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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2619Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004165Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01292Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1406Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5345Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004891InformativeDirect
Disease Ontology (DO)breast cancer0.0002872InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006067InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004274InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004564InformativeInherited
Disease Ontology (DO)infertility0.000001999Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007924Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007713Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.07631Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5662Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8189Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02005Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.08186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1834Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2573Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4354Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.5264Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5778Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.00009998InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01378InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.03337InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.04593InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.04633InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.07695InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.1882InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.1919InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4472InformativeInherited
Phenotypic Abnormality (PA)Abnormal subarachnoid space morphology0.0002243Highly InformativeDirect
Phenotypic Abnormality (PA)Intracranial hemorrhage0.001141Highly InformativeInherited
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.001958Highly InformativeInherited
Phenotypic Abnormality (PA)Diarrhea0.006034Highly InformativeInherited
Phenotypic Abnormality (PA)Thrombocytopenia0.01863Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.2403Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008144Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001252Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007846Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01074Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2812Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4382Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1104Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1117Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.6442Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002314InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003309InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008001InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0009988InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002328InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009529InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.0469InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06476InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07428InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08642InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.167InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1786InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3201InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6896InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.7951InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007297Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001713Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.0003026Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003067Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004595Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0005003Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007511Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005508Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006156Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01211Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02994Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05261Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06373Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.1809Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.005363Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.01036Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01037Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01456Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05026Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000003732Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00003214Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007873Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0000942Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001519Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0004224Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0007274Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.004274Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000004028InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001548InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000003122InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005235InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00001596InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.0000001061Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000005514Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001827Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.0196Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)cell number defective0.00292InformativeInherited
Fly Phenotype (FP)decreased cell number0.0002155Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.2197Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)gonad0.02265Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02795Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1025Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2317Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0002227InformativeDirect
Fly Anatomy (FA)tracheal system0.00125InformativeInherited
Fly Anatomy (FA)epithelial tube0.001746InformativeInherited
Fly Anatomy (FA)primordium0.002092InformativeInherited
Fly Anatomy (FA)ovariole0.009065InformativeInherited
Fly Anatomy (FA)germline cyst0.01063InformativeInherited
Fly Anatomy (FA)gut section0.01408InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.01496InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.01984InformativeInherited
Fly Anatomy (FA)germline cell0.02254InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.0383InformativeInherited
Fly Anatomy (FA)muscle attachment site0.000000451Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.000001743Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.000008083Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00001409Highly InformativeDirect
Fly Anatomy (FA)germ layer derivative0.00001618Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.00002198Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.00003145Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.00004362Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.00004985Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8317Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8497Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2447InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]