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Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,023) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,819 132,753 62
Proteins 23,209 117,793 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000000002124 Least Informative Direct
Biological Process (BP) response to stimulus 0.000138 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01517 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.308 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2351 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7057 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) oxidation-reduction process 0.0000000000003345 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000003271 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.00000009074 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000006264 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002293 Moderately Informative Direct
Biological Process (BP) ion transport 0.0004042 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.7398 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7093 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.09062 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.08565 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01453 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.2335 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05819 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.004487 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4038 Moderately Informative Inherited
Biological Process (BP) cell communication 0.7 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8603 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2795 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.345 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4585 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02754 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2768 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9524 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9808 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.009656 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3283 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.06707 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.2893 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1526 Moderately Informative Inherited
Biological Process (BP) electron transport chain 0.00002797 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000967 Informative Direct
Biological Process (BP) lipid localization 0.000112 Informative Direct
Biological Process (BP) secretion by cell 0.0002199 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0002276 Informative Direct
Biological Process (BP) response to cytokine 0.0003458 Informative Direct
Biological Process (BP) organic acid transport 0.0005539 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0009286 Informative Direct
Biological Process (BP) alcohol metabolic process 0.8465 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.04855 Informative Inherited
Biological Process (BP) response to metal ion 0.1291 Informative Inherited
Biological Process (BP) ion homeostasis 0.4998 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.008679 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.00957 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.0865 Informative Inherited
Biological Process (BP) regulation of defense response 0.1033 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.5215 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01272 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4047 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4986 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1343 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.001961 Informative Inherited
Biological Process (BP) anion transport 0.05986 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.8385 Informative Inherited
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.003968 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.1604 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.006481 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3807 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1225 Informative Inherited
Biological Process (BP) regulation of system process 0.01618 Informative Inherited
Biological Process (BP) system process 0.4804 Informative Inherited
Biological Process (BP) metal ion transport 0.09733 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.05297 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.05244 Informative Inherited
Biological Process (BP) behavior 0.2526 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.1048 Informative Inherited
Biological Process (BP) response to purine-containing compound 0.0000000000004969 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000000000009299 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000000003324 Highly Informative Direct
Biological Process (BP) protein secretion 0.00000004659 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.0000001126 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.0000008172 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.000001003 Highly Informative Direct
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.000002304 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000004711 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00002481 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00005358 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.00013 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0003001 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0003004 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) aging 0.008775 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.002778 Highly Informative Inherited
Molecular Function (MF) binding 0.9835 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00003844 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003079 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000000000001473 Informative Direct
Molecular Function (MF) electron carrier activity 0.00000005445 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.00005327 Informative Direct
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) FMN binding 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.00000000000009913 Highly Informative Direct
Molecular Function (MF) iron-sulfur cluster binding 0.00005818 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on iron-sulfur proteins as donors 0.001255 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.002301 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.7576 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.7152 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.02169 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.05788 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4241 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0002276 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0185 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.3562 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.000000000005662 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0004389 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.01536 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000001461InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.8049Least InformativeInherited
Disease Ontology (DO)artery disease0.004297Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.01416Moderately InformativeInherited
Disease Ontology (DO)brain disease0.05809Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.1824Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.855Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00001535InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00003884InformativeDirect
Disease Ontology (DO)migraine0.0001448InformativeDirect
Disease Ontology (DO)hypertension0.0003548InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06453InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.000000329Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00002399Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.01373Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0196Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06748Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2216Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3373Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4227Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.5Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5307Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0008778Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.002216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01751Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02373Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05305Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.123Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1435Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1833Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.3007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4676Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4742Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.00005477InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001337InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002841InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0005866InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.000629InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.000708InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.001271InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001471InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003424InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003689InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.004012InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.005625InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.007617InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01158InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01642InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.0206InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02185InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.02308InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.0258InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.03214InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.03954InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03976InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.04562InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06435InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.0716InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.09996InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.108InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1237InformativeInherited
Mammalian Phenotype (MP)abnormal intestine physiology0.1688InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.2102InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2499InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.3435InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000001835Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000008974Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001482Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.00000007596Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001162Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.0000001356Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000002302Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000007286Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000007286Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.0000007286Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000002678Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000005516Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.00000748Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000009952Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00001306Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00002585Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00003584Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00003613Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004045Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.00004045Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00005034Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00005176Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00006303Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00006618Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.00008635Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.00009647Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00009682Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0001452Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002571Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0003901Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004901Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0006102Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0006102Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0008171Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.00136Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.1101Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1161Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001531Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.006733Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.0002227Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.09405Moderately InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.0002436InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.001005InformativeInherited
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0006336Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000001031InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.00001001InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.05428Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processLipid metabolism0.000343Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.0004149Moderately InformativeDirect
Biological processIon transport0.6216Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.002462InformativeInherited
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processOxygen transport4.844e-16Highly InformativeDirect
Biological processSterol biosynthesis0.0000003143Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0.000006524Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionIron-sulfur0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionCalcium0.0001483Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationIon channel0.01919InformativeInherited
Post-translational modificationVoltage-gated channel0.0007092Highly InformativeDirect
Post-translational modificationMyristate0.0000004091InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.000000000001292Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)hormone biosynthesis0.000000000007443InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis0.00000007498InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis2.314e-16Highly InformativeDirect
UniPathway (UP)vanillyl-alcohol degradation0.00001153Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]