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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (503) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,576 36,637 8
Proteins 10,276 25,375 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000000009834 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000000004927 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000007128 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000005962 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.06048 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000003965 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000001008 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00001412 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.00002403 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00003916 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00003941 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002422 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0003569 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.01696 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.0547 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9498 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.04233 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04556 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1543 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8309 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.581 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01853 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4072 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.01318 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.339 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000000000003956 Informative Direct
Biological Process (BP) organelle localization 0.000000000002541 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000000008332 Informative Direct
Biological Process (BP) generation of neurons 0.0000000000233 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000005621 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000000001135 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000122 Informative Direct
Biological Process (BP) response to wounding 0.0000001795 Informative Direct
Biological Process (BP) cell activation 0.0000006186 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000002081 Informative Direct
Biological Process (BP) secretion by cell 0.000002871 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000003492 Informative Direct
Biological Process (BP) microtubule-based process 0.000009382 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000009615 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00001062 Informative Direct
Biological Process (BP) locomotion 0.0000172 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00004752 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00006946 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00007419 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0001085 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0001944 Informative Direct
Biological Process (BP) intracellular transport 0.000195 Informative Direct
Biological Process (BP) cell cycle process 0.0002495 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002553 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0005266 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0005436 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0005947 Informative Direct
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.8208 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.07363 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.002037 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.2583 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.496 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2503 Informative Inherited
Biological Process (BP) post-embryonic development 0.004584 Informative Inherited
Biological Process (BP) growth 0.06144 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.00105 Informative Inherited
Biological Process (BP) epithelium development 0.006972 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3755 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.00124 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.867 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.01226 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.7709 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.2888 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.001743 Informative Inherited
Biological Process (BP) single organism reproductive process 0.531 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.268 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.02486 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.004698 Informative Inherited
Biological Process (BP) chromosome organization 0.8326 Informative Inherited
Biological Process (BP) embryo development 0.6437 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.09469 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4889 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.3689 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.1329 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3633 Informative Inherited
Biological Process (BP) regulation of secretion 0.235 Informative Inherited
Biological Process (BP) localization of cell 0.03935 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.002439 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5268 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02575 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1548 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.147 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002139 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.918 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1324 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.2227 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7987 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) system process 0.9082 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.9435 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1154 Informative Inherited
Biological Process (BP) regulation of immune response 0.5286 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.7065 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.7704 Informative Inherited
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0000000000002407 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000000000001308 Highly Informative Direct
Biological Process (BP) coagulation 0.000000000005622 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000000001448 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00000000004343 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000000001193 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0000001101 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000009481 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000001392 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000001529 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000005803 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.000009016 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.00001053 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.00001923 Highly Informative Direct
Biological Process (BP) appendage development 0.00002854 Highly Informative Direct
Biological Process (BP) gastrulation 0.00003399 Highly Informative Direct
Biological Process (BP) nuclear division 0.0000374 Highly Informative Direct
Biological Process (BP) regulation of cell division 0.00004742 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0001935 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0003504 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.0008593 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.8794 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.3457 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.4752 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.4647 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.7224 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.003504 Highly Informative Inherited
Biological Process (BP) cell growth 0.00137 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.03442 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.01072 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.002306 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.7439 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.1283 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01515 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2715 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.061 Highly Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.01293 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.886 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.00901 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.02951 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.356 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.001301 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.02851 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.5544 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.954 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.6758 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.003354 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.3807 Highly Informative Inherited
Biological Process (BP) hemostasis 0.01093 Highly Informative Inherited
Biological Process (BP) wound healing 0.01578 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.05557 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.4342 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.8423 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.0337 Highly Informative Inherited
Biological Process (BP) germ cell development 0.6957 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.02526 Highly Informative Inherited
Biological Process (BP) cell maturation 0.4114 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.1717 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.04399 Highly Informative Inherited
Biological Process (BP) muscle system process 0.01721 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.777 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.17 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.453 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.01094 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.8866 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.02183 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.6548 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.003057 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.005043 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.8768 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.00001586 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.2992 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1929 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.6846 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.04614 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 8.27e-16 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000000000000003188 Informative Direct
Molecular Function (MF) enzyme binding 0.000000000002193 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.003707 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.002933 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00122 Informative Inherited
Molecular Function (MF) signal transducer activity 0.7308 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000002758 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000116 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 1 Highly Informative Inherited
Molecular Function (MF) small GTPase binding 1 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.2351 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.06117 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0005545 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.7603 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.006076 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000000000003172 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000001395 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0001575 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.3362 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.899 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic region 0.00000000000000156 Informative Direct
Cellular Component (CC) apical part of cell 0.00001742 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0007264 Informative Direct
Cellular Component (CC) plasma membrane region 0.009284 Informative Inherited
Cellular Component (CC) neuron projection 0.4151 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.93 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.01859 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1215 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0000000000484 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00000000007487 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0000000007444 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0.000002982 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.00001259 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00001314 Highly Informative Direct
Cellular Component (CC) ruffle 0.00003419 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.00006039 Highly Informative Direct
Cellular Component (CC) presynapse 0.0002103 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.04444 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processCell cycle0.000003966Moderately InformativeDirect
Biological processAngiogenesis0.000000000000003803InformativeDirect
Biological processBiological rhythms0.000000000003992InformativeDirect
Biological processInflammatory response0.000000000005504InformativeDirect
Biological processCell adhesion0.000000001395InformativeDirect
Biological processNeurogenesis0.00000002143InformativeDirect
Biological processExocytosis0.00000000000002185Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.0000000000009966Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0.000000000000001306Moderately InformativeDirect
Cellular componentGolgi apparatus0.0000000000000426Moderately InformativeDirect
Cellular componentEndosome0.00007524Moderately InformativeDirect
Cellular componentCell membrane0.0001127Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0009977Moderately InformativeDirect
Cellular componentMicrotubule0.00000002546InformativeDirect
Cellular componentSynapse0.5101InformativeInherited
Cellular componentSynaptosome0.00004447Highly InformativeDirect
DiseaseProto-oncogene0.000000000000006976Moderately InformativeDirect
DiseaseTumor suppressor0.00001649Moderately InformativeDirect
DomainRepeat0.00000000000000246Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH3 domain0.00001874InformativeDirect
DomainSH2 domain0.0000401InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding0.00000006088Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000171Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.00009621InformativeDirect
Post-translational modificationActin-binding0.0002424InformativeDirect
Post-translational modificationMyosin0.00000002128Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]