SUPERFAMILY 1.75 HMM library and genome assignments server

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Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,943 8,985 4
Proteins 7,740 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.0000000011960Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000008410Least InformativeDirect
Biological Process (BP)response to stimulus0.0017710Least InformativeInherited
Biological Process (BP)regulation of cellular process0.81161Least InformativeInherited
Biological Process (BP)single-organism cellular process0.48090.0000000000002093Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)system process0.000011310Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000090880.000003621Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00063290.0000000098Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.40561Moderately InformativeInherited
Biological Process (BP)immune system process0.000045250.7195Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.10180.3489Moderately InformativeInherited
Biological Process (BP)response to organic substance0.18650.005649Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00012830.06515Moderately InformativeInherited
Biological Process (BP)synaptic transmission0.00000000000017180InformativeDirect
Biological Process (BP)single-organism behavior0.0000000000038140.00002777InformativeDirect
Biological Process (BP)leukocyte activation0.0000000020350.0000005777InformativeDirect
Biological Process (BP)response to organonitrogen compound0.000000077850InformativeDirect
Biological Process (BP)response to organic cyclic compound0.00000013530InformativeDirect
Biological Process (BP)regulation of system process0.000022580.000000006885InformativeDirect
Biological Process (BP)locomotion0.00024530.0005516InformativeDirect
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)regulation of secretion0.0072430.00000001854InformativeInherited
Biological Process (BP)regulation of ion transport0.030690.000002699InformativeInherited
Biological Process (BP)response to alkaloid0.00000000000086630Highly InformativeDirect
Biological Process (BP)B cell activation0.0000000000012770.00000000000004763Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.000000000040470Highly InformativeDirect
Biological Process (BP)regulation of amine transport0.000000060750Highly InformativeDirect
Biological Process (BP)adult behavior0.00000031240Highly InformativeDirect
Biological Process (BP)calcium ion transport0.00000039880.00000000005727Highly InformativeDirect
Biological Process (BP)response to alcohol0.0054740.3741Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.0000006020.9226Highly InformativeInherited
Biological Process (BP)sensory perception0.81721Highly InformativeInherited
Biological Process (BP)learning or memory0.045171Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)ion gated channel activity00Highly InformativeDirect
Molecular Function (MF)cation channel activity0.000000000078310.0000003355Highly InformativeDirect
Cellular Component (CC)membrane0.000000000040650Least InformativeDirect
Cellular Component (CC)protein complex0.0000012790Least InformativeDirect
Cellular Component (CC)plasma membrane0.00000029640Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0049820Moderately InformativeInherited
Cellular Component (CC)integral to membrane0.000000000053330InformativeDirect
Cellular Component (CC)cell surface0.00000000420.00001037InformativeDirect
Cellular Component (CC)synapse part0.0000056420InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.0005720InformativeDirect
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)ion channel complex00Highly InformativeDirect
Cellular Component (CC)integral to plasma membrane0.00000000000012730Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane0.00000000065710.000004766Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000002093 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.04344 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000003621 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000000098 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000000000002561 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00000002093 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4541 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8031 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6311 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7474 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7195 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3489 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6352 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005649 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001092 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06515 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1592 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02641 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1529 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) single-organism behavior 0.00002777 Informative Direct
Biological Process (BP) leukocyte activation 0.0000005777 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) regulation of system process 0.000000006885 Informative Direct
Biological Process (BP) locomotion 0.0005516 Informative Direct
Biological Process (BP) regulation of secretion 0.00000001854 Informative Direct
Biological Process (BP) regulation of ion transport 0.000002699 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) response to light stimulus 0.0009663 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.06137 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7297 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8387 Informative Inherited
Biological Process (BP) protein oligomerization 0.01069 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2615 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001946 Informative Inherited
Biological Process (BP) regulation of cell development 0.002696 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01134 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01686 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01896 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.06434 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5067 Informative Inherited
Biological Process (BP) positive regulation of transport 0.007082 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1338 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8782 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.08289 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001502 Informative Inherited
Biological Process (BP) single organism reproductive process 0.308 Informative Inherited
Biological Process (BP) secretion by cell 0.674 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.5774 Informative Inherited
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) B cell activation 0.00000000000004763 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00000000005727 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.000000000000188 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0000000005995 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0000000008355 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.0000001422 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000001466 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.00001447 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00001586 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0003848 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0006177 Highly Informative Direct
Biological Process (BP) exocytosis 0.0007257 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.007466 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01822 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1629 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3528 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3741 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.001037 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9531 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3485 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.008279 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.9226 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.07068 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001633 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.002043 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.7929 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.3467 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.01122 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.09692 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9676 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6759 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000000000003177 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000000002306 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.1257 Informative Inherited
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000003355 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0000000000002325 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000002955 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.904 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) cell surface 0.00001037 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0.0000000945 Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 0.000004766 Highly Informative Direct
Cellular Component (CC) cell body 0.00000003468 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.000000000007878Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.4169Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000000000003414InformativeDirect
Disease Ontology (DO)schizophrenia0.0005075InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1062InformativeInherited
Disease Ontology (DO)cocaine dependence0.0000004709Highly InformativeDirect
Disease Ontology (DO)autistic disorder0.0000008926Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00009945Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.08526Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5258Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8781Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9084Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.003041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.004032Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04626Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.125Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.142Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2888Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.414Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6575Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0001365InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0006043InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.0008515InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.001119InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.001786InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.002863InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01071InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.01248InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01694InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03036InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.04011InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.04318InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.05206InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.05868InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.06332InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.2794InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.3126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.5462InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents0.00000000031Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness0.00000000031Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.000000002332Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy0.000000009662Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.00000004005Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.0000001031Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0000001031Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized amyoplasia0.0000001213Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0000001705Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita0.0000002018Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium0.0000002876Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes0.0000002876Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign0.0000008169Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.000001143Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement0.000001326Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.00000235Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.000002623Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.000005858Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.000005858Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck0.000008052Highly InformativeDirect
Phenotypic Abnormality (PA)Thin ribs0.00002306Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma0.00002872Highly InformativeDirect
Phenotypic Abnormality (PA)Vertebral fusion0.00007398Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.00009427Highly InformativeDirect
Phenotypic Abnormality (PA)Short thorax0.0001717Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal malrotation0.0002161Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0002418Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000000001017Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9714Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08189Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1018Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2897Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5592Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6671Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00003145InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.002303InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.002852InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004714InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.005382InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.005509InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01498InformativeInherited
Mammalian Phenotype (MP)seizures0.02316InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.04847InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.07684InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.07744InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08733InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08865InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1677InformativeInherited
Mammalian Phenotype (MP)urinary incontinence0.00000003096Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.000000211Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.0000006212Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000003584Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.000008876Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001886Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00001995Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex0.00002581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.00006035Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.00008828Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.0001038Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001215Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001398Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0003407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0004313Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0005025Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.0008271Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.0009651Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.01054Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.02524Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03236Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1119Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3189Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000000000000005231Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000009099Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00004983Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00006982InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000003933Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000006152Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.00000003642Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.0000947Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.005882Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.0002555InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation0.000000000003632Least InformativeDirect
DiseaseEpilepsy0.000000004356InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000000001015Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]