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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (498) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,379 14,257 8
Proteins 10,126 10,031 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000002012 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.04668 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000000007239 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000002741 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000001687 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000002339 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000007418 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000009644 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0007482 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0008629 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.2203 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1894 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5827 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.6037 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.05529 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001325 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.26 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003583 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1819 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1274 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3714 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2007 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01455 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) system development 0.4654 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1522 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.124 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01601 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.766 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000000001068 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000000000000788 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000000004669 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000000000003206 Informative Direct
Biological Process (BP) generation of neurons 0.00000000000693 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000001113 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000000001354 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000004556 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00000000916 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000002469 Informative Direct
Biological Process (BP) secretion 0.0000003752 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000002561 Informative Direct
Biological Process (BP) locomotion 0.00003851 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00004578 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0001059 Informative Direct
Biological Process (BP) microtubule-based process 0.0001198 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0001367 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0001884 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0001981 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0002095 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0003274 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006713 Informative Direct
Biological Process (BP) regulation of locomotion 0.0007336 Informative Direct
Biological Process (BP) cell cycle process 0.0009696 Informative Direct
Biological Process (BP) regulation of secretion 0.265 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.007107 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.008609 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.846 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.009529 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2991 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.3758 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001847 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.365 Informative Inherited
Biological Process (BP) growth 0.03047 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.009263 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01586 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2651 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.06441 Informative Inherited
Biological Process (BP) regulation of immune response 0.4734 Informative Inherited
Biological Process (BP) post-embryonic development 0.01076 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.01501 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.004275 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6194 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6576 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3352 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.1863 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.7949 Informative Inherited
Biological Process (BP) embryo development 0.267 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4306 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.3246 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5279 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1658 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1058 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.04917 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.04761 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.06851 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3575 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1175 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.8156 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.7563 Informative Inherited
Biological Process (BP) cell development 0.8703 Informative Inherited
Biological Process (BP) system process 0.9859 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.9066 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 0.01127 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02362 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.552 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.007785 Informative Inherited
Biological Process (BP) organelle fission 0.1687 Informative Inherited
Biological Process (BP) regulated exocytosis 0 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00000000000001409 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000000000003712 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000000005667 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.000000000008491 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000001673 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00000004435 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000001389 Highly Informative Direct
Biological Process (BP) metamorphosis 0.0000003047 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000331 Highly Informative Direct
Biological Process (BP) signal release 0.000000389 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0000006657 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000001617 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000002561 Highly Informative Direct
Biological Process (BP) cell division 0.000003641 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.0000104 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.00001227 Highly Informative Direct
Biological Process (BP) appendage development 0.00002087 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00004989 Highly Informative Direct
Biological Process (BP) cell migration 0.00007029 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0000714 Highly Informative Direct
Biological Process (BP) synaptic signaling 0.0003459 Highly Informative Direct
Biological Process (BP) gastrulation 0.0005002 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.0005795 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000721 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.07231 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6312 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.2733 Highly Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001995 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) cell growth 0.003214 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.09301 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.01493 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.003234 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.01734 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2594 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.006885 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.007249 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.6449 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.277 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.3053 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.4755 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.005299 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.5193 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.8804 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.5563 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.2236 Highly Informative Inherited
Biological Process (BP) wound healing 0.01388 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3181 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) regulation of cell shape 0.00157 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.01852 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.261 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.8777 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03294 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.04708 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.2308 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01674 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2082 Highly Informative Inherited
Biological Process (BP) germ cell development 0.382 Highly Informative Inherited
Biological Process (BP) cell maturation 0.1088 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.7847 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.04145 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.2179 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.2212 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8807 Highly Informative Inherited
Biological Process (BP) muscle system process 0.005813 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.06732 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.2446 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.00439 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.8003 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02777 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.4013 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.04162 Highly Informative Inherited
Biological Process (BP) mitotic nuclear division 0.04544 Highly Informative Inherited
Biological Process (BP) chromosome organization 0.8153 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.0000000149 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00000000002181 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.1032 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1003 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.006175 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.3072 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8216 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000000001646 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000006997 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.00005398 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.00005576 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001322 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0001731 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0008877 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.05898 Informative Inherited
Molecular Function (MF) signal transducer activity 0.4692 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000002071 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000005586 Highly Informative Direct
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.1792 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.3515 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.04946 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0173 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.006194 Least Informative Inherited
Cellular Component (CC) protein complex 0.2433 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000000000004992 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000008528 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00003399 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1525 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0.00000000000001182 Informative Direct
Cellular Component (CC) cell junction 0.000000008571 Informative Direct
Cellular Component (CC) synapse 0.000000132 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.000005764 Informative Direct
Cellular Component (CC) cell projection part 0.00002544 Informative Direct
Cellular Component (CC) apical part of cell 0.0000312 Informative Direct
Cellular Component (CC) transport vesicle 0.0002463 Informative Direct
Cellular Component (CC) plasma membrane region 0.002353 Informative Inherited
Cellular Component (CC) secretory vesicle 0.003863 Informative Inherited
Cellular Component (CC) neuron projection 0.01252 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.005259 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.04058 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000001997 Highly Informative Direct
Cellular Component (CC) cell division site 0.00000003621 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.000007721 Highly Informative Direct
Cellular Component (CC) ruffle 0.0000365 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.001209Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0101Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2045Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0007194Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.05573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02592InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1706InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7294InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8538InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002931Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004736Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02738Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0001917Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.002531Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.004377Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.07086Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.1008Least InformativeInherited
Worm Phenotype (WP)cell development variant0.1103Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2047Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01797Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.04384Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1979Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2349Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.3337Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7241Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.7276Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.829Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.000001423InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00004796InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0001046InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.001161InformativeInherited
Worm Phenotype (WP)tail morphology variant0.03788InformativeInherited
Worm Phenotype (WP)cell stress response variant0.04016InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.2092InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3642InformativeInherited
Worm Phenotype (WP)antimicrobial gene expression variant0.000000000002727Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001371Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000003915Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00000463Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.00001137Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.0000244Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.00009627Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.03062Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.0002323InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.04891Least InformativeInherited
Fly Anatomy (FA)larva0.2182Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0001821InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1928Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007785InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8379Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007683InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4398InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000006975Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008789Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0Least InformativeDirect
Drugbank ATC_code (DB)hormone antagonists and related agents0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processCell cycle0.000003931Moderately InformativeDirect
Biological processAngiogenesis0.000000000000003321InformativeDirect
Biological processBiological rhythms0.000000000003792InformativeDirect
Biological processInflammatory response0.00000000000551InformativeDirect
Biological processCell adhesion0.000000001354InformativeDirect
Biological processNeurogenesis0.00000001945InformativeDirect
Biological processMitosis0.0008359InformativeDirect
Biological processExocytosis0.00000000000002041Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.0000000000002452Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000002581Moderately InformativeDirect
Cellular componentCell projection0.000000000003833Moderately InformativeDirect
Cellular componentEndosome0.00005471Moderately InformativeDirect
Cellular componentCell membrane0.000257Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0007109Moderately InformativeDirect
Cellular componentMicrotubule0.00000001833InformativeDirect
Cellular componentSynapse0.5055InformativeInherited
Cellular componentSynaptosome0.00003889Highly InformativeDirect
DiseaseProto-oncogene0.000000000000002595Moderately InformativeDirect
DiseaseTumor suppressor0.00001117Moderately InformativeDirect
DomainRepeat0.000000000000002157Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH3 domain0.00001806InformativeDirect
DomainSH2 domain0.00004102InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding0.000000000000001395Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00002547Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.0001319InformativeDirect
Post-translational modificationMyosin0.00000002243Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]