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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2614Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004054Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01284Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1404Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5346Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004827InformativeDirect
Disease Ontology (DO)breast cancer0.0002879InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006002InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004245InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004533InformativeInherited
Disease Ontology (DO)infertility0.00000213Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007797Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007621Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007319Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008289Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001255Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007938Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01077Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2813Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4382Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1103Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.112Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2612Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002314InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003321InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008046InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002338InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009541InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04704InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06488InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07436InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08615InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1788InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2841InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.32InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.795InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001417Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001714Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002844Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.000302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003072Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004589Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0004991Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005583Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006175Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01213Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02994Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05257Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06373Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002629Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004784Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008444Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04694Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000366Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00001001Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007672Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0000916Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001395Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.000268Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0006733Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000000474InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001558InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002915InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005113InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000003198Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000009874Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00000173Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.02234Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0.3269Least InformativeInherited
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1227Least InformativeInherited
Fly Anatomy (FA)integumentary system0.1335Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1389Least InformativeInherited
Fly Anatomy (FA)adult0.1791Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)non-connected developing system0.0007221Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001829Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.004745Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01093Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.01301Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02385Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.02902Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.0329Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.03409Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.04202Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04783Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05376Moderately InformativeInherited
Fly Anatomy (FA)gonad0.06203Moderately InformativeInherited
Fly Anatomy (FA)endocuticle0.000002636InformativeDirect
Fly Anatomy (FA)gland0.00001329InformativeDirect
Fly Anatomy (FA)anatomical space0.00006221InformativeDirect
Fly Anatomy (FA)epithelial tube0.00009792InformativeDirect
Fly Anatomy (FA)ipsilateral tract0.0002372InformativeDirect
Fly Anatomy (FA)primordium0.0003284InformativeDirect
Fly Anatomy (FA)wing blade0.0003385InformativeDirect
Fly Anatomy (FA)gastrula embryo0.000583InformativeDirect
Fly Anatomy (FA)circulatory system0.001254InformativeInherited
Fly Anatomy (FA)digestive system0.002317InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.005131InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.006261InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.007351InformativeInherited
Fly Anatomy (FA)embryonic/larval tracheal system0.007973InformativeInherited
Fly Anatomy (FA)muscle system0.00876InformativeInherited
Fly Anatomy (FA)ovariole0.02788InformativeInherited
Fly Anatomy (FA)germline cell0.06337InformativeInherited
Fly Anatomy (FA)germline cyst0.06579InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.09189InformativeInherited
Fly Anatomy (FA)mitotic domain 10.00000007408Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0000008967Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.000002354Highly InformativeDirect
Fly Anatomy (FA)fascicle0.000005357Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.00002047Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.0002159Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.02708Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.7981Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8056Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1466InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]