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Nuclear receptor coactivator interlocking domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Nuclear receptor coactivator interlocking domain [ 69124]
Superfamily:   Nuclear receptor coactivator interlocking domain [ 69125]
Families:   Nuclear receptor coactivator interlocking domain [ 69126] (3)


Superfamily statistics
Genomes (105) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 488 1,129 5
Proteins 488 1,124 5


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.00000002982 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000002146 Least Informative Direct
Biological Process (BP) response to stimulus 0.00008522 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.02958 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.05244 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.09548 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1672 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00000000000001079 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.00004349 Moderately Informative Direct
Biological Process (BP) immune system process 0.00008688 Moderately Informative Direct
Biological Process (BP) reproduction 0.000269 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0004456 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0009704 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00271 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02341 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001306 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.05494 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006648 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01286 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.1365 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.09596 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.05094 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1832 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2317 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.4545 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.00000002665 Informative Direct
Biological Process (BP) chromosome organization 0.0000008521 Informative Direct
Biological Process (BP) hemopoiesis 0.000005793 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00003372 Informative Direct
Biological Process (BP) behavior 0.00006448 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0001153 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000188 Informative Direct
Biological Process (BP) reproductive system development 0.000436 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0004375 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.004701 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1384 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03143 Informative Inherited
Biological Process (BP) response to radiation 0.01892 Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.00000000008599 Highly Informative Direct
Biological Process (BP) histone modification 0.0000000003598 Highly Informative Direct
Biological Process (BP) response to UV 0.000000004695 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000003446 Highly Informative Direct
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.00001442 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0002526 Highly Informative Direct
Molecular Function (MF) binding 0.000000007821 Least Informative Direct
Molecular Function (MF) transferase activity 0.003977 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0000002653 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000000005484 Informative Direct
Molecular Function (MF) DNA binding 0.000000002009 Informative Direct
Molecular Function (MF) receptor binding 0.000000002869 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0004652 Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.000000000001135 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.0000000001153 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.00000008848 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.3028 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.7974 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000001864 Least Informative Direct
Cellular Component (CC) protein complex 0.0001887 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.6276 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.02021 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00001588 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.004679 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0007555 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainBromodomain0.0000000000007165Highly InformativeDirect
Post-translational modificationTransferase0.00004029Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000001057Least InformativeDirect
Post-translational modificationMethylation0.000000000000001442Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000000000217Moderately InformativeDirect
Post-translational modificationUbl conjugation0.000000001352Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009110 SSF69125 Protein matches
Abstract

This entry represents the interlocking domain of various eukaryotic nuclear receptor coactivators, including CREBP, P300, Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.

Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein), P300 and ACTR (activator for thyroid and retinoid receptors) [PubMed11823864]. CBP and P300 both have histone acetyltransferase activity . CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1 [PubMed11583620].

Ncoa1, Ncoa2 and Ncoa3 are all coactivators of various nuclear receptors. In addition, Ncoa1 and Ncoa3 both have histone acetyltransferase activity, but Ncoa2 does not [PubMed14757047, PubMed15145939].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nuclear receptor coactivator interlocking domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Nuclear receptor coactivator interlocking domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]