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RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (697) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 115,075 252,298 32
Proteins 102,869 225,711 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.00000052760Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00001050Least InformativeDirect
Biological Process (BP)primary metabolic process0.00061730Least InformativeDirect
Biological Process (BP)biological regulation0.28210Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0043150.05606Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0038270Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.010750Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.051460Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.053611Moderately InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.000019150InformativeDirect
Biological Process (BP)regulation of organelle organization0.0013570.0000008172InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.018530.8237InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000000000053010Highly InformativeDirect
Biological Process (BP)positive regulation of organelle organization0.000090730.0003765Highly InformativeDirect
Biological Process (BP)cellular protein catabolic process0.00014870Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.00000680.007598Highly InformativeInherited
Molecular Function (MF)transferase activity0.00000044910Least InformativeDirect
Molecular Function (MF)binding0.029770Least InformativeInherited
Molecular Function (MF)ubiquitin-like protein transferase activity00Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00059030.2866Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.16160.0000004337Least InformativeInherited
Cellular Component (CC)transferase complex00Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0011680.00000000000008442Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.000000000012650Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1405 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002586 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00001245 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00003618 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000095 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000000000003429 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000000003429 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000001044 Moderately Informative Direct
Biological Process (BP) immune system process 0.000000005294 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0002327 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0005684 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.08278 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.0975 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05606 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8971 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01072 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.09488 Moderately Informative Inherited
Biological Process (BP) reproduction 0.999 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7086 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1197 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.528 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01893 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5736 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7598 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000008172 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) chromosome organization 0.000000000006169 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000000002873 Informative Direct
Biological Process (BP) immune response 0.00001771 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00004451 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.000224 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0003521 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.9038 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.9775 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.6622 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.01215 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.4234 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.007622 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.06872 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1457 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04533 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1372 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7683 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) intracellular transport 0.1637 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.5317 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2343 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.5938 Informative Inherited
Biological Process (BP) cell activation 0.1971 Informative Inherited
Biological Process (BP) generation of neurons 0.7424 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.6608 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5344 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9582 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.07814 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.6163 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.6791 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.14 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5846 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.9384 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.8237 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.008715 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.06881 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2311 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) protein transport 0.3208 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.5157 Informative Inherited
Biological Process (BP) regulation of system process 0.9932 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.903 Informative Inherited
Biological Process (BP) response to radiation 0.03083 Informative Inherited
Biological Process (BP) response to acid chemical 0.08733 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.4921 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) cell development 0.9965 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6316 Informative Inherited
Biological Process (BP) cell cycle process 0.3817 Informative Inherited
Biological Process (BP) protein localization to organelle 0.05796 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.03469 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2255 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.4149 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0003765 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000000000001597 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.000000000009849 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000000001522 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.000000002305 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.00000000266 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000000138 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000001002 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000002355 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00001116 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.00001118 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00001589 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.00003288 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00009876 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0001074 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0001921 Highly Informative Direct
Biological Process (BP) pigmentation 0.0003867 Highly Informative Direct
Biological Process (BP) protein targeting 0.0005065 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.0007292 Highly Informative Direct
Biological Process (BP) protein import 0.0009022 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.06292 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.5814 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.1205 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.5907 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1138 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.001019 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.9263 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.04687 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.05404 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.04695 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.06029 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.01428 Highly Informative Inherited
Biological Process (BP) regulation of RNA stability 0.0918 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.006777 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.4458 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.3647 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.5921 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.01071 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.01031 Highly Informative Inherited
Biological Process (BP) viral process 0.5989 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2814 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.3405 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.004291 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.001218 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.05285 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.634 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.0407 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.3801 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.04604 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.7262 Highly Informative Inherited
Biological Process (BP) gene silencing 0.1399 Highly Informative Inherited
Biological Process (BP) protein-DNA complex subunit organization 0.03737 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.007598 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.2398 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.8432 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.5582 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.6968 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 0.8898 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2577 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.7964 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.006746 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.3403 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.1932 Highly Informative Inherited
Biological Process (BP) germ cell development 0.007933 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.4705 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.2918 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.8483 Highly Informative Inherited
Biological Process (BP) DNA methylation or demethylation 0.001816 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.7628 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) autophagy 0.7241 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0000003704 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000004917 Informative Direct
Molecular Function (MF) receptor binding 0.9388 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) RNA binding 0.7159 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.9957 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.002319 Informative Inherited
Molecular Function (MF) DNA binding 0.9904 Informative Inherited
Molecular Function (MF) phospholipid binding 0.4235 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0.00000000003529 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000000002012 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00009408 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.327 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.001309 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.9643 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.09068 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0000004337 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000231 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2866 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000000008442 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00000009125 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000165 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0002659 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.3603 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.9261 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.001096 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) chromosome 0.000000000001946 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.00000001094 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0000001094 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0000002057 Informative Direct
Cellular Component (CC) nucleoplasm part 0.00001286 Informative Direct
Cellular Component (CC) endosome 0.00001786 Informative Direct
Cellular Component (CC) microbody 0.00008471 Informative Direct
Cellular Component (CC) outer membrane 0.000556 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 1 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) P-body 0 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000000003965 Highly Informative Direct
Cellular Component (CC) tethering complex 0.0000000008754 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000000001871 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0000003231 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0000005373 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00005012 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.0001047 Highly Informative Direct
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.2707 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited
Cellular Component (CC) peptidase complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000001652Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000004836Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000000006579InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDNA damage0.000000000004162Moderately InformativeDirect
Biological processHost-virus interaction0.0000000001742Moderately InformativeDirect
Biological processTranscription regulation0.0000000002074Moderately InformativeDirect
Biological processCell cycle0.000000004314Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processWnt signaling pathway0.00000000000004739InformativeDirect
Biological processEndocytosis0.0000000000002243InformativeDirect
Biological processMeiosis0.000008607InformativeDirect
Biological processPlant defense0.0000726InformativeDirect
Biological processmRNA processing0.0006843InformativeDirect
Biological processViral immunoevasion0.05127InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processAbscisic acid signaling pathway0.000000001297Highly InformativeDirect
Biological processVirus exit from host cell0.00002413Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000000007724Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000001503Moderately InformativeDirect
Cellular componentCell junction0.000002323Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentSpliceosome0.00000000000003665InformativeDirect
Cellular componentChromosome0.0000000000001535InformativeDirect
Cellular componentSynapse0.0000001155InformativeDirect
Cellular componentMitochondrion outer membrane0.0000009103InformativeDirect
Cellular componentVacuole0.000001083InformativeDirect
Cellular componentHost cytoplasm0.0001656InformativeDirect
Cellular componentLipid droplet0.000000002374Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000000000000009012Least InformativeDirect
Developmental stageEarly protein0.0001577Least InformativeDirect
DiseaseTumor suppressor0.0003453Moderately InformativeDirect
DiseaseOsteopetrosis0.0000001796Highly InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain0.000001055Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000000000004345Moderately InformativeDirect
Post-translational modificationActivator0.00000005103Moderately InformativeDirect
Post-translational modificationProtease0.03525Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationActin-binding0.000002088InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000003309Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]