SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,552 14,257 8
Proteins 10,255 10,031 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000004183 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000008749 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000004271 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05681 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000001783 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000001448 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000105 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0000009519 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00001386 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00006949 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000154 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0002443 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0006008 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.002595 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1452 Moderately Informative Inherited
Biological Process (BP) system development 0.3368 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.5421 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1598 Moderately Informative Inherited
Biological Process (BP) immune system process 0.008193 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.06237 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4596 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.00221 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8189 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01661 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008577 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.00272 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5585 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1846 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) generation of neurons 0.0000000000001279 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000000000001778 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0000000000002515 Informative Direct
Biological Process (BP) cell-cell signaling 0.000000000004287 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000001478 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000000002191 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000008939 Informative Direct
Biological Process (BP) organelle localization 0.0000000004968 Informative Direct
Biological Process (BP) regulation of protein modification process 0.000000002446 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000001218 Informative Direct
Biological Process (BP) cell activation 0.00000007584 Informative Direct
Biological Process (BP) secretion by cell 0.0000005444 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000003079 Informative Direct
Biological Process (BP) microtubule-based process 0.00000887 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000211 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00004276 Informative Direct
Biological Process (BP) locomotion 0.00005819 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00006843 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000899 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00009054 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00009254 Informative Direct
Biological Process (BP) cell cycle process 0.0001557 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0001654 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003851 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0005732 Informative Direct
Biological Process (BP) regulation of cellular localization 0.2504 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.7299 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.04294 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1465 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.001351 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5628 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2496 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3624 Informative Inherited
Biological Process (BP) growth 0.03921 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03576 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004058 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.5361 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.008275 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.09246 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3719 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5612 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.0484 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5249 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3412 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1235 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.2342 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1201 Informative Inherited
Biological Process (BP) embryo development 0.6575 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.6355 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2504 Informative Inherited
Biological Process (BP) regulation of secretion 0.2187 Informative Inherited
Biological Process (BP) chromosome organization 0.7011 Informative Inherited
Biological Process (BP) sensory organ development 0.8403 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.002128 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1082 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.0564 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.02178 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.3306 Informative Inherited
Biological Process (BP) cell development 0.951 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.004315 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.03701 Informative Inherited
Biological Process (BP) system process 0.7611 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.9703 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03896 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.0315 Informative Inherited
Biological Process (BP) post-embryonic development 0.00749 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4972 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.003739 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.9796 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.003663 Informative Inherited
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00000000000001783 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000000000003628 Highly Informative Direct
Biological Process (BP) coagulation 0.000000000001521 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.00000001868 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000003844 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.0000001072 Highly Informative Direct
Biological Process (BP) cell division 0.0000001142 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000001577 Highly Informative Direct
Biological Process (BP) signal release 0.0000002607 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000003491 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0000008405 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000002655 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000003696 Highly Informative Direct
Biological Process (BP) nuclear division 0.000007642 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.00001719 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.00001758 Highly Informative Direct
Biological Process (BP) appendage development 0.00002114 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00007095 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00007918 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0001036 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0002808 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.0003947 Highly Informative Direct
Biological Process (BP) gastrulation 0.0005002 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0007378 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.3217 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.8389 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.001379 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.2369 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.01303 Highly Informative Inherited
Biological Process (BP) cell growth 0.002645 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.1177 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.01675 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.001434 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.2069 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.09114 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1887 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.06943 Highly Informative Inherited
Biological Process (BP) neutral lipid metabolic process 0.001042 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.01576 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.358 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.5048 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1733 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.008668 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.8323 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.5924 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.24 Highly Informative Inherited
Biological Process (BP) hemostasis 0.009055 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.03461 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.02054 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.7464 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03477 Highly Informative Inherited
Biological Process (BP) germ cell development 0.6528 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.4441 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0411 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.2066 Highly Informative Inherited
Biological Process (BP) wound healing 0.01286 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.2656 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9602 Highly Informative Inherited
Biological Process (BP) cell maturation 0.2414 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.08714 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01985 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1261 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02595 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.004687 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.03799 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.04332 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6902 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.00000007442 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.1854 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1937 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.5768 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.0103 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8825 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.425e-16 Informative Direct
Molecular Function (MF) enzyme binding 0.000000000001592 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0007816 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.0715 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.001001 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.001457 Informative Inherited
Molecular Function (MF) signal transducer activity 0.4401 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.000002303 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00001037 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.04488 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.1771 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2778 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000568 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.006575 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00000000000001784 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000002393 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000649 Moderately Informative Direct
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1895 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0.000000000000006155 Informative Direct
Cellular Component (CC) synapse 0.0000003041 Informative Direct
Cellular Component (CC) apical part of cell 0.0000375 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0002341 Informative Direct
Cellular Component (CC) plasma membrane region 0.002871 Informative Inherited
Cellular Component (CC) neuron projection 0.06979 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.6054 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.02072 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.04861 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.00000000001609 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000007391 Highly Informative Direct
Cellular Component (CC) cortical actin cytoskeleton 0.00002812 Highly Informative Direct
Cellular Component (CC) ruffle 0.00004688 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0008016Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.009365Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1666Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0004325Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.06289Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.06741Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.0861Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2091Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2283Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02835InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.1569InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4388InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.753InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.8583InformativeInherited
Mammalian Phenotype (MP)reduced long term potentiation0.0002422Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0003969Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell selection0.02755Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0003051Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001564Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.003807Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01671Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.02702Least InformativeInherited
Worm Phenotype (WP)cell development variant0.05318Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.07271Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.001129Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01849Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.03876Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2523Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.4676Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.5209Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.7079Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.7234Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.8723Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.00000156InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005637InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0001467InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0004169InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.001131InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.001307InformativeInherited
Worm Phenotype (WP)tail morphology variant0.03993InformativeInherited
Worm Phenotype (WP)cell stress response variant0.06928InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1529InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.3673InformativeInherited
Worm Phenotype (WP)antimicrobial gene expression variant0.000000000002784Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001115Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000003972Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.000006918Highly InformativeDirect
Worm Phenotype (WP)bacterially unswollen0.0000115Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.00002612Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.03007Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.0002938InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.08174Least InformativeInherited
Fly Anatomy (FA)larva0.3219Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0003223InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1928Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007785InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8404Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007542InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4414InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007148Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000845Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processCell cycle0.000003892Moderately InformativeDirect
Biological processAngiogenesis0.000000000000003569InformativeDirect
Biological processBiological rhythms0.000000000004026InformativeDirect
Biological processInflammatory response0.000000000005648InformativeDirect
Biological processCell adhesion0.00000000136InformativeDirect
Biological processNeurogenesis0.00000002122InformativeDirect
Biological processMitosis0.0008751InformativeDirect
Biological processExocytosis0.0000000000000209Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.0000000000009292Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection9.83e-16Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000004399Moderately InformativeDirect
Cellular componentEndosome0.00007438Moderately InformativeDirect
Cellular componentCell membrane0.00009574Moderately InformativeDirect
Cellular componentMicrotubule0.00000002528InformativeDirect
Cellular componentSynapse0.5167InformativeInherited
Cellular componentSynaptosome0.00004509Highly InformativeDirect
DiseaseProto-oncogene0.000000000000006944Moderately InformativeDirect
DiseaseTumor suppressor0.00001728Moderately InformativeDirect
DomainRepeat0.000000000000003076Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH3 domain0.00001929InformativeDirect
DomainSH2 domain0.00004145InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding0.00000006996Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000171Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00009734InformativeDirect
Post-translational modificationActin-binding0.0002427InformativeDirect
Post-translational modificationMyosin0.00000002165Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]