SUPERFAMILY 1.75 HMM library and genome assignments server


Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,943 8,985 4
Proteins 7,740 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process8.278e-060Least InformativeDirect
Biological Process (BP)localization1.118e-090Least InformativeDirect
Biological Process (BP)response to stimulus0.0016210Least InformativeInherited
Biological Process (BP)regulation of cellular process0.81421Least InformativeInherited
Biological Process (BP)single-organism cellular process0.4871.023e-13Least InformativeInherited
Biological Process (BP)system process1.129e-050Moderately InformativeDirect
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0006381.088e-08Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.40961Moderately InformativeInherited
Biological Process (BP)immune system process4.451e-050.7043Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.10240.3717Moderately InformativeInherited
Biological Process (BP)response to organic substance0.18610.005306Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00012560.06796Moderately InformativeInherited
Biological Process (BP)synaptic transmission1.665e-130InformativeDirect
Biological Process (BP)response to organonitrogen compound7.421e-080InformativeDirect
Biological Process (BP)response to organic cyclic compound1.302e-070InformativeDirect
Biological Process (BP)locomotion0.00024390.0004828InformativeDirect
Biological Process (BP)regulation of system process2.116e-055.739e-09InformativeDirect
Biological Process (BP)single-organism behavior3.383e-122.413e-05InformativeDirect
Biological Process (BP)leukocyte activation1.992e-094.935e-07InformativeDirect
Biological Process (BP)metal ion transport11InformativeInherited
Biological Process (BP)regulation of secretion0.0063031.668e-08InformativeInherited
Biological Process (BP)regulation of ion transport0.032282.722e-06InformativeInherited
Biological Process (BP)calcium ion transport3.922e-075.164e-11Highly InformativeDirect
Biological Process (BP)adult behavior3.146e-070Highly InformativeDirect
Biological Process (BP)B cell activation1.255e-123.801e-14Highly InformativeDirect
Biological Process (BP)regulation of membrane potential4.61e-110Highly InformativeDirect
Biological Process (BP)response to alkaloid8.542e-130Highly InformativeDirect
Biological Process (BP)regulation of amine transport6.716e-080Highly InformativeDirect
Biological Process (BP)response to alcohol0.0055670.3799Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission5.546e-070.9493Highly InformativeInherited
Biological Process (BP)sensory perception0.81741Highly InformativeInherited
Biological Process (BP)learning or memory0.047291Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)cation channel activity8.084e-111.804e-07Highly InformativeDirect
Molecular Function (MF)ion gated channel activity00Highly InformativeDirect
Cellular Component (CC)membrane3.183e-110Least InformativeDirect
Cellular Component (CC)protein complex1.187e-060Least InformativeDirect
Cellular Component (CC)plasma membrane2.868e-070Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane0.0051660Moderately InformativeInherited
Cellular Component (CC)cell surface4.708e-091.045e-05InformativeDirect
Cellular Component (CC)integral to membrane5.518e-110InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane0.00056480InformativeDirect
Cellular Component (CC)synapse part5.07e-060InformativeDirect
Cellular Component (CC)integral to plasma membrane1.223e-130Highly InformativeDirect
Cellular Component (CC)ion channel complex00Highly InformativeDirect
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane6.445e-107.849e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.023e-13 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.03717 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) signal transduction 1.601e-08 Moderately Informative Direct
Biological Process (BP) nervous system development 2.424e-12 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.088e-08 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0008824 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4214 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7712 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5988 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.7197 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7043 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3717 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6366 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005306 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06796 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1502 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2031 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04394 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0001173 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) response to light stimulus 0.0008551 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) locomotion 0.0004828 Informative Direct
Biological Process (BP) regulation of ion transport 2.722e-06 Informative Direct
Biological Process (BP) regulation of system process 5.739e-09 Informative Direct
Biological Process (BP) single-organism behavior 2.413e-05 Informative Direct
Biological Process (BP) leukocyte activation 4.935e-07 Informative Direct
Biological Process (BP) regulation of secretion 1.668e-08 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.06417 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.843 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.734 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.2492 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002012 Informative Inherited
Biological Process (BP) regulation of cell development 0.0025 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.01021 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.05704 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01416 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01553 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5188 Informative Inherited
Biological Process (BP) positive regulation of transport 0.006387 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1347 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.03067 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8625 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.07977 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00124 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3147 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.676 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.558 Informative Inherited
Biological Process (BP) response to hypoxia 3.982e-10 Highly Informative Direct
Biological Process (BP) calcium ion transport 5.164e-11 Highly Informative Direct
Biological Process (BP) exocytosis 0.0006362 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 1.287e-07 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 4.954e-10 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1.707e-05 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) diencephalon development 0.000679 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.319e-05 Highly Informative Direct
Biological Process (BP) B cell activation 3.801e-14 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0009798 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0003456 Highly Informative Direct
Biological Process (BP) regulation of behavior 2.102e-13 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 1.544e-06 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.006844 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.02034 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.9493 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.362 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1655 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3799 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9509 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3639 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.008475 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.05376 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.001607 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.001939 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.9583 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.3119 Highly Informative Inherited
Biological Process (BP) axon development 0.1662 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.01004 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.09246 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9445 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6805 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 2.229e-12 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.1688 Informative Inherited
Molecular Function (MF) cation channel activity 1.804e-07 Highly Informative Direct
Molecular Function (MF) drug binding 2.012e-13 Highly Informative Direct
Molecular Function (MF) amino acid binding 8.007e-16 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.672e-06 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.8877 Moderately Informative Inherited
Cellular Component (CC) cell surface 1.045e-05 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) neuron projection 9.461e-08 Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) cell body 2.639e-08 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 7.849e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.002007Least InformativeInherited
Disease Ontology (DO)disease of mental health1.644e-12Moderately InformativeDirect
Disease Ontology (DO)central nervous system disease0.04341Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.39Moderately InformativeInherited
Disease Ontology (DO)substance dependence2.799e-13InformativeDirect
Disease Ontology (DO)schizophrenia0.0001408InformativeDirect
Disease Ontology (DO)leukodystrophy0.005341InformativeInherited
Disease Ontology (DO)focal epilepsy0.04831InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.06956InformativeInherited
Disease Ontology (DO)autistic disorder9.52e-08Highly InformativeDirect
Disease Ontology (DO)cocaine dependence5.382e-07Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0001047Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.0001545Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.000568Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.0008489Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2907Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9082Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1757Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4825Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7025Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.002128InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.003367InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.00965InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01594InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.06237InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.146InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4837InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents3.607e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness3.607e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.669e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy1.642e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry7.662e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness7.662e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement8.157e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita9.348e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement2.362e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign4.086e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability7.157e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness9.527e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.03e-09Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9706Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1014Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2906Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic3.262e-05InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.002333InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.002877InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004755InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.00514InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.00514InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01461InformativeInherited
Mammalian Phenotype (MP)seizures0.02313InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.04788InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.0771InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0774InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08805InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1655InformativeInherited
Mammalian Phenotype (MP)urinary incontinence3.132e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents2.105e-07Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder6.283e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology3.625e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential8.966e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures1.903e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis2.008e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex2.594e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission4.952e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception8.917e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.0001048Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001227Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001397Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.000344Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0004313Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0005068Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.0008022Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.0009739Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.01043Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0259Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1116Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3182Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant5.231e-15Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant9.099e-08Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant4.983e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant6.982e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant3.933e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant6.152e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant3.977e-08Highly InformativeDirect
Fly Phenotype (FP)temperature response defective8.519e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.005784Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.0002605InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation3.632e-12Least InformativeDirect
DiseaseEpilepsy4.356e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate1.015e-10Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]