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Tricorn protease domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Tricorn protease domain 2 [ 69322]
Families:   Tricorn protease domain 2 [ 69323]


Superfamily statistics
Genomes (939) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,357 11,888 2
Proteins 3,340 11,830 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.01012 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3113 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.0864 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2474 Least Informative Inherited
Biological Process (BP) biological regulation 0.182 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4338 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.023 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2896 Least Informative Inherited
Biological Process (BP) cellular component assembly 0.0001676 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0005025 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0006179 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.002161 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.0106 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.413 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02342 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.05799 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.001331 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.005452 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.07539 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.003847 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.006905 Moderately Informative Inherited
Biological Process (BP) gene expression 0.005187 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.02824 Moderately Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.0000001248 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000008432 Informative Direct
Biological Process (BP) organelle assembly 0.000001687 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00008632 Informative Direct
Biological Process (BP) microtubule-based process 0.0001297 Informative Direct
Biological Process (BP) intracellular protein transport 0.0006948 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0008349 Informative Direct
Biological Process (BP) cell projection assembly 0.00000003242 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000001018 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000007359 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.00165 Highly Informative Inherited
Molecular Function (MF) binding 0.5724 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2701 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000001259 Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.000000002077 Highly Informative Direct
Cellular Component (CC) macromolecular complex 0.000000001133 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00001337 Moderately Informative Direct
Cellular Component (CC) cilium 0.00000000001357 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.3585 Informative Inherited

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the tongue0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of refraction0InformativeDirect
Phenotypic Abnormality (PA)Growth delay0InformativeDirect
Phenotypic Abnormality (PA)Azotemia0InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0InformativeDirect
Phenotypic Abnormality (PA)Abnormal bone structure0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coordination0InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Respiratory tract infection0InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0InformativeDirect
Phenotypic Abnormality (PA)Myopia0Highly InformativeDirect
Phenotypic Abnormality (PA)Incoordination0Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated serum creatinine0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0.0000000002687InformativeDirect
Cellular componentCell projection0.0000000009493Moderately InformativeDirect
Cellular componentCilium0.00000902InformativeDirect
DomainRepeat0.00000000000001275Least InformativeDirect
DomainCoiled coil0.00009291Moderately InformativeDirect
DomainWD repeat0InformativeDirect
DomainTPR repeat0.000000008493Highly InformativeDirect
Post-translational modificationHydrolase0.7008Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000003805Moderately InformativeDirect
Post-translational modificationRNA-binding0.000001403Moderately InformativeDirect
Post-translational modificationProtease0.00002856Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0.000000001072InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tricorn protease domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Tricorn protease domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]