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Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (206) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,704 8,985 4
Proteins 7,514 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)passive transmembrane transporter activity00InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)ion channel activity00Highly InformativeDirect
Molecular Function (MF)gated channel activity00.0000001014Highly InformativeDirect
Cellular Component (CC)membrane0.00059450Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000001246 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000003274 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001659 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1245 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.881 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.08329 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.01104 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5903 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.1932 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6149 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) system process 0.00000000000005657 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00000000001175 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000006384 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000397 Informative Direct
Biological Process (BP) ion homeostasis 0.000554 Informative Direct
Biological Process (BP) protein oligomerization 0.0008661 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.1301 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) anion transport 0.8699 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7878 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.8609 Informative Inherited
Biological Process (BP) regulation of system process 0.002575 Informative Inherited
Biological Process (BP) response to acid chemical 0.3537 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5179 Informative Inherited
Biological Process (BP) locomotion 0.003656 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.3252 Informative Inherited
Biological Process (BP) regulation of secretion 0.01452 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1614 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.5524 Informative Inherited
Biological Process (BP) response to radiation 0.894 Informative Inherited
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) synaptic signaling 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.00000000006083 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0000001567 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00000122 Highly Informative Direct
Biological Process (BP) muscle system process 0.00007086 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00007158 Highly Informative Direct
Biological Process (BP) cellular response to metal ion 0.000263 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0003452 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0006906 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.06567 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.8464 Highly Informative Inherited
Biological Process (BP) renal system process 0.02071 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.02314 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.01263 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.001975 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.008042 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.04501 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000001276 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.000346 Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0000001014 Highly Informative Direct
Molecular Function (MF) amino acid binding 8.405e-16 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000000005004 Moderately Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) neuron projection 0.00000000007633 Informative Direct
Cellular Component (CC) plasma membrane region 0.2752 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000004743 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.001563Least InformativeInherited
Disease Ontology (DO)immune system disease0.06469Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000000000000009655Moderately InformativeDirect
Disease Ontology (DO)bone marrow disease0.0000133Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.3555Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease1Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00000000000002876InformativeDirect
Disease Ontology (DO)schizophrenia0.00003819InformativeDirect
Disease Ontology (DO)focal epilepsy0.04409InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1317InformativeInherited
Disease Ontology (DO)autistic disorder0.00000001278Highly InformativeDirect
Disease Ontology (DO)cocaine dependence0.0000006505Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.00001042Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.00004043Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00009013Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.0007027Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Juvenile onset0.0004586Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.05447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.546Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.7341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.9206Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.9584Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9693Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.07279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.08418Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.0998Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1221Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3099Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.3154Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.428Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.4455Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.4707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.6088Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.7603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.003351InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.01146InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.01256InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.01257InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.03013InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.04451InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.04728InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.06228InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.06666InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.09412InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.1046InformativeInherited
Phenotypic Abnormality (PA)Seizures0.1484InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1788InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.2749InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the external nose0.3128InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.382InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.3964InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.6417InformativeInherited
Phenotypic Abnormality (PA)Generalized tonic-clonic seizures0.00000005765Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness0.00000008445Highly InformativeDirect
Phenotypic Abnormality (PA)EEG with polyspike wave complexes0.0000001343Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged miniature endplate currents0.0000001343Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.0000001472Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized hypotonia due to defect at the neuromuscular junction0.0000004315Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased miniature endplate potentials0.0000004315Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.0000005914Highly InformativeDirect
Phenotypic Abnormality (PA)Amyoplasia0.0000005914Highly InformativeDirect
Phenotypic Abnormality (PA)Type 2 muscle fiber atrophy0.000001088Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes0.000001184Highly InformativeDirect
Phenotypic Abnormality (PA)EMG: impaired neuromuscular transmission0.000001422Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium0.000002142Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.000003571Highly InformativeDirect
Phenotypic Abnormality (PA)Personality disorder0.000006923Highly InformativeDirect
Phenotypic Abnormality (PA)Status epilepticus0.00000832Highly InformativeDirect
Phenotypic Abnormality (PA)Hemiclonic seizures0.00000832Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.00001132Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.00001522Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita0.00002115Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign0.00002386Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.00002728Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.00003085Highly InformativeDirect
Phenotypic Abnormality (PA)External ophthalmoplegia0.00006176Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00006875Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased muscle mass0.0000902Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.00009641Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement0.0001289Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0001435Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0002465Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0003276Highly InformativeDirect
Phenotypic Abnormality (PA)Sudden episodic apnea0.0004839Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck0.0004891Highly InformativeDirect
Phenotypic Abnormality (PA)Apneic episodes precipitated by illness, fatigue, stress0.0006436Highly InformativeDirect
Phenotypic Abnormality (PA)Long face0.0007516Highly InformativeDirect
Phenotypic Abnormality (PA)Depressed nasal ridge0.0007791Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.0008929Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0009119Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory distress0.0009574Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000000006001Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9993Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0003721Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.008151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08746Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.2941Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4474Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.7424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000000001472InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0004941InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.001217InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.001269InformativeInherited
Mammalian Phenotype (MP)seizures0.001343InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.004373InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.01371InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.02006InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.03034InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.2399InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2614InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.5414InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.6595InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7489InformativeInherited
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.00000000445Highly InformativeDirect
Mammalian Phenotype (MP)urinary incontinence0.00000005353Highly InformativeDirect
Mammalian Phenotype (MP)abnormal type IV spiral ligament fibrocytes0.0000006015Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.000002768Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.000005354Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000008375Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001784Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.00001784Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00002483Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.00009874Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001469Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0001635Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.0001926Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0002257Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.0004691Highly InformativeDirect
Mammalian Phenotype (MP)decreased fear-related response0.0008576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.01022Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01302Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01423Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.03852Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.08538Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.1118Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.3546Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.6492Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00000000000002727Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000000001036Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001003Least InformativeDirect
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00000001329Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001181Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0001511Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)body posture variant0.0000000000002323InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00000000004164InformativeDirect
Worm Phenotype (WP)localized movement variant0.0000000009264InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.000000005179InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0000000562InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.000001609InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00006363InformativeDirect
Worm Phenotype (WP)locomotion reduced0.1265InformativeInherited
Worm Phenotype (WP)body width variant0.3212InformativeInherited
Worm Phenotype (WP)nicotine response variant0.5713InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)chemotaxis variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000002224Highly InformativeDirect
Worm Phenotype (WP)fat0.000004801Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000006708Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.00001005Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000146Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002726Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0003196Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.05989Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.0000008455Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.0006993Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk musculature0.0004683Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00001458Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00004769Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.000000749Least InformativeDirect
Drugbank ATC_code (DB)alimentary tract and metabolism0.2812Least InformativeInherited
Drugbank ATC_code (DB)dermatologicals0Moderately InformativeDirect
Drugbank ATC_code (DB)other nervous system drugs0.00000001766Moderately InformativeDirect
Drugbank ATC_code (DB)anesthetics0.00003309Moderately InformativeDirect
Drugbank ATC_code (DB)psycholeptics0.001399Moderately InformativeInherited
Drugbank ATC_code (DB)analgesics0.007733Moderately InformativeInherited
Drugbank ATC_code (DB)musculo-skeletal system0.5716Moderately InformativeInherited
Drugbank ATC_code (DB)antidepressants0.9765Moderately InformativeInherited
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)other antiseptics and disinfectants0InformativeDirect
Drugbank ATC_code (DB)barbiturates and derivatives0InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0InformativeDirect
Drugbank ATC_code (DB)pentobarbital0InformativeDirect
Drugbank ATC_code (DB)acamprosate0InformativeDirect
Drugbank ATC_code (DB)prasterone0.00000000000001077InformativeDirect
Drugbank ATC_code (DB)nerve depressants0.00000000000001077InformativeDirect
Drugbank ATC_code (DB)amoxapine0.00000000000006272InformativeDirect
Drugbank ATC_code (DB)ethanol0.0000000000005227InformativeDirect
Drugbank ATC_code (DB)diazepines, oxazepines, thiazepines and oxepines0.0000000000009768InformativeDirect
Drugbank ATC_code (DB)anti-dementia drugs0.0000004137InformativeDirect
Drugbank ATC_code (DB)antiparasitic products, insecticides and repellents0.000002333InformativeDirect
Drugbank ATC_code (DB)opium alkaloids and derivatives0.00001938InformativeDirect
Drugbank ATC_code (DB)muscle relaxants0.01026InformativeInherited
Drugbank ATC_code (DB)other hypnotics and sedatives0.02498InformativeInherited
Drugbank ATC_code (DB)anesthetics, general0.09321InformativeInherited
Drugbank ATC_code (DB)other antiepileptics0.1747InformativeInherited
Drugbank ATC_code (DB)peripheral vasodilators1InformativeInherited
Drugbank ATC_code (DB)ergot alkaloids0Highly InformativeDirect
Drugbank ATC_code (DB)enflurane0Highly InformativeDirect
Drugbank ATC_code (DB)etomidate0Highly InformativeDirect
Drugbank ATC_code (DB)propofol0Highly InformativeDirect
Drugbank ATC_code (DB)methoxyflurane0Highly InformativeDirect
Drugbank ATC_code (DB)primidone0Highly InformativeDirect
Drugbank ATC_code (DB)metharbital0Highly InformativeDirect
Drugbank ATC_code (DB)topiramate0Highly InformativeDirect
Drugbank ATC_code (DB)diazepam0Highly InformativeDirect
Drugbank ATC_code (DB)oxazepam0Highly InformativeDirect
Drugbank ATC_code (DB)bromazepam0Highly InformativeDirect
Drugbank ATC_code (DB)prazepam0Highly InformativeDirect
Drugbank ATC_code (DB)halazepam0Highly InformativeDirect
Drugbank ATC_code (DB)talbutal0Highly InformativeDirect
Drugbank ATC_code (DB)flurazepam0Highly InformativeDirect
Drugbank ATC_code (DB)estazolam0Highly InformativeDirect
Drugbank ATC_code (DB)triazolam0Highly InformativeDirect
Drugbank ATC_code (DB)temazepam0Highly InformativeDirect
Drugbank ATC_code (DB)midazolam0Highly InformativeDirect
Drugbank ATC_code (DB)quazepam0Highly InformativeDirect
Drugbank ATC_code (DB)ethchlorvynol0Highly InformativeDirect
Drugbank ATC_code (DB)galantamine0Highly InformativeDirect
Drugbank ATC_code (DB)olanzapine0.0000000000002689Highly InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0.00000000008169Highly InformativeDirect
Drugbank ATC_code (DB)hexobarbital0.0000000007615Highly InformativeDirect
Drugbank ATC_code (DB)chlorine containing products0.0000001696Highly InformativeDirect
Drugbank ATC_code (DB)flumazenil0.000001461Highly InformativeDirect
Drugbank ATC_code (DB)piperidinedione derivatives0.000002384Highly InformativeDirect
Drugbank ATC_code (DB)benzodiazepine related drugs0.000002384Highly InformativeDirect
Drugbank ATC_code (DB)desflurane0.0002841Highly InformativeDirect
Drugbank ATC_code (DB)sevoflurane0.0002841Highly InformativeDirect
Drugbank ATC_code (DB)isoflurane0.0006207Highly InformativeDirect
Drugbank ATC_code (DB)muscle relaxants, peripherally acting agents0.0008355Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.533e-16Moderately InformativeDirect
Cellular componentCell projection0.00000000000004545Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation0.00000000002351Least InformativeDirect
DiseaseEpilepsy0.00000005267InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000000001488Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]