SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (445) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 13,982 10,494 8
Proteins 9,080 7,591 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0024483.107e-08Least InformativeInherited
Biological Process (BP)regulation of signal transduction8.906e-064.205e-07Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 3.107e-08 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) localization 8.362e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.361e-06 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 4.205e-07 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 3.544e-13 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 8.45e-12 Moderately Informative Direct
Biological Process (BP) immune system process 4.342e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 4.967e-10 Moderately Informative Direct
Biological Process (BP) organelle organization 2.23e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 1.619e-07 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 2.61e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 3.859e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 5.615e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 5.764e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0006179 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0272 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01821 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8758 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5789 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.07695 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1982 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.6777 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.8597 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.556 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6837 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03516 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.005927 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.5341 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5427 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1853 Moderately Informative Inherited
Biological Process (BP) system process 0.0486 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.002611 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) organelle localization 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 3.231e-12 Informative Direct
Biological Process (BP) negative regulation of cell death 1.245e-11 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 1.576e-11 Informative Direct
Biological Process (BP) cell activation 2.054e-11 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 1.363e-07 Informative Direct
Biological Process (BP) microtubule-based process 3.72e-07 Informative Direct
Biological Process (BP) locomotion 1.972e-06 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 4.423e-06 Informative Direct
Biological Process (BP) regulation of organelle organization 1.043e-05 Informative Direct
Biological Process (BP) response to wounding 1.813e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 3.445e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 5.533e-05 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 8.135e-05 Informative Direct
Biological Process (BP) positive regulation of developmental process 9.802e-05 Informative Direct
Biological Process (BP) secretion by cell 0.0001101 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001477 Informative Direct
Biological Process (BP) single-organism behavior 0.0001532 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0002652 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0002887 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002921 Informative Direct
Biological Process (BP) immune effector process 0.0003563 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0004346 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00053 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.1442 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1402 Informative Inherited
Biological Process (BP) cell projection organization 0.0741 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1895 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.3005 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.8813 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9864 Informative Inherited
Biological Process (BP) cell cycle process 0.196 Informative Inherited
Biological Process (BP) regulation of cell development 0.001801 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9489 Informative Inherited
Biological Process (BP) muscle structure development 0.9193 Informative Inherited
Biological Process (BP) regulation of system process 0.1743 Informative Inherited
Biological Process (BP) regulation of secretion 0.165 Informative Inherited
Biological Process (BP) sensory organ development 0.2463 Informative Inherited
Biological Process (BP) cell death 0.05735 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9951 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.89 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) defense response 0.3359 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01408 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004459 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1855 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.7114 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1547 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9624 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.05399 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.06583 Informative Inherited
Biological Process (BP) epithelium development 0.009487 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.04822 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.5823 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.03656 Informative Inherited
Biological Process (BP) growth 0.001579 Informative Inherited
Biological Process (BP) cellular component movement 0.007362 Informative Inherited
Biological Process (BP) localization of cell 0.01573 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.06966 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) sexual reproduction 0.01497 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01745 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1005 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.04376 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4039 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.03269 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1393 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1584 Informative Inherited
Biological Process (BP) pigment metabolic process 0.003515 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) immune response 0.02563 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.0211 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.9229 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 1.604e-14 Highly Informative Direct
Biological Process (BP) hemostasis 7.491e-14 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 1.267e-13 Highly Informative Direct
Biological Process (BP) exocytosis 3.618e-13 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 4.821e-13 Highly Informative Direct
Biological Process (BP) regulation of wound healing 9.733e-12 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 3.718e-11 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 2.103e-10 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 5.267e-10 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 3.747e-08 Highly Informative Direct
Biological Process (BP) coagulation 7.368e-08 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 5.482e-07 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.621e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 1.79e-06 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 2.18e-06 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 2.62e-06 Highly Informative Direct
Biological Process (BP) regulation of coagulation 4.943e-06 Highly Informative Direct
Biological Process (BP) eye morphogenesis 6.654e-06 Highly Informative Direct
Biological Process (BP) B cell activation 8.418e-06 Highly Informative Direct
Biological Process (BP) cell junction organization 9.766e-06 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.865e-05 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 2.909e-05 Highly Informative Direct
Biological Process (BP) actin filament organization 4.451e-05 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 4.827e-05 Highly Informative Direct
Biological Process (BP) signal release 0.0001167 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.000117 Highly Informative Direct
Biological Process (BP) cell division 0.0001535 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0001845 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0002194 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0002725 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0003101 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0003277 Highly Informative Direct
Biological Process (BP) cell growth 0.0003341 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0003395 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0.0003843 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.0004913 Highly Informative Direct
Biological Process (BP) wound healing 0.0004941 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0006026 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0006522 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0.0007929 Highly Informative Direct
Biological Process (BP) response to ethanol 0.0009956 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0.005399 Highly Informative Inherited
Biological Process (BP) developmental growth 0.1298 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.515 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.002393 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1815 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.085 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.8608 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1772 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.006915 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1928 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.8358 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1799 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01149 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.06041 Highly Informative Inherited
Biological Process (BP) regulation of transmission of nerve impulse 0.2962 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.3426 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.4435 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.05923 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.3199 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.2103 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.1958 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.2274 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.03872 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.02153 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.0245 Highly Informative Inherited
Biological Process (BP) regulation of response to biotic stimulus 0.9312 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06444 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.1664 Highly Informative Inherited
Biological Process (BP) synaptic vesicle localization 0.169 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.04727 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.002761 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.6804 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002582 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.4797 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.7641 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.002065 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1261 Highly Informative Inherited
Biological Process (BP) mitosis 0.009393 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.7213 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8089 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.2015 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.01877 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.2675 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.7955 Highly Informative Inherited
Biological Process (BP) regulation of neural precursor cell proliferation 0.007101 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.1922 Highly Informative Inherited
Biological Process (BP) neural tube development 0.07651 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.1161 Highly Informative Inherited
Molecular Function (MF) binding 1.898e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02703 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.0598 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 3.05e-15 Informative Direct
Molecular Function (MF) enzyme binding 1.54e-09 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 5.481e-08 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 2.031e-05 Informative Direct
Molecular Function (MF) lipid binding 0.0001191 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0008131 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2198 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1415 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4271 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ATP binding 5.021e-08 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0002353 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.1356 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.4953 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.001947 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.007903 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.006655 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.002902 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.3754 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.12e-13 Moderately Informative Direct
Cellular Component (CC) cytosol 3.825e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01985 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.05072 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9668 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell cortex 5.236e-12 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 2.259e-06 Informative Direct
Cellular Component (CC) synapse part 0.0001871 Informative Direct
Cellular Component (CC) coated vesicle 0.0007547 Informative Direct
Cellular Component (CC) neuron projection 0.006463 Informative Inherited
Cellular Component (CC) cell-cell junction 0.001649 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.05653 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.3114 Informative Inherited
Cellular Component (CC) cell body 5.824e-15 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 5.647e-13 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 4.106e-12 Highly Informative Direct
Cellular Component (CC) nuclear periphery 1.021e-10 Highly Informative Direct
Cellular Component (CC) contractile ring 7.866e-08 Highly Informative Direct
Cellular Component (CC) ruffle 2.87e-07 Highly Informative Direct
Cellular Component (CC) cell division site part 1.599e-06 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 7.501e-05 Highly Informative Direct
Cellular Component (CC) synaptic membrane 0.0005074 Highly Informative Direct
Cellular Component (CC) spindle 0.0005707 Highly Informative Direct
Cellular Component (CC) dendrite 0.4954 Highly Informative Inherited
Cellular Component (CC) axon part 0.2886 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1989 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.01599 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.003555 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.101e-06InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase4.229e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4059Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.518Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.7525Least InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3387Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02437InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.114InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1401InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1721InformativeInherited
Phenotypic Abnormality (PA)Webbed neck0.000188Highly InformativeDirect
Phenotypic Abnormality (PA)Low posterior hairline0.0002226Highly InformativeDirect
Phenotypic Abnormality (PA)Irregular hyperpigmentation0.0006191Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.003889Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.003996Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01673Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.941InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.01132Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1.332e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000145Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.427Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.03891Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.09207Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2254Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant4.936e-06InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003274InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01106InformativeInherited
Worm Phenotype (WP)protein expression variant0.05202InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.6657InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant7.02e-10Highly InformativeDirect
Worm Phenotype (WP)response to injury variant1.358e-07Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant2.889e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant1.285e-05Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant1.575e-05Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant4.394e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.0002901InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0007829InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2263Least InformativeInherited
Fly Anatomy (FA)organ system0.3399Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.000357InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1917Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis7.751e-06InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.753Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007876InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4117InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.358e-06Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase8.107e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell cycle2.734e-06Moderately InformativeDirect
Biological processAngiogenesis1.856e-15InformativeDirect
Biological processInflammatory response1.006e-12InformativeDirect
Biological processCell adhesion7.293e-10InformativeDirect
Biological processNeurogenesis5.781e-09InformativeDirect
Biological processMitosis0.0006972InformativeDirect
Biological processExocytosis8.668e-15Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus1.816e-12Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus5.319e-15Moderately InformativeDirect
Cellular componentCell projection3.073e-12Moderately InformativeDirect
Cellular componentEndosome1.635e-05Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002125Moderately InformativeDirect
Cellular componentCell membrane0.0006871Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0008057Moderately InformativeDirect
Cellular componentMicrotubule7.903e-09InformativeDirect
Cellular componentSynapse0.5536InformativeInherited
Cellular componentSynaptosome2.648e-05Highly InformativeDirect
DiseaseProto-oncogene2.199e-15Moderately InformativeDirect
DiseaseTumor suppressor1.118e-05Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain3.547e-05InformativeDirect
DomainSH3 domain7.64e-05InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding5.02e-15Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.433e-05Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator9.447e-05InformativeDirect
Post-translational modificationMyosin1.816e-08Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]