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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2614Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004054Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01284Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1404Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5346Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004827InformativeDirect
Disease Ontology (DO)breast cancer0.0002879InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006002InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004245InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004533InformativeInherited
Disease Ontology (DO)infertility0.00000213Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007797Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007621Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007319Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008268Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001253Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.00793Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01075Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2814Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4386Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1105Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1119Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2509Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2611Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002314InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003317InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008039InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002337InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009537InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04704InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06485InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07434InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.0861InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1785InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3201InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.795InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007287Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001713Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.0003019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.000307Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004588Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0004989Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007525Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005581Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006173Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01213Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05259Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.0637Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002646Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004823Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008522Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04719Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000003657Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00001013Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007758Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0000921Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000141Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.000271Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0006785Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000004793InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001553InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002912InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005171InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000003106Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000009988Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00000175Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.02234Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0.3211Least InformativeInherited
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1211Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1405Least InformativeInherited
Fly Anatomy (FA)adult0.1779Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001724Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.004697Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01078Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.01247Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02355Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.02899Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.03251Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.0338Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.04202Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04785Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05259Moderately InformativeInherited
Fly Anatomy (FA)gonad0.06297Moderately InformativeInherited
Fly Anatomy (FA)endocuticle0.000002519InformativeDirect
Fly Anatomy (FA)gland0.00001452InformativeDirect
Fly Anatomy (FA)epithelial tube0.00008821InformativeDirect
Fly Anatomy (FA)tracheal system0.0001771InformativeDirect
Fly Anatomy (FA)hemocyte0.0002406InformativeDirect
Fly Anatomy (FA)primordium0.0003099InformativeDirect
Fly Anatomy (FA)wing blade0.0003382InformativeDirect
Fly Anatomy (FA)gastrula embryo0.0005666InformativeDirect
Fly Anatomy (FA)digestive system0.0023InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.004888InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.006015InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.00723InformativeInherited
Fly Anatomy (FA)muscle system0.008455InformativeInherited
Fly Anatomy (FA)ovariole0.02771InformativeInherited
Fly Anatomy (FA)germline cell0.06472InformativeInherited
Fly Anatomy (FA)germline cyst0.06686InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.09162InformativeInherited
Fly Anatomy (FA)tract0.2079InformativeInherited
Fly Anatomy (FA)mitotic domain 10.00000006924Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.000000931Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.000002246Highly InformativeDirect
Fly Anatomy (FA)fascicle0.000004638Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.0000196Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.0002191Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.02619Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval trachea0.1958Highly InformativeInherited
Fly Anatomy (FA)primary trachea0.4308Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8074Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8127Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1536InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]