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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2617Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004141Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.0129Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1405Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5345Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004883InformativeDirect
Disease Ontology (DO)breast cancer0.0002864InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006055InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004273InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004551InformativeInherited
Disease Ontology (DO)infertility0.000002164Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007905Highly InformativeDirect
Disease Ontology (DO)pertussis0.000077Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007384Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.07307Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1556Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.4104Moderately InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.0196InformativeInherited
Phenotypic Abnormality (PA)Bruising susceptibility0.0009973Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.000827Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001253Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007933Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01076Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2813Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4386Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0222Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1105Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1119Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2611Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3359Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002316InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003319InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008042InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002338InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00954InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04704InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06484InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07433InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08609InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1785InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3201InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.795InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007293Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001714Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.000302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003072Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.000459Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.0004991Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007529Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005583Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006175Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01213Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05258Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06369Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002768Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004961Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008655Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04737Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000377Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00001114Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007665Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00009198Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001435Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0002823Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0006912Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000005164InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001567InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002932InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005141InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000003215Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.0000001087Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001714Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.02288Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1455Least InformativeInherited
Fly Anatomy (FA)adult0.1778Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001914Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.01076Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02355Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.02907Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.03287Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.0339Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.04207Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.04437Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.05337Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.05503Moderately InformativeInherited
Fly Anatomy (FA)gonad0.06313Moderately InformativeInherited
Fly Anatomy (FA)endocuticle0.000002531InformativeDirect
Fly Anatomy (FA)gland0.00001492InformativeDirect
Fly Anatomy (FA)anatomical space0.000066InformativeDirect
Fly Anatomy (FA)tracheal system0.0001696InformativeDirect
Fly Anatomy (FA)epithelial tube0.0002623InformativeDirect
Fly Anatomy (FA)primordium0.0003286InformativeDirect
Fly Anatomy (FA)wing blade0.0003429InformativeDirect
Fly Anatomy (FA)gastrula embryo0.0005406InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.002272InformativeInherited
Fly Anatomy (FA)gut section0.003864InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.004995InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.005957InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.006881InformativeInherited
Fly Anatomy (FA)muscle system0.008733InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01688InformativeInherited
Fly Anatomy (FA)ovariole0.02792InformativeInherited
Fly Anatomy (FA)germline cell0.06434InformativeInherited
Fly Anatomy (FA)germline cyst0.06593InformativeInherited
Fly Anatomy (FA)tract0.2201InformativeInherited
Fly Anatomy (FA)mitotic domain 10.00000006941Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.000001208Highly InformativeDirect
Fly Anatomy (FA)muscle attachment site0.000002256Highly InformativeDirect
Fly Anatomy (FA)fascicle0.000004674Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.0002197Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.02525Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval digestive system0.06884Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval trachea0.1956Highly InformativeInherited
Fly Anatomy (FA)primary trachea0.4281Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8129Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8212Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1701InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]