SUPERFAMILY 1.75 HMM library and genome assignments server


Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,016) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,703 113,797 62
Proteins 23,094 98,873 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle3.224e-051Least InformativeInherited
Cellular Component (CC)cytoplasmic part3.096e-050.01106Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 7.708e-05 Least Informative Direct
Biological Process (BP) response to stimulus 8.951e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7102 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7743 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9772 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0007633 Moderately Informative Direct
Biological Process (BP) multi-organism process 7.552e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 8.75e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0002792 Moderately Informative Direct
Biological Process (BP) reproduction 0.7282 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9988 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4704 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.05313 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6628 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.742 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8238 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7576 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.0451 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.301 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.6377 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.1926 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.003968 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.6712 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.8243 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5327 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 1.271e-06 Informative Direct
Biological Process (BP) blood circulation 0.0006648 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0009163 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.0008682 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000222 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0001155 Informative Direct
Biological Process (BP) regulation of ion transport 0.0004913 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.1146 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.2091 Informative Inherited
Biological Process (BP) reproductive system development 0.04479 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.1883 Informative Inherited
Biological Process (BP) negative regulation of transport 0.001434 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.02462 Informative Inherited
Biological Process (BP) cellular cation homeostasis 0.1838 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.33 Informative Inherited
Biological Process (BP) metal ion transport 0.2826 Informative Inherited
Biological Process (BP) regulation of system process 0.0429 Informative Inherited
Biological Process (BP) transition metal ion transport 0.0008134 Highly Informative Direct
Biological Process (BP) superoxide metabolic process 9.859e-07 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.0008966 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.044e-07 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 1.053e-11 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 2.45e-08 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 9.751e-05 Highly Informative Direct
Biological Process (BP) cellular transition metal ion homeostasis 0.0006699 Highly Informative Direct
Biological Process (BP) iron ion homeostasis 1.091e-07 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.05492 Highly Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1 Highly Informative Inherited
Biological Process (BP) aging 0.004379 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.01828 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0007469 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0 Informative Direct
Molecular Function (MF) electron carrier activity 1.676e-07 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0006838 Informative Direct
Molecular Function (MF) tetrapyrrole binding 3.116e-14 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.506e-07 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Highly Informative Direct
Molecular Function (MF) heme binding 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.04016 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.3381 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 0.4178 Highly Informative Inherited
Cellular Component (CC) membrane 0.1013 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01106 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.007828 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.1457 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.3579 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.00628 Informative Inherited
Cellular Component (CC) membrane raft 0.0009826 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0.02989 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors7.826e-15Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions1.461e-11InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase1.117e-12Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)4.944e-10Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor4.206e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.07554Least InformativeInherited
Disease Ontology (DO)nervous system disease0.6683Least InformativeInherited
Disease Ontology (DO)lung disease0.0007224Moderately InformativeDirect
Disease Ontology (DO)artery disease0.004226Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02749Moderately InformativeInherited
Disease Ontology (DO)central nervous system disease0.1948Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis1.428e-05InformativeDirect
Disease Ontology (DO)malaria1.5e-05InformativeDirect
Disease Ontology (DO)migraine0.0001257InformativeDirect
Disease Ontology (DO)hypertension0.0003453InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06244InformativeInherited
Disease Ontology (DO)thyroid gland disease0.09283InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction3.192e-07Highly InformativeDirect
Disease Ontology (DO)hypothyroidism2.678e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.001908Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01813Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.08546Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2156Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3309Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3445Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4837Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.001236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.002108Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.002554Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.02313Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05143Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0542Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.07184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.08663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology4.456e-05InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount8.765e-05InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0002299InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineral density0.0005601InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0007233InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0009314InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001587InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.002373InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.004825InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.008497InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/ coenzyme level0.008583InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.01004InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.01238InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01632InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.01737InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01749InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02079InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.02097InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.04787InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.06571InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.08154InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.0851InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton physiology0.08964InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.1095InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.1468InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cholesterol level0.1579InformativeInherited
Mammalian Phenotype (MP)increased cholesterol level0.2333InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2382InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3105InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy1.195e-09Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level1.64e-08Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis1.805e-08Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure1.746e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis1.99e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.702e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis1.205e-06Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis1.205e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level1.468e-06Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis1.955e-06Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion4.033e-06Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia6.077e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level7.75e-06Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion9.712e-06Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall1.811e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount2.164e-05Highly InformativeDirect
Mammalian Phenotype (MP)hypertension2.781e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level4.381e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function4.492e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level6.147e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number7.384e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure8.83e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure9.519e-05Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.0001347Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.0001786Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.000281Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0004324Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0004455Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0005074Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0005356Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.0006379Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001628Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.002737Highly InformativeInherited
Mammalian Phenotype (MP)cardiac fibrosis0.02898Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.04106Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.119Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1214Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.01064InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors2.38e-15InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1.376e-08InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor2.913e-08Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.2342Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0.0002709Moderately InformativeDirect
Biological processLipid metabolism0.009616Moderately InformativeInherited
Biological processIon transport0.5662Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processLipid biosynthesis0.0003293InformativeDirect
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processDetoxification0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Biological processSteroid biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processOxygen transport4.713e-16Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionCalcium9.284e-07Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionHeme0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionUbiquinone0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.02248InformativeInherited
Post-translational modificationVoltage-gated channel0.000929Highly InformativeDirect
Post-translational modificationMyristate1.411e-07InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism2.118e-12Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)energy metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation6.625e-05Moderately InformativeDirect
UniPathway (UP)UMP biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)hormone biosynthesis1.326e-12InformativeDirect
UniPathway (UP)hydrogen sulfide biosynthesis2.43e-07InformativeDirect
UniPathway (UP)xenobiotic degradation1InformativeInherited
UniPathway (UP)thyroid hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)riboflavin biosynthesis2.453e-15Highly InformativeDirect
UniPathway (UP)vanillyl-alcohol degradation1.294e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]