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Cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Families:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)
  TFIIH p44 subunit cysteine-rich domain [ 57899]
  C1-like domain [ 111463]


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,335 14,257 8
Proteins 10,084 10,031 8


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0026290.000000856Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000099880.0000003953Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.000000856 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0000000000002009 Least Informative Direct
Biological Process (BP) localization 0.0000007304 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00001152 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0000003953 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000000008324 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000000000958 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000003274 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000000006982 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.00000005834 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000001113 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000001804 Moderately Informative Direct
Biological Process (BP) immune system process 0.0000005824 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00001069 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001497 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0002454 Moderately Informative Direct
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04925 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5872 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01967 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1019 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2681 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) system process 0.03009 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5932 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7503 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2935 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7376 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.4704 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1727 Moderately Informative Inherited
Biological Process (BP) reproduction 0.05297 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002546 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) organelle localization 0.000000000000005594 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000000002478 Informative Direct
Biological Process (BP) negative regulation of cell death 0.00000000002442 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00000000003158 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00000000007482 Informative Direct
Biological Process (BP) secretion by cell 0.000001532 Informative Direct
Biological Process (BP) locomotion 0.000001558 Informative Direct
Biological Process (BP) response to wounding 0.000001591 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0.000004907 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000007692 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00000786 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00004801 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00005829 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001318 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0001629 Informative Direct
Biological Process (BP) microtubule-based process 0.0001701 Informative Direct
Biological Process (BP) negative regulation of transport 0.0002037 Informative Direct
Biological Process (BP) leukocyte activation 0.0003008 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004752 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0005495 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0007804 Informative Direct
Biological Process (BP) regulation of cell activation 0.00973 Informative Inherited
Biological Process (BP) regulation of secretion 0.08909 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3243 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.0896 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.5359 Informative Inherited
Biological Process (BP) cell projection organization 0.01246 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.222 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.3366 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.7571 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6425 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.004267 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.2801 Informative Inherited
Biological Process (BP) regulation of cell development 0.01233 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9163 Informative Inherited
Biological Process (BP) muscle structure development 0.9041 Informative Inherited
Biological Process (BP) regulation of system process 0.04558 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02108 Informative Inherited
Biological Process (BP) cell cycle process 0.5256 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8562 Informative Inherited
Biological Process (BP) sensory organ development 0.8357 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.004887 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1585 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.301 Informative Inherited
Biological Process (BP) response to nutrient levels 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02842 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.7765 Informative Inherited
Biological Process (BP) synaptic transmission 0.00224 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.6623 Informative Inherited
Biological Process (BP) growth 0.01021 Informative Inherited
Biological Process (BP) cellular component movement 0.00956 Informative Inherited
Biological Process (BP) localization of cell 0.007259 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.03942 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.04801 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.4756 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.0662 Informative Inherited
Biological Process (BP) tube development 0.1371 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.3801 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4753 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1185 Informative Inherited
Biological Process (BP) sexual reproduction 0.1269 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6099 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.7022 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.001296 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) immune response 0.2473 Informative Inherited
Biological Process (BP) immune effector process 0.008743 Informative Inherited
Biological Process (BP) epithelium development 0.05764 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.5393 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000000002793 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00000000000003788 Highly Informative Direct
Biological Process (BP) exocytosis 0.00000000000006238 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000000000009114 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000000000001048 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.000000000253 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.000000001091 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000006322 Highly Informative Direct
Biological Process (BP) coagulation 0.00000005706 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.00000008535 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0000002929 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.000002189 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.000002336 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000002438 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.000004233 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.000008286 Highly Informative Direct
Biological Process (BP) B cell activation 0.000009473 Highly Informative Direct
Biological Process (BP) signal release 0.0000103 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.0000163 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.00002313 Highly Informative Direct
Biological Process (BP) mitosis 0.00004028 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.00006163 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0001052 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.0001066 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0001893 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0001974 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0002415 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00032 Highly Informative Direct
Biological Process (BP) cell growth 0.0004486 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0004808 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.0005106 Highly Informative Direct
Biological Process (BP) wound healing 0.0006681 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.001091 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.07127 Highly Informative Inherited
Biological Process (BP) developmental growth 0.09875 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) cytoskeleton-dependent intracellular transport 0.01268 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.4511 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.002008 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.03168 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.6137 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.8223 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1676 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01376 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.7434 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.2232 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.01255 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.03476 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.3795 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.4379 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.5584 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.03382 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.233 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell differentiation 0.1513 Highly Informative Inherited
Biological Process (BP) response to alkaloid 0.2132 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.001522 Highly Informative Inherited
Biological Process (BP) leukocyte proliferation 0.001766 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.001053 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.00135 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.03924 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.003951 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.02307 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.02593 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.003011 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02478 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06269 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.00949 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.8253 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.007755 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.008251 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.09319 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.1225 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.3929 Highly Informative Inherited
Biological Process (BP) regulation of microtubule polymerization or depolymerization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytoskeleton organization 0.8267 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response 0.01994 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.292 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.7803 Highly Informative Inherited
Biological Process (BP) positive regulation of epithelial cell proliferation 0.04729 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.004137 Highly Informative Inherited
Biological Process (BP) neural tube development 0.06321 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.9268 Highly Informative Inherited
Biological Process (BP) cell division 0.009203 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000469 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.009452 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.07668 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000000001562 Informative Direct
Molecular Function (MF) enzyme binding 0.000000007088 Informative Direct
Molecular Function (MF) lipid binding 0.000003949 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00003751 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00004405 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.2252 Informative Inherited
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.006698 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.6435 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.1555 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4348 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0.0000001165 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00002233 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.0003185 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.3138 Highly Informative Inherited
Molecular Function (MF) kinase binding 0.5055 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 1 Highly Informative Inherited
Molecular Function (MF) Ras GTPase binding 0.5154 Highly Informative Inherited
Molecular Function (MF) GTPase activator activity 0.2485 Highly Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.008205 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.04418 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.01331 Least Informative Inherited
Cellular Component (CC) protein complex 0.453 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000000000003095 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000000000004609 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0000006928 Moderately Informative Direct
Cellular Component (CC) vesicle 0.09118 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000003572 Informative Direct
Cellular Component (CC) cell cortex 0.00000007772 Informative Direct
Cellular Component (CC) synapse part 0.0000001429 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.000002681 Informative Direct
Cellular Component (CC) neuron projection 0.00299 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) coated vesicle 0.001104 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.0501 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.3229 Informative Inherited
Cellular Component (CC) cell body 0.000000000000008984 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000006284 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00000003165 Highly Informative Direct
Cellular Component (CC) cell division site part 0.0000002919 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 0.0001246 Highly Informative Direct
Cellular Component (CC) spindle 0.0003356 Highly Informative Direct
Cellular Component (CC) dendrite 0.705 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1903 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.004131 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0007862Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.7416Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007101InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0.00000000004229Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4003Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7217Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1681Moderately InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.3382Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.02214InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.1088InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.1394InformativeInherited
Phenotypic Abnormality (PA)Low posterior hairline0.0002057Highly InformativeDirect
Phenotypic Abnormality (PA)Irregular hyperpigmentation0.0006148Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.004043Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.002652Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01199Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.1217Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.9576InformativeInherited
Mammalian Phenotype (MP)abnormal T cell selection0.01133Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00001332Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000145Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.427Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.03891Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.09207Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.2026Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.2254Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.3357Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.000004936InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0003274InformativeDirect
Worm Phenotype (WP)cell stress response variant0.01106InformativeInherited
Worm Phenotype (WP)protein expression variant0.05202InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.6657InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000000702Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000001358Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.000002889Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00001285Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.00001575Highly InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.00004394Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective0.00023InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.2168Least InformativeInherited
Fly Anatomy (FA)organ system0.3353Least InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0003041InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1917Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.000007751InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.7987Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0.0008014InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.4177InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000007276Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00008053Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processDifferentiation0Moderately InformativeDirect
Biological processCell cycle0.00000252Moderately InformativeDirect
Biological processAngiogenesis0.000000000000002085InformativeDirect
Biological processInflammatory response0.000000000001505InformativeDirect
Biological processCell adhesion0.000000000851InformativeDirect
Biological processNeurogenesis0.000000007417InformativeDirect
Biological processBiological rhythms0.000002444InformativeDirect
Biological processMitosis0.0006411InformativeDirect
Biological processExocytosis0.000000000000008684Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000000000001068Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000000000007264Moderately InformativeDirect
Cellular componentCell projection0.000000000005304Moderately InformativeDirect
Cellular componentEndosome0.00001894Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0002572Moderately InformativeDirect
Cellular componentCell membrane0.0005065Moderately InformativeDirect
Cellular componentMicrotubule0.000000008415InformativeDirect
Cellular componentSynapse0.5875InformativeInherited
Cellular componentSynaptosome0.00002636Highly InformativeDirect
DiseaseProto-oncogene0.000000000000001525Moderately InformativeDirect
DiseaseTumor suppressor0.000009675Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain0.00003537InformativeDirect
DomainSH3 domain0.00007554InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding4.62e-16Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00001562Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationChromatin regulator0.0001116InformativeDirect
Post-translational modificationMyosin0.00000001846Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]