SUPERFAMILY 1.75 HMM library and genome assignments server


Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (188) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 7,188 7,050 4
Proteins 7,018 6,900 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization2.066e-100Least InformativeDirect
Biological Process (BP)multicellular organismal process3.267e-060Least InformativeDirect
Biological Process (BP)response to stimulus0.00082950Least InformativeDirect
Biological Process (BP)regulation of cellular process0.88611Least InformativeInherited
Biological Process (BP)single-organism cellular process0.47526.057e-12Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)system process1.015e-050Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00061640.0002018Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.40921Moderately InformativeInherited
Biological Process (BP)immune system process2.353e-050.5349Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.062210.2919Moderately InformativeInherited
Biological Process (BP)response to organic substance0.18450.05613Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00048930.06627Moderately InformativeInherited
Biological Process (BP)single-organism behavior1.677e-122.277e-05InformativeDirect
Biological Process (BP)cell-cell signaling5.357e-120InformativeDirect
Biological Process (BP)regulation of secretion5.008e-092.358e-09InformativeDirect
Biological Process (BP)transmission of nerve impulse5.018e-080InformativeDirect
Biological Process (BP)response to organonitrogen compound5.994e-080InformativeDirect
Biological Process (BP)response to organic cyclic compound9.32e-080InformativeDirect
Biological Process (BP)regulation of system process1.561e-056.325e-09InformativeDirect
Biological Process (BP)locomotion0.00017620.0001685InformativeDirect
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)cell activation8.452e-080.03148InformativeInherited
Biological Process (BP)regulation of ion transport0.079624.803e-06InformativeInherited
Biological Process (BP)response to alkaloid6.83e-130Highly InformativeDirect
Biological Process (BP)B cell activation9.193e-131.948e-14Highly InformativeDirect
Biological Process (BP)regulation of membrane potential2.799e-110Highly InformativeDirect
Biological Process (BP)response to ethanol8.066e-082.613e-10Highly InformativeDirect
Biological Process (BP)calcium ion transport2.781e-072.372e-11Highly InformativeDirect
Biological Process (BP)adult behavior2.813e-070Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission3.751e-070.9682Highly InformativeInherited
Biological Process (BP)sensory perception0.80441Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)ion gated channel activity00Highly InformativeDirect
Molecular Function (MF)ion channel activity00Highly InformativeDirect
Cellular Component (CC)membrane1.683e-110Least InformativeDirect
Cellular Component (CC)protein complex6.468e-070Least InformativeDirect
Cellular Component (CC)plasma membrane part1.279e-100Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0045430Moderately InformativeInherited
Cellular Component (CC)integral to membrane2.562e-110InformativeDirect
Cellular Component (CC)cell surface4.796e-095.814e-06InformativeDirect
Cellular Component (CC)synapse part4.304e-060InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.00062210InformativeDirect
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)ion channel complex00Highly InformativeDirect
Cellular Component (CC)integral to plasma membrane6.893e-140Highly InformativeDirect
Cellular Component (CC)synaptic membrane1.793e-060Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 6.057e-12 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1725 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002018 Moderately Informative Direct
Biological Process (BP) nervous system development 6.911e-10 Moderately Informative Direct
Biological Process (BP) signal transduction 2.078e-08 Moderately Informative Direct
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.2512 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7259 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5417 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6469 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5349 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2919 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4955 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05613 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02851 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06627 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.09126 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02887 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1488 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 2.277e-05 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) regulation of secretion 2.358e-09 Informative Direct
Biological Process (BP) transmission of nerve impulse 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) regulation of system process 6.325e-09 Informative Direct
Biological Process (BP) locomotion 0.0001685 Informative Direct
Biological Process (BP) regulation of ion transport 4.803e-06 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) protein complex assembly 5.537e-05 Informative Direct
Biological Process (BP) response to light stimulus 0.0005877 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0008176 Informative Direct
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6809 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7911 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2236 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001733 Informative Inherited
Biological Process (BP) regulation of cell development 0.001377 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.008403 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01307 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.04517 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.05348 Informative Inherited
Biological Process (BP) cell activation 0.03148 Informative Inherited
Biological Process (BP) regulation of locomotion 0.4873 Informative Inherited
Biological Process (BP) positive regulation of transport 0.003664 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1312 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.0221 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.721 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.0207 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1781 Informative Inherited
Biological Process (BP) secretion by cell 0.5805 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) B cell activation 1.948e-14 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) response to ethanol 2.613e-10 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.372e-11 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 2.875e-13 Highly Informative Direct
Biological Process (BP) response to toxic substance 1.135e-10 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.727e-10 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 1.03e-07 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.229e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.204e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.498e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0002792 Highly Informative Direct
Biological Process (BP) diencephalon development 0.000353 Highly Informative Direct
Biological Process (BP) exocytosis 0.0006493 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.005829 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02045 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1563 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3505 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3711 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.2815 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.006388 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.9682 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.06742 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001521 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.001509 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.807 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2724 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.01141 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.08488 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.8776 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.5962 Highly Informative Inherited
Molecular Function (MF) binding 0.5399 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 1.442e-12 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.7892 Informative Inherited
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 4.33e-13 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 5.233e-07 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.7295 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell surface 5.814e-06 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron projection 6.845e-08 Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) synaptic membrane 0 Highly Informative Direct
Cellular Component (CC) cell body 2.584e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0007892Least InformativeDirect
Disease Ontology (DO)disease of mental health1.511e-12Moderately InformativeDirect
Disease Ontology (DO)brain disease0.0003816Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.3981Moderately InformativeInherited
Disease Ontology (DO)substance dependence2.525e-13InformativeDirect
Disease Ontology (DO)schizophrenia0.0001453InformativeDirect
Disease Ontology (DO)leukodystrophy0.005224InformativeInherited
Disease Ontology (DO)focal epilepsy0.04859InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.07115InformativeInherited
Disease Ontology (DO)autistic disorder9.529e-08Highly InformativeDirect
Disease Ontology (DO)cocaine dependence5.214e-07Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0001055Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.0001517Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.0005559Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.000853Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.3214Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9071Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02056Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1471Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.33Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4569Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.002176InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.003416InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.006783InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01633InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.06453InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.1487InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.484InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents3.791e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness3.791e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.82e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy1.719e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry8.02e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness8.02e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement8.534e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita9.775e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement2.459e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gower sign4.284e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability7.489e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness9.925e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype9.234e-10Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9715Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.004388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08509Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1069Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2947Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5606Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8263Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic3.23e-05InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.002372InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.002572InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004714InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.004982InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.004982InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01442InformativeInherited
Mammalian Phenotype (MP)seizures0.02174InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.04876InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.07777InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.07906InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08071InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08662InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1553InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7894InformativeInherited
Mammalian Phenotype (MP)urinary incontinence3.307e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents1.583e-07Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder6.617e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology2.487e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential9.455e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures2.01e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis2.079e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex2.079e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission5.271e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception9.296e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology9.296e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.0001095Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001532Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0002993Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.00041Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0004825Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.0007835Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.0009478Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.01001Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.02256Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.02912Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1026Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3205Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant5.231e-15Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant9.099e-08Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant4.983e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant6.982e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant3.933e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant6.152e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)temperature response defective4.09e-06InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.004979Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.0002286InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation2.592e-12Least InformativeDirect
DiseaseEpilepsy3.354e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate8.922e-11Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]