SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (441) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 13,885 10,494 8
Proteins 9,002 7,591 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0030992.185e-07Least InformativeInherited
Biological Process (BP)regulation of signaling1.171e-050Moderately InformativeDirect
Biological Process (BP)regulation of cell communication1.211e-050Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus5.705e-050Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 2.185e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 2.076e-15 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.42e-07 Least Informative Direct
Biological Process (BP) localization 1.526e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.612e-13 Moderately Informative Direct
Biological Process (BP) organelle organization 3.646e-10 Moderately Informative Direct
Biological Process (BP) immune system process 1.526e-08 Moderately Informative Direct
Biological Process (BP) signal transduction 4.674e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1.17e-07 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 7.812e-07 Moderately Informative Direct
Biological Process (BP) nervous system development 5.465e-06 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.72e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001719 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0002153 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.9344 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4424 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.008467 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7584 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.131 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.4752 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9905 Moderately Informative Inherited
Biological Process (BP) system process 0.09961 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01321 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.4701 Moderately Informative Inherited
Biological Process (BP) tissue development 0.9478 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.05432 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.1074 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01182 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) protein phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) intracellular signal transduction 9.02e-14 Informative Direct
Biological Process (BP) negative regulation of cell death 3.65e-12 Informative Direct
Biological Process (BP) cell activation 2.203e-10 Informative Direct
Biological Process (BP) regulation of apoptotic process 5.203e-08 Informative Direct
Biological Process (BP) positive regulation of immune system process 5.855e-08 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 6.511e-08 Informative Direct
Biological Process (BP) secretion 7.848e-08 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 3.046e-07 Informative Direct
Biological Process (BP) microtubule-based process 3.605e-07 Informative Direct
Biological Process (BP) regulation of cell development 3.931e-07 Informative Direct
Biological Process (BP) positive regulation of developmental process 8.069e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 2.788e-05 Informative Direct
Biological Process (BP) response to wounding 3.579e-05 Informative Direct
Biological Process (BP) regulation of nervous system development 5.779e-05 Informative Direct
Biological Process (BP) immune effector process 6.411e-05 Informative Direct
Biological Process (BP) cell proliferation 0.0001554 Informative Direct
Biological Process (BP) locomotion 0.0001789 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002045 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0002303 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0002354 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000268 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.0006092 Informative Direct
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.03894 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.07038 Informative Inherited
Biological Process (BP) growth 0.1419 Informative Inherited
Biological Process (BP) cell projection organization 0.1367 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9533 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1695 Informative Inherited
Biological Process (BP) cell cycle process 0.1922 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.8451 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001391 Informative Inherited
Biological Process (BP) response to external stimulus 0.5676 Informative Inherited
Biological Process (BP) localization of cell 0.09044 Informative Inherited
Biological Process (BP) regulation of system process 0.2786 Informative Inherited
Biological Process (BP) cellular component movement 0.08949 Informative Inherited
Biological Process (BP) sensory organ development 0.1488 Informative Inherited
Biological Process (BP) regulation of reproductive process 0.4934 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9223 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9771 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.0162 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8551 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) defense response 0.1719 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.6057 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.1133 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.311 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7217 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1176 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.6689 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02784 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.03557 Informative Inherited
Biological Process (BP) epithelium development 0.002687 Informative Inherited
Biological Process (BP) synaptic transmission 0.007684 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5527 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.007055 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.07252 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.8909 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.001422 Informative Inherited
Biological Process (BP) sexual reproduction 0.001864 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1593 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03296 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.9725 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04394 Informative Inherited
Biological Process (BP) tube development 0.003574 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1007 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.7582 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.003834 Informative Inherited
Biological Process (BP) regulation of immune response 0.969 Informative Inherited
Biological Process (BP) immune response 0.03096 Informative Inherited
Biological Process (BP) chordate embryonic development 1 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 2.421e-13 Highly Informative Direct
Biological Process (BP) hemostasis 3.899e-13 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 1.656e-12 Highly Informative Direct
Biological Process (BP) exocytosis 2.254e-12 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 3.351e-12 Highly Informative Direct
Biological Process (BP) B cell activation 3.54e-12 Highly Informative Direct
Biological Process (BP) synaptic vesicle transport 1.988e-11 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 4.36e-11 Highly Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 9.571e-11 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 9.351e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 8.332e-09 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 3.198e-08 Highly Informative Direct
Biological Process (BP) coagulation 3.478e-08 Highly Informative Direct
Biological Process (BP) organelle localization 3.611e-08 Highly Informative Direct
Biological Process (BP) regulation of cell projection organization 1.762e-07 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 2.047e-07 Highly Informative Direct
Biological Process (BP) signal release 8.776e-07 Highly Informative Direct
Biological Process (BP) nuclear division 1.265e-06 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 2.257e-06 Highly Informative Direct
Biological Process (BP) regulation of blood coagulation 3.122e-06 Highly Informative Direct
Biological Process (BP) protein complex localization 3.388e-06 Highly Informative Direct
Biological Process (BP) eye morphogenesis 5.491e-06 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 7.238e-06 Highly Informative Direct
Biological Process (BP) cell division 8.89e-06 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.653e-05 Highly Informative Direct
Biological Process (BP) mitotic cell cycle 1.83e-05 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 3.58e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 4.812e-05 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.66e-05 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0001435 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0002987 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000301 Highly Informative Direct
Biological Process (BP) wound healing 0.0004464 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0006178 Highly Informative Direct
Biological Process (BP) neural precursor cell proliferation 0.0006997 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0008914 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte activation 0.001703 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.3839 Highly Informative Inherited
Biological Process (BP) cell growth 0.01828 Highly Informative Inherited
Biological Process (BP) developmental growth 0.5558 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.5344 Highly Informative Inherited
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.001559 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.3339 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.06467 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6965 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.0431 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.3279 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.4819 Highly Informative Inherited
Biological Process (BP) regulation of neuron differentiation 1 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.002729 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6992 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1383 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01732 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01043 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.02357 Highly Informative Inherited
Biological Process (BP) regulation of neurological system process 0.09706 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1601 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.09656 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.3254 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1671 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.1283 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.05747 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.1213 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.008452 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.5729 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide catabolic process 0.007134 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.002493 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.03128 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.001073 Highly Informative Inherited
Biological Process (BP) regulation of Ras protein signal transduction 0.8193 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.005 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.05961 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.2283 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.7446 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.6232 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.002093 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.9236 Highly Informative Inherited
Biological Process (BP) stem cell proliferation 0.002193 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.09152 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.6551 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.06057 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.04093 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 0.03609 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.03818 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.1956 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.5897 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.002379 Highly Informative Inherited
Biological Process (BP) regulation of stem cell proliferation 0.02602 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.1873 Highly Informative Inherited
Biological Process (BP) tube formation 0.04736 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) gastrulation 0.5027 Highly Informative Inherited
Molecular Function (MF) binding 3.725e-08 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 4.434e-10 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01694 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.1792 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) enzyme binding 1.121e-08 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 4.144e-05 Informative Direct
Molecular Function (MF) lipid binding 0.0003144 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.1685 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.2443 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.476 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ATP binding 1.257e-09 Highly Informative Direct
Molecular Function (MF) tubulin binding 1.387e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0001903 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.8475 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.7463 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.004347 Highly Informative Inherited
Cellular Component (CC) membrane 1.062e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.1914 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.02041 Least Informative Inherited
Cellular Component (CC) protein complex 0.3702 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 5.331e-13 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 8.318e-13 Moderately Informative Direct
Cellular Component (CC) cytosol 1.819e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.7375 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) neuron part 2.647e-13 Informative Direct
Cellular Component (CC) cell junction 7.857e-13 Informative Direct
Cellular Component (CC) cell cortex 1.544e-12 Informative Direct
Cellular Component (CC) cell projection part 2.148e-10 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 4.668e-06 Informative Direct
Cellular Component (CC) synapse 3.376e-05 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.003414 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.09796 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.4115 Informative Inherited
Cellular Component (CC) apical plasma membrane 2.632e-14 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.72e-13 Highly Informative Direct
Cellular Component (CC) cell body 5.417e-12 Highly Informative Direct
Cellular Component (CC) ruffle 3.581e-08 Highly Informative Direct
Cellular Component (CC) cell division site part 1.071e-06 Highly Informative Direct
Cellular Component (CC) spindle 0.0003435 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.0006357 Highly Informative Direct
Cellular Component (CC) dendrite 0.1311 Highly Informative Inherited
Cellular Component (CC) axon part 0.6208 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.00423 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.01516 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.007763 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.101e-06InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase4.229e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.5089Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.6125Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7185Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.7186Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1637Moderately InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.2479Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02014InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.1171InformativeInherited
Phenotypic Abnormality (PA)Webbed neck0.0001723Highly InformativeDirect
Phenotypic Abnormality (PA)Low posterior hairline0.0002465Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.003379Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.005747Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1322Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.08216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.2039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.2198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.3093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.5699InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.006096Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.332e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000145Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.427Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.03891Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.09207Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2254Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant4.936e-06InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003274InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01106InformativeInherited
Worm Phenotype (WP)protein expression variant0.05202InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.6657InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant7.02e-10Highly InformativeDirect
Worm Phenotype (WP)response to injury variant1.358e-07Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant2.889e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant1.285e-05Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.575e-05Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant4.394e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.0001942InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0006291InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2493Least InformativeInherited
Fly Anatomy (FA)organ system0.339Least InformativeInherited
Fly Anatomy (FA)cuticle0.06927Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval cuticle0.02514InformativeInherited
Fly Anatomy (FA)embryonic/first instar larval cuticle0.0001973Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermal cell2.204e-06InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.6667Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007421InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4112InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor6.8e-06Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase7.93e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.0003054Least InformativeDirect
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)tocopherol (vit e)3.532e-07InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell cycle2.464e-06Moderately InformativeDirect
Biological processAngiogenesis4.622e-16InformativeDirect
Biological processInflammatory response2.253e-12InformativeDirect
Biological processCell adhesion1.709e-09InformativeDirect
Biological processNeurogenesis4.123e-09InformativeDirect
Biological processMitosis0.0005661InformativeDirect
Biological processExocytosis6.743e-15Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus1.87e-12Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus3.768e-15Moderately InformativeDirect
Cellular componentCell projection5.652e-13Moderately InformativeDirect
Cellular componentEndosome5.882e-06Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0007421Moderately InformativeDirect
Cellular componentMicrotubule9.155e-09InformativeDirect
Cellular componentSynapse0.6385InformativeInherited
Cellular componentSynaptosome1.433e-05Highly InformativeDirect
DiseaseProto-oncogene4.132e-15Moderately InformativeDirect
DiseaseTumor suppressor1.168e-05Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain8.967e-06InformativeDirect
DomainSH3 domain1.267e-05InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding1.647e-13Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionZinc-finger0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.408e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator9.949e-05InformativeDirect
Post-translational modificationMyosin1.36e-08Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0005675Moderately InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]