SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (545) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,911 6,290 8
Proteins 4,786 6,200 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.000000000001498 Least Informative Direct
Biological Process (BP) biological regulation 0.0000001003 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0004789 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0009183 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0101 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01547 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0286 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03001 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.005343 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000002832 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00008176 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000216 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0005672 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.0007326 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.002386 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.08892 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.001062 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.129 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0261 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.973 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1957 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5601 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.8571 Moderately Informative Inherited
Biological Process (BP) response to stress 0.01179 Moderately Informative Inherited
Biological Process (BP) immune system process 0.004115 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.007681 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2776 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5981 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.7412 Moderately Informative Inherited
Biological Process (BP) cell communication 0.6934 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9681 Moderately Informative Inherited
Biological Process (BP) system development 0.01601 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.01152 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7277 Moderately Informative Inherited
Biological Process (BP) signaling 0.8846 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.02424 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9273 Moderately Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.000000104 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000001213 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000005887 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000001562 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000001837 Informative Direct
Biological Process (BP) DNA metabolic process 0.000007589 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.00004219 Informative Direct
Biological Process (BP) defense response to other organism 0.00006702 Informative Direct
Biological Process (BP) cell cycle process 0.0002332 Informative Direct
Biological Process (BP) growth 0.0002473 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0003374 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0005209 Informative Direct
Biological Process (BP) regulation of defense response 0.0005508 Informative Direct
Biological Process (BP) regulation of immune response 0.0007955 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.001659 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3928 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.9175 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.002524 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.005033 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.06078 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.03564 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.003566 Informative Inherited
Biological Process (BP) cellular response to lipid 0.005884 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2118 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4131 Informative Inherited
Biological Process (BP) circulatory system development 0.6545 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0614 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.04855 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.003522 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.007856 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1025 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.0557 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02156 Informative Inherited
Biological Process (BP) response to bacterium 0.005582 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.05522 Informative Inherited
Biological Process (BP) proteolysis 0.2984 Informative Inherited
Biological Process (BP) response to radiation 0.06088 Informative Inherited
Biological Process (BP) epithelium development 0.1631 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0.000000000005428 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.0000000031 Highly Informative Direct
Biological Process (BP) chromosome organization 0.00000001777 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.000000159 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000001617 Highly Informative Direct
Biological Process (BP) cell cycle checkpoint 0.0000002013 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000002748 Highly Informative Direct
Biological Process (BP) hemopoiesis 0.0000005021 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.0000005131 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000001566 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00003058 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.00005818 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00008571 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.00009409 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.000102 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.0002108 Highly Informative Direct
Biological Process (BP) muscle structure development 0.0436 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.04158 Highly Informative Inherited
Molecular Function (MF) binding 0.0000002131 Least Informative Direct
Molecular Function (MF) transferase activity 0.007861 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.4927 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.9181 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0.05346 Informative Inherited
Molecular Function (MF) phospholipid binding 0.001844 Informative Inherited
Molecular Function (MF) enzyme binding 0.01387 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000000000004402 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00006296 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000997 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000003143 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000012 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0000000001346 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0.9544 Informative Inherited
Cellular Component (CC) chromosome 0.001278 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.00000000002257Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8949Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.44Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0009642Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0002711Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0.001117Least InformativeInherited
Xenopus ANatomical entity (XAN)genital system0.1195Least InformativeInherited
Xenopus ANatomical entity (XAN)egg0.0002864Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0003545Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000004201Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.000000000001186Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.002942Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0003248InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.00000000002704Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.822e-16Moderately InformativeDirect
Biological processDNA damage0.000001587Moderately InformativeDirect
Biological processDNA recombination0.0000000001834InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0003922Moderately InformativeDirect
Cellular componentChromosome0.00000000006945InformativeDirect
Cellular componentTelomere0.000004149Highly InformativeDirect
DomainZinc-finger0.0000002635Moderately InformativeDirect
DomainCoiled coil0.0000361Moderately InformativeDirect
Molecular functionDNA-binding0.000000000000001164Least InformativeDirect
Molecular functionZinc0.000006764Least InformativeDirect
Post-translational modificationHydrolase0.4123Least InformativeInherited
Post-translational modificationActivator0.0000000000000672Moderately InformativeDirect
Post-translational modificationRepressor0.00000000003634Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000001752Moderately InformativeDirect
Post-translational modificationLigase0.0000005135Moderately InformativeDirect
Post-translational modificationHelicase0.00000000002326InformativeDirect
Post-translational modificationGrowth factor0.000000001257InformativeDirect
Post-translational modificationPhosphoprotein0.000000008524Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationMethylation0.000000384Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]