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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2619Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004165Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01292Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1406Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5345Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004891InformativeDirect
Disease Ontology (DO)breast cancer0.0002872InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006067InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004274InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004564InformativeInherited
Disease Ontology (DO)infertility0.000001999Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007924Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007713Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.08012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5713Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8275Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02131Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.08566Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1097Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1869Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4503Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.5409Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5591Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5858Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.0001156InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01402InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.03267InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.045InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.04792InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.07621InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.1898InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.1961InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4606InformativeInherited
Phenotypic Abnormality (PA)Abnormal subarachnoid space morphology0.000231Highly InformativeDirect
Phenotypic Abnormality (PA)Intracranial hemorrhage0.001147Highly InformativeInherited
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.001998Highly InformativeInherited
Phenotypic Abnormality (PA)Diarrhea0.005707Highly InformativeInherited
Phenotypic Abnormality (PA)Thrombocytopenia0.01921Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.2397Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008132Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001251Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007877Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01072Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2814Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4386Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1104Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1117Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2501Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3371Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.6463Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002314InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003343InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0007994InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002328InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009524InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04692InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06476InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07428InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08638InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1671InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1787InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3203InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6903InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.7956InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007307Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001712Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.000303Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003071Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0005002Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007511Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005559Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006157Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05263Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06357Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.1821Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2936Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.005325Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.009835Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01112Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05826Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000004115Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00008175Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00008403Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0000992Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001582Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0005189Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000004084InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001567InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000003457InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005471InformativeDirect
Worm Phenotype (WP)egg laying variant0.0001378InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.000000111Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000005923Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001905Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.01962Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)cell number defective0.003024InformativeInherited
Fly Phenotype (FP)decreased cell number0.0002502Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.2056Least InformativeInherited
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0.01047Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02104Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.02203Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02569Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2105Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.000198InformativeDirect
Fly Anatomy (FA)anatomical space0.0006085InformativeDirect
Fly Anatomy (FA)tracheal system0.001057InformativeInherited
Fly Anatomy (FA)epithelial tube0.001684InformativeInherited
Fly Anatomy (FA)primordium0.001901InformativeInherited
Fly Anatomy (FA)muscle system0.002625InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.003251InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.004902InformativeInherited
Fly Anatomy (FA)female germline cyst0.004959InformativeInherited
Fly Anatomy (FA)gut section0.01424InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.02146InformativeInherited
Fly Anatomy (FA)germline cell0.02244InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.02785InformativeInherited
Fly Anatomy (FA)muscle attachment site0.0000003978Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.00000155Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.00000801Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00001257Highly InformativeDirect
Fly Anatomy (FA)germ layer derivative0.00001441Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.00002037Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.00003351Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.00004124Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.00004262Highly InformativeDirect
Fly Anatomy (FA)oocyte0.0001774Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.831Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8491Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2518InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]