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Microbial and mitochondrial ADK, insert "zinc finger" domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Rubredoxin-like [ 57769] (17)
Superfamily:   Microbial and mitochondrial ADK, insert "zinc finger" domain [ 57774]
Families:   Microbial and mitochondrial ADK, insert "zinc finger" domain [ 57775]


Superfamily statistics
Genomes (439) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 730 2,193 3
Proteins 687 2,123 3


Functional annotation
General category General
Detailed category Ion binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0000000331 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00000003801 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000009218 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0000001372 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000007028 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00002712 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0002822 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0006844 Least Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0000000007187 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000001576 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000298 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000008323 Moderately Informative Direct
Biological Process (BP) phosphorylation 0.09082 Informative Inherited
Biological Process (BP) nucleoside triphosphate biosynthetic process 0.0000004314 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000000001712 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000000001728 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.0000000000000138 Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.1176 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.006175 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2049 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03459 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0002202Least InformativeDirect
Cellular componentMitochondrion0.000000634Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0.0000001072Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001295Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007862 SSF57774 Protein matches
Abstract Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function [PubMed9715904].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Microbial and mitochondrial ADK, insert "zinc finger" domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Microbial and mitochondrial ADK, insert "zinc finger" domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]