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9356Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.985Moderately InformativeInherited
Xenopus ANatomical entity (XAN)hematological system2.412e-05InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001974InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0002471InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0004172InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.002071InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.003171InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.019InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.2435InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8423InformativeInherited
Xenopus ANatomical entity (XAN)involuted ventral mesoderm1.814e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region1.937e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)diencephalon5.848e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0004117Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.0004501Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0005266Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0006942Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.003852Highly InformativeInherited
Xenopus ANatomical entity (XAN)fused heart primordium0.02848Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.5516InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation1.769e-07Moderately InformativeDirect
Biological processBiological rhythms8.014e-11InformativeDirect
Biological processCell adhesion0.0001793InformativeDirect
Biological processDNA synthesis0Highly InformativeDirect
Biological processNitrate assimilation1.079e-05Highly InformativeDirect
Biological processMyogenesis0.000396Highly InformativeDirect
Biological processOsteogenesis0.0007709Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0007915Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton4.502e-13Moderately InformativeDirect
Coding sequence diversityAlternative splicing6.601e-06Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.0002236Moderately InformativeDirect
DiseaseDisease mutation0.0003261Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainLIM domain0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionATP-binding1.597e-05Moderately InformativeDirect
Molecular functionLipid-binding0InformativeDirect
Molecular functionrRNA-binding0InformativeDirect
Molecular functionSteroid-binding0Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationRepressor6.469e-08Moderately InformativeDirect
Post-translational modificationKinase0.0002982Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationPhosphoprotein2.127e-09Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation1.587e-06InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 109 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 109 hidden Markov models representing the Glucocorticoid receptor-like (DNA-binding domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]