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SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (552) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,016 11,107 8
Proteins 4,888 10,879 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.0000000000001372 Least Informative Direct
Biological Process (BP) biological regulation 0.0000000004169 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00001463 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00003015 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0002964 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0004336 Least Informative Direct
Biological Process (BP) primary metabolic process 0.01998 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.0615 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007562 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01048 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.00000000003857 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00001582 Moderately Informative Direct
Biological Process (BP) immune system process 0.00006924 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001154 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001261 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0004107 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0005009 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.1896 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.007813 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5442 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.002487 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01431 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7791 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.07592 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.01677 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6479 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.001629 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5475 Moderately Informative Inherited
Biological Process (BP) defense response 0.02046 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.999 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1845 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8992 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.3452 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001433 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7564 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.001566 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) hemopoiesis 0.0000000001628 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000003387 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000000006139 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000000007203 Informative Direct
Biological Process (BP) DNA metabolic process 0.00000001034 Informative Direct
Biological Process (BP) chromosome organization 0.0000003554 Informative Direct
Biological Process (BP) cell cycle process 0.0000003944 Informative Direct
Biological Process (BP) defense response to other organism 0.00000116 Informative Direct
Biological Process (BP) growth 0.00000123 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000001299 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000004797 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.000005966 Informative Direct
Biological Process (BP) regulation of immune response 0.000008117 Informative Direct
Biological Process (BP) regulation of defense response 0.00004183 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0001273 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0004869 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0005804 Informative Direct
Biological Process (BP) response to bacterium 0.0007331 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.003684 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.08045 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1248 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8371 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.002499 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.04405 Informative Inherited
Biological Process (BP) cellular response to lipid 0.002781 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.7114 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3644 Informative Inherited
Biological Process (BP) circulatory system development 0.8804 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.004903 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.2039 Informative Inherited
Biological Process (BP) proteolysis 0.2496 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9554 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06873 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04277 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04103 Informative Inherited
Biological Process (BP) response to radiation 0.02244 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.001492 Informative Inherited
Biological Process (BP) epithelium development 0.04074 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01965 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0000000000009251 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.000000000003894 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.00000000001156 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000000005917 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.000000005809 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00000005305 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0000001037 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.0000006739 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000007772 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000001904 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00008483 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00008793 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0001409 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0005781 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.07784 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.02545 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.1331 Highly Informative Inherited
Biological Process (BP) heart development 0.2261 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.01727 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.2041 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.03093 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.04618 Highly Informative Inherited
Molecular Function (MF) binding 0.00000004928 Least Informative Direct
Molecular Function (MF) transferase activity 0.01707 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6047 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.06977 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.1645 Informative Inherited
Molecular Function (MF) phospholipid binding 0.003037 Informative Inherited
Molecular Function (MF) enzyme binding 0.01447 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.0000000000135 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.00003665 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00003713 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000006799 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000001065 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.4971 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00000000001427 Moderately Informative Direct
Cellular Component (CC) chromosome 0.000002243 Informative Direct
Cellular Component (CC) nucleoplasm part 0.3429 Informative Inherited
Cellular Component (CC) nuclear body 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002257Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.848e-16Moderately InformativeDirect
Biological processDNA damage0.000001536Moderately InformativeDirect
Biological processDNA recombination0.000000000174InformativeDirect
Biological processDNA repair0.0000003855InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0004812Moderately InformativeDirect
Cellular componentChromosome0.00000000009085InformativeDirect
Cellular componentTelomere0.000003639Highly InformativeDirect
DomainZinc-finger0.0000002589Moderately InformativeDirect
DomainCoiled coil0.00003651Moderately InformativeDirect
Molecular functionZinc0.000007291Least InformativeDirect
Post-translational modificationHydrolase0.4543Least InformativeInherited
Post-translational modificationDNA-binding0.000000000000001753Moderately InformativeDirect
Post-translational modificationActivator0.0000000000001167Moderately InformativeDirect
Post-translational modificationRepressor0.00000000005604Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000002709Moderately InformativeDirect
Post-translational modificationHelicase0.00000000002127InformativeDirect
Post-translational modificationGrowth factor0.000000001434Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000007488Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.0000004051Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.00000221InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]