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Leukotriene A4 hydrolase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Leukotriene A4 hydrolase N-terminal domain [ 63736]
Superfamily:   Leukotriene A4 hydrolase N-terminal domain [ 63737]
Families:   Leukotriene A4 hydrolase N-terminal domain [ 63738]


Superfamily statistics
Genomes (2,066) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,794 29,514 7
Proteins 6,664 29,143 7


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.0000000000008319 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00003484 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3382 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0008571 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.02005 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000000004085 Informative Direct
Biological Process (BP) system process 0.000000164 Informative Direct
Biological Process (BP) localization of cell 0.00004091 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.002512 Informative Inherited
Biological Process (BP) locomotion 0.002376 Informative Inherited
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000000007473 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000003077 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000002023 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.0409 Least Informative Inherited
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0 Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0003157 Highly Informative Direct
Cellular Component (CC) membrane 0.0007919 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.06309 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3895 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9876 Least Informative Inherited
Cellular Component (CC) vacuole 0.000000000001555 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00001034 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0009227 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0235 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.000000000000007429 Informative Direct
Cellular Component (CC) lytic vacuole 0.0002158 Informative Direct
Cellular Component (CC) lysosomal membrane 0.00000007606 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000000000002536Least InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00000001138Moderately InformativeDirect
Biological processImmunity0.0000134Moderately InformativeDirect
Biological processAngiogenesis0.0000000000002227InformativeDirect
Biological processAdaptive immunity0.000000001923Highly InformativeDirect
Cellular componentNucleus0.0000000008937Least InformativeDirect
Cellular componentEndoplasmic reticulum0.00002795Moderately InformativeDirect
DomainTransmembrane0.00000359Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0004117Moderately InformativeDirect
Post-translational modificationReceptor0.05799Moderately InformativeInherited
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.00000000000064Highly InformativeDirect
Post-translational modificationGlycoprotein0.0000000003112Least InformativeDirect
Post-translational modificationSulfation0.00000000000135InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leukotriene A4 hydrolase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Leukotriene A4 hydrolase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]