SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,025) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,880 172,269 62
Proteins 23,267 151,979 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000001461InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.689Least InformativeInherited
Disease Ontology (DO)artery disease0.006836Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.01797Moderately InformativeInherited
Disease Ontology (DO)brain disease0.1501Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2252Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8572Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.0000225InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00005709InformativeDirect
Disease Ontology (DO)migraine0.0001907InformativeDirect
Disease Ontology (DO)hypertension0.0006168InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06442InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.0000004488Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00003237Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.01362Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0193Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06745Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2213Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3369Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4218Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4991Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5301Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0008826Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001752Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.002195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01749Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02566Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05309Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.123Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1835Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2622Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3446Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3792Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4679Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4745Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.00005508InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.000131InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002847InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.000567InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.000631InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0007107InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.001258InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001458InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003437InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003653InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.003993InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.005603InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.007636InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01165InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01648InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.02048InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02215InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.02322InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.026InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.03158InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04031InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.0453InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06423InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.07143InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.09929InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.1072InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1235InformativeInherited
Mammalian Phenotype (MP)abnormal intestine physiology0.1683InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.212InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2492InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.3488InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000001841Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000009018Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001228Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.00000007737Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001164Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.000000136Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000002308Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000007323Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000007323Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.0000007323Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000002682Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000005534Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000007512Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000009983Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00002262Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00002594Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00003596Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00003649Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004059Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.00004059Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00005062Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00005193Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00006002Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.0000665Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.00008674Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00009735Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.00009797Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0001345Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002491Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0003906Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004916Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0006108Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0006108Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0008019Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001363Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.111Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1161Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001698Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.007507Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.0002436Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.1071Moderately InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.0002786InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.0009946InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0006294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000005782InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.0000009236InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.002845Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]