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Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,018) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,744 113,797 62
Proteins 23,134 98,873 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000000007239 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00002576 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002125 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01094 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01452 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8888 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0000000000004191 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000005841 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000005118 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000008025 Moderately Informative Direct
Biological Process (BP) ion transport 0.0002495 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.7162 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.1267 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6323 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1937 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.005588 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1623 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1952 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.003936 Moderately Informative Inherited
Biological Process (BP) signaling 0.4698 Moderately Informative Inherited
Biological Process (BP) cell communication 0.6888 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4138 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1387 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3072 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.05896 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 0.4421 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.05664 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7991 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.007154 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2637 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9163 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.008489 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.05397 Moderately Informative Inherited
Biological Process (BP) electron transport chain 0.00003475 Informative Direct
Biological Process (BP) lipid localization 0.00011 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0001207 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0001461 Informative Direct
Biological Process (BP) response to cytokine 0.0001663 Informative Direct
Biological Process (BP) organic acid transport 0.0005148 Informative Direct
Biological Process (BP) secretion 0.0006264 Informative Direct
Biological Process (BP) regulation of system process 0.01667 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.8538 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.08085 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.001217 Informative Inherited
Biological Process (BP) ion homeostasis 0.5621 Informative Inherited
Biological Process (BP) behavior 0.2631 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.003892 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.008831 Informative Inherited
Biological Process (BP) regulation of defense response 0.08139 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.5636 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.00767 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.2848 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.399 Informative Inherited
Biological Process (BP) anion transport 0.05632 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1273 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001977 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.7764 Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.01837 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.006841 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3883 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.05078 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.0503 Informative Inherited
Biological Process (BP) system process 0.7116 Informative Inherited
Biological Process (BP) metal ion transport 0.09792 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.05131 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.0869 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.1702 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.09283 Informative Inherited
Biological Process (BP) reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000000009792 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000001273 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000000002067 Highly Informative Direct
Biological Process (BP) protein secretion 0.00000001862 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000001361 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.0000006506 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.00000118 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.000002164 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000005929 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00004042 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000133 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.0001404 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.0001627 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0002429 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0004934 Highly Informative Direct
Biological Process (BP) aging 0.007553 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.002939 Highly Informative Inherited
Molecular Function (MF) binding 0.9842 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00003377 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00242 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000000000003616 Informative Direct
Molecular Function (MF) electron carrier activity 0.00000006928 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.00005618 Informative Direct
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.000000000001934 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0.00004041 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on iron-sulfur proteins as donors 0.001481 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.02679 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.002997 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.7474 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.7037 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.02766 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1462 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0001001 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.007323 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.3471 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.000000000004705 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0003315 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.07216 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000001461InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.0643Least InformativeInherited
Disease Ontology (DO)nervous system disease0.7291Least InformativeInherited
Disease Ontology (DO)artery disease0.002619Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.01002Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.1412Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.2445Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8598Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00001051InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00002547InformativeDirect
Disease Ontology (DO)migraine0.00009917InformativeDirect
Disease Ontology (DO)hypertension0.0001991InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.0345InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.0000002418Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00001794Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.01398Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01698Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06966Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.233Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3318Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3949Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5095Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.524Least InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.0009555Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0009596Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01884Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02489Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05325Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1716Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2472Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2645Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3626Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.474Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.0000485InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.000143InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0003101InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0006171InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0006581InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0007465InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.001348InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001581InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.003341InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003569InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003886InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.006651InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.008035InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01332InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01775InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02218InformativeInherited
Mammalian Phenotype (MP)abnormal lipoprotein level0.02641InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.03619InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.03741InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.03928InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04411InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06236InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.08721InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.09133InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.09338InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.1106InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.1646InformativeInherited
Mammalian Phenotype (MP)abnormal intestine physiology0.1673InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.23InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2471InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.3325InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000001957Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000009581Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001335Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.00000007717Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001261Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.0000001493Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000002445Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000007762Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000007762Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.0000007762Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000002856Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000005844Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000007952Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.00001054Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00002285Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00002387Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.0000274Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00003748Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00003797Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004041Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.00004041Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00005423Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00006327Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00007008Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.00009271Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0001017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.0001038Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0001374Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002637Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0004017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004937Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0005838Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0006304Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0007775Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.0009253Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001411Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.1128Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1163Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001145Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.005626Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.0001385Moderately InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0001605InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.001544InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000000000008717InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.00001042InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.000006224Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.06469Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.0003396Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.0003965Moderately InformativeDirect
Biological processIon transport0.6065Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.002523InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processOxygen transport4.822e-16Highly InformativeDirect
Biological processSterol biosynthesis0.0000003956Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionCalcium0.000001975Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.02543InformativeInherited
Post-translational modificationVoltage-gated channel0.000687Highly InformativeDirect
Post-translational modificationMyristate0.000000391InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.000000000003459Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.00006987Moderately InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)hormone biosynthesis0.000000000005341InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0.0000001022InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis2.305e-16Highly InformativeDirect
UniPathway (UP)vanillyl-alcohol degradation0.00001125Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]