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Galactose mutarotase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Supersandwich [ 49993] (3)
Superfamily:   Galactose mutarotase-like [ 74650] (11)
Families:   Aldose 1-epimerase (mutarotase) [ 74911] (2)
  Hypothetical protein HI1317 [ 89279]
  beta-Galactosidase, domain 5 [ 49995]
  Hyaluronate lyase-like, central domain [ 50006] (4)
  Glycosyltransferase family 36 N-terminal domain [ 63733] (2)
  Bacterial glucoamylase N-terminal domain-like [ 82042] (2)
  4-alpha-glucanotransferase, C-terminal domain [ 89286]
  alpha-mannosidase, C-terminal domain [ 88656] (2)
  MdoG-like [ 110148]
  Rhamnogalacturonase B, RhgB, N-terminal domain [ 110151]
  YicI N-terminal domain-like [ 117139] (2)


Superfamily statistics
Genomes (2,559) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,252 82,896 56
Proteins 16,677 81,584 56


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.30710Least InformativeInherited
Biological Process (BP)primary metabolic process0.94450.001429Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0014870Moderately InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.000048150.00007714InformativeDirect
Molecular Function (MF)isomerase activity0.000000076790.0004583Moderately InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.00000000000091960.00000000000003326InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.000000000000048320Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.001429 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000005993 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00004248 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.0001826 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0005431 Moderately Informative Direct
Biological Process (BP) immune system process 0.7995 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.001038 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.001379 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1316 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.4704 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00007714 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000000009722 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0005101 Informative Direct
Biological Process (BP) pigment metabolic process 0.03974 Informative Inherited
Biological Process (BP) oligosaccharide metabolic process 0.000000000000198 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0.0000000000006108 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000000007566 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000001694 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.000006892 Highly Informative Direct
Biological Process (BP) pigmentation 0.00007911 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0002233 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000000000004924 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0004583 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.5531 Moderately Informative Inherited
Molecular Function (MF) racemase and epimerase activity 0.00000000000003326 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.00001608 Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.1367 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0000000007185 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001836 Informative Direct
Cellular Component (CC) periplasmic space 0.0000005333 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.02Least InformativeInherited
Enzyme Commission (EC)Lyases0.474Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.000000000000002098Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000472Highly InformativeDirect
Enzyme Commission (EC)Hyaluronate lyase0.0000004854Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000002008Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002708Moderately InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.5925Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.001209Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.001472Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.01276Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000000001355InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.0006765Least InformativeDirect
Drugbank ATC_code (DB)drugs used in diabetes0.000001314Moderately InformativeDirect
Drugbank ATC_code (DB)alpha glucosidase inhibitors0.000000000000524InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell wall biogenesis/degradation7.223e-16InformativeDirect
Biological processPolysaccharide degradation0.000000001022InformativeDirect
Cellular componentSecreted0.000000000000005451Moderately InformativeDirect
Cellular componentGolgi apparatus0.00006724Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentLysosome0.0000000000003339InformativeDirect
Cellular componentVacuole0.0001144InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000007375InformativeDirect
Molecular functionMagnesium0.0004184Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0.00003803Moderately InformativeDirect
Post-translational modificationLyase0.0003056Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation0.0000001848InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.4953Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)protein glycosylation0.000005731InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011013 SSF74650 Protein matches
Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase [PubMed11907040]; domain 5 of beta-galactosidase ; the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC , xanthan lyase , chrondroitin ABC lyase I, and hyaluronate lyase itself [PubMed12829379]; the N-terminal domain of lactobacillus maltose phosphorylase and bacterial glucoamylase [PubMed11587643, PubMed12501412]; the C-terminal domain of eukaryotic alpha-mannosidase and archaeon 4-alpha-glucanotransferase [PubMed12618437].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose mutarotase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Galactose mutarotase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]