SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (508) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,129 17,538 6
Proteins 7,008 17,323 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.04912Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.001864Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.003576Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0002048InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01734InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.2522InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.0001032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.0003357Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.000005748Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0005542Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002923Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.0000000032Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000009198Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00003565Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00005607Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0019Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.002229Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.000000001279InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.000000007893InformativeDirect
Worm Phenotype (WP)apoptosis increased0.00000000004261Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000002413Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00001144Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01404Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.417Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5593Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7475Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00000004705InformativeDirect
Plant ANatomical entity (PAN)root tip0.000002408InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0000722InformativeDirect
Plant ANatomical entity (PAN)primordium0.000179InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.000004253Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.00005301Highly InformativeDirect
Plant ANatomical entity (PAN)root stele0.00005452Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.000102Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05805Highly InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]