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RING/U-box superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Families:   RING finger domain, C3HC4 [ 57851] (14)
  U-box [ 90222] (4)
  Variant RING domain [ 118300] (2)
  IBR domain [ 144228]
  Zf-UBP [ 161204] (3)
  ZZ domain [ 161211] (3)


Superfamily statistics
Genomes (695) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 114,404 252,298 32
Proteins 102,271 225,711 32


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0000015740Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000026760Least InformativeDirect
Biological Process (BP)biological regulation0.21590Least InformativeInherited
Biological Process (BP)primary metabolic process0.0012240Least InformativeInherited
Biological Process (BP)cellular catabolic process0.0023520Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.062970Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0044780.1361Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.054891Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.007020Moderately InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.000010920InformativeDirect
Biological Process (BP)proteolysis0.00076480.000000000000001945InformativeDirect
Biological Process (BP)regulation of organelle organization0.0011940.0000004969InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.01890.9888InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000000000038860Highly InformativeDirect
Biological Process (BP)regulation of chromosome segregation0.0000081250.008172Highly InformativeInherited
Molecular Function (MF)transferase activity0.0000015980Least InformativeDirect
Molecular Function (MF)binding0.035090Least InformativeInherited
Molecular Function (MF)ubiquitin-like protein transferase activity00Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.0000000027720.00000000000008391Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00032640.2488Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.16660.000001866Least InformativeInherited
Cellular Component (CC)transferase complex00Moderately InformativeDirect
Cellular Component (CC)nuclear part0.0010590.00000000000008933Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex00InformativeDirect
Cellular Component (CC)nuclear ubiquitin ligase complex0.000000000016280Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1253 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002891 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00002274 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00009672 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000118 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000000000000109 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000000000006092 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000000006419 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000000002274 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000001309 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.00008872 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003052 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.1455 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.6353 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.02129 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.821 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1444 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.006369 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.6651 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05929 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1361 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1172 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5036 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7221 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0.000000000000001945 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000004969 Informative Direct
Biological Process (BP) chromosome organization 0.00000000005419 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000000000844 Informative Direct
Biological Process (BP) immune response 0.000006367 Informative Direct
Biological Process (BP) response to nitrogen compound 0.00004476 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.0001309 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0002216 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0003219 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.9701 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1454 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1374 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09153 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.5039 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9888 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.03448 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8927 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) response to cytokine 0.002 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1777 Informative Inherited
Biological Process (BP) embryo development 0.8672 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.1083 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.00851 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.7127 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6351 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01171 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.0341 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9192 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.9787 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.6413 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4626 Informative Inherited
Biological Process (BP) generation of neurons 0.7643 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) cell activation 0.173 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.4108 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.01645 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.4519 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6521 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.05115 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.9751 Informative Inherited
Biological Process (BP) response to radiation 0.0234 Informative Inherited
Biological Process (BP) cell cycle process 0.3477 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.2186 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.2334 Informative Inherited
Biological Process (BP) response to acid chemical 0.1447 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.03392 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) sensory organ development 0.7504 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.7174 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.1017 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.6616 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000000000001439 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.00000000000004133 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.000000003072 Highly Informative Direct
Biological Process (BP) innate immune response 0.00000001603 Highly Informative Direct
Biological Process (BP) activation of innate immune response 0.00000003191 Highly Informative Direct
Biological Process (BP) DNA recombination 0.00000004031 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000001719 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0000007973 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.00002362 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.00003875 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00006044 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00009071 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0001203 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.0001452 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0001471 Highly Informative Direct
Biological Process (BP) protein import 0.0003242 Highly Informative Direct
Biological Process (BP) pigmentation 0.0004949 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.9343 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.05648 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.001788 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.05975 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.001164 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1152 Highly Informative Inherited
Biological Process (BP) organelle fusion 0.04957 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.001602 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.008277 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular amide metabolic process 0.9865 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.001409 Highly Informative Inherited
Biological Process (BP) gastrulation 0.6464 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.8461 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.3852 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.3666 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.008172 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.1178 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.6582 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.4737 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.007997 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) viral process 0.6081 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.05654 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.2764 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.05565 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.361 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 0.07638 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.0046 Highly Informative Inherited
Biological Process (BP) gene silencing 0.1247 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.03296 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.07019 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.2691 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 0.9501 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.2369 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.7641 Highly Informative Inherited
Biological Process (BP) cell division 0.0827 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.005499 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.2111 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.7531 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.8617 Highly Informative Inherited
Biological Process (BP) DNA methylation or demethylation 0.001704 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 1 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.07313 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.2307 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.3089 Highly Informative Inherited
Biological Process (BP) autophagy 0.6747 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.4487 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00000008371 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.9094 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) enzyme binding 0.00000005464 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.635 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) DNA binding 0.9091 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.001558 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.9809 Informative Inherited
Molecular Function (MF) phospholipid binding 0.3522 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0.00000000002709 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00000001389 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.00006986 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0005359 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 1 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding 0.9092 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.4358 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.08542 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0.00000000000008391 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000001866 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.00133 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2488 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000000008933 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00000008257 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0005273 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0005836 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.4887 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.006545 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) chromosome 0.000000000004832 Informative Direct
Cellular Component (CC) ribonucleoprotein granule 0.00000000691 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0000001617 Informative Direct
Cellular Component (CC) nucleoplasm part 0.000003832 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000009294 Informative Direct
Cellular Component (CC) endosome 0.00001119 Informative Direct
Cellular Component (CC) microbody 0.00005438 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 1 Informative Inherited
Cellular Component (CC) outer membrane 0.001163 Informative Inherited
Cellular Component (CC) nuclear ubiquitin ligase complex 0 Highly Informative Direct
Cellular Component (CC) P-body 0 Highly Informative Direct
Cellular Component (CC) microbody membrane 0.00000000002875 Highly Informative Direct
Cellular Component (CC) tethering complex 0.0000000003467 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000000001432 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.0000001944 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000009356 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.00000176 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00004054 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.00008288 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) receptor complex 1 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.4421 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited
Cellular Component (CC) peptidase complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.0228Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.000000001652Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000004836Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000000006579InformativeDirect
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.2826Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.3461Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4506Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4717Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.852Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.8833Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.8882Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.9501Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.002482Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08291Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.3035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.5011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5443Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.7235Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.7446Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.7752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.9569Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.9906Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.0006535InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.06418InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.2559InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2816InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2996InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.3091InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.3861InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.4039InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uvea0.4059InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.4287InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.5249InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.6923InformativeInherited
Phenotypic Abnormality (PA)Unsteady gait0.0003763Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of olfactory lobe morphology0.01219Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.05623Highly InformativeInherited
Phenotypic Abnormality (PA)Renal cyst0.1185Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.1598Highly InformativeInherited
Phenotypic Abnormality (PA)Neonatal hypotonia0.2192Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.356Highly InformativeInherited
Phenotypic Abnormality (PA)Ectopic calcification0.3568Highly InformativeInherited
Phenotypic Abnormality (PA)Brachycephaly0.3718Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.3948Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.009561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3539Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.7538Moderately InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.0006835InformativeDirect
Mammalian Phenotype (MP)abnormal intestine morphology0.5914InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.7019InformativeInherited
Mammalian Phenotype (MP)abnormal small intestine morphology0.04732Highly InformativeInherited
Mammalian Phenotype (MP)abnormal crypts of Lieberkuhn morphology0.3535Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.8125Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.8719Least InformativeInherited
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000000000172Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.005065Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.77Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000009742InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.2083InformativeInherited
Worm Phenotype (WP)axon morphology variant0.1968Highly InformativeInherited
Worm Phenotype (WP)germ cell ionizing radiation response variant0.5597Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.615Least InformativeInherited
Fly Anatomy (FA)somatic cell0.8885Least InformativeInherited
Fly Anatomy (FA)late embryo0.8869Moderately InformativeInherited
Fly Anatomy (FA)circulatory system0.07324InformativeInherited
Fly Anatomy (FA)embryonic/larval garland cell0.0001181Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0.0001203Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0.000269Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0.000698Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.6305Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00008752InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0001955Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.00572Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.000009811Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.0003452Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.0000000000001884InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.2911InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDNA damage0.000000000003948Moderately InformativeDirect
Biological processHost-virus interaction0.0000000001704Moderately InformativeDirect
Biological processTranscription regulation0.000000000185Moderately InformativeDirect
Biological processCell cycle0.0000000035Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processMitosis0InformativeDirect
Biological processWnt signaling pathway0.00000000000004548InformativeDirect
Biological processEndocytosis0.0000000000002243InformativeDirect
Biological processMeiosis0.000007729InformativeDirect
Biological processPlant defense0.00003652InformativeDirect
Biological processmRNA processing0.0006521InformativeDirect
Biological processViral immunoevasion0.04823InformativeInherited
Biological processAntiviral defense0Highly InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Biological processAbscisic acid signaling pathway0.00000001251Highly InformativeDirect
Biological processVirus exit from host cell0.00002357Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton3.305e-16Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000000005793Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000001788Moderately InformativeDirect
Cellular componentCell junction0.000005109Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Cellular componentSpliceosome0.00000000000003721InformativeDirect
Cellular componentChromosome0.0000000000001349InformativeDirect
Cellular componentSynapse0.0000002033InformativeDirect
Cellular componentMitochondrion outer membrane0.0000007466InformativeDirect
Cellular componentVacuole0.000001007InformativeDirect
Cellular componentHost cytoplasm0.0001482InformativeDirect
Cellular componentLipid droplet0.000000002379Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00000000000003088Least InformativeDirect
Developmental stageEarly protein0.0001557Least InformativeDirect
DiseaseTumor suppressor0.0003149Moderately InformativeDirect
DiseaseOsteopetrosis0.0000001737Highly InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainBromodomain0.000001107Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000000000003893Moderately InformativeDirect
Post-translational modificationActivator0.00000004677Moderately InformativeDirect
Post-translational modificationProtease0.03364Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationActin-binding0.000006404InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000006147Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000000000000009344Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)cellulose metabolism0.000000000000004071InformativeDirect
UniPathway (UP)cellulose biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the RING/U-box superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]