SUPERFAMILY 1.75 HMM library and genome assignments server

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Galactose mutarotase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Supersandwich [ 49993] (3)
Superfamily:   Galactose mutarotase-like [ 74650] (11)
Families:   Aldose 1-epimerase (mutarotase) [ 74911] (2)
  Hypothetical protein HI1317 [ 89279]
  beta-Galactosidase, domain 5 [ 49995]
  Hyaluronate lyase-like, central domain [ 50006] (4)
  Glycosyltransferase family 36 N-terminal domain [ 63733] (2)
  Bacterial glucoamylase N-terminal domain-like [ 82042] (2)
  4-alpha-glucanotransferase, C-terminal domain [ 89286]
  alpha-mannosidase, C-terminal domain [ 88656] (2)
  MdoG-like [ 110148]
  Rhamnogalacturonase B, RhgB, N-terminal domain [ 110151]
  YicI N-terminal domain-like [ 117139] (2)


Superfamily statistics
Genomes (2,566) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,435 110,605 56
Proteins 16,850 107,326 56


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.02Least InformativeInherited
Enzyme Commission (EC)Lyases0.474Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.000000000000002098Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000472Highly InformativeDirect
Enzyme Commission (EC)Hyaluronate lyase0.0000004854Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000002008Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1072Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002847Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.1044InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.00008099Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.0694Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.0000003709Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.004503Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.02651Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases4.999e-16InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000001636InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011013 SSF74650 Protein matches
Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase [PubMed11907040]; domain 5 of beta-galactosidase ; the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC , xanthan lyase , chrondroitin ABC lyase I, and hyaluronate lyase itself [PubMed12829379]; the N-terminal domain of lactobacillus maltose phosphorylase and bacterial glucoamylase [PubMed11587643, PubMed12501412]; the C-terminal domain of eukaryotic alpha-mannosidase and archaeon 4-alpha-glucanotransferase [PubMed12618437].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose mutarotase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Galactose mutarotase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]