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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2618Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004066Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01287Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1405Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5345Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004834InformativeDirect
Disease Ontology (DO)breast cancer0.0002848InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006013InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004249InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004537InformativeInherited
Disease Ontology (DO)infertility0.000002136Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.00000781Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007631Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007338Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.07299Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1557Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.4105Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.01956InformativeInherited
Phenotypic Abnormality (PA)Bruising susceptibility0.0009896Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008268Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001253Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.00793Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01075Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2814Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4386Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1105Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1119Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2509Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2611Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002314InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003317InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008039InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002337InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009537InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04704InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06485InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07434InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.0861InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1785InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3201InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.795InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007287Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001713Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.0003019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.000307Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004588Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0004989Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007525Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005581Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006173Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01213Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05259Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.0637Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002631Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004904Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008508Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04682Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000373Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00001039Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007643Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00009275Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001413Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0002763Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0006813Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000004835InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00000159InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002972InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005153InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000003264Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.0000001008Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001713Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.02286Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1245Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1456Least InformativeInherited
Fly Anatomy (FA)adult0.1795Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001868Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.005499Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01081Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.01221Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02351Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.02899Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.03284Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.03394Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.04213Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04459Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05339Moderately InformativeInherited
Fly Anatomy (FA)gonad0.06353Moderately InformativeInherited
Fly Anatomy (FA)procuticle0.000004688InformativeDirect
Fly Anatomy (FA)gland0.000015InformativeDirect
Fly Anatomy (FA)tracheal system0.0001753InformativeDirect
Fly Anatomy (FA)hemocyte0.0002428InformativeDirect
Fly Anatomy (FA)epithelial tube0.000264InformativeDirect
Fly Anatomy (FA)primordium0.0003302InformativeDirect
Fly Anatomy (FA)wing blade0.0003402InformativeDirect
Fly Anatomy (FA)gastrula embryo0.0005606InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.002244InformativeInherited
Fly Anatomy (FA)gut section0.003861InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.005162InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.005997InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.007137InformativeInherited
Fly Anatomy (FA)muscle system0.008561InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01718InformativeInherited
Fly Anatomy (FA)ovariole0.02812InformativeInherited
Fly Anatomy (FA)prepupa0.03627InformativeInherited
Fly Anatomy (FA)germline cell0.06498InformativeInherited
Fly Anatomy (FA)germline cyst0.06596InformativeInherited
Fly Anatomy (FA)tract0.2277InformativeInherited
Fly Anatomy (FA)mitotic domain 10.00000006979Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0000009386Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.000002264Highly InformativeDirect
Fly Anatomy (FA)fascicle0.000004688Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.0002194Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.02536Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.07016Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval trachea0.1963Highly InformativeInherited
Fly Anatomy (FA)primary trachea0.4291Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8084Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8152Least InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]