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RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (690) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 113,238 114,720 32
Proteins 101,306 103,447 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0000012690Least InformativeDirect
Biological Process (BP)primary metabolic process0.00098060Least InformativeDirect
Biological Process (BP)organic substance catabolic process0.0071140Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.056010Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0015380Moderately InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.0000160InformativeDirect
Biological Process (BP)proteolysis0.0010020.00000000002829InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00Highly InformativeDirect
Biological Process (BP)modification-dependent protein catabolic process0.000000000033930.0002044Highly InformativeDirect
Molecular Function (MF)transferase activity0.0000015250Least InformativeDirect
Molecular Function (MF)binding0.025020Least InformativeInherited
Molecular Function (MF)protein binding0.00060010Moderately InformativeDirect
Molecular Function (MF)ubiquitin-like protein transferase activity00Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.16150.00008341Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00021610.1204Least InformativeInherited
Cellular Component (CC)transferase complex00Moderately InformativeDirect
Cellular Component (CC)nuclear part0.00085950.00000000006138Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.00000000000008840Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00004918 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07472 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000002917 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00008377 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000001053 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000001072 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000005688 Moderately Informative Direct
Biological Process (BP) response to stress 0.000000000006171 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000004357 Moderately Informative Direct
Biological Process (BP) immune system process 0.000000001096 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002756 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03593 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3397 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.03596 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.7984 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8616 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.6681 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.005656 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.4515 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01534 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.4682 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.8204 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1331 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3475 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7026 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0.00000000002829 Informative Direct
Biological Process (BP) immune response 0.00000003257 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00004383 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0002557 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.0004887 Informative Direct
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2875 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.327 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.002014 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.001244 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.8432 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.908 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1391 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.1182 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8623 Informative Inherited
Biological Process (BP) cell adhesion 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.8051 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) response to cytokine 0.0032 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.113 Informative Inherited
Biological Process (BP) embryo development 0.6903 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.05539 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.4437 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9937 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.0097 Informative Inherited
Biological Process (BP) microtubule-based process 0.5697 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.7523 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1268 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.06548 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3656 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.876 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.515 Informative Inherited
Biological Process (BP) generation of neurons 0.6396 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.4012 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.2429 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.01415 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.002896 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01343 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.9473 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7371 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.9564 Informative Inherited
Biological Process (BP) response to radiation 0.04156 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.371 Informative Inherited
Biological Process (BP) cell cycle process 0.01314 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2143 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.8977 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) protein targeting 0.382 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.006956 Informative Inherited
Biological Process (BP) regulation of defense response 0.6428 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) organelle fission 0.001991 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.1949 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.0002044 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000000000004691 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000000006326 Highly Informative Direct
Biological Process (BP) DNA recombination 0.00000002822 Highly Informative Direct
Biological Process (BP) innate immune response 0.00000005497 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000007905 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.0000007988 Highly Informative Direct
Biological Process (BP) autophagy 0.000001066 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00000124 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.00002039 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.00004022 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00007196 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00007679 Highly Informative Direct
Biological Process (BP) endosomal transport 0.00009253 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0002498 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0002598 Highly Informative Direct
Biological Process (BP) protein import 0.00082 Highly Informative Direct
Biological Process (BP) pigmentation 0.0008317 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0008595 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.1529 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.7013 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.9785 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.3228 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.0729 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.529 Highly Informative Inherited
Biological Process (BP) regulation of viral life cycle 0.002385 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.08014 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.101 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.3105 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.07938 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.2532 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.003861 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.007722 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.2245 Highly Informative Inherited
Biological Process (BP) endocytosis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.8446 Highly Informative Inherited
Biological Process (BP) gastrulation 0.6347 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9572 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3632 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.3207 Highly Informative Inherited
Biological Process (BP) regulation of RNA stability 0.1424 Highly Informative Inherited
Biological Process (BP) viral life cycle 0.8246 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2244 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.07823 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.06336 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.6211 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.06867 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.5475 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.001788 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 0.02074 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.002109 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2313 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.008123 Highly Informative Inherited
Biological Process (BP) gene silencing 0.0942 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.237 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.3117 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.7276 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01832 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.9335 Highly Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.002821 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.5619 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.2577 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.8984 Highly Informative Inherited
Biological Process (BP) cell division 0.07866 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.1603 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.1171 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.1425 Highly Informative Inherited
Biological Process (BP) DNA methylation or demethylation 0.001578 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.01287 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.006382 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) chromosome organization 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.1837 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00000003663 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.8484 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.999 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.00000001249 Informative Direct
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.8309 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.002516 Informative Inherited
Molecular Function (MF) DNA binding 0.6437 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.1038 Informative Inherited
Molecular Function (MF) phospholipid binding 0.3112 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0000000000113 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0.00000000001223 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0008126 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.000869 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.4433 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.0772 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.00008341 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1204 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.002077 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000006138 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000000005504 Moderately Informative Direct
Cellular Component (CC) vacuole 0.001043 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.7533 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.01613 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.001991 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.007785 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) chromosome 0.0000000000001386 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.000000003483 Informative Direct
Cellular Component (CC) nucleoplasm part 0.000001193 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000002885 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000003945 Informative Direct
Cellular Component (CC) endosome 0.000007008 Informative Direct
Cellular Component (CC) microbody 0.00005316 Informative Direct
Cellular Component (CC) vacuolar part 0.01589 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.4554 Informative Inherited
Cellular Component (CC) outer membrane 0.0011 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic mRNA processing body 0 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.000000000008788 Highly Informative Direct
Cellular Component (CC) tethering complex 0.0000000003898 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.0000000005928 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0000001242 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0000007426 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00003129 Highly Informative Direct
Cellular Component (CC) lytic vacuole membrane 0.000355 Highly Informative Direct
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.1304 Highly Informative Inherited
Cellular Component (CC) condensed chromosome 0.09294 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 0.06603 Highly Informative Inherited
Cellular Component (CC) peptidase complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000001652Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000004836Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000000006579InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.2649Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2715Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4586Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4771Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5613Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8127Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8862Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8894Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.911Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.06024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3154Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.399Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.5297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.6705Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.6922Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.8125Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.9564Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.972Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.252InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2647InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2768InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.2785InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.3676InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uvea0.3725InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.3847InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.4039InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.5002InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.6285InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.04748Highly InformativeInherited
Phenotypic Abnormality (PA)Renal cyst0.09946Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.1462Highly InformativeInherited
Phenotypic Abnormality (PA)Neonatal hypotonia0.2062Highly InformativeInherited
Phenotypic Abnormality (PA)Proteinuria0.252Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.3297Highly InformativeInherited
Phenotypic Abnormality (PA)Ectopic calcification0.3422Highly InformativeInherited
Phenotypic Abnormality (PA)Brachycephaly0.3678Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.336Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4862Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.007854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.2802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.7221Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0006184InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.5336InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.577InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.6959InformativeInherited
Mammalian Phenotype (MP)abnormal small intestine morphology0.04435Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.1016Highly InformativeInherited
Mammalian Phenotype (MP)abnormal crypts of Lieberkuhn morphology0.3779Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.8386Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.9039Least InformativeInherited
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000000000444Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.006043Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.7471Moderately InformativeInherited
Worm Phenotype (WP)cell migration variant0InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0000007565InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.1789InformativeInherited
Worm Phenotype (WP)axon morphology variant0.1957Highly InformativeInherited
Worm Phenotype (WP)germ cell ionizing radiation response variant0.5464Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.0001279Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0.0005529Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.6305Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00008752InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0001955Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.00572Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.000009811Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.1059Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.4279Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.6491Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.9507Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000000008235InformativeDirect
Enzyme Commission (EC)In linear amides0.821InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000245Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processTranscription regulation0.0000000001446Moderately InformativeDirect
Biological processHost-virus interaction0.0000000001712Moderately InformativeDirect
Biological processDNA damage0.0000000001752Moderately InformativeDirect
Biological processCell cycle0.00000000192Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processWnt signaling pathway0.00000000000003682InformativeDirect
Biological processEndocytosis0.0000000000001573InformativeDirect
Biological processMeiosis0.000005284InformativeDirect
Biological processPlant defense0.00002127InformativeDirect
Biological processmRNA processing0.0004833InformativeDirect
Biological processViral immunoevasion0.09345InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processVirus exit from host cell0.00002003Highly InformativeDirect
Biological processModulation of host cell apoptosis by virus0.0003118Highly InformativeDirect
Biological processRNA-mediated gene silencing0.0009248Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000000001298Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000001066Moderately InformativeDirect
Cellular componentCell junction0.000003448Moderately InformativeDirect
Cellular componentCell projection0.000959Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentSpliceosome0.00000000000003345InformativeDirect
Cellular componentChromosome0.00000000000004455InformativeDirect
Cellular componentSynapse0.0000001872InformativeDirect
Cellular componentMitochondrion outer membrane0.0000006478InformativeDirect
Cellular componentVacuole0.000000886InformativeDirect
Cellular componentHost cytoplasm0.00004936InformativeDirect
Cellular componentLipid droplet0.000000002268Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000000000000527Least InformativeDirect
Developmental stageEarly protein0.0001537Least InformativeDirect
DiseaseTumor suppressor0.0002588Moderately InformativeDirect
DiseaseOsteopetrosis0.0000001052Highly InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain0.0000009454Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLigase0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000001038Moderately InformativeDirect
Post-translational modificationActivator0.00000002938Moderately InformativeDirect
Post-translational modificationProtease0.02682Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000008646Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000000000002172Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellulose metabolism0.000000000000003386InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]