SUPERFAMILY 1.75 HMM library and genome assignments server


Microbial and mitochondrial ADK, insert "zinc finger" domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Rubredoxin-like [ 57769] (17)
Superfamily:   Microbial and mitochondrial ADK, insert "zinc finger" domain [ 57774]
Families:   Microbial and mitochondrial ADK, insert "zinc finger" domain [ 57775]


Superfamily statistics
Genomes (423) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 687 0 3
Proteins 644 0 3


Functional annotation
General category General
Detailed category Ion binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 6.192e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 7.835e-09 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.093e-08 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 7.803e-08 Least Informative Direct
Biological Process (BP) single-organism metabolic process 3.792e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0006575 Least Informative Direct
Biological Process (BP) organophosphate metabolic process 4.194e-11 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 7.262e-10 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 4.546e-09 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.46e-05 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.707e-05 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.899e-05 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 5.208e-05 Moderately Informative Direct
Biological Process (BP) phosphorylation 8.596e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0004486 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.01584 Informative Inherited
Biological Process (BP) nucleoside diphosphate metabolic process 3.694e-13 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 7.005e-13 Moderately Informative Direct
Molecular Function (MF) kinase activity 9.601e-14 Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.0001622 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.002243 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0InformativeDirect
Enzyme Commission (EC)Adenylate kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0001186Least InformativeDirect
Cellular componentMitochondrion4.668e-07Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc7.819e-10Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcetylation7.547e-05Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)AMP biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR007862 SSF57774 Protein matches
Abstract Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function [PubMed9715904].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Microbial and mitochondrial ADK, insert "zinc finger" domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Microbial and mitochondrial ADK, insert "zinc finger" domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]