SUPERFAMILY 1.75 HMM library and genome assignments server


Leukotriene A4 hydrolase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Leukotriene A4 hydrolase N-terminal domain [ 63736]
Superfamily:   Leukotriene A4 hydrolase N-terminal domain [ 63737]
Families:   Leukotriene A4 hydrolase N-terminal domain [ 63738]


Superfamily statistics
Genomes (2,060) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,715 16,255 7
Proteins 6,599 16,174 7


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 4.087e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) localization 0.7284 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003298 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6672 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) system process 0.0001498 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.0007087 Moderately Informative Direct
Biological Process (BP) immune system process 0.8576 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.01677 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.002428 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.09244 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) proteolysis 8.927e-08 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 2.738e-06 Informative Direct
Biological Process (BP) fatty acid metabolic process 1.078e-05 Informative Direct
Biological Process (BP) localization of cell 4.025e-05 Informative Direct
Biological Process (BP) locomotion 0.00401 Informative Inherited
Biological Process (BP) cellular component movement 0.004644 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1433 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4274 Informative Inherited
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 4.463e-14 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 1.021e-11 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 8.557e-11 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 7.864e-05 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0005084 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.02286 Least Informative Inherited
Molecular Function (MF) cation binding 3.987e-13 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0.0007195 Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.0003913 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.04457 Least Informative Inherited
Cellular Component (CC) membrane 0.001679 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0409 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 6.314e-07 Moderately Informative Direct
Cellular Component (CC) vesicle 8.485e-06 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.04697 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 3.128e-15 Informative Direct
Cellular Component (CC) lytic vacuole 3.128e-15 Informative Direct
Cellular Component (CC) cell surface 0.001833 Informative Inherited
Cellular Component (CC) lysosome 0 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 4.294e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)2.536e-13Least InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.0004836Moderately InformativeDirect
Disease Ontology (DO)hypertension6.512e-05InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant7.564e-05Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant3.139e-05InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.9058InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.894e-06Moderately InformativeDirect
Biological processAngiogenesis6.77e-12InformativeDirect
Biological processAdaptive immunity4.15e-11Highly InformativeDirect
Cellular componentNucleus3.328e-10Least InformativeDirect
Cellular componentEndoplasmic reticulum9.231e-06Moderately InformativeDirect
DomainTransmembrane2.439e-06Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein5.89e-09Least InformativeDirect
Post-translational modificationSulfation3.449e-11InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leukotriene A4 hydrolase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Leukotriene A4 hydrolase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]