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Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (209) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,865 8,985 4
Proteins 7,674 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transporter activity0.0000027520Moderately InformativeDirect
Molecular Function (MF)passive transmembrane transporter activity0.00000000010320InformativeDirect
Molecular Function (MF)molecular transducer activity0.000000042790InformativeDirect
Molecular Function (MF)signal transducer activity0.000000065140InformativeDirect
Molecular Function (MF)gated channel activity0.000000000000081840.000001865Highly InformativeDirect
Molecular Function (MF)ion channel activity0.0000000000003420Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.00000001680.00000005892Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000001178 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04309 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00003533 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0003132 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5304 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1663 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) system development 0.6738 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.00643 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7011 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02806 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5683 Moderately Informative Inherited
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) system process 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.000000000004614 Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000000000009808 Informative Direct
Biological Process (BP) regulation of system process 0.000002976 Informative Direct
Biological Process (BP) transmembrane transport 0.000004005 Informative Direct
Biological Process (BP) regulation of ion transport 0.00001547 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.1651 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1491 Informative Inherited
Biological Process (BP) response to metal ion 0.05035 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.01549 Informative Inherited
Biological Process (BP) ion homeostasis 0.001134 Informative Inherited
Biological Process (BP) protein oligomerization 0.001497 Informative Inherited
Biological Process (BP) sensory organ development 0.246 Informative Inherited
Biological Process (BP) response to acid chemical 0.3354 Informative Inherited
Biological Process (BP) regulation of locomotion 0.4356 Informative Inherited
Biological Process (BP) locomotion 0.006301 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.2213 Informative Inherited
Biological Process (BP) cell activation 0.3899 Informative Inherited
Biological Process (BP) positive regulation of transport 0.02271 Informative Inherited
Biological Process (BP) regulation of secretion 0.03115 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.5774 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.9075 Informative Inherited
Biological Process (BP) anion transport 0.1434 Informative Inherited
Biological Process (BP) response to radiation 0.949 Informative Inherited
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) trans-synaptic signaling 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0000008112 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000002199 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00004321 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.00005328 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0005155 Highly Informative Direct
Biological Process (BP) muscle system process 0.0005514 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0005596 Highly Informative Direct
Biological Process (BP) inner ear development 0.0007228 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.0007961 Highly Informative Direct
Biological Process (BP) import into cell 0.03637 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.08919 Highly Informative Inherited
Biological Process (BP) renal system process 0.07712 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.03774 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.074 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.005664 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.0021 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01855 Highly Informative Inherited
Biological Process (BP) neurological system process 0.04581 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.08437 Moderately Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000006179 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.00005936 Informative Direct
Molecular Function (MF) gated channel activity 0.000001865 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.00000005892 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ammonium ion binding 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000000000001646 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000000006622 Moderately Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.000000007893 Informative Direct
Cellular Component (CC) plasma membrane region 0.04707 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000005533 Highly Informative Direct
Cellular Component (CC) dendrite 0.00006283 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.000747Least InformativeDirect
Disease Ontology (DO)disease of mental health0.0000000000000295Moderately InformativeDirect
Disease Ontology (DO)brain disease0.001322Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.3679Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease1Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.00000000000004893InformativeDirect
Disease Ontology (DO)schizophrenia0.00005553InformativeDirect
Disease Ontology (DO)focal epilepsy0.07729InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.13InformativeInherited
Disease Ontology (DO)autistic disorder0.00000001803Highly InformativeDirect
Disease Ontology (DO)cocaine dependence0.0000009978Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.00001126Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.00004383Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0000868Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.000707Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Juvenile onset0.0004536Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.05299Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2319Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2343Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5486Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.7563Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8918Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.9198Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.9585Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9852Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06628Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0733Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.09523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1008Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1131Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.286Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.3328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3431Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.4276Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.4816Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.6054Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.6304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.76Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.0039InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.01153InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.01231InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.01269InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.03124InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.04476InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.04888InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.06171InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.06573InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.09491InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.1052InformativeInherited
Phenotypic Abnormality (PA)Seizures0.1692InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1796InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.2209InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.289InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the external nose0.3126InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.3825InformativeInherited
Phenotypic Abnormality (PA)Muscular hypotonia0.6341InformativeInherited
Phenotypic Abnormality (PA)Generalized tonic-clonic seizures0.00000007314Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness0.00000008042Highly InformativeDirect
Phenotypic Abnormality (PA)EEG with polyspike wave complexes0.000000128Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged miniature endplate currents0.000000128Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.0000001412Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized hypotonia due to defect at the neuromuscular junction0.0000004119Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased miniature endplate potentials0.0000004119Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.0000005715Highly InformativeDirect
Phenotypic Abnormality (PA)Amyoplasia0.0000005715Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes0.000001147Highly InformativeDirect
Phenotypic Abnormality (PA)Type 2 muscle fiber atrophy0.000001361Highly InformativeDirect
Phenotypic Abnormality (PA)EMG: impaired neuromuscular transmission0.000001361Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium0.000002073Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.000003501Highly InformativeDirect
Phenotypic Abnormality (PA)Personality disorder0.000006857Highly InformativeDirect
Phenotypic Abnormality (PA)Hemiclonic seizures0.000008051Highly InformativeDirect
Phenotypic Abnormality (PA)Status epilepticus0.0000111Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.00001266Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.00001458Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita0.00001836Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign0.00002285Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.00002615Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.00002947Highly InformativeDirect
Phenotypic Abnormality (PA)External ophthalmoplegia0.00006563Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00006673Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased muscle mass0.00008507Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.0001194Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement0.0001205Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.0001545Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0002731Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0002983Highly InformativeDirect
Phenotypic Abnormality (PA)Sudden episodic apnea0.0004549Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck0.0004635Highly InformativeDirect
Phenotypic Abnormality (PA)Apneic episodes precipitated by illness, fatigue, stress0.0006055Highly InformativeDirect
Phenotypic Abnormality (PA)Depressed nasal ridge0.0007455Highly InformativeDirect
Phenotypic Abnormality (PA)Long face0.0007702Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0009221Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory distress0.0009221Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.0009523Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0000000003596Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.0004095Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.05762Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.09022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.3033Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3465Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4784Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.6831Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.7475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.000000001958InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0009886InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.00124InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.001314InformativeInherited
Mammalian Phenotype (MP)seizures0.001689InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.004657InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.01138InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.0216InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.03451InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2997InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.3032InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.5437InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.6968InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7815InformativeInherited
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.000000002954Highly InformativeDirect
Mammalian Phenotype (MP)urinary incontinence0.00000005666Highly InformativeDirect
Mammalian Phenotype (MP)abnormal type IV spiral ligament fibrocytes0.0000006308Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.000002913Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.000006995Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000008847Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001883Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.00001883Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00003301Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.0001028Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0001286Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001297Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.0002123Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0002357Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.0005113Highly InformativeDirect
Mammalian Phenotype (MP)decreased fear-related response0.0008854Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.01209Highly InformativeInherited
Mammalian Phenotype (MP)renal/urinary system inflammation0.01372Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01455Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.02524Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.09081Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.1006Highly InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.2731Highly InformativeInherited
Mammalian Phenotype (MP)abnormal reflex0.6838Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000000002054Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0000000000006231Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001257Least InformativeDirect
Worm Phenotype (WP)cell development variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.000000007248Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000128Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0001447Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)body posture variant0.0000000000002414InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00000000004151InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0000000007887InformativeDirect
Worm Phenotype (WP)localized movement variant0.0000000009139InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000005751InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.000001371InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00007783InformativeDirect
Worm Phenotype (WP)pesticide response variant0.02024InformativeInherited
Worm Phenotype (WP)locomotion reduced0.1371InformativeInherited
Worm Phenotype (WP)body width variant0.3167InformativeInherited
Worm Phenotype (WP)metal response variant0.3828InformativeInherited
Worm Phenotype (WP)nicotine response variant0.5349InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)chemotaxis variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000002768Highly InformativeDirect
Worm Phenotype (WP)fat0.000004838Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000006807Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.00000833Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.000031Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0.0002048Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002612Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0005489Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.0807Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.0000006271Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.0008832Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)trunk musculature0.0005619Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00001507Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00004908Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell projection0.000000000000137Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation0.000000000004291Least InformativeDirect
DiseaseEpilepsy0.000000006162InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000000001473Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]