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FYVE/PHD zinc finger superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   FYVE/PHD zinc finger [ 57902]
Superfamily:   FYVE/PHD zinc finger [ 57903] (3)
Families:   FYVE, a phosphatidylinositol-3-phosphate binding domain [ 57904] (6)
  PHD domain [ 57911] (13)
  variant PHD-like domain [ 118346]


Superfamily statistics
Genomes (561) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 40,972 97,838 26
Proteins 34,367 81,418 26


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000000000003734 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000000001051 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000002722 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4852 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000001683 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000001006 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000007206 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000001403 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000005058 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000101 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0002757 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0003032 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9126 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2088 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5082 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3813 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1089 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.05231 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.677 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2231 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8214 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2064 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5664 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01153 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.7182 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000000000000376 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00000000005219 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000000687 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000000004757 Informative Direct
Biological Process (BP) secretion by cell 0.00000003184 Informative Direct
Biological Process (BP) organelle localization 0.0000001253 Informative Direct
Biological Process (BP) intracellular transport 0.0000003389 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00008506 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000902 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.03381 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1722 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9864 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.861 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.9063 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.001283 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.004923 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.03107 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.3671 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.001004 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.1327 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.1907 Informative Inherited
Biological Process (BP) microtubule-based process 0.9147 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.6549 Informative Inherited
Biological Process (BP) hemopoiesis 0.1175 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell development 0.402 Informative Inherited
Biological Process (BP) regulation of growth 0.9126 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.006513 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.01868 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.0324 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1991 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) behavior 0.8966 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.3077 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) generation of neurons 0.8478 Informative Inherited
Biological Process (BP) cell cycle process 0.09474 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.1418 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.4061 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.001159 Informative Inherited
Biological Process (BP) DNA metabolic process 0.00146 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.2063 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cell activation 0.991 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.8513 Informative Inherited
Biological Process (BP) supramolecular fiber organization 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.01206 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.3318 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02805 Informative Inherited
Biological Process (BP) post-embryonic development 0.08892 Informative Inherited
Biological Process (BP) reproductive system development 0.1289 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) macromolecule methylation 0 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) demethylation 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0.00000000000001422 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.00000000000007466 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000000000006136 Highly Informative Direct
Biological Process (BP) protein alkylation 0.0000000000008149 Highly Informative Direct
Biological Process (BP) gene silencing 0.000000003065 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.000000003429 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.000005554 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00001594 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.00001666 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.0001105 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.0001555 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0001969 Highly Informative Direct
Biological Process (BP) nuclear division 0.0003746 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0005143 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.8436 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.0121 Highly Informative Inherited
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.1404 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.2582 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.003095 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01602 Highly Informative Inherited
Biological Process (BP) regulation of protein complex disassembly 0.04743 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.1408 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.09484 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.1571 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) digestion 0.03202 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.3757 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.002153 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.113 Highly Informative Inherited
Biological Process (BP) neuron development 0.003136 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2781 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1113 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.174 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.1741 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.848 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.004071 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.005151 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.2509 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.002405 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.001196 Highly Informative Inherited
Biological Process (BP) cell maturation 0.008126 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.1503 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.9255 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.17 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.1219 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 0.9739 Highly Informative Inherited
Biological Process (BP) DNA replication 0.04287 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.002837 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.6008 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.7045 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.7513 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.6304 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.583 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.2024 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.3832 Highly Informative Inherited
Biological Process (BP) appendage development 0.3541 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.2263 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2525 Highly Informative Inherited
Biological Process (BP) nucleus organization 0.9842 Highly Informative Inherited
Biological Process (BP) DNA recombination 1 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.2041 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000000001689 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.000000000001144 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00007309 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.1953 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.000000000000003188 Informative Direct
Molecular Function (MF) DNA binding 0.000000000009716 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000000001129 Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.00000143 Informative Direct
Molecular Function (MF) ATPase activity 0.5094 Informative Inherited
Molecular Function (MF) enzyme binding 0.1862 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) phosphatase activity 0.3539 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) chromatin binding 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000000000001926 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0000000006 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0000000006102 Highly Informative Direct
Molecular Function (MF) dioxygenase activity 0.000003025 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0002829 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0005128 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.9009 Highly Informative Inherited
Molecular Function (MF) phosphatidylinositol phosphate binding 0.1007 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.0194 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.1245 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2193 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1293 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00006329 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0002359 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.006878 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1134 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.04048 Moderately Informative Inherited
Cellular Component (CC) chromosome 0 Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) endosome 0.0000000000000766 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000004452 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00000009782 Informative Direct
Cellular Component (CC) cytoplasmic region 0.001564 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.7511 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) histone deacetylase complex 0 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) endosome membrane 0.00000000001096 Highly Informative Direct
Cellular Component (CC) presynapse 0.000000000588 Highly Informative Direct
Cellular Component (CC) chromatin 0.00000002152 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.00000006548 Highly Informative Direct
Cellular Component (CC) RNA polymerase II transcription factor complex 0.00001807 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.0001339 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.03862 Highly Informative Inherited
Cellular Component (CC) growth cone 0.1639 Highly Informative Inherited
Cellular Component (CC) cell division site part 0.0122 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000006577Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.008364Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.2911Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.067Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.0000000268Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.0000003973Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0005085Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0831Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000000008157InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processApoptosis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.000000221Moderately InformativeDirect
Biological processProtein transport0.000006765Moderately InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processBiological rhythms0.000000002774InformativeDirect
Biological processAutophagy0.000000003501InformativeDirect
Biological processMeiosis0.00000001139InformativeDirect
Biological processEndocytosis0.000004789InformativeDirect
Biological processExocytosis0.0000000000001564Highly InformativeDirect
Biological processGrowth regulation0.000000000001757Highly InformativeDirect
Biological processNeurotransmitter transport0.0000008722Highly InformativeDirect
Biological processFlowering0.000001153Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000002978Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000000395Moderately InformativeDirect
Cellular componentCell junction0.000000000496Moderately InformativeDirect
Cellular componentChromosome0.0000000000003041InformativeDirect
Cellular componentCentromere0.0001356Highly InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
Coding sequence diversityChromosomal rearrangement0.0000001696InformativeDirect
DiseaseTumor suppressor0.000006346Moderately InformativeDirect
DiseaseMental retardation0.0004422InformativeDirect
DomainRepeat0.000000000000003069Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainCoiled coil0.00000000000000246Moderately InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionLipid-binding0.0007553Moderately InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000000000002187Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000009118Moderately InformativeDirect
Post-translational modificationOxidoreductase0.3485Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationActin-binding0.000004973InformativeDirect
Post-translational modificationMethyltransferase0.00005809InformativeDirect
Post-translational modificationHelicase0.000179InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.00028InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00000000000008525Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationCitrullination0.000000009587Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011011 SSF57903 Protein matches
Abstract

The FYVE zinc finger domain is conserved from yeast to man, and is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes [PubMed11911884, PubMed12665246].

The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif, and is widely distributed in eukaryotes, being found in many chromatin regulatory factors [PubMed14679290].

Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.

More information about these proteins can be found at Protein of the Month: Zinc Fingers.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FYVE/PHD zinc finger domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the FYVE/PHD zinc finger superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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