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Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)


Superfamily statistics
Genomes (180) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,267 6,209 2
Proteins 2,126 5,769 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.07326Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.00918Moderately InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.0002034InformativeDirect
Disease Ontology (DO)multiple myeloma0.000019Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005285Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01244Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.09361Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0002362Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0006944Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.04492Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2693Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3618Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00004753InformativeDirect
Mammalian Phenotype (MP)abnormal neural tube morphology0.005768InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.038InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.04452InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.4191InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.6047InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.00000007479Highly InformativeDirect
Mammalian Phenotype (MP)fused somites0.000002309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.00001594Highly InformativeDirect
Mammalian Phenotype (MP)decreased somite size0.00004344Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0001674Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.04679Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.1059Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.4151Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006763Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002229Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.00227Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01122Least InformativeInherited
Worm Phenotype (WP)cell division variant0.00002288Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.01439Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.02433Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1447Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000001559InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.00000296InformativeDirect
Worm Phenotype (WP)cell number increased0.00001515InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.0000267InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000428InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.1003InformativeInherited
Worm Phenotype (WP)neuropil development variant0Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000000000000124Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.00000000008405Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.00000003876Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.00000005418Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.00000008546Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.0000009423Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000001423Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect
Fly Anatomy (FA)developing embryonic structure0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)epithelial cell0InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)adult procephalic segment0InformativeDirect
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)mechanosensory chaeta0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3729Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.1018Moderately InformativeInherited
Zebrafish Anatomy (ZA)stromal cell0.0001267Highly InformativeDirect
Zebrafish Anatomy (ZA)mesenchyme0.0005105Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.009728Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.0102Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.06265Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3253Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000003955Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0000003556Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00000168Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.001701Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.07186Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1747Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.00000000001026InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000003883InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000001244InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000002365InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000009421InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00003958InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.00004914InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001651InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0001775InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0006149InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.01818InformativeInherited
Xenopus ANatomical entity (XAN)tail0.51InformativeInherited
Xenopus ANatomical entity (XAN)intestine1InformativeInherited
Xenopus ANatomical entity (XAN)otic vesicle0.000000001077Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.00000001963Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00000002986Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0000007862Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001147Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.000004795Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.000009142Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001413Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0000159Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0001572Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0001747Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001922Highly InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below:
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]