SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)


Superfamily statistics
Genomes (180) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,267 5,220 2
Proteins 2,126 4,925 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00003329 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000002615 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.09961 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000003583 Moderately Informative Direct
Biological Process (BP) tissue development 0.000006904 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000005724 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000009109 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00007317 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000000386 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0006975 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000000000005563 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000002731 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00002729 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00019 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01242 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8667 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.02167 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7919 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8002 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.002033 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1045 Moderately Informative Inherited
Biological Process (BP) immune system process 0.219 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7939 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1104 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.01227 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.00006382 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00000000000002937 Informative Direct
Biological Process (BP) response to wounding 0.00003157 Informative Direct
Biological Process (BP) embryo development 0.0000005263 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0000004456 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000000002442 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0001349 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000006044 Informative Direct
Biological Process (BP) hemopoiesis 0.0002129 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0003004 Informative Direct
Biological Process (BP) growth 0.00009623 Informative Direct
Biological Process (BP) locomotion 0.0000000003302 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000001288 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000007706 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000002995 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) localization of cell 0.00000003134 Informative Direct
Biological Process (BP) epithelium development 0.0007776 Informative Direct
Biological Process (BP) cellular response to lipid 0.000003327 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0008693 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.001023 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1395 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.122 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.09552 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8426 Informative Inherited
Biological Process (BP) cell development 0.9825 Informative Inherited
Biological Process (BP) response to acid chemical 0.2202 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.284 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5011 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.03676 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.02324 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1826 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.1261 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01926 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.01886 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.05148 Informative Inherited
Biological Process (BP) central nervous system development 0.001596 Informative Inherited
Biological Process (BP) cell death 0.2249 Informative Inherited
Biological Process (BP) circulatory system development 0.03503 Informative Inherited
Biological Process (BP) vasculogenesis 0.0007329 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.000000000131 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0009153 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000577 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0008912 Highly Informative Direct
Biological Process (BP) forebrain development 0.0001953 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000005676 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0003263 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.00000002087 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00003847 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0002366 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0009712 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000004895 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00000000003137 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0000005851 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00001459 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.001354 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.001844 Highly Informative Inherited
Biological Process (BP) gastrulation 0.4674 Highly Informative Inherited
Biological Process (BP) neuron development 0.5985 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.008926 Highly Informative Inherited
Biological Process (BP) heart development 0.06645 Highly Informative Inherited
Molecular Function (MF) binding 0.0005504 Least Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0005367 Highly Informative Direct
Cellular Component (CC) membrane 0.0000000003374 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0000000000003099 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000004141 Moderately Informative Direct
Cellular Component (CC) cell projection 0.002437 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.002122 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.2697 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.8448 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.03385 Moderately Informative Inherited
Cellular Component (CC) cilium 0.0001115 Informative Direct
Cellular Component (CC) cell surface 0.0005019 Informative Direct
Cellular Component (CC) plasma membrane region 0.1855 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.342 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.003563 Informative Inherited
Cellular Component (CC) endocytic vesicle 0.01994 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.03155 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processNeurogenesis0.000000005725InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0.00000000001672Moderately InformativeDirect
Cellular componentCell membrane0.00000009724Moderately InformativeDirect
Cellular componentEndosome0.000002345Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0004777Moderately InformativeDirect
Cellular componentGolgi apparatus0.0006771Moderately InformativeDirect
Cellular componentExtracellular matrix0.0004613InformativeDirect
DiseaseDisease mutation0.00008787Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.00000000000003357Least InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationG-protein coupled receptor0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000005751Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below:
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]