SUPERFAMILY 1.75 HMM library and genome assignments server


SAP domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   LEM/SAP HeH motif [ 63450] (6)
Superfamily:   SAP domain [ 68906]
Families:   SAP domain [ 68907] (7)


Superfamily statistics
Genomes (492) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 4,368 3,823 8
Proteins 4,261 3,750 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 7.37e-06 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0004273 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.041e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.108e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0002635 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.06123 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02779 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01948 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5448 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6861 Least Informative Inherited
Biological Process (BP) developmental process 0.329 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2591 Least Informative Inherited
Biological Process (BP) cellular protein modification process 3e-08 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0002997 Moderately Informative Direct
Biological Process (BP) cellular response to stress 4.035e-11 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 4.414e-09 Moderately Informative Direct
Biological Process (BP) organ development 0.0007884 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.721 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9289 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.004216 Moderately Informative Inherited
Biological Process (BP) tissue development 0.357 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1809 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.7625 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.06995 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01246 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1311 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.004318 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3093 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.003384 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.7924 Moderately Informative Inherited
Biological Process (BP) immune system process 0.0181 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.149 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.8432 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.2058 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5449 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9973 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003988 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6303 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9582 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 9.307e-07 Informative Direct
Biological Process (BP) response to DNA damage stimulus 6.336e-06 Informative Direct
Biological Process (BP) cell death 1.019e-07 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0001 Informative Direct
Biological Process (BP) positive regulation of gene expression 2.475e-05 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.675e-09 Informative Direct
Biological Process (BP) negative regulation of signaling 8.341e-10 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0001127 Informative Direct
Biological Process (BP) growth 0.0005635 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 9.56e-09 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 6.859e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 4.24e-08 Informative Direct
Biological Process (BP) chromosome organization 6.925e-08 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.728e-11 Informative Direct
Biological Process (BP) muscle tissue development 0.0002919 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 8.541e-10 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.04785 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.003536 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08244 Informative Inherited
Biological Process (BP) muscle structure development 0.00244 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.07708 Informative Inherited
Biological Process (BP) sensory organ development 0.009848 Informative Inherited
Biological Process (BP) cardiovascular system development 0.1508 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.9363 Informative Inherited
Biological Process (BP) regulation of immune response 0.09046 Informative Inherited
Biological Process (BP) regulation of defense response 0.4524 Informative Inherited
Biological Process (BP) defense response 0.3647 Informative Inherited
Biological Process (BP) response to bacterium 0.003282 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.05071 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.3161 Informative Inherited
Biological Process (BP) cell cycle process 0.08577 Informative Inherited
Biological Process (BP) protein catabolic process 0.04439 Informative Inherited
Biological Process (BP) proteolysis 0.2497 Informative Inherited
Biological Process (BP) RNA processing 0.4654 Informative Inherited
Biological Process (BP) cell cycle checkpoint 1.35e-07 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0004046 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.0001511 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 4.99e-05 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 9.321e-06 Highly Informative Direct
Biological Process (BP) negative regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 2.512e-06 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 8.17e-08 Highly Informative Direct
Biological Process (BP) defense response to bacterium 2.113e-06 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 1.708e-09 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0001839 Highly Informative Direct
Biological Process (BP) developmental growth 3.814e-06 Highly Informative Direct
Biological Process (BP) cardiac muscle tissue development 1.136e-07 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 2.839e-08 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity 7.328e-14 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 2.396e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.01318 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.01475 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.02982 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.03839 Highly Informative Inherited
Molecular Function (MF) binding 2.527e-12 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 8.638e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3145 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.3858 Moderately Informative Inherited
Molecular Function (MF) nuclease activity 0.0008553 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) lipid binding 0.1646 Informative Inherited
Molecular Function (MF) DNA binding 0.009233 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.01685 Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 1.554e-15 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 9.133e-05 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0001538 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1055 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.004423 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6871 Least Informative Inherited
Cellular Component (CC) nuclear part 9.972e-07 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 2.177e-09 Moderately Informative Direct
Cellular Component (CC) chromosome 0.0008089 Informative Direct
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) nuclear body 3.626e-07 Highly Informative Direct
Cellular Component (CC) nuclear periphery 4.439e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides2.257e-11Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an4.713e-16Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2778Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7138Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.08782Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03399InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.3226InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.0002937Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0InformativeDirect
Fly Phenotype (FP)some die during larval stage0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases3.851e-06Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.37e-12Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.003154Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.0003692InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase2.722e-11Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis4.701e-16Moderately InformativeDirect
Biological processDNA damage2.755e-06Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processDNA recombination6.932e-10InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentSecreted0.0002628Moderately InformativeDirect
Cellular componentChromosome4.731e-11InformativeDirect
Cellular componentTelomere5.62e-06Highly InformativeDirect
DomainZinc-finger3.598e-07Moderately InformativeDirect
DomainCoiled coil2.807e-05Moderately InformativeDirect
Molecular functionDNA-binding4.618e-16Least InformativeDirect
Molecular functionZinc3.844e-06Least InformativeDirect
Post-translational modificationHydrolase0.3251Least InformativeInherited
Post-translational modificationActivator7.295e-11Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.217e-09Moderately InformativeDirect
Post-translational modificationRepressor2.132e-09Moderately InformativeDirect
Post-translational modificationLigase7.758e-07Moderately InformativeDirect
Post-translational modificationHelicase2.021e-11InformativeDirect
Post-translational modificationGrowth factor1.131e-09InformativeDirect
Post-translational modificationPhosphoprotein2.857e-08Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond2.056e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein sumoylation0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SAP domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the SAP domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]