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Metallothionein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Metallothionein [ 57867]
Superfamily:   Metallothionein [ 57868]
Families:   Metallothionein [ 57869] (2)


Superfamily statistics
Genomes (188) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 514 1,278 23
Proteins 511 1,218 23


Functional annotation
General category General
Detailed category Ion binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00.00000000005858Least InformativeDirect
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.78930.9097Least InformativeInherited
Biological Process (BP)multicellular organismal process0.13421Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.84560.6525Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.41331Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.4590.9933Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.27920.3755Least InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.000000000082280.0000000000182Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy0.00000041530.0000002081Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.0000052220.000002967Moderately InformativeDirect
Biological Process (BP)ion transport0.000066330.0001062Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.00022530.0001699Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.00059210.0000967Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00023510.2217Moderately InformativeInherited
Biological Process (BP)cellular localization0.00023840.004664Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0076580.01317Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.000089190.01705Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0002190.2184Moderately InformativeInherited
Biological Process (BP)multi-organism process0.058440.2265Moderately InformativeInherited
Biological Process (BP)organelle organization0.0048410.1156Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00055780.2756Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.0019650.3796Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.00030110.01062Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0036520.003424Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.97211Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus0.96360.7965Moderately InformativeInherited
Biological Process (BP)cell communication0.19220.8125Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.56680.5077Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.77241Moderately InformativeInherited
Biological Process (BP)single organism signaling0.00044010.05395Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.98761Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.00051820.04242Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0022240.04808Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.4540.9471Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0018910.000488Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0013220.001091Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.7611Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0025870.229Moderately InformativeInherited
Biological Process (BP)cell differentiation0.00051710.215Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.011380.006125Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00046890.09723Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.000083440.001476Moderately InformativeInherited
Biological Process (BP)cellular response to inorganic substance00InformativeDirect
Biological Process (BP)regulation of growth00InformativeDirect
Biological Process (BP)response to metal ion00InformativeDirect
Biological Process (BP)cellular chemical homeostasis0.0000000000064480.0000000001358InformativeDirect
Biological Process (BP)cation homeostasis0.0000000000084110.0000000001585InformativeDirect
Biological Process (BP)inorganic ion homeostasis0.000000000008980.0000000001959InformativeDirect
Biological Process (BP)metal ion transport0.00000000018160.0000000741InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000000083140.0000006961InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.00000000087460.000001464InformativeDirect
Biological Process (BP)lipid catabolic process0.0000000014740.0000000004337InformativeDirect
Biological Process (BP)alcohol metabolic process0.0000000016370.000000009015InformativeDirect
Biological Process (BP)regulation of transferase activity0.0000000020750.0000009452InformativeDirect
Biological Process (BP)single-organism membrane organization0.000000005380.00000005329InformativeDirect
Biological Process (BP)protein localization to organelle0.0000000055420.00000006314InformativeDirect
Biological Process (BP)chromosome organization0.0000000062460.00009315InformativeDirect
Biological Process (BP)negative regulation of cell death0.0000000095980.0000004708InformativeDirect
Biological Process (BP)regulation of catabolic process0.000000010430.0000002561InformativeDirect
Biological Process (BP)intracellular signal transduction0.000000016750.000004526InformativeDirect
Biological Process (BP)single-organism cellular localization0.000000020790.000001204InformativeDirect
Biological Process (BP)negative regulation of macromolecule biosynthetic process0.000000022460.0006559InformativeDirect
Biological Process (BP)negative regulation of molecular function0.000000026790.0000008321InformativeDirect
Biological Process (BP)negative regulation of cellular protein metabolic process0.000000064110.000002265InformativeDirect
Biological Process (BP)negative regulation of cellular biosynthetic process0.000000064110.000922InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000000073120.00001487InformativeDirect
Biological Process (BP)regulation of hydrolase activity0.000000081530.000002077InformativeDirect
Biological Process (BP)response to oxidative stress0.00000010370.00000004083InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.00000010640.0000009859InformativeDirect
Biological Process (BP)regulation of proteolysis0.00000014290.0000000944InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.00000016410.00001315InformativeDirect
Biological Process (BP)response to bacterium0.00000024250.0000005602InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000027940.00002017InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00000033490.000003087InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00000048460.0001053InformativeDirect
Biological Process (BP)regulation of phosphorylation0.00000049320.0001108InformativeDirect
Biological Process (BP)protein transport0.00000086250.000004769InformativeDirect
Biological Process (BP)regulation of protein modification process0.0000010590.0003577InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000015430.0001619InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.0000019450.0004348InformativeDirect
Biological Process (BP)phosphorylation0.0000050960.0002344InformativeDirect
Biological Process (BP)central nervous system development0.0000099630.00005657InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.000013330.000008577InformativeDirect
Biological Process (BP)intracellular transport0.000018530.0001498InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.00000027420.004112InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00000006850.002889InformativeInherited
Biological Process (BP)response to nitrogen compound11InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.3830.7347InformativeInherited
Biological Process (BP)generation of neurons0.00000077230.004904InformativeInherited
Biological Process (BP)positive regulation of gene expression0.00000080960.005533InformativeInherited
Biological Process (BP)negative regulation of gene expression0.0000007480.00269InformativeInherited
Biological Process (BP)regulation of cell differentiation0.00000083580.00183InformativeInherited
Biological Process (BP)regulation of transcription from RNA polymerase II promoter0.0000000093370.002143InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.000000032650.002327InformativeInherited
Biological Process (BP)regulation of nervous system development0.00035720.003327InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.00083470.004583InformativeInherited
Biological Process (BP)cell development0.00097130.02695InformativeInherited
Biological Process (BP)detoxification00Highly InformativeDirect
Biological Process (BP)negative regulation of growth00Highly InformativeDirect
Biological Process (BP)negative regulation of reactive oxygen species metabolic process00Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process00.000000000000003734Highly InformativeDirect
Biological Process (BP)regulation of transcription from RNA polymerase II promoter in response to stress00.000000000000003734Highly InformativeDirect
Biological Process (BP)regulation of oxidoreductase activity0.0000000000000016250Highly InformativeDirect
Biological Process (BP)regulation of cellular response to growth factor stimulus0.0000000000000016250.0000000003215Highly InformativeDirect
Biological Process (BP)secondary alcohol metabolic process0.0000000000000031440.000000000000007296Highly InformativeDirect
Biological Process (BP)sterol metabolic process0.0000000000000031440.00000000000003429Highly InformativeDirect
Biological Process (BP)divalent inorganic cation transport0.00000000000001350.00000000008928Highly InformativeDirect
Biological Process (BP)regulation of cell size0.00000000000001780.0000000001004Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.000000000000020640.0000000000005513Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.000000000000022070.0000000000006668Highly InformativeDirect
Biological Process (BP)negative regulation of cell development0.000000000000024880.0000000006689Highly InformativeDirect
Biological Process (BP)negative regulation of nervous system development0.000000000000024880.000000001125Highly InformativeDirect
Biological Process (BP)gliogenesis0.000000000000056530.00000000006402Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.000000000000063360.000000002847Highly InformativeDirect
Biological Process (BP)alcohol catabolic process0.00000000000013330Highly InformativeDirect
Biological Process (BP)protein localization to nucleus0.00000000000013330.000000000004135Highly InformativeDirect
Biological Process (BP)activation of protein kinase activity0.00000000000014630.0000000000536Highly InformativeDirect
Biological Process (BP)regulation of membrane permeability0.00000000000017340Highly InformativeDirect
Biological Process (BP)protein import0.0000000000005870.000000000007447Highly InformativeDirect
Biological Process (BP)negative regulation of endopeptidase activity0.0000000000006380.000000000000009084Highly InformativeDirect
Biological Process (BP)regulation of cysteine-type endopeptidase activity0.00000000000069390.000000000005729Highly InformativeDirect
Biological Process (BP)histone modification0.00000000000069390.00000001154Highly InformativeDirect
Biological Process (BP)transition metal ion transport0.0000000000014370.0000000000001294Highly InformativeDirect
Biological Process (BP)regulation of autophagy0.0000000000028150.00000000006487Highly InformativeDirect
Biological Process (BP)negative regulation of catabolic process0.0000000000032470.000000000002835Highly InformativeDirect
Biological Process (BP)regulation of neuron projection development0.0000000000068730.00000005199Highly InformativeDirect
Biological Process (BP)positive regulation of transcription from RNA polymerase II promoter0.000000000018330.00002575Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.000000000046830.00000002819Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000000053230.00000000002626Highly InformativeDirect
Biological Process (BP)response to hypoxia0.00000000084860.000000001377Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process0.0000000032930.000000145Highly InformativeDirect
Biological Process (BP)negative regulation of RNA metabolic process0.0000000035030.0001956Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000000030420.0000000002956Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.00000080420.00000214Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.0000013580.0000000238Highly InformativeDirect
Biological Process (BP)MAPK cascade0.0000047310.000004282Highly InformativeDirect
Biological Process (BP)transition metal ion homeostasis0.000055310.000003069Highly InformativeDirect
Biological Process (BP)lysosome organization10Highly InformativeInherited
Biological Process (BP)regulation of developmental growth0.1020.6326Highly InformativeInherited
Biological Process (BP)regulation of cell growth0.4710.5814Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)metal ion binding00Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.00011370.0002702Moderately InformativeDirect
Molecular Function (MF)zinc ion binding00InformativeDirect
Molecular Function (MF)enzyme activator activity0.0000000002890.000000003746InformativeDirect
Molecular Function (MF)peptidase regulator activity0.0000000020230.000000000003161InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.000000020720.0000000001323InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.0000000000000013860Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase inhibitor activity0.000000000000044250Highly InformativeDirect
Molecular Function (MF)kinase regulator activity0.000000000000044250.0000000000004199Highly InformativeDirect
Molecular Function (MF)drug binding0.00000000042710.000000002714Highly InformativeDirect
Cellular Component (CC)cytoplasmic part00Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.000023860.00004437Least InformativeDirect
Cellular Component (CC)endomembrane system0.41450.4791Moderately InformativeInherited
Cellular Component (CC)vesicle0.87560.651Moderately InformativeInherited
Cellular Component (CC)perinuclear region of cytoplasm00Highly InformativeDirect
Cellular Component (CC)exocytic vesicle0.000000000000084080.000000000002759Highly InformativeDirect
Cellular Component (CC)presynapse0.00000000000073150.0000000009208Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00000000005858 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9097 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6525 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.9933 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3755 Least Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.0000000000182 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000002081 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000002967 Moderately Informative Direct
Biological Process (BP) ion transport 0.0001062 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0.0001699 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000967 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000488 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2217 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.004664 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.01317 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01705 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.2184 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2265 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1156 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2756 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.3796 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01062 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003424 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.7965 Moderately Informative Inherited
Biological Process (BP) cell communication 0.8125 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5077 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.05395 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.04242 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.04808 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9471 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.001091 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.229 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.215 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.006125 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.09723 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.001476 Moderately Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0 Informative Direct
Biological Process (BP) regulation of growth 0 Informative Direct
Biological Process (BP) response to metal ion 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0000000001358 Informative Direct
Biological Process (BP) cation homeostasis 0.0000000001585 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.0000000001959 Informative Direct
Biological Process (BP) metal ion transport 0.0000000741 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000006961 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001464 Informative Direct
Biological Process (BP) lipid catabolic process 0.0000000004337 Informative Direct
Biological Process (BP) alcohol metabolic process 0.000000009015 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000009452 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00000005329 Informative Direct
Biological Process (BP) protein localization to organelle 0.00000006314 Informative Direct
Biological Process (BP) chromosome organization 0.00009315 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000004708 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000002561 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000004526 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000001204 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.0006559 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0000008321 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000002265 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.000922 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00001487 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000002077 Informative Direct
Biological Process (BP) response to oxidative stress 0.00000004083 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0000009859 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000000944 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.00001315 Informative Direct
Biological Process (BP) response to bacterium 0.0000005602 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00002017 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000003087 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0001053 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0001108 Informative Direct
Biological Process (BP) protein transport 0.000004769 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0003577 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0001619 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0004348 Informative Direct
Biological Process (BP) phosphorylation 0.0002344 Informative Direct
Biological Process (BP) central nervous system development 0.00005657 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.000008577 Informative Direct
Biological Process (BP) intracellular transport 0.0001498 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.004112 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.002889 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7347 Informative Inherited
Biological Process (BP) generation of neurons 0.004904 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.005533 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.00269 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.00183 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.002143 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.002327 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003327 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.004583 Informative Inherited
Biological Process (BP) cell development 0.02695 Informative Inherited
Biological Process (BP) detoxification 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0 Highly Informative Direct
Biological Process (BP) negative regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter in response to stress 0.000000000000003734 Highly Informative Direct
Biological Process (BP) regulation of oxidoreductase activity 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000000003215 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.000000000000007296 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000000000003429 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.00000000008928 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0000000001004 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000000000005513 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.0000000000006668 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.0000000006689 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 0.000000001125 Highly Informative Direct
Biological Process (BP) gliogenesis 0.00000000006402 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.000000002847 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000000000004135 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.0000000000536 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0 Highly Informative Direct
Biological Process (BP) protein import 0.000000000007447 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000000000000009084 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.000000000005729 Highly Informative Direct
Biological Process (BP) histone modification 0.00000001154 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0000000000001294 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000000006487 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000000000002835 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00000005199 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.00002575 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00000002819 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000000002626 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000001377 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.000000145 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0001956 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0000000002956 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.00000214 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000238 Highly Informative Direct
Biological Process (BP) MAPK cascade 0.000004282 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000003069 Highly Informative Direct
Biological Process (BP) cellular response to cadmium ion 0.00005866 Highly Informative Direct
Biological Process (BP) lysosome organization 0 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.6326 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.5814 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0002702 Moderately Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000003746 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.000000000003161 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.0000000001323 Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0000000000004199 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000002714 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00004437 Least Informative Direct
Cellular Component (CC) endomembrane system 0.4791 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.651 Moderately Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.000000000002759 Highly Informative Direct
Cellular Component (CC) presynapse 0.0000000009208 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0.0000009051Least InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallothionein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Metallothionein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]