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Leukotriene A4 hydrolase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Leukotriene A4 hydrolase N-terminal domain [ 63736]
Superfamily:   Leukotriene A4 hydrolase N-terminal domain [ 63737]
Families:   Leukotriene A4 hydrolase N-terminal domain [ 63738]


Superfamily statistics
Genomes (2,066) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,794 29,514 7
Proteins 6,664 29,143 7


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.000000000001945 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00001289 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.9644 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001637 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0236 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.0000000000009481 Informative Direct
Biological Process (BP) system process 0.0000001465 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.000004154 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.002034 Informative Inherited
Biological Process (BP) locomotion 0.002052 Informative Inherited
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000000009821 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000004193 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000002214 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.0701 Least Informative Inherited
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.001864 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.07147 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4378 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.985 Least Informative Inherited
Cellular Component (CC) whole membrane 0.00000865 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.02359 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0.00000000000001356 Informative Direct
Cellular Component (CC) lytic vacuole 0.0001936 Informative Direct
Cellular Component (CC) lysosomal membrane 0.00000008526 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0000000000002536Least InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.00008872Moderately InformativeDirect
Disease Ontology (DO)hypertension0.000007198InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.00003294Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000009776InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.1039Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.00003332InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0.9297InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.000007997Moderately InformativeDirect
Biological processDifferentiation0.00000943Moderately InformativeDirect
Biological processAngiogenesis0.000000000008915InformativeDirect
Biological processAdaptive immunity0.0000000004938Highly InformativeDirect
Cellular componentNucleus0.0000000003386Least InformativeDirect
Cellular componentEndoplasmic reticulum0.00002146Moderately InformativeDirect
DomainTransmembrane0.00000442Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0.000000002123Least InformativeDirect
Post-translational modificationSulfation0.00000000005422InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leukotriene A4 hydrolase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Leukotriene A4 hydrolase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]