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Tricorn protease domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Tricorn protease domain 2 [ 69322]
Families:   Tricorn protease domain 2 [ 69323]


Superfamily statistics
Genomes (934) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,320 5,130 2
Proteins 3,304 5,105 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.5952 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01021 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4585 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.2874 Least Informative Inherited
Biological Process (BP) biological regulation 0.1025 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.4961 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.03764 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.364 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0.0005077 Moderately Informative Direct
Biological Process (BP) organelle organization 0.01164 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.0022 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.002694 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.003291 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.05065 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09237 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.2133 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.02522 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.01935 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.07905 Moderately Informative Inherited
Biological Process (BP) gene expression 0.005441 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.03808 Moderately Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.0004742 Informative Direct
Biological Process (BP) microtubule-based process 0.00015 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000008481 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.0000001169 Informative Direct
Biological Process (BP) organelle assembly 0.00002044 Informative Direct
Biological Process (BP) translational initiation 0.0000001673 Highly Informative Direct
Biological Process (BP) cell projection organization 0.00005896 Highly Informative Direct
Molecular Function (MF) binding 0.6477 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2462 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000001361 Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.000000003716 Highly Informative Direct
Cellular Component (CC) protein complex 0.000000000000001578 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00002293 Moderately Informative Direct
Cellular Component (CC) cilium 0.00000000001622 Informative Direct
Cellular Component (CC) cell projection part 0.0000696 Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the oral cavity0Moderately InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vertebral column0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal joint morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin adnexa0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the tongue0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of refraction0InformativeDirect
Phenotypic Abnormality (PA)Dermatological manifestations of systemic disorders0InformativeDirect
Phenotypic Abnormality (PA)Growth delay0InformativeDirect
Phenotypic Abnormality (PA)Azotemia0InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0InformativeDirect
Phenotypic Abnormality (PA)Abnormal bone structure0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of coordination0InformativeDirect
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Respiratory tract infection0InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0InformativeDirect
Phenotypic Abnormality (PA)Myopia0Highly InformativeDirect
Phenotypic Abnormality (PA)Incoordination0Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated serum creatinine0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0.000000000279InformativeDirect
Cellular componentCell projection0.0000000005555Moderately InformativeDirect
Cellular componentCilium0.00001005InformativeDirect
DomainRepeat0.000000000000004288Least InformativeDirect
DomainCoiled coil0.0001132Moderately InformativeDirect
DomainWD repeat0InformativeDirect
DomainTPR repeat0.000000009326Highly InformativeDirect
Molecular functionRNA-binding0.000001472Moderately InformativeDirect
Post-translational modificationHydrolase0.7016Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000003569Moderately InformativeDirect
Post-translational modificationProtease0.00002749Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0.000000001104InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tricorn protease domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Tricorn protease domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]