SUPERFAMILY 1.75 HMM library and genome assignments server

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Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (508) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,129 17,538 6
Proteins 7,008 17,323 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.04911Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.001865Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.003577Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0002049InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01735InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.2522InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.0001033Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.0003359Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00000656Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0005714Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003004Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.000000003883Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000009244Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.00003523Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.000062Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.001891Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.002236Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.000000001248InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.000000007854InformativeDirect
Worm Phenotype (WP)apoptosis increased0.00000000004336Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.00000238Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00001078Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01409Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.4171Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5597Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7477Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00000004726InformativeDirect
Plant ANatomical entity (PAN)root tip0.000002419InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.00007253InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001798InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.000004274Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.00005329Highly InformativeDirect
Plant ANatomical entity (PAN)root stele0.0000548Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001025Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05833Highly InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]