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Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)


Superfamily statistics
Genomes (180) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,267 6,209 2
Proteins 2,126 5,769 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0735Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.009214Moderately InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.000205InformativeDirect
Disease Ontology (DO)multiple myeloma0.00001922Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005288Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01245Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.09359Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0006948Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.04492Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2693Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3618Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00004757InformativeDirect
Mammalian Phenotype (MP)abnormal neural tube morphology0.00577InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.038InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.04452InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.4191InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.6048InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.00000007485Highly InformativeDirect
Mammalian Phenotype (MP)fused somites0.000002311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.00001595Highly InformativeDirect
Mammalian Phenotype (MP)decreased somite size0.00004347Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0001675Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.04678Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.1058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.4151Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006827Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002239Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.002267Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01115Least InformativeInherited
Worm Phenotype (WP)cell division variant0.00002284Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0146Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.02462Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1464Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000001573InformativeDirect
Worm Phenotype (WP)cell number increased0.00001546InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00002719InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0004291InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.1007InformativeInherited
Worm Phenotype (WP)neuropil development variant0Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0000000000001601Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.00000000008493Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.0000000391Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.00000005765Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.00000008449Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.0000009498Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000001469Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)thoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0Moderately InformativeDirect
Fly Anatomy (FA)developing embryonic structure0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)epithelial cell0InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)adult procephalic segment0InformativeDirect
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)mechanosensory chaeta0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5281Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.07117Moderately InformativeInherited
Zebrafish Anatomy (ZA)stromal cell0.0001843Highly InformativeDirect
Zebrafish Anatomy (ZA)mesenchyme0.000928Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.009744Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.01049Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.06285Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3285Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000005317Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000000138Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0000003693Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.001705Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01831Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1758Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.00000000001178InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000001406InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000002452InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000001271InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.000004523InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000005014InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00001067InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.00001091InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00002598InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00002914InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00008811InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001848InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0003267InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.01899InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3204InformativeInherited
Xenopus ANatomical entity (XAN)intestine1InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.00000003159Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00000004877Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0000004136Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001272Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.000004126Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.000005277Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00001142Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001367Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0001735Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0001752Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.000447Highly InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below:
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]