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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (505) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,776 44,568 8
Proteins 10,430 31,039 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2735Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal ear morphology0.2047InformativeInherited
Phenotypic Abnormality (PA)Spina bifida occulta0.0004703Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0007922Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.009276Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1664Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0004201Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.06289Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.06682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.5208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02825InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1566InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8569InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002433Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02773Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0004124Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001697Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.006968Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.008438Least InformativeInherited
Worm Phenotype (WP)cell development variant0.009791Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.01131Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.07672Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.001666Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01941Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02063Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2494Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.6748Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.7177Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7387Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.8132Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.9777Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.00005922InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000904InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0001474InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0004177InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00112InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.001345InformativeInherited
Worm Phenotype (WP)tail morphology variant0.04202InformativeInherited
Worm Phenotype (WP)cell stress response variant0.07039InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1473InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3614InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000001107Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000004011Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.000008044Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.00001162Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.00002633Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.03175Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1844Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0002505InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1928Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007785InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8261Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0009864InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4402InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000008324Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00009152Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]