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SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (549) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,968 6,290 8
Proteins 4,840 6,200 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000000000001025 Least Informative Direct
Biological Process (BP) biological regulation 0.0000000421 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0002098 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0004013 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.003411 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03453 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.03868 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02146 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.00255 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.000000002615 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000005056 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001771 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.02561 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.04719 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.01439 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8668 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.002136 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02896 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.04946 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9415 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.652 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.07285 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.7638 Moderately Informative Inherited
Biological Process (BP) system development 0.01363 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003817 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.002581 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.8021 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.2597 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.00129 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.64 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4216 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1598 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002656 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7894 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9418 Moderately Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00000009648 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000001686 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000001914 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000001318 Informative Direct
Biological Process (BP) DNA metabolic process 0.000002101 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000002136 Informative Direct
Biological Process (BP) chromosome organization 0.00002439 Informative Direct
Biological Process (BP) defense response to other organism 0.0000831 Informative Direct
Biological Process (BP) cell cycle process 0.000175 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0001813 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.0001819 Informative Direct
Biological Process (BP) growth 0.0002824 Informative Direct
Biological Process (BP) regulation of defense response 0.0007152 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.08593 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8227 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00246 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.005162 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.02334 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.06121 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3594 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.004674 Informative Inherited
Biological Process (BP) cellular response to lipid 0.008534 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.07256 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.08934 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.008711 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2101 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4598 Informative Inherited
Biological Process (BP) response to bacterium 0.005934 Informative Inherited
Biological Process (BP) sensory organ development 0.01036 Informative Inherited
Biological Process (BP) tissue development 0.01145 Informative Inherited
Biological Process (BP) circulatory system development 0.6716 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.09748 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02322 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.04155 Informative Inherited
Biological Process (BP) proteolysis 0.2749 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.01915 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9528 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0507 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04627 Informative Inherited
Biological Process (BP) response to radiation 0.0213 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000000000007199 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.000000003432 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle phase transition 0.000000003617 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0000002332 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000003179 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000009192 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000002341 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.00001753 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00003057 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00005398 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.00009847 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.0001249 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.0001345 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.01334 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.04551 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.2124 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02995 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.04328 Highly Informative Inherited
Molecular Function (MF) binding 0.00000128 Least Informative Direct
Molecular Function (MF) transferase activity 0.008584 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 8.425e-16 Moderately Informative Direct
Molecular Function (MF) anion binding 0.5424 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.002096 Informative Inherited
Molecular Function (MF) enzyme binding 0.01422 Informative Inherited
Molecular Function (MF) DNA binding 0.04883 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000000000005108 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00006003 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000958 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000006006 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000161 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.6704 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000000000001616 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0000000008145 Moderately Informative Direct
Cellular Component (CC) chromosome 0.0002583 Informative Direct
Cellular Component (CC) nucleoplasm part 0.1514 Informative Inherited
Cellular Component (CC) nuclear body 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002257Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8903Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0009079Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0002966Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.00114Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.1185Least InformativeInherited
Xenopus ANatomical entity (XAN)egg0.0002783Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000388Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00924Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.0000000002835Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.00000001889Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.08695Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)DNA helicase4.944e-16InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.003524InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000003219Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.844e-16Moderately InformativeDirect
Biological processDNA damage0.000001573Moderately InformativeDirect
Biological processDNA recombination0.0000000001782InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0003969Moderately InformativeDirect
Cellular componentChromosome0.00000000009066InformativeDirect
Cellular componentTelomere0.000003756Highly InformativeDirect
DomainZinc-finger0.0000002807Moderately InformativeDirect
DomainCoiled coil0.00003814Moderately InformativeDirect
Molecular functionZinc0.000007147Least InformativeDirect
Post-translational modificationHydrolase0.4574Least InformativeInherited
Post-translational modificationDNA-binding0.000000000000001748Moderately InformativeDirect
Post-translational modificationActivator0.0000000000001157Moderately InformativeDirect
Post-translational modificationRepressor0.00000000005611Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000002706Moderately InformativeDirect
Post-translational modificationHelicase0.00000000002206InformativeDirect
Post-translational modificationGrowth factor0.00000000145Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000009155Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.0000004382Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000002191InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]