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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,776 44,568 8
Proteins 10,430 31,039 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1531Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.2693Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.07086InformativeInherited
Phenotypic Abnormality (PA)Spina bifida occulta0.0009314Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0007906Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.009271Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1667Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0004195Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.06287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.06665Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2982Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.5209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02826InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1566InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7519InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8569InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002432Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004028Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02774Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0004152Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001761Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.002368Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.002841Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.004173Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0103Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.07715Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.001685Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01937Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.05111Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1755Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2449Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.7114Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7453Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.7916Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00005839InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.00008854InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0001456InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0001833InformativeDirect
Worm Phenotype (WP)positive chemotaxis variant0.0002715InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0002932InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0004197InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.001069InformativeInherited
Worm Phenotype (WP)tail morphology variant0.04262InformativeInherited
Worm Phenotype (WP)cell stress response variant0.07192InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1453InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3601InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000001098Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000003974Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00000926Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.00001301Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.00002604Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.03252Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)stress response defective0.5241Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1913Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0002576InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1931Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007818InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8266Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.001006InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0.435InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000008131Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008488Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]