SUPERFAMILY 1.75 HMM library and genome assignments server

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Methionyl-tRNA synthetase (MetRS), Zn-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Rubredoxin-like [ 57769] (17)
Superfamily:   Methionyl-tRNA synthetase (MetRS), Zn-domain [ 57770]
Families:   Methionyl-tRNA synthetase (MetRS), Zn-domain [ 57771]


Superfamily statistics
Genomes (1,835) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,976 8,507 5
Proteins 1,976 8,507 5


Functional annotation
General category General
Detailed category Ion binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00002876 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00003582 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0005294 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.007059 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005181 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.005099 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.006947 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.004524 Least Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000008269 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000001658 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000002192 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0004495 Moderately Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0000000005396 Informative Direct
Molecular Function (MF) ligase activity 0.00000000002789 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functiontRNA-binding0InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Methionyl-tRNA synthetase (MetRS), Zn-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Methionyl-tRNA synthetase (MetRS), Zn-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]