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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,686 11,954 5
Proteins 2,648 5,902 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000000175 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000002207 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000004273 Least Informative Direct
Biological Process (BP) biological regulation 0.00000115 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of localization 0.00000000000003101 Moderately Informative Direct
Biological Process (BP) immune system process 0.00000000009957 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000009307 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000001387 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.000008574 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00005833 Moderately Informative Direct
Biological Process (BP) reproduction 0.0005956 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0008451 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.08166 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.09823 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5464 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5078 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6954 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6963 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9562 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.09814 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3045 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1124 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2379 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02079 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05509 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.3773 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03203 Moderately Informative Inherited
Biological Process (BP) cell communication 0.02525 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.2889 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0243 Moderately Informative Inherited
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000000000000341 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000000007143 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000008678 Informative Direct
Biological Process (BP) circulatory system development 0.00000000002326 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000000001036 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000000005574 Informative Direct
Biological Process (BP) cell activation 0.00000001127 Informative Direct
Biological Process (BP) response to wounding 0.00000003471 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000001471 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.000001843 Informative Direct
Biological Process (BP) growth 0.000004846 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00002594 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.0002428 Informative Direct
Biological Process (BP) embryo development 0.0003668 Informative Direct
Biological Process (BP) regulation of protein localization 0.4519 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.04079 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) cell development 0.9383 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.209 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3455 Informative Inherited
Biological Process (BP) secretion by cell 0.01951 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.06757 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.09883 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2307 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.02318 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.05665 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.01598 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1998 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.00104 Informative Inherited
Biological Process (BP) cation homeostasis 0.001916 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.00213 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.01448 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.00356 Informative Inherited
Biological Process (BP) immune effector process 0.7403 Informative Inherited
Biological Process (BP) immune response 0.4304 Informative Inherited
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000000000002436 Highly Informative Direct
Biological Process (BP) wound healing 0.00000000001475 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00000000002357 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000000003787 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.000000000091 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0000000005767 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000005032 Highly Informative Direct
Biological Process (BP) coagulation 0.000001091 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000009378 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00002058 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00002859 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.0001487 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.0001982 Highly Informative Direct
Biological Process (BP) gastrulation 0.0002573 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0003893 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0.0005891 Highly Informative Direct
Biological Process (BP) cell chemotaxis 0.01025 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.02316 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.01812 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.004031 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.07144 Highly Informative Inherited
Biological Process (BP) leukocyte degranulation 0.01531 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.1661 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.008671 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.0112 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.002506 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.0852 Highly Informative Inherited
Biological Process (BP) granulocyte activation 0.1655 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000001018 Informative Direct
Molecular Function (MF) receptor binding 0.000008199 Informative Direct
Molecular Function (MF) amide binding 0.0007425 Informative Direct
Molecular Function (MF) enzyme binding 0.5356 Informative Inherited
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0000008183 Highly Informative Direct
Molecular Function (MF) protease binding 0.00004509 Highly Informative Direct
Molecular Function (MF) kinase binding 0.07193 Highly Informative Inherited
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000003839 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004174 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.000233 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.000822 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.9818 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.02696 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) secretory granule 0.000000005177 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000004757 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000001069 Informative Direct
Cellular Component (CC) side of membrane 0.0000446 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.0001494 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0006537 Informative Direct
Cellular Component (CC) extracellular space 0.7549 Informative Inherited
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.0000000001971 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0000001355 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.0000001983 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.000002661 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00000311 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000005184 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.000000002602Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processPhagocytosis0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00000002796Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0.00000002049Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.00000000001337Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]