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Galactose mutarotase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Supersandwich [ 49993] (3)
Superfamily:   Galactose mutarotase-like [ 74650] (11)
Families:   Aldose 1-epimerase (mutarotase) [ 74911] (2)
  Hypothetical protein HI1317 [ 89279]
  beta-Galactosidase, domain 5 [ 49995]
  Hyaluronate lyase-like, central domain [ 50006] (4)
  Glycosyltransferase family 36 N-terminal domain [ 63733] (2)
  Bacterial glucoamylase N-terminal domain-like [ 82042] (2)
  4-alpha-glucanotransferase, C-terminal domain [ 89286]
  alpha-mannosidase, C-terminal domain [ 88656] (2)
  MdoG-like [ 110148]
  Rhamnogalacturonase B, RhgB, N-terminal domain [ 110151]
  YicI N-terminal domain-like [ 117139] (2)


Superfamily statistics
Genomes (2,563) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 17,357 82,896 56
Proteins 16,775 81,584 56


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process10.00774Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.21030Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0016720Moderately InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.000054910.0000293InformativeDirect
Molecular Function (MF)isomerase activity0.000000098190.0007736Moderately InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.0000000000011610.00000000000005222InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.00000000000006570Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00774 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8647 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0005508 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00001154 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00005064 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000000008743 Moderately Informative Direct
Biological Process (BP) immune system process 0.09817 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.004012 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.5337 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3558 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.000002544 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000293 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0005724 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000000000002408 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.04312 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.001344 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.000002675 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000003906 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000000002211 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0.000009715 Highly Informative Direct
Biological Process (BP) pigmentation 0.0001224 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.0002272 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000000000000004806 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.0007736 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.6269 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000003338 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.00000000000005222 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.000004191 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9649 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1881 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.00006174 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.02Least InformativeInherited
Enzyme Commission (EC)Lyases0.474Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.000000000000002098Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Alpha-mannosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Rhamnogalacturonan endolyase0.000000000000472Highly InformativeDirect
Enzyme Commission (EC)Hyaluronate lyase0.0000004854Highly InformativeDirect
Enzyme Commission (EC)Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase0.000002008Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1076Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002854Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.1047InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.00008067Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.05018Least InformativeInherited
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.0000001884Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.003215Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.02041Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases2.486e-16InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00000000801InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell wall biogenesis/degradation7.253e-16InformativeDirect
Biological processPolysaccharide degradation0.000000001664InformativeDirect
Cellular componentSecreted0.000000000000007068Moderately InformativeDirect
Cellular componentGolgi apparatus0.00007336Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentLysosome0.0000000000007351InformativeDirect
Cellular componentCell wall0.0006986Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000008066InformativeDirect
Molecular functionMagnesium0.0008046Least InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0.0000358Moderately InformativeDirect
Post-translational modificationLyase0.0004144Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationSulfation0.0000003563InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0.4898Least InformativeInherited
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)protein glycosylation0.000006562InformativeDirect
UniPathway (UP)beta-glucan biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011013 SSF74650 Protein matches
Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase [PubMed11907040]; domain 5 of beta-galactosidase ; the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC , xanthan lyase , chrondroitin ABC lyase I, and hyaluronate lyase itself [PubMed12829379]; the N-terminal domain of lactobacillus maltose phosphorylase and bacterial glucoamylase [PubMed11587643, PubMed12501412]; the C-terminal domain of eukaryotic alpha-mannosidase and archaeon 4-alpha-glucanotransferase [PubMed12618437].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Galactose mutarotase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the Galactose mutarotase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]