SUPERFAMILY 1.75 HMM library and genome assignments server


Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,943 8,985 4
Proteins 7,740 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process8.558e-060Least InformativeDirect
Biological Process (BP)localization3.08e-080Least InformativeDirect
Biological Process (BP)response to stimulus0.0018070Least InformativeInherited
Biological Process (BP)regulation of cellular process0.81521Least InformativeInherited
Biological Process (BP)single-organism cellular process0.36333.755e-15Least InformativeInherited
Biological Process (BP)system process1.179e-050Moderately InformativeDirect
Biological Process (BP)ion transport1.688e-150Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00063711.325e-08Moderately InformativeDirect
Biological Process (BP)regulation of biological quality9.384e-055.4e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.41291Moderately InformativeInherited
Biological Process (BP)immune system process4.533e-050.7202Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.10550.3835Moderately InformativeInherited
Biological Process (BP)response to organic substance0.18850.006094Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00013540.07301Moderately InformativeInherited
Biological Process (BP)synaptic transmission1.83e-130InformativeDirect
Biological Process (BP)response to organonitrogen compound7.956e-080InformativeDirect
Biological Process (BP)response to organic cyclic compound1.363e-070InformativeDirect
Biological Process (BP)locomotion0.00024190.0005416InformativeDirect
Biological Process (BP)regulation of system process2.477e-057.808e-09InformativeDirect
Biological Process (BP)single-organism behavior4.251e-122.367e-05InformativeDirect
Biological Process (BP)leukocyte activation2.027e-095.757e-07InformativeDirect
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)regulation of secretion0.0075572.358e-08InformativeInherited
Biological Process (BP)regulation of ion transport0.030962.586e-06InformativeInherited
Biological Process (BP)calcium ion transport3.837e-075.508e-11Highly InformativeDirect
Biological Process (BP)adult behavior3.088e-070Highly InformativeDirect
Biological Process (BP)B cell activation1.273e-124.613e-14Highly InformativeDirect
Biological Process (BP)regulation of membrane potential3.968e-110Highly InformativeDirect
Biological Process (BP)response to alkaloid8.629e-130Highly InformativeDirect
Biological Process (BP)regulation of amine transport5.426e-080Highly InformativeDirect
Biological Process (BP)response to alcohol0.0054460.377Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission7.73e-070.9391Highly InformativeInherited
Biological Process (BP)sensory perception0.80671Highly InformativeInherited
Biological Process (BP)learning or memory0.051811Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)cation channel activity7.819e-113.356e-07Highly InformativeDirect
Molecular Function (MF)ion gated channel activity00Highly InformativeDirect
Cellular Component (CC)membrane4.556e-110Least InformativeDirect
Cellular Component (CC)protein complex1.284e-060Least InformativeDirect
Cellular Component (CC)plasma membrane3.236e-070Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0048790Moderately InformativeInherited
Cellular Component (CC)cell surface4.17e-091.027e-05InformativeDirect
Cellular Component (CC)integral to membrane5.454e-110InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.00058680InformativeDirect
Cellular Component (CC)synapse part6.615e-060InformativeDirect
Cellular Component (CC)integral to plasma membrane1.353e-130Highly InformativeDirect
Cellular Component (CC)ion channel complex00Highly InformativeDirect
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane6.466e-103.74e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.755e-15 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.04366 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) signal transduction 9.629e-09 Moderately Informative Direct
Biological Process (BP) nervous system development 2.794e-12 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.325e-08 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 5.4e-06 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.438 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7996 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.6371 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7584 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7202 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3835 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6565 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006094 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001118 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.07301 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1613 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02842 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1609 Moderately Informative Inherited
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) response to light stimulus 0.0009911 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) locomotion 0.0005416 Informative Direct
Biological Process (BP) regulation of ion transport 2.586e-06 Informative Direct
Biological Process (BP) regulation of system process 7.808e-09 Informative Direct
Biological Process (BP) single-organism behavior 2.367e-05 Informative Direct
Biological Process (BP) leukocyte activation 5.757e-07 Informative Direct
Biological Process (BP) regulation of secretion 2.358e-08 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.06412 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.8481 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7414 Informative Inherited
Biological Process (BP) protein oligomerization 0.0103 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2626 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.001903 Informative Inherited
Biological Process (BP) regulation of cell development 0.003179 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.0118 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.06806 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.0204 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.08347 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5128 Informative Inherited
Biological Process (BP) positive regulation of transport 0.007646 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1314 Informative Inherited
Biological Process (BP) regulation of cell activation 0.3866 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8761 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.08509 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001622 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2895 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.6838 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.5675 Informative Inherited
Biological Process (BP) response to hypoxia 6.787e-10 Highly Informative Direct
Biological Process (BP) calcium ion transport 5.508e-11 Highly Informative Direct
Biological Process (BP) exocytosis 0.0007586 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 1.436e-07 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 8.331e-10 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.366e-05 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0006428 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.435e-05 Highly Informative Direct
Biological Process (BP) B cell activation 4.613e-14 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0003944 Highly Informative Direct
Biological Process (BP) regulation of behavior 2.131e-13 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.465e-06 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00742 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0179 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3685 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1652 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.377 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.001043 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9743 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2467 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.008443 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.9391 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.06326 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001603 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.002063 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.784 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.348 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.01193 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.09761 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9681 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6622 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2.968e-13 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.62e-13 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.1274 Informative Inherited
Molecular Function (MF) cation channel activity 3.356e-07 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 3.638e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.9056 Moderately Informative Inherited
Cellular Component (CC) cell surface 1.027e-05 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron projection 1.169e-07 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) cell body 3.422e-08 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 3.74e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health7.942e-12Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.4186Moderately InformativeInherited
Disease Ontology (DO)substance dependence3.471e-12InformativeDirect
Disease Ontology (DO)schizophrenia0.0005014InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1086InformativeInherited
Disease Ontology (DO)cocaine dependence4.718e-07Highly InformativeDirect
Disease Ontology (DO)autistic disorder9.512e-07Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome9.831e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.08517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.878Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9092Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.003024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.003952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6575Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0001348InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0005926InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.0008539InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.001109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.001772InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.00284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01066InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.01241InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01687InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.0303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.04002InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.04307InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.05194InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.05852InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.06324InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.281InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.3126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.5461InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents3.035e-10Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness3.035e-10Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.283e-09Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy9.461e-09Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia3.924e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry1.011e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness1.011e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized amyoplasia1.189e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement1.671e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita1.979e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium2.821e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes2.821e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign8.019e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature1.123e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement1.288e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness2.309e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability2.577e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart5.76e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia5.76e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck7.932e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Thin ribs2.274e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma2.83e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Vertebral fusion7.297e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy9.303e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Short thorax0.0001692Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal malrotation0.0002136Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0002391Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype2.89e-09Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9591Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3966Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8223Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic1.915e-05InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.002306InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004532InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.007795InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01298InformativeInherited
Mammalian Phenotype (MP)seizures0.01996InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.03516InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.06335InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08339InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08647InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.145InformativeInherited
Mammalian Phenotype (MP)urinary incontinence2.576e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents1.992e-07Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder7.009e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology3.713e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures1.616e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis1.765e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex2.299e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission5.184e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pupil morphology6.962e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception7.844e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open9.269e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001378Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0002162Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0003153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.000495Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.000524Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.00924Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01092Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03174Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1107Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3101Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant5.231e-15Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant9.099e-08Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant4.983e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant6.982e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant3.933e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant6.152e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant3.636e-08Highly InformativeDirect
Fly Phenotype (FP)temperature response defective9.457e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.0058Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.000258InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation4.045e-12Least InformativeDirect
DiseaseEpilepsy5.261e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate9.819e-11Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]