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Galactose mutarotase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Supersandwich [ 49993] (3)
Superfamily:   Galactose mutarotase-like [ 74650] (11)
Families:   Aldose 1-epimerase (mutarotase) [ 74911] (2)
  Hypothetical protein HI1317 [ 89279]
  beta-Galactosidase, domain 5 [ 49995]
  Hyaluronate lyase-like, central domain [ 50006] (4)
  Glycosyltransferase family 36 N-terminal domain [ 63733] (2)
  Bacterial glucoamylase N-terminal domain-like [ 82042] (2)
  4-alpha-glucanotransferase, C-terminal domain [ 89286]
  alpha-mannosidase, C-terminal domain [ 88656] (2)
  MdoG-like [ 110148]
  Rhamnogalacturonase B, RhgB, N-terminal domain [ 110151]
  YicI N-terminal domain-like [ 117139] (2)


Superfamily statistics
Genomes (2,564) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 17,363 88,109 56
Proteins 16,781 85,566 56


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.22820Least InformativeInherited
Biological Process (BP)primary metabolic process10.0063Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0018470Moderately InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.000059660.000001821InformativeDirect
Molecular Function (MF)isomerase activity0.00000011320.0002628Moderately InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.0000000000014110.000000000000001615InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.000000000000082960Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.0063 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9699 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0005243 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001446 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00002594 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000003985 Moderately Informative Direct
Biological Process (BP) immune system process 0.122 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5745 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.00575 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3995 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.000003706 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.000001821 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0008201 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000000000001094 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.04892 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.000002991 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000005599 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000000004405 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0.00001743 Highly Informative Direct
Biological Process (BP) pigmentation 0.0001564 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0002549 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000000001615 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0002628 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.6635 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000004237 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.000000000000001615 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.000002668 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9843 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1955 Least Informative Inherited
Cellular Component (CC) vacuole 0.0000000006111 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.00006679 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.02Least InformativeInherited
Enzyme Commission (EC)Lyases0.474Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.000000000000002098Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000472Highly InformativeDirect
Enzyme Commission (EC)Hyaluronate lyase0.0000004854Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000002008Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell wall biogenesis/degradation9.637e-16InformativeDirect
Biological processPolysaccharide degradation0.000000002587InformativeDirect
Cellular componentSecreted0.00000000000002168Moderately InformativeDirect
Cellular componentGolgi apparatus0.00001789Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentLysosome0.000000000000853InformativeDirect
Cellular componentVacuole0.0009045InformativeDirect
Cellular componentCell wall0.0006454Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000001385InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0.00004323Moderately InformativeDirect
Post-translational modificationLyase0.0005441Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation0.0000004194InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011013 SSF74650 Protein matches
Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase [PubMed11907040]; domain 5 of beta-galactosidase ; the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC , xanthan lyase , chrondroitin ABC lyase I, and hyaluronate lyase itself [PubMed12829379]; the N-terminal domain of lactobacillus maltose phosphorylase and bacterial glucoamylase [PubMed11587643, PubMed12501412]; the C-terminal domain of eukaryotic alpha-mannosidase and archaeon 4-alpha-glucanotransferase [PubMed12618437].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose mutarotase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Galactose mutarotase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]