SUPERFAMILY 1.73 HMM library and genome assignments server


Galactose mutarotase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   Supersandwich [ 49993] (3)
  sandwich; 18 strands in 2 sheets
Superfamily:   Galactose mutarotase-like [ 74650] (11)
Families:   Aldose 1-epimerase (mutarotase) [ 74911] (2)
  Hypothetical protein HI1317 [ 89279]
  beta-Galactosidase, domain 5 [ 49995]
  Hyaluronate lyase-like, central domain [ 50006] (4)
  Glycosyltransferase family 36 N-terminal domain [ 63733] (2)
  overall domain organization is similar to Bacterial glucoamylase
  Bacterial glucoamylase N-terminal domain-like [ 82042] (2)
  overall domain organization is similar to Lactobacillus maltose phosphorylase
  4-alpha-glucanotransferase, C-terminal domain [ 89286]
  family 57 glycoside hydrolase; overall domain organization is similar to that of the alpha-mannosidase family
  alpha-mannosidase, C-terminal domain [ 88656] (2)
  family 38 glycoside hydrolase; overall domain organization is similar to that of the 4-alpha-glucanotransferase family
the supersandwich domain is elaborated with additional beta-strands and beta-sandwich subdomains
  MdoG-like [ 110148]
  Pfam 04349; Pfam coverage extends to the C-terminal immunoglobulin-like domain
  Rhamnogalacturonase B, RhgB, N-terminal domain [ 110151]
  YicI N-terminal domain-like [ 117139] (2)


Superfamily statistics
Genomes (999) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 6,516 6,279 55
Proteins 6,328 6,150 55


Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR011013 SSF74650 Protein matches
Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase [PubMed11907040]; domain 5 of beta-galactosidase ; the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC , xanthan lyase , chrondroitin ABC lyase I, and hyaluronate lyase itself [PubMed12829379]; the N-terminal domain of lactobacillus maltose phosphorylase and bacterial glucoamylase [PubMed11587643, PubMed12501412]; the C-terminal domain of eukaryotic alpha-mannosidase and archaeon 4-alpha-glucanotransferase [PubMed12618437].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose mutarotase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Galactose mutarotase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]