SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)

Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2616Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000416Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01291Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1407Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5347Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004886InformativeDirect
Disease Ontology (DO)breast cancer0.0002872InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006056InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004272InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.00456InformativeInherited
Disease Ontology (DO)infertility0.000001999Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000007912Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007705Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007392Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008207Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001251Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007897Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0107Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2815Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4387Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1104Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1117Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002318InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003311InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008024InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002338InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009529InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04692InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06478InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07429InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08643InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1671InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1786InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3203InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.7952InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007299Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001415Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001712Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.0003027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003069Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004602Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.000501Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005569Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006169Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02997Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05263Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06353Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002684Least InformativeInherited
Worm Phenotype (WP)cell development variant0.004726Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008425Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04701Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000003612Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00001182Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007529Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00008898Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001412Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0002868Moderately InformativeDirect
Worm Phenotype (WP)cell component morphology variant0.0006582Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00000003795InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000005193InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001506InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000291InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000004886InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000009995Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001697Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.01994Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.2164Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.0167Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02265Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02832Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2376Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0002154InformativeDirect
Fly Anatomy (FA)anatomical space0.0006358InformativeDirect
Fly Anatomy (FA)tracheal system0.001219InformativeInherited
Fly Anatomy (FA)primordium0.00204InformativeInherited
Fly Anatomy (FA)muscle system0.002426InformativeInherited
Fly Anatomy (FA)germline cyst0.01056InformativeInherited
Fly Anatomy (FA)gut section0.01377InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.015InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.01957InformativeInherited
Fly Anatomy (FA)germline cell0.02322InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.03905InformativeInherited
Fly Anatomy (FA)muscle attachment site0.0000004475Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.000001736Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.000008056Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00001462Highly InformativeDirect
Fly Anatomy (FA)germ layer derivative0.00001603Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.00002184Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.00003008Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.00004309Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.00004773Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8212Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.834Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2067InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]