SUPERFAMILY 1.75 HMM library and genome assignments server


Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (198) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,608 0 4
Proteins 7,411 0 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process7.218e-060Least InformativeDirect
Biological Process (BP)localization9.804e-100Least InformativeDirect
Biological Process (BP)response to stimulus0.0014220Least InformativeInherited
Biological Process (BP)regulation of cellular process0.83221Least InformativeInherited
Biological Process (BP)single-organism cellular process0.48511.761e-14Least InformativeInherited
Biological Process (BP)system process1.138e-050Moderately InformativeDirect
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00058255.022e-09Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.41211Moderately InformativeInherited
Biological Process (BP)immune system process4.199e-050.6628Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.10450.3708Moderately InformativeInherited
Biological Process (BP)response to organic substance0.18020.004074Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00012980.06629Moderately InformativeInherited
Biological Process (BP)cell-cell signaling7.087e-120InformativeDirect
Biological Process (BP)response to organonitrogen compound6.98e-080InformativeDirect
Biological Process (BP)response to organic cyclic compound1.189e-070InformativeDirect
Biological Process (BP)transmission of nerve impulse4.713e-080InformativeDirect
Biological Process (BP)locomotion0.00023510.0003626InformativeDirect
Biological Process (BP)regulation of system process1.946e-055.922e-09InformativeDirect
Biological Process (BP)single-organism behavior2.839e-122.067e-05InformativeDirect
Biological Process (BP)leukocyte activation1.883e-093.579e-07InformativeDirect
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)regulation of secretion0.0061651.612e-08InformativeInherited
Biological Process (BP)regulation of ion transport0.032992.378e-06InformativeInherited
Biological Process (BP)calcium ion transport3.785e-073.414e-11Highly InformativeDirect
Biological Process (BP)adult behavior3.281e-070Highly InformativeDirect
Biological Process (BP)B cell activation1.18e-122.434e-14Highly InformativeDirect
Biological Process (BP)regulation of membrane potential4.642e-110Highly InformativeDirect
Biological Process (BP)response to alkaloid8.009e-130Highly InformativeDirect
Biological Process (BP)response to ethanol9.238e-083.275e-10Highly InformativeDirect
Biological Process (BP)regulation of amine transport6.164e-080Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission4.846e-070.9454Highly InformativeInherited
Biological Process (BP)sensory perception0.81431Highly InformativeInherited
Biological Process (BP)learning or memory0.049621Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)cation channel activity8.503e-111.216e-07Highly InformativeDirect
Molecular Function (MF)ion gated channel activity00Highly InformativeDirect
Cellular Component (CC)membrane1.093e-110Least InformativeDirect
Cellular Component (CC)protein complex1.06e-060Least InformativeDirect
Cellular Component (CC)plasma membrane1.377e-070Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0051310Moderately InformativeInherited
Cellular Component (CC)cell surface5.134e-098.847e-06InformativeDirect
Cellular Component (CC)integral to membrane5.031e-110InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.00056160InformativeDirect
Cellular Component (CC)synapse part4.4e-060InformativeDirect
Cellular Component (CC)integral to plasma membrane1.114e-130Highly InformativeDirect
Cellular Component (CC)ion channel complex00Highly InformativeDirect
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane5.073e-108.537e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.761e-14 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.02353 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.419e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 2.478e-12 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 5.022e-09 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0005069 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3908 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7465 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5664 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6877 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6628 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3708 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6366 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.004074 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06629 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1253 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1675 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.03703 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 7.314e-05 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) response to light stimulus 0.0006962 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) locomotion 0.0003626 Informative Direct
Biological Process (BP) regulation of ion transport 2.378e-06 Informative Direct
Biological Process (BP) regulation of system process 5.922e-09 Informative Direct
Biological Process (BP) single-organism behavior 2.067e-05 Informative Direct
Biological Process (BP) leukocyte activation 3.579e-07 Informative Direct
Biological Process (BP) regulation of secretion 1.612e-08 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.0643 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8325 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7242 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2325 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001923 Informative Inherited
Biological Process (BP) regulation of cell development 0.001927 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.009126 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.05106 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01253 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01369 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5154 Informative Inherited
Biological Process (BP) positive regulation of transport 0.005195 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.134 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8597 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.07834 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001061 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2952 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.6759 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.5631 Informative Inherited
Biological Process (BP) response to hypoxia 2.167e-10 Highly Informative Direct
Biological Process (BP) calcium ion transport 3.414e-11 Highly Informative Direct
Biological Process (BP) exocytosis 0.0005875 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 1.01e-07 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 5.243e-10 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.481e-05 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0006775 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.164e-05 Highly Informative Direct
Biological Process (BP) B cell activation 2.434e-14 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0008089 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) response to ethanol 3.275e-10 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0002984 Highly Informative Direct
Biological Process (BP) regulation of behavior 2.499e-13 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.609e-06 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00631 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01939 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3649 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1661 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9408 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3745 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.007957 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.9454 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.0568 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001685 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.001778 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.9576 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.2869 Highly Informative Inherited
Biological Process (BP) axon development 0.1609 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.01003 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.08571 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9502 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6336 Highly Informative Inherited
Molecular Function (MF) binding 0.9431 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.62e-12 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.1932 Informative Inherited
Molecular Function (MF) cation channel activity 1.216e-07 Highly Informative Direct
Molecular Function (MF) drug binding 2.084e-13 Highly Informative Direct
Molecular Function (MF) amino acid binding 7.982e-16 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.915e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.8577 Moderately Informative Inherited
Cellular Component (CC) cell surface 8.847e-06 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron projection 9.268e-08 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) cell body 3.197e-08 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 8.537e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.005546Least InformativeInherited
Disease Ontology (DO)disease of mental health1.501e-12Moderately InformativeDirect
Disease Ontology (DO)brain disease0.001253Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.3948Moderately InformativeInherited
Disease Ontology (DO)substance dependence2.524e-13InformativeDirect
Disease Ontology (DO)schizophrenia0.0001449InformativeDirect
Disease Ontology (DO)leukodystrophy0.005197InformativeInherited
Disease Ontology (DO)focal epilepsy0.04831InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.07073InformativeInherited
Disease Ontology (DO)autistic disorder9.511e-08Highly InformativeDirect
Disease Ontology (DO)cocaine dependence5.209e-07Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0001055Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.0001513Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.0005558Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.000854Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2922Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9067Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01638Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0205Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4803Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7022Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.002169InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.003437InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.009749InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01604InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.06084InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.1465InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4842InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents3.79e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness3.79e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.819e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy1.718e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry8.015e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness8.015e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement8.528e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita9.768e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement2.456e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign4.274e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability7.471e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness9.912e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.099e-09Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9712Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.00104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.0809Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1001Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.293Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5642Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8238Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic3.366e-05InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.00235InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.002746InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004839InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.005092InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.005092InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.0145InformativeInherited
Mammalian Phenotype (MP)seizures0.02271InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.0484InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.0776InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0776InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08528InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08735InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1627InformativeInherited
Mammalian Phenotype (MP)urinary incontinence3.218e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents2.16e-07Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder6.431e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology2.389e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential9.125e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures1.938e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis2.035e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex2.035e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission5.045e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception9.062e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology9.062e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.0001063Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001415Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0003285Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0004392Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0005149Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.0008597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.0009898Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.01035Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.02621Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03263Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.109Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3184Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant5.231e-15Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant9.099e-08Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant4.983e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant6.982e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant3.933e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant6.152e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)temperature response defective3.766e-06Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.005723Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.0002518InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation3.722e-12Least InformativeDirect
DiseaseEpilepsy4.356e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate9.995e-11Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]