SUPERFAMILY 1.75 HMM library and genome assignments server


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (543) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,805 6,290 8
Proteins 4,684 6,200 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.938e-14 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 4.753e-05 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 6.97e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.2113 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02145 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.0188 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2525 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.5983 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.002525 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.001123 Least Informative Inherited
Biological Process (BP) developmental process 0.3684 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3096 Least Informative Inherited
Biological Process (BP) cellular response to stress 4.973e-10 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 6.174e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.000274 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.8324 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5174 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9061 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0019 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3778 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7601 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1252 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.02352 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.544 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.004686 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4179 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.008566 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03126 Moderately Informative Inherited
Biological Process (BP) organ development 0.002447 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.217 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8718 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.654 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.007675 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7655 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of peptidase activity 4.941e-11 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 2.23e-09 Informative Direct
Biological Process (BP) negative regulation of signaling 9.258e-09 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 1.132e-08 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.947e-08 Informative Direct
Biological Process (BP) chromosome organization 1.71e-07 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 3.207e-07 Informative Direct
Biological Process (BP) DNA metabolic process 2.398e-06 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.456e-05 Informative Direct
Biological Process (BP) positive regulation of gene expression 1.719e-05 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 7.585e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 8.531e-05 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.0001391 Informative Direct
Biological Process (BP) muscle tissue development 0.0003068 Informative Direct
Biological Process (BP) apoptotic process 0.08379 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08346 Informative Inherited
Biological Process (BP) muscle structure development 0.002816 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.07073 Informative Inherited
Biological Process (BP) sensory organ development 0.01005 Informative Inherited
Biological Process (BP) cardiovascular system development 0.137 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.956 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.00101 Informative Inherited
Biological Process (BP) regulation of immune response 0.07705 Informative Inherited
Biological Process (BP) regulation of defense response 0.413 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02545 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04512 Informative Inherited
Biological Process (BP) response to bacterium 0.003204 Informative Inherited
Biological Process (BP) defense response 0.4239 Informative Inherited
Biological Process (BP) growth 0.001031 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.007134 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.387 Informative Inherited
Biological Process (BP) cell cycle process 0.07355 Informative Inherited
Biological Process (BP) protein catabolic process 0.05375 Informative Inherited
Biological Process (BP) proteolysis 0.2966 Informative Inherited
Biological Process (BP) RNA processing 0.3776 Informative Inherited
Biological Process (BP) negative regulation of endopeptidase activity 3.755e-15 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 4.216e-09 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 8.066e-08 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.952e-07 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 3.635e-07 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.316e-06 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 1.693e-06 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 1.887e-06 Highly Informative Direct
Biological Process (BP) defense response to bacterium 2.471e-06 Highly Informative Direct
Biological Process (BP) developmental growth 4.973e-06 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 1.825e-05 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 2.071e-05 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 5.456e-05 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001555 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0002925 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0004533 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01979 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 1 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.009715 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02935 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.04025 Highly Informative Inherited
Molecular Function (MF) binding 2.027e-09 Least Informative Direct
Molecular Function (MF) nucleic acid binding 8.345e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3524 Moderately Informative Inherited
Molecular Function (MF) ligase activity 2.089e-12 Informative Direct
Molecular Function (MF) lipid binding 0.1603 Informative Inherited
Molecular Function (MF) enzyme binding 0.01204 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.008077 Informative Inherited
Molecular Function (MF) DNA binding 0.01245 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 6.053e-15 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0.0001715 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.0531 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0009925 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.1185 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 8.839e-12 Moderately Informative Direct
Cellular Component (CC) nuclear part 1.131e-06 Moderately Informative Direct
Cellular Component (CC) chromosome 0.06399 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 4.137e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides2.257e-11Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.09282Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6377Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2196Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2598Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.02591InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.04491InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.5523InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0002133Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.676e-06Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.262e-12Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00314Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.000365InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.566e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis4.711e-16Moderately InformativeDirect
Biological processDNA damage2.61e-06Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processDNA recombination6.788e-10InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.000283Moderately InformativeDirect
Cellular componentChromosome5.06e-11InformativeDirect
Cellular componentTelomere8.006e-06Highly InformativeDirect
DomainZinc-finger3.565e-07Moderately InformativeDirect
DomainCoiled coil3.022e-05Moderately InformativeDirect
Molecular functionDNA-binding9.203e-16Least InformativeDirect
Molecular functionZinc4.555e-06Least InformativeDirect
Post-translational modificationHydrolase0.3317Least InformativeInherited
Post-translational modificationActivator7.343e-11Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.168e-09Moderately InformativeDirect
Post-translational modificationRepressor2.691e-09Moderately InformativeDirect
Post-translational modificationLigase7.287e-07Moderately InformativeDirect
Post-translational modificationHelicase2.18e-11InformativeDirect
Post-translational modificationGrowth factor1.19e-09InformativeDirect
Post-translational modificationPhosphoprotein2.894e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond2.783e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]