SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Integrin domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Families:   Integrin domains [ 69180] (2)


Superfamily statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,686 14,943 5
Proteins 2,648 7,274 3


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2616Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004173Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01292Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1407Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5345Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.00004896InformativeDirect
Disease Ontology (DO)breast cancer0.0002876InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0006067InformativeDirect
Disease Ontology (DO)inherited blood coagulation disease0.004275InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.004568InformativeInherited
Disease Ontology (DO)infertility0.000002001Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.00000793Highly InformativeDirect
Disease Ontology (DO)pertussis0.00007718Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0007403Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.08196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09986Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2165Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.02146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.08376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1039Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2562Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4285Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.516Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5561Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.00005472InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01345InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.01363InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.04099InformativeInherited
Phenotypic Abnormality (PA)Generalized abnormality of skin0.04335InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.1009InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.1769InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4663InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.5287InformativeInherited
Phenotypic Abnormality (PA)Spontaneous hematomas0.000002543Highly InformativeDirect
Phenotypic Abnormality (PA)Subarachnoid hemorrhage0.00001364Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.002146Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.0191Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.2276Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0008207Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.001251Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007897Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0107Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2815Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4387Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.02221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1104Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1117Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1541Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.646Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.00002318InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0003311InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0008024InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.002338InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.009529InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.04692InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.06478InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.07429InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.08643InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.1671InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1786InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2842InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3203InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.6894InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.7952InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000007299Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digit development0.0001415Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001712Highly InformativeDirect
Mammalian Phenotype (MP)podocyte foot process effacement0.0002843Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lung lobe morphology0.0003027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0003069Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0004602Highly InformativeDirect
Mammalian Phenotype (MP)abnormal right lung morphology0.000501Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0007536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.005569Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.006169Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01212Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung development0.02997Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.05263Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.06353Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.181Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00533Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.009839Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.009846Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.04869Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.000003741Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.0000298Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00007767Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0000918Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0001465Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.0004013Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0000000394InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000001561InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002978InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.000005064InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00001503InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.0000001038Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0000005389Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000001761Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.02008Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.2172Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.01677Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02285Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02819Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2371Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.0002193InformativeDirect
Fly Anatomy (FA)anatomical space0.000636InformativeDirect
Fly Anatomy (FA)tracheal system0.001209InformativeInherited
Fly Anatomy (FA)epithelial tube0.001729InformativeInherited
Fly Anatomy (FA)primordium0.002032InformativeInherited
Fly Anatomy (FA)muscle system0.002438InformativeInherited
Fly Anatomy (FA)germline cyst0.01062InformativeInherited
Fly Anatomy (FA)gut section0.01394InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.01488InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.01957InformativeInherited
Fly Anatomy (FA)germline cell0.02324InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.03878InformativeInherited
Fly Anatomy (FA)muscle attachment site0.0000004444Highly InformativeDirect
Fly Anatomy (FA)embryonic foregut0.00000172Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.000008004Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.00001456Highly InformativeDirect
Fly Anatomy (FA)germ layer derivative0.00001595Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0000226Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0000322Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.00004436Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0.00004745Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8271Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8415Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2216InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Integrin domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]