SUPERFAMILY 1.75 HMM library and genome assignments server

Nicotinic receptor ligand binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Nicotinic receptor ligand binding domain-like [ 63711]
Superfamily:   Nicotinic receptor ligand binding domain-like [ 63712]
Families:   Nicotinic receptor ligand binding domain-like [ 63713]


Superfamily statistics
Genomes (206) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,954 8,985 4
Proteins 7,751 8,793 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.0000000017930Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000064540Least InformativeDirect
Biological Process (BP)regulation of cellular process0.87281Least InformativeInherited
Biological Process (BP)single-organism cellular process0.037680Least InformativeInherited
Biological Process (BP)response to stimulus0.0017470Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000083380.000003338Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00065960.00000001414Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.41651Moderately InformativeInherited
Biological Process (BP)immune system process0.000044080.7304Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00014730.08579Moderately InformativeInherited
Biological Process (BP)response to organic substance0.19570.006831Moderately InformativeInherited
Biological Process (BP)ion transmembrane transport00InformativeDirect
Biological Process (BP)synaptic transmission0.00000000000018760InformativeDirect
Biological Process (BP)leukocyte activation0.0000000020160.000000636InformativeDirect
Biological Process (BP)single-organism behavior0.000000027070InformativeDirect
Biological Process (BP)response to organonitrogen compound0.000000077580InformativeDirect
Biological Process (BP)response to organic cyclic compound0.00000013780InformativeDirect
Biological Process (BP)locomotion0.0002490.0005923InformativeDirect
Biological Process (BP)metal ion transport0.93121InformativeInherited
Biological Process (BP)regulation of secretion0.008060.00000002291InformativeInherited
Biological Process (BP)regulation of ion transport0.030560.00000329InformativeInherited
Biological Process (BP)neurological system process0.0000000038330.05619InformativeInherited
Biological Process (BP)response to alkaloid0.00000000000085580Highly InformativeDirect
Biological Process (BP)B cell activation0.0000000000012610.00000000000005029Highly InformativeDirect
Biological Process (BP)regulation of membrane potential0.0000000000040670Highly InformativeDirect
Biological Process (BP)regulation of amine transport0.000000048310Highly InformativeDirect
Biological Process (BP)adult behavior0.000000063850Highly InformativeDirect
Biological Process (BP)calcium ion transport0.00000031570.0000000000392Highly InformativeDirect
Biological Process (BP)regulation of synaptic transmission0.00019070.000000786Highly InformativeDirect
Biological Process (BP)response to alcohol0.0054640.3808Highly InformativeInherited
Biological Process (BP)sensory perception0.91870.8157Highly InformativeInherited
Biological Process (BP)learning or memory0.067731Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)gated channel activity00.0000008366Highly InformativeDirect
Molecular Function (MF)cation channel activity0.000000000087790.0000007262Highly InformativeDirect
Cellular Component (CC)membrane0.000000000045610Least InformativeDirect
Cellular Component (CC)protein complex0.0000012450Least InformativeDirect
Cellular Component (CC)plasma membrane part0.000000000010850Moderately InformativeDirect
Cellular Component (CC)intrinsic component of membrane0.018270Moderately InformativeInherited
Cellular Component (CC)transporter complex00InformativeDirect
Cellular Component (CC)cell surface0.000000018070.000002529InformativeDirect
Cellular Component (CC)synapse0.0000012120InformativeDirect
Cellular Component (CC)integral component of membrane0.01010InformativeInherited
Cellular Component (CC)intrinsic component of plasma membrane0.0015540InformativeInherited
Cellular Component (CC)receptor complex00Highly InformativeDirect
Cellular Component (CC)ion channel complex0.0000000000000160Highly InformativeDirect
Cellular Component (CC)postsynaptic membrane0.00000000063840.000003733Highly InformativeDirect
Cellular Component (CC)integral component of plasma membrane0.001090Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.04942 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000003338 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000001414 Moderately Informative Direct
Biological Process (BP) nervous system development 0.000000000004693 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000000009228 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2937 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8207 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7304 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.9822 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.08579 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.002868 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006831 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.4709 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9479 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.8445 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.178 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2962 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6632 Moderately Informative Inherited
Biological Process (BP) ion transmembrane transport 0 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) leukocyte activation 0.000000636 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) locomotion 0.0005923 Informative Direct
Biological Process (BP) regulation of secretion 0.00000002291 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000329 Informative Direct
Biological Process (BP) regulation of system process 0.00000009751 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00001676 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.06352 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) protein oligomerization 0.005475 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3611 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.002145 Informative Inherited
Biological Process (BP) regulation of cell activation 0.3837 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001596 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.0754 Informative Inherited
Biological Process (BP) regulation of locomotion 0.5157 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5176 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.02381 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3142 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01107 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.01481 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.1509 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.1011 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9483 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) central nervous system development 0.09407 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.001574 Informative Inherited
Biological Process (BP) response to light stimulus 0.001088 Informative Inherited
Biological Process (BP) neurological system process 0.05619 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) secretion by cell 0.71 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) muscle system process 0.01103 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) B cell activation 0.00000000000005029 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0000000000392 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000000786 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000000001049 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000001093 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.000000005934 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0.000003754 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.00001621 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00002448 Highly Informative Direct
Biological Process (BP) fertilization 0.00009567 Highly Informative Direct
Biological Process (BP) diencephalon development 0.0003607 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0004651 Highly Informative Direct
Biological Process (BP) exocytosis 0.0008224 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.001534 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.008181 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01842 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1012 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3815 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.3808 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.001023 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.9795 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.197 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.02709 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.002296 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.002261 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.3411 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.6835 Highly Informative Inherited
Biological Process (BP) neuron projection development 1 Highly Informative Inherited
Biological Process (BP) sensory perception 0.8157 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1004 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 0.29 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9725 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.0207 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000000000003095 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.004739 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000000003176 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.1563 Informative Inherited
Molecular Function (MF) gated channel activity 0.0000008366 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000007262 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0005929 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000396 Moderately Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) cell surface 0.000002529 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Informative Direct
Cellular Component (CC) integral component of membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0.000000007214 Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) postsynaptic membrane 0.000003733 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) cell body 0.00000008132 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.000000000007942Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.4186Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000000000003471InformativeDirect
Disease Ontology (DO)schizophrenia0.0005014InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1086InformativeInherited
Disease Ontology (DO)cocaine dependence0.0000004718Highly InformativeDirect
Disease Ontology (DO)autistic disorder0.0000009512Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00009831Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.08517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.878Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9092Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.003024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.003952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6575Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0001348InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0005926InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.0008539InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.001109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.001772InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.00284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01066InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.01241InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01687InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.0303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.04002InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.04307InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.05194InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.05852InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.06324InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.281InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.3126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.5461InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents0.0000000003035Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness0.0000000003035Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.000000002283Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy0.000000009461Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.00000003924Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.0000001011Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0000001011Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized amyoplasia0.0000001189Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0000001671Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita0.0000001979Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium0.0000002821Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes0.0000002821Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign0.0000008019Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.000001123Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement0.000001288Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.000002309Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.000002577Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.00000576Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00000576Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck0.000007932Highly InformativeDirect
Phenotypic Abnormality (PA)Thin ribs0.00002274Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma0.0000283Highly InformativeDirect
Phenotypic Abnormality (PA)Vertebral fusion0.00007297Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.00009303Highly InformativeDirect
Phenotypic Abnormality (PA)Short thorax0.0001692Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal malrotation0.0002136Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0002391Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000000289Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9591Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3966Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8223Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00001915InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.002306InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004532InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.007795InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01298InformativeInherited
Mammalian Phenotype (MP)seizures0.01996InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.03516InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.06335InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08339InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08647InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.145InformativeInherited
Mammalian Phenotype (MP)urinary incontinence0.00000002576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.0000001992Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.0000007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000003713Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001616Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00001765Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex0.00002299Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.00005184Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pupil morphology0.00006962Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.00007844Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.00009269Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001378Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0002162Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0003153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.000495Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.000524Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.00924Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01092Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03174Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1107Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3101Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000000000000005231Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000009099Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00004983Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.003868Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00006982InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0004039InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004387InformativeDirect
Worm Phenotype (WP)neuron development variant0.02383InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000003933Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000006152Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0002215Highly InformativeDirect
Worm Phenotype (WP)pesticide response variant0.00208Highly InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.003354Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.05835Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.00000003636Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.00009457Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.0058Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.000258InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.0000000000001637Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.00009312Least InformativeDirect
Drugbank ATC_code (DB)alimentary tract and metabolism0.005743Least InformativeInherited
Drugbank ATC_code (DB)antiinfectives0.000000002257Moderately InformativeDirect
Drugbank ATC_code (DB)other nervous system drugs0.0000001059Moderately InformativeDirect
Drugbank ATC_code (DB)psychoanaleptics0.0000002486Moderately InformativeDirect
Drugbank ATC_code (DB)anesthetics0.00005266Moderately InformativeDirect
Drugbank ATC_code (DB)psycholeptics0.0005775Moderately InformativeDirect
Drugbank ATC_code (DB)other analgesics and antipyretics0.01006Moderately InformativeInherited
Drugbank ATC_code (DB)nasal preparations0.02766Moderately InformativeInherited
Drugbank ATC_code (DB)other plain vitamin preparations1Moderately InformativeInherited
Drugbank ATC_code (DB)antifungals for topical use1Moderately InformativeInherited
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)peripheral vasodilators0InformativeDirect
Drugbank ATC_code (DB)barbiturates and derivatives0InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0InformativeDirect
Drugbank ATC_code (DB)pentobarbital0InformativeDirect
Drugbank ATC_code (DB)acamprosate0InformativeDirect
Drugbank ATC_code (DB)prasterone0.000000000000005698InformativeDirect
Drugbank ATC_code (DB)diazepines, oxazepines, thiazepines and oxepines0.0000000000005199InformativeDirect
Drugbank ATC_code (DB)opium alkaloids and derivatives0.0000002303InformativeDirect
Drugbank ATC_code (DB)anti-dementia drugs0.0000003699InformativeDirect
Drugbank ATC_code (DB)2-(4-chlorphenoxy)-ethanol0.0003032InformativeDirect
Drugbank ATC_code (DB)ethanol0.0003032InformativeDirect
Drugbank ATC_code (DB)anthelmintics0.0007661InformativeDirect
Drugbank ATC_code (DB)non-selective monoamine reuptake inhibitors0.007819InformativeInherited
Drugbank ATC_code (DB)other hypnotics and sedatives0.02544InformativeInherited
Drugbank ATC_code (DB)anesthetics, general0.04899InformativeInherited
Drugbank ATC_code (DB)other antiepileptics0.1737InformativeInherited
Drugbank ATC_code (DB)lipid modifying agents, plain1InformativeInherited
Drugbank ATC_code (DB)throat preparations1InformativeInherited
Drugbank ATC_code (DB)antiinfectives1InformativeInherited
Drugbank ATC_code (DB)enflurane0Highly InformativeDirect
Drugbank ATC_code (DB)etomidate0Highly InformativeDirect
Drugbank ATC_code (DB)propofol0Highly InformativeDirect
Drugbank ATC_code (DB)other analgesics and antipyretics0Highly InformativeDirect
Drugbank ATC_code (DB)primidone0Highly InformativeDirect
Drugbank ATC_code (DB)metharbital0Highly InformativeDirect
Drugbank ATC_code (DB)topiramate0Highly InformativeDirect
Drugbank ATC_code (DB)diazepam0Highly InformativeDirect
Drugbank ATC_code (DB)oxazepam0Highly InformativeDirect
Drugbank ATC_code (DB)bromazepam0Highly InformativeDirect
Drugbank ATC_code (DB)prazepam0Highly InformativeDirect
Drugbank ATC_code (DB)halazepam0Highly InformativeDirect
Drugbank ATC_code (DB)fludiazepam0Highly InformativeDirect
Drugbank ATC_code (DB)talbutal0Highly InformativeDirect
Drugbank ATC_code (DB)flurazepam0Highly InformativeDirect
Drugbank ATC_code (DB)estazolam0Highly InformativeDirect
Drugbank ATC_code (DB)triazolam0Highly InformativeDirect
Drugbank ATC_code (DB)temazepam0Highly InformativeDirect
Drugbank ATC_code (DB)midazolam0Highly InformativeDirect
Drugbank ATC_code (DB)quazepam0Highly InformativeDirect
Drugbank ATC_code (DB)ethchlorvynol0Highly InformativeDirect
Drugbank ATC_code (DB)galantamine0Highly InformativeDirect
Drugbank ATC_code (DB)hexamidine0Highly InformativeDirect
Drugbank ATC_code (DB)hexamidine0Highly InformativeDirect
Drugbank ATC_code (DB)hexamidine0Highly InformativeDirect
Drugbank ATC_code (DB)hexamidine0Highly InformativeDirect
Drugbank ATC_code (DB)amoxapine0.00000000000003357Highly InformativeDirect
Drugbank ATC_code (DB)olanzapine0.0000000000001404Highly InformativeDirect
Drugbank ATC_code (DB)nicotinamide0.0000000000002335Highly InformativeDirect
Drugbank ATC_code (DB)nicotinic acid0.0000000000002335Highly InformativeDirect
Drugbank ATC_code (DB)flumazenil0.000000000003341Highly InformativeDirect
Drugbank ATC_code (DB)benzodiazepine derivatives0.00000000008569Highly InformativeDirect
Drugbank ATC_code (DB)hexobarbital0.0000000005502Highly InformativeDirect
Drugbank ATC_code (DB)hexachlorophene0.0000001391Highly InformativeDirect
Drugbank ATC_code (DB)chlorine containing products0.0000001391Highly InformativeDirect
Drugbank ATC_code (DB)piperidinedione derivatives0.000002412Highly InformativeDirect
Drugbank ATC_code (DB)benzodiazepine related drugs0.000002412Highly InformativeDirect
Drugbank ATC_code (DB)biguanides and amidines0.00009283Highly InformativeDirect
Drugbank ATC_code (DB)desflurane0.0002882Highly InformativeDirect
Drugbank ATC_code (DB)sevoflurane0.0002882Highly InformativeDirect
Drugbank ATC_code (DB)isoflurane0.0006261Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation0.000000000004045Least InformativeDirect
DiseaseEpilepsy0.000000005261InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.00000000009819Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006202 SSF63712 Protein matches
Abstract

This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nicotinic receptor ligand binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Nicotinic receptor ligand binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]