SUPERFAMILY 1.75 HMM library and genome assignments server

RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (689) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 113,717 114,720 32
Proteins 101,770 103,447 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.00000000056290Least InformativeDirect
Biological Process (BP)protein metabolic process0.000000016760Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.02720.0009481Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.34321Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00013760.2747Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.64130.003994Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.24851Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.28580.2484Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.34431Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.22951Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.46861Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.15680.1075Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.030540.04631Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.17561Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0023980.07748Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.75971Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.055630Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.057171Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.083270.000000003357Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.041850Moderately InformativeInherited
Biological Process (BP)gene expression0.97161Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.077540.00000000000006308Moderately InformativeInherited
Biological Process (BP)signal transduction0.69531Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.0000000000068180InformativeDirect
Biological Process (BP)protein catabolic process0.00004850InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00023520InformativeDirect
Biological Process (BP)anatomical structure homeostasis0.00029940.000008711InformativeDirect
Biological Process (BP)regulation of peptidase activity0.12160.02637InformativeInherited
Biological Process (BP)positive regulation of gene expression0.27231InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.0098871InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.000074650.002558InformativeInherited
Biological Process (BP)response to oxidative stress0.003761InformativeInherited
Biological Process (BP)protein maturation0.0064941InformativeInherited
Biological Process (BP)proteolysis0.0060410.000000000000001913InformativeInherited
Biological Process (BP)apoptotic process0.00014750.2868InformativeInherited
Biological Process (BP)intracellular signal transduction0.013240.661InformativeInherited
Biological Process (BP)zymogen activation0.00000048760.0003936Highly InformativeDirect
Biological Process (BP)positive regulation of endopeptidase activity0.00000048760.2514Highly InformativeInherited
Biological Process (BP)intrinsic apoptotic signaling pathway0.000003130.03036Highly InformativeInherited
Molecular Function (MF)transferase activity0.000056180Least InformativeDirect
Molecular Function (MF)binding0.00086310Least InformativeDirect
Molecular Function (MF)ligase activity0.0011730.4462InformativeInherited
Molecular Function (MF)ubiquitin-protein transferase activity00Highly InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.000017390.000000000001637Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.000058820.4228Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.27180.03598Least InformativeInherited
Cellular Component (CC)protein complex0.00000047920.9953Least InformativeInherited
Cellular Component (CC)transferase complex00Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0025990.000000000005974Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.10160.02519Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nucleoplasm part0.2870.0000009107InformativeInherited
Cellular Component (CC)nuclear ubiquitin ligase complex0.0000000032690Highly InformativeDirect
Cellular Component (CC)nuclear body0.0000096270.00000001936Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002251 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0009481 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2747 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.003994 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000001551 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000000006308 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000000003357 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000005863 Moderately Informative Direct
Biological Process (BP) immune system process 0.000000000005118 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000000004708 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1075 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8028 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05583 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.001283 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9046 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.07748 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.09274 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.04493 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2075 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.2851 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.07119 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.04631 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2484 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.4866 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.04023 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.03805 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000008711 Informative Direct
Biological Process (BP) chromosome organization 0.00000000000378 Informative Direct
Biological Process (BP) cell cycle process 0.000000009119 Informative Direct
Biological Process (BP) proteolysis 0.000000000000001913 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001739 Informative Direct
Biological Process (BP) immune response 0.000000000008658 Informative Direct
Biological Process (BP) DNA repair 0.0000000003743 Informative Direct
Biological Process (BP) protein oligomerization 0.0002448 Informative Direct
Biological Process (BP) protein transport 0.000944 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.4406 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1859 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.02637 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8389 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.002558 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.4029 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7469 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8111 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) secretion by cell 0.8276 Informative Inherited
Biological Process (BP) response to acid chemical 0.03587 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.4797 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to cytokine 0.396 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.616 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8184 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.009098 Informative Inherited
Biological Process (BP) negative regulation of protein processing 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.9127 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1614 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.8225 Informative Inherited
Biological Process (BP) microtubule-based process 0.7472 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.7475 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.1407 Informative Inherited
Biological Process (BP) regulation of protein localization 0.003942 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.6437 Informative Inherited
Biological Process (BP) regulation of defense response 0.8668 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3018 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7244 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.05429 Informative Inherited
Biological Process (BP) apoptotic process 0.2868 Informative Inherited
Biological Process (BP) response to oxidative stress 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.1319 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.006386 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.05376 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.02212 Informative Inherited
Biological Process (BP) protein maturation 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.01469 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.9738 Informative Inherited
Biological Process (BP) tube development 0.7104 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4858 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.7815 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.423 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.4838 Informative Inherited
Biological Process (BP) response to nutrient levels 0.8061 Informative Inherited
Biological Process (BP) immune effector process 0.02413 Informative Inherited
Biological Process (BP) muscle structure development 0.4395 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.9019 Informative Inherited
Biological Process (BP) epithelium development 0.9436 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 0.05545 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.661 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.06017 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.07134 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.423 Informative Inherited
Biological Process (BP) leukocyte activation 0.9629 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.3007 Informative Inherited
Biological Process (BP) regulation of immune response 0.6223 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.5476 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) organelle fission 0.4483 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.007219 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) zymogen activation 0.0003936 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0001468 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00003267 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.0000000000003876 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.000000000008756 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000000002149 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000000001156 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.000000004882 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000000007449 Highly Informative Direct
Biological Process (BP) regulation of ligase activity 0.0000000754 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.0000002184 Highly Informative Direct
Biological Process (BP) macroautophagy 0.0000003469 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000005023 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0000006123 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0000009965 Highly Informative Direct
Biological Process (BP) protein import 0.000003623 Highly Informative Direct
Biological Process (BP) B cell activation 0.00001051 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.00002559 Highly Informative Direct
Biological Process (BP) neural tube development 0.0001038 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0002006 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0003587 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0003969 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.4104 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.3624 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.2514 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2278 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.05445 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule biosynthetic process 0.04633 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.08751 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.2597 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.09979 Highly Informative Inherited
Biological Process (BP) negative regulation of protein catabolic process 0.007596 Highly Informative Inherited
Biological Process (BP) negative regulation of cell division 0.1694 Highly Informative Inherited
Biological Process (BP) negative regulation of chromosome organization 0.4665 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.5153 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.8588 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.2549 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.05715 Highly Informative Inherited
Biological Process (BP) regulation of protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.03068 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.03258 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.264 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.4206 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.176 Highly Informative Inherited
Biological Process (BP) regulation of translation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.1128 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.003382 Highly Informative Inherited
Biological Process (BP) cell wall polysaccharide metabolic process 0.01639 Highly Informative Inherited
Biological Process (BP) DNA modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.7444 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.2901 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell fate commitment 1 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.7995 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.6926 Highly Informative Inherited
Biological Process (BP) innate immune response 0.001006 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.3933 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.05664 Highly Informative Inherited
Biological Process (BP) gene silencing 0.103 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.6107 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.4312 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.4319 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.6853 Highly Informative Inherited
Biological Process (BP) DNA integrity checkpoint 0.9272 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.702 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3501 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.04941 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.993 Highly Informative Inherited
Biological Process (BP) response to fungus 0.001673 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.03036 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.514 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.3448 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.4561 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.03277 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.3581 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.08963 Highly Informative Inherited
Biological Process (BP) protein deacylation 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.004144 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.01924 Highly Informative Inherited
Biological Process (BP) plasma membrane organization 0.2471 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.3764 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 0.0000002742 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) chromatin binding 0.000009763 Informative Direct
Molecular Function (MF) enzyme binding 0.0001207 Informative Direct
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 0.867 Informative Inherited
Molecular Function (MF) protein complex binding 1 Informative Inherited
Molecular Function (MF) peptidase activity 0.1275 Informative Inherited
Molecular Function (MF) ligase activity 0.4462 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) DNA binding 0.8517 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.9405 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.7875 Informative Inherited
Molecular Function (MF) lipid binding 1 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.000000000001637 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.0001138 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.001238 Highly Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.4713 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.8076 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.001035 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 0.2098 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.7598 Highly Informative Inherited
Molecular Function (MF) amino acid binding 0.1845 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0000009421 Least Informative Direct
Cellular Component (CC) protein complex 0.9953 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.03598 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4228 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000000000005974 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.02519 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.01709 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.6435 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0.0000009107 Informative Direct
Cellular Component (CC) chromosome 0.0000000001163 Informative Direct
Cellular Component (CC) endosome 0.0002416 Informative Direct
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) lytic vacuole 0.05747 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 1 Informative Inherited
Cellular Component (CC) mitochondrial membrane part 1 Informative Inherited
Cellular Component (CC) integral component of membrane 1 Informative Inherited
Cellular Component (CC) contractile fiber part 0.1326 Informative Inherited
Cellular Component (CC) microbody 0.001992 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00000001936 Highly Informative Direct
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00000000007791 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.000002099 Highly Informative Direct
Cellular Component (CC) chromatin 0.0000205 Highly Informative Direct
Cellular Component (CC) integral component of organelle membrane 0.0002849 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) endosomal part 0.09038 Highly Informative Inherited
Cellular Component (CC) organelle outer membrane 0.2269 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.693 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000001652Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000004836Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000000006579InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3864Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.5681Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.7549Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.7683Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9233Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.1038InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.2907InformativeInherited
Phenotypic Abnormality (PA)Generalized neonatal hypotonia0.000006986Highly InformativeDirect
Phenotypic Abnormality (PA)Brushfield spots0.0001321Highly InformativeDirect
Phenotypic Abnormality (PA)Clubbing of toes0.0008987Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.05738Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.8261Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal chromosome stability0.000397InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.611InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.00002743Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.04091Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000000000000001122Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.5632Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000000002914Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00099Moderately InformativeDirect
Worm Phenotype (WP)cell stress response variant0.00000000714InformativeDirect
Worm Phenotype (WP)neuron development variant0.2742InformativeInherited
Worm Phenotype (WP)cell ionizing radiation response variant0.00000004226Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.1107Highly InformativeInherited
Worm Phenotype (WP)germ cell ionizing radiation response variant0.1541Highly InformativeInherited

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)gonad0.001832Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.002271Least InformativeInherited
Xenopus ANatomical entity (XAN)ovary0.0006074Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.6547Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00009658InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0001737Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.005802Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.00001142Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000000000000001917Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000009282Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00009Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.03085Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.08362Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)In linear amides0.1456InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.2243InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000000007776Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processHost-virus interaction0.00000000001063Moderately InformativeDirect
Biological processTranscription regulation0.0000000001022Moderately InformativeDirect
Biological processCell cycle0.0000000003114Moderately InformativeDirect
Biological processDNA damage0.000005083Moderately InformativeDirect
Biological processDifferentiation0.0007372Moderately InformativeDirect
Biological processMitosis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processEndocytosis0.00000000000003498InformativeDirect
Biological processWnt signaling pathway0.00000000000007372InformativeDirect
Biological processmRNA splicing0.0000000007982InformativeDirect
Biological processPlant defense0.000006879InformativeDirect
Biological processMeiosis0.00001827InformativeDirect
Biological processViral immunoevasion0.03309InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processAutophagy0.000000000001256Highly InformativeDirect
Biological processVirus exit from host cell0.000003765Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0001434Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000000008988Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000004892Moderately InformativeDirect
Cellular componentCell junction0.000001679Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentSpliceosome0.000000000001047InformativeDirect
Cellular componentChromosome0.000000000008095InformativeDirect
Cellular componentVacuole0.00000007408InformativeDirect
Cellular componentMitochondrion outer membrane0.0000001773InformativeDirect
Cellular componentSynapse0.000001742InformativeDirect
Cellular componentHost cytoplasm0.00002511InformativeDirect
Cellular componentLipid droplet0.000001756Highly InformativeDirect
Cellular componentHost endosome0.0003838Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000000000001275Least InformativeDirect
Developmental stageEarly protein0.0001762Least InformativeDirect
DiseaseTumor suppressor0.00008611Moderately InformativeDirect
DiseaseOsteopetrosis0.00000006555Highly InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain0.0000008672Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000000007386Moderately InformativeDirect
Post-translational modificationActivator0.00001176Moderately InformativeDirect
Post-translational modificationProtease0.01414Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0000000000001743Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000002559Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellulose metabolism8.993e-16InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]